期刊
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
卷 60, 期 5, 页码 1225-1233出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2012.2230631
关键词
Capsule colonoscopy; CRC screening; robotic capsules; wireless capsule endoscopy; wireless insufflation
资金
- Vanderbilt University
- Center for Compact and Efficient Fluid Power [0540834]
- National Center for Advancing Translational Sciences [2 UL1 TR000445-06]
- National Science Foundation [IIS-1054331]
- Graduate Research Fellowship
Despite clear patient experience advantages, low specificity rates have thus far prevented swallowable capsule endoscopes from replacing traditional endoscopy for diagnosis of colon disease. One explanation for this is that capsule endoscopes lack the ability to provide insufflation, which traditional endoscopes use to distend the intestine for a clear view of the internal wall. To provide a means of insufflation from a wireless capsule platform, in this paper we use biocompatible effervescent chemical reactions to convert liquids and powders carried onboard a capsule into gas. We experimentally evaluate the quantity of gas needed to enhance capsule visualization and locomotion, and determine how much gas can be generated from a given volume of reactants. These experiments motivate the design of a wireless insufflation capsule, which is evaluated in ex vivo experiments. These experiments illustrate the feasibility of enhancing visualization and locomotion of endoscopic capsules through wireless insufflation.
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