Article
Chemistry, Analytical
Raviraj Thakur, Felix P. Aplin, Gene Y. Fridman
Summary: The study developed a silicone-based nerve cuff lead for stimulating and recording nerves, providing greater spatial separation and reversible nerve block through the delivery of direct current. Unlike most metallic electrodes, this cuff was manufactured using consumer-grade equipment, making it a cost-effective solution for neuro modulation experiments.
Article
Materials Science, Multidisciplinary
Samuel Lienemann, Mary J. Donahue, Johan Zotterman, Simon Farnebo, Klas Tybrandt
Summary: Bioelectronic medicine is a promising approach for treating diseases and disorders by electrically stimulating peripheral nerves. This paper presents the development of a soft and stretchable multielectrode cuff that can achieve selective nerve stimulation. The device is made of silicone with embedded gold nanowire conductors, allowing it to be functional even under strain.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Nanoscience & Nanotechnology
Mei Yu, Changxian Wang, Huanqing Cui, Jianping Huang, Qianhengyuan Yu, Ping Wang, Chao Huang, Guanglin Li, Yang Zhao, Xuemin Du, Zhiyuan Liu
Summary: We propose a self-closing stretchable cuff electrode that can close onto tissue bundles after dropping water. The curliness is achieved by the mechanical stress mismatch between different layers of the elastic substrate. The material of the substrate can be selected to match the modulus of the target tissue to achieve minimal constraint on the tissue. In vivo testing with rat's sciatic nerve stimulation and electromyographic signal monitoring for 1 month demonstrates the excellent conformity of our proposed electrode to the curved surface of biological tissue.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Neurosciences
J. R. Nadeau, B. M. Arnold, J. M. Johnston, G. D. Muir, V. M. K. Verge
Summary: Brief electrical stimulation (ES) or acute intermittent hypoxia (AIH) treatment during surgical repair can enhance the regeneration of injured peripheral nerves by influencing the expression of regeneration-associated genes (RAG). These treatments lead to significant improvements in growth indicators and functional recovery, showing promising potential for non-invasive therapies in nerve regeneration.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Engineering, Biomedical
Carrie A. Kubiak, Shelby R. Svientek, Amir Dehdashtian, Nathan G. Lawera, Vidhya Nadarajan, Jarred Bratley, Theodore A. Kung, Paul S. Cederna, Stephen W. P. Kemp
Summary: The muscle cuff regenerative peripheral nerve interface (MC-RPNI) can amplify efferent motor action potentials from intact nerves by several magnitudes without negatively impacting distal muscle function.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Ryan B. Budde, Michael T. Williams, Pedro P. Irazoqui
Summary: Electrical neuromodulation is an effective therapy for neurological disorders. Temporal interference stimulation has gained attention as a method to improve neurostimulation. This study investigated the neuronal response to interferential signals and found that neurons do not extract envelopes and the response can be explained by a resistor-capacitor membrane with a fixed firing threshold.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Biophysics
Rongyu Tang, Chenglin Zhang, Bingxin Liu, Chanyuan Jiang, Lei Wang, Xuerui Zhang, Qiang Huang, Jing Liu, Lei Li
Summary: A fluidic cuff electrode using gallium-based liquid metal conductor has been developed as an artificial peripheral nerve device. The LM cuff electrode has high flexibility and conductivity. It has been shown to maintain long-term effectiveness in transmitting nerve signals and triggering event-related potentials.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Clinical Neurology
Lawrence R. Robinson
Summary: This article reviews the epidemiology, classification, localization, prognosis, and mechanisms of recovery of traumatic peripheral nerve injuries (PNIs). Electrodiagnostic assessments are critical in treating patients with PNIs, as they aid in localizing the injury and determining the extent of axon loss. Mechanisms of recovery may include recovery from conduction block, muscle fiber hypertrophy, distal axonal sprouting, and axon regrowth. Early surgical intervention is recommended for patients with complete or severe nerve injuries.
Review
Environmental Sciences
Wolfgang Grisold, Valentina Alda Carozzi
Summary: Toxic neuropathies are caused by various substances through different mechanisms, with a wide range of toxic agents that can affect the nervous system in different ways. Clinically, the most common type is cumulative toxicities, presenting as axonal symmetric neuropathies.
Article
Clinical Neurology
Stewart Yeoh, Wesley S. Warner, Ilyas Eli, Mark A. Mahan
Summary: The study compared different types of nerve injuries in mice and found that closed traction injuries resulted in more severe and long-term neurological deficits compared to other types of injuries. This suggests that stretch injuries present unique pathology and functional deficits, providing an opportunity to study the pathophysiology of clinical injury mechanisms. Further validation in large animal models will be needed for comparison with human injuries.
JOURNAL OF NEUROSURGERY
(2021)
Article
Engineering, Biomedical
Boris Botzanowski, Mary J. Donahue, Malin Silvera Ejneby, Alessandro L. Gallina, Ibrahima Ngom, Florian Missey, Emma Acerbo, Donghak Byun, Romain Carron, Antonino M. Cassara, Esra Neufeld, Viktor Jirsa, Peder S. Olofsson, Eric Daniel Glowacki, Adam Williamson
Summary: This study demonstrates the technique of temporal interference nerve stimulation (TINS), which allows noninvasive stimulation of deep peripheral nerves without the need for surgically implanted devices. TINS can achieve effective activation at lower current amplitudes compared to standard transcutaneous electrical stimulation, and precise alignment of stimulation can be achieved using flexible and conformable on-skin multielectrode arrays. This research has important clinical implications and potential applications.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Qi Quan, Lei Hong, Yu Wang, Rui Li, Xin Yin, Xiaoqing Cheng, Guangbo Liu, He Tang, Haoye Meng, Shuyun Liu, Quanyi Guo, Biqin Lai, Qing Zhao, Min Wei, Jiang Peng, Peifu Tang
Summary: Hypoxia in damaged tissues may play a key role in stimulating macrophages, promoting endothelial-to-mesenchymal transition, and driving the migration of endothelial cells to the injured region to form regenerative bridge tissue. The final nerve defect repair outcomes were similar with autografts after intervention by this material, challenging the view that hypoxia is exclusively involved in peripheral nerve regeneration.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kanav Goyal, Purnima Aggarwal, Monica Gupta
Summary: This study compared the CSA of the sural and tibial nerves in diabetic peripheral neuropathy patients, finding that the CSA of the tibial nerve had higher sensitivity in the DPN group for screening purposes. Ultrasound can be used as the initial diagnostic tool for detecting DPN, especially in cases where nerve conduction studies are negative.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Anesthesiology
Graeme A. McLeod, Alistair Cowie, Amy Sadler, Fiona Watson, Paul Wasik, Miguel Angel Reina
Summary: Using 40 MHz ultrasound, the study aimed to accurately locate the needle tip and measure injection pressure in different tissue layers. Needle tip position was not discernible, but injection compartments in the circumneurium and subcircumneural were observed.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Behavioral Sciences
Alison M. Luckey, Katherine Adcock, Sven Vanneste
Summary: Recent technological improvements have opened up new possibilities for innovative discoveries in research. There is growing interest in peripheral nerve stimulation, particularly the vagus, trigeminal, or greater occipital nerve, due to their involvement in higher cognitive processes. This opinion piece suggests that the effects of transcutaneous electrical stimulation may be influenced by the interaction of multiple neuromodulatory networks, and calls for further consideration of these networks in future research.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Acoustics
Martin Andersen, Cooper Moore, Peter Sogaard, Daniel Friedman, Brett D. Atwater, Kristine Arges, Melissa LeFevre, Johannes J. Struijk, Joseph Kisslo, Samuel E. Schmidt, Olaf T. von Ramm
ULTRASOUND IN MEDICINE AND BIOLOGY
(2019)
Article
Medicine, General & Internal
Christoffer Polcwiartek, Kristian Kragholm, Daniel J. Friedman, Brett D. Atwater, Claus Graff, Jonas B. Nielsen, Anders G. Holst, Johannes J. Struijk, Adrian Pietersen, Jesper H. Svendsen, Lars Kober, Peter Sogaard, Svend E. Jensen, Christian Torp-Pedersen, Steen M. Hansen
AMERICAN JOURNAL OF MEDICINE
(2020)
Article
Sport Sciences
Kasper Sorensen, Mathias Krogh Poulsen, Dan Stieper Karbing, Peter Sogaard, Johannes Jan Struijk, Samuel Emil Schmidt
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2020)
Article
Biochemical Research Methods
Lars Stumpp, Hugo Smets, Simone Vespa, Joaquin Cury, Pascal Doguet, Jean Delbeke, Emmanuel Hermans, Christian Sevcencu, Thomas N. Nielsen, Antoine Nonclercq, Riem El Tahry
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Biophysics
Kim Munck, Kasper Sorensen, Johannes J. Struijk, Samuel E. Schmidt
PHYSIOLOGICAL MEASUREMENT
(2020)
Article
Acoustics
Martin S. Andersen, Cooper Moore, Melissa Lefevre, Kristine Arges, Daniel J. Friedman, Brett D. Atwater, Joseph Kisslo, Peter Sogaard, Johannes J. Struijk, Olaf T. von Ramm, Samuel E. Schmidt
ULTRASOUND IN MEDICINE AND BIOLOGY
(2020)
Correction
Multidisciplinary Sciences
Kasper Sorensen, Samuel E. Schmidt, Ask S. Jensen, Peter Sogaard, Johannes J. Struijk
SCIENTIFIC REPORTS
(2020)
Article
Biophysics
Bjarke Skogstad Larsen, Simon Winther, Louise Nissen, Axel Diederichsen, Morten Bottcher, Johannes Jan Struijk, Mads Graesboll Christensen, Samuel Emil Schmidt
Summary: This study aimed to find spectral differences in heart sound recordings between patients with coronary artery disease (CAD) and healthy subjects. Analysis revealed increased energy at certain frequencies in the diastole and systole segments of CAD patients, as well as differences in the mid-S1 and mid-S2 segments. The time-frequency spectra of S1 and S2 segments indicated potential for untapped information for risk assessment of CAD using phonocardiography.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Chemistry, Analytical
Felipe Rettore Andreis, Benjamin Metcalfe, Taha Al Muhammadee Janjua, Winnie Jensen, Suzan Meijs, Thomas Gomes Norgaard dos Santos Nielsen
Summary: The VSR technique can improve the classification of neural traffic and enhance the performance of neural prostheses and bioelectronic medicine applications.
Article
Neurosciences
Taha Al Muhammadee Janjua, Thomas Gomes Norgaard dos Santos Nielsen, Felipe Rettore Andreis, Suzan Meijs, Winnie Jensen
Summary: This study successfully utilized Danish Landrace pigs as subjects for the LTP-like pain model, demonstrating the impact of HFS on the cortical response in S1. The results indicate that this pain model can be effectively implemented in pigs.
IBRO NEUROSCIENCE REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Samuel Emil Schmidt, Lene Helleskov Madsen, John Hansen, Henrik Zimmermann, Henning Kelbaek, Simon Winter, Dorte Hammershoi, Egon Toft, Johannes Jan Struijk, Peter Clemmensen
Summary: This study developed a computerized acoustic CAD-score based on heart sounds for the non-invasive detection of coronary artery disease (CAD). The CAD-score showed significant differences between CAD and non-CAD patients, and had a moderate diagnostic performance in the validation group.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2022)
Article
Biophysics
Kasper Sorensen, Peter Sogaard, Kasper Emerek, Ask Schou Jensen, Johannes Jan Struijk, Samuel Emil Schmidt
Summary: Conduction-induced heart failure patients with left bundle branch block can benefit from cardiac resynchronization therapy. Pacing-induced changes in the seismocardiogram (SCG) can be used to detect cardio-mechanic changes, but interpreting the SCG in patients remains challenging.
PHYSIOLOGICAL MEASUREMENT
(2022)
Article
Anatomy & Morphology
Felipe Rettore Andreis, Benjamin Metcalfe, Taha Al Muhammadee Janjua, Valeria Paula Sassoli Fazan, Winnie Jensen, Suzan Meijs, Thomas Gomes Norgaard dos Santos Nielsen
Summary: This study investigated the morphological characteristics of the Ulnar Nerve (UN) in pigs and found that the proximal segment of the UN had a larger diameter and a higher number of fascicles compared to the distal segment and the dorsal cutaneous branch (DCBUN). Additionally, the mean fascicle diameter was smaller at the DCBUN compared to the other segments.
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Taha Al Muhammadee Janjua, Thomas Gomes Norgaard dos Santos Nielsen, Felipe Rettore Andreis, Suzan Meijs, Winnie Jensen
Summary: This study investigated changes in the spike activity in the primary somatosensory cortex of Danish landrace pigs in response to LTP-like neuroplasticity induced by high-frequency electrical stimulation. The results showed a significant increase in cortical excitability after intervention, highlighting the potential for developing a translational, large-animal model of LTP-like pain.
2023 11TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING, NER
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Felipe Rettore Andreis, Benjamin Metcalfe, Taha Al Muhammadee Janjua, Valeria Paula Sassoli Fazan, Winnie Jensen, Suzan Meijs, Thomas Gomes Norgaard dos Santos Nielsen
Summary: This study measured the perineurium thickness in the ulnar nerve of pigs and found that the thickness was influenced by the location of the nerve section. Equations were provided to estimate the perineurium thickness based on the fascicle diameter, which can be used to develop more realistic peripheral nerve models and improve the selectivity and reliability of neural interfaces.
2023 11TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING, NER
(2023)