期刊
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
卷 3, 期 5, 页码 267-276出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBCAS.2009.2023511
关键词
Baseline cancellation; chemiresistor; sensor array microsystem; volatile organic compounds
Chemiresistor (CR) sensors and sensor arrays coated with thiolate-monolayer-protected gold nanoparticle (MPN) interfaces show great promise as detectors in gas-chromatographic microsystems with applications in biomedical and environmental analysis including breath biomarkers of disease. This paper describes a new readout circuit that overcomes the wide range of baseline resistances and drift in baseline values inherent to MPN-coated CRs to achieve a 57 ppm readout resolution. The 0.5-mu m CMOS circuit operates at 5 V and provides a response resolution of 74 mu V. It can cancel baseline voltages from 0.3 to 4.3 V with an accuracy of 4.2 mV and can track and compensate for drifts up to 30 mV/min. Performance was verified with MPN-coated CRs, where drift was measured and effectively cancelled. The circuit topology and size support an on-chip MPN-coated CR sensor array.
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