Article
Veterinary Sciences
Ram Das, Kapil Vashisht, Kailash C. Pandey
Summary: A novel multiplex qPCR assay was developed to detect non-human malaria parasites in Indian populations at risk. The assay showed high specificity and sensitivity, making it a valuable tool for mass screening and surveillance programs, aiming to control and eliminate malaria from India by 2030.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Letter
Public, Environmental & Occupational Health
Chaturong Putaporntip, Chew Weng Cheng, Rattanaporn Rojrung, Napaporn Kuamsab, Somchai Jongwutiwes
Summary: Emerging zoonotic malaria caused by Plasmodium knowlesi, Plasmodium cynomolgi and Plasmodium inui has been observed in humans in Thailand over the past decade. The diagnosis of non-human primate malaria in ecotourists is difficult and requires molecular diagnostic techniques.
JOURNAL OF TRAVEL MEDICINE
(2023)
Review
Public, Environmental & Occupational Health
Spinello Antinori, Cecilia Bonazzetti, Andrea Giacomelli, Mario Corbellino, Massimo Galli, Carlo Parravicini, Anna Lisa Ridolfo
Summary: Research on non-human primate malaria parasites has increased our understanding of the biology and origins of human malaria. The discovery that some NHP malaria parasites can be transmitted to humans raises concerns about controlling human malaria, while advancements in molecular techniques have enhanced our knowledge of the diversity and distribution of these parasites and their relationship with human malaria.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Microbiology
Franziska Mohring, Donelly A. van Schalkwyk, Ryan C. Henrici, Benjamin Blasco, Didier Leroy, Colin J. Sutherland, Robert W. Moon
Summary: Several unrelated antimalarial compounds targeting PfATP4 have lower efficacy against other malaria parasite species infecting humans. By replacing the ATP4 genes in P. knowlesi with orthologues from different species, researchers found significant differences in susceptibility to ATP4 inhibitors among the parasites. This study highlights the importance of developing antimalarials that can effectively target all human malaria parasite species.
Article
Public, Environmental & Occupational Health
Huma Aftab, Michael Kemp, Christen R. Stensvold, Henrik V. Nielsen, Marie M. Jakobsen, Anders Porskrog, Ram B. Dessau
Summary: Plasmodium knowlesi is an emerging infection in the Southeast Asian region, especially in Sabah, Malaysia, and is the main cause of reported malaria cases. However, imported P. knowlesi infection is rarely seen in Europe. We report a case of P. knowlesi infection in a Danish woman returning from a short trip to Malaysian Borneo. Although microscopy revealed 0.8% infected erythrocytes, molecular methods were used for conclusive species identification due to atypical morphological presentation.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Immunology
Seong-Kyun Lee, Tuyet Kha Nguyen, Franziska Mohring, Jin-Hee Han, Egy Rahman Firdaus, Sung-Hun Na, Won-Sun Park, Robert W. Moon, Eun-Taek Han
Summary: This study investigated the function of Plasmodium knowlesi merozoite surface protein 1 paralog (PkMSP1P) through recombinant protein and gene editing techniques. The results demonstrated that PkMSP1P is involved in the in vitro growth of P. knowlesi, playing a distinct role from PkMSP1. Additionally, the study revealed immune cross-reactivity between PkMSP1P-19 antibodies and PkMSP1-19.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Parasitology
Noorazian Md Yusuf, Jannah Zulkefli, Adela Ida Jiram, Indra Vythilingam, Shamilah Hisam, Renuka Devi, Afiqah Salehhuddin, Nurulshuhada Md Ali, Maccallyster Isa, Norwahida Alias, Nurhainis Ogu Salim, Adli Abd Aziz, Lokman Hakim Sulaiman
Summary: This study investigated the distribution of simian Plasmodium infections among long-tailed macaques in Malaysia. The results showed that P. cynomolgi infection was the most prevalent, and the infection rates of P. cynomolgi and P. knowlesi were highest in areas with close human-macaque contact. The risk of zoonotic infection in these areas needs to be addressed and preventive measures should be taken.
Article
Chemistry, Medicinal
Ilaria D'Agostino, Susi Zara, Simone Carradori, Viviana De Luca, Clemente Capasso, Clemens H. M. Kocken, Anne-Marie Zeeman, Andrea Angeli, Fabrizio Carta, Claudiu T. Supuran
Summary: The hybrid compounds synthesized in this study, which combine the Artesunate core with a sulfonamide moiety, showed high inhibition potency against the protozoan PfCA, while exhibiting low cytotoxic effects on human cells, indicating a wide therapeutic window.
Article
Immunology
Mariko S. Peterson, Chester J. Joyner, Stacey A. Lapp, Jessica A. Brady, Jennifer S. Wood, Monica Cabrera-Mora, Celia L. Saney, Luis L. Fonseca, Wayne T. Cheng, Jianlin Jiang, Stephanie R. Soderberg, Mustafa Nural, Allison Hankus, Deepa Machiah, Ebru Karpuzoglu, Jeremy D. DeBarry, Rabindra Tirouvanziam, Jessica C. Kissinger, Alberto Moreno, Sanjeev Gumber, Eberhard O. Voit, Juan B. Gutierrez, Regina Joice Cordy, Mary R. Galinski
Summary: This study provides a comprehensive analysis of P. knowlesi infections in rhesus monkeys, showing a higher parasite burden and extensive margination in the gastrointestinal tissues, which may explain the gastrointestinal symptoms frequently reported by patients with P. knowlesi malaria infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Parasitology
Ibrahim Bin Said, Yobouet Ines Kouakou, Roukayatou Omorou, Anne-Lise Bienvenu, Kamruddin Ahmed, Richard Culleton, Stephane Picot
Summary: The planned capital relocation in Indonesia may increase the risks of deforestation, decreased biodiversity, and the emergence of zoonotic infections like Plasmodium knowlesi malaria. Based on our analysis, the main vectors of P. knowlesi are present in the area of the future capital, emphasizing the need for strengthened surveillance. We reported 545 documented cases of P. knowlesi in Indonesia, mostly occurring in the last 4 years.
PARASITES & VECTORS
(2022)
Article
Infectious Diseases
Sri Riyati Sugiarto, J. Kevin Baird, Balbir Singh, Iqbal Elyazar, Timothy M. E. Davis
Summary: Kalimantan, a part of Indonesia, has low and stable transmission of malaria except for the province of East Kalimantan. Recent deforestation and potential exposure to zoonotic malaria differentiate it from other parts of Indonesia. This review examines the history and current epidemiology of malaria in Kalimantan, including control efforts, mosquito vector prevalence, anti-malarial use, and the presence of knowlesi malaria.
Review
Infectious Diseases
Wenn-Chyau Lee, Fei Wen Cheong, Amirah Amir, Meng Yee Lai, Jia Hui Tan, Wei Kit Phang, Shahhaziq Shahari, Yee-Ling Lau
Summary: This article reviews recent studies on Plasmodium knowlesi, a zoonotic malaria parasite, summarizing key information and discussing knowledge gaps in research. It also describes the challenges and strategies required to control and eradicate this potentially fatal zoonosis.
Article
Immunology
Chaturong Putaporntip, Napaporn Kuamsab, Urassaya Pattanawong, Surasuk Yanmanee, Sunee Seethamchai, Somchai Jongwutiwes
Summary: Among symptomatic malaria patients in Thailand, a study found a prevalence of Plasmodium cynomolgi co-infection with P. vivax, P. falciparum, or P. knowlesi, suggesting its widespread distribution in the country.
EMERGING INFECTIOUS DISEASES
(2021)
Review
Immunology
Benoit Gamain, Arnaud Chene, Nicola K. Viebig, Nicaise Tuikue Ndam, Morten A. Nielsen
Summary: Adults in malaria endemic areas usually acquire clinical immunity against malaria, but pregnant women, especially during their first pregnancies, are susceptible to placental malaria. Placental malaria is characterized by the accumulation of P. falciparum-infected erythrocytes and monocytes in the placenta, leading to maternal anaemia, hypertension, and fetal growth retardation. However, the prevalence of placental malaria decreases significantly with successive pregnancies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Andre Barateiro, Alexsander Rodrigues Carvalho Junior, Sabrina Epiphanio, Claudio Romero Farias Marinho
Summary: Malaria is a significant health burden for populations in developing countries, particularly affecting pregnant women. The inflammation caused by P. falciparum sequestration in the placenta leads to changes in the organ, disrupting local homeostasis. These events are associated with poor gestational outcomes, such as growth restriction and premature delivery. However, the molecular mechanisms governing these outcomes are still poorly understood.
FRONTIERS IN IMMUNOLOGY
(2022)
Meeting Abstract
Infectious Diseases
F. I. Onditi
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2016)
Meeting Abstract
Infectious Diseases
J. M. O. Oduor, W. Nyamongo Onkoba, F. Maloba, W. Ouma Arodi, A. Nyachieo, F. I. Onditi
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2016)
Article
Biotechnology & Applied Microbiology
Esperance Umumararungu, Fabien Ntaganda, John Kagira, Naomi Maina
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Biotechnology & Applied Microbiology
Adele Nyambura Njuguna, John Maina Kagira, Simon Muturi Karanja, Maina Ngotho, Lucy Mutharia, Naomi Wangari Maina
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Pharmacology & Pharmacy
Francisca Kama-Kama, Leonidah K. Omosa, Joseph Nganga, Naomi Maina, Georges Osanjo, Souaibou Yaouba, Muhammad Ilias, Jacob Midiwo, Jan Naessens
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Veterinary Sciences
Maloba Fredrick, Mwangi Danson, Kagira John, Kivai Stanislaus, Ndeereh David, Ngotho Maina, Gicheru Michael, Mbaruk Suleiman, Akinyi Mercy
Summary: The study investigated the presence of zoonotic gastrointestinal helminths in olive baboons at the human-wildlife interface in Kenya, finding varying prevalence rates of parasites. Baboons can serve as a potential source of zoonotic transmission to humans, highlighting the need for measures to reduce interactions and control infections in baboons.
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Ahmota Romain Daiba, John Maina Kagira, Maina Ngotho, James Kimotho, Naomi Maina
Summary: This study investigated the in vitro anticoccidial activity of encapsulated bromelain in chitosan nanocarriers. The results showed that bromelain exhibited anticoccidial activity by inhibiting the sporulation of coccidia oocysts.
Article
Public, Environmental & Occupational Health
Julius I. N. Sombie, John Kagira, Naomi Maina
Summary: A high prevalence of Staphylococcus spp. and Escherichia coli, along with multidrug resistance, was found in milk products sold in Juja Sub-County, Kenya. Proper handling and processing of milk are crucial to reducing the zoonotic transfer of multidrug-resistant bacteria.
JOURNAL OF TROPICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Kate Obaayaa Sagoe, Mutinda Cleophas Kyama, Naomi Maina, Moses Kamita, Muturi Njokah, Kelvin Thiong'o, Bernard N. Kanoi, Ernest Apondi Wandera, Davies Ndegwa, Dickson Mwenda Kinyua, Jesse Gitaka
Summary: This study presents a proof of concept for using hybridization chain reaction (HCR) and clustered regularly interspaces short palindromic repeats (CRISPR)/Cas12a complex to detect SARS-CoV-2. The results show the comparative efficiency of HCR to RT-PCR, indicating that HCR and CRISPR are viable alternatives for diagnosing SARS-CoV-2 in samples.
Correction
Veterinary Sciences
Jean de Dieu Baziki, S. Charles Bodjo, Nick Nwankpa, Naomi Maina, Ethel Chitsungo, Cisse Rahamatou Moustapha Boukary, A. Takele Tefera, Rume Veronica Nwankpa, Nduta Mwangi
VETERINARY MEDICINE INTERNATIONAL
(2021)
Article
Clinical Neurology
Queensley Eghianruwa, Omolaja Osoniyi, Naomi Maina, Sabina Wachira, Mabel Imbuga
JOURNAL OF PAIN RESEARCH
(2020)
Article
Agriculture, Dairy & Animal Science
Irene Mkavi Okoko, Naomi Maina, Daniel Kiboi, John Kagira
Article
Agriculture, Dairy & Animal Science
Shukuru Wasso, Naomi Maina, John Kagira
Article
Veterinary Sciences
Baziki Jean de Dieu, Bodjo S. Charles, Nick Nwankpa, Ethel Chitsungo, Cisse Rahamatou Moustapha Boukary, Naomi Maina, Takele A. Tefera, Rume Veronica Nwankpa, Nduta Mwangi, Yao Mathurin Koffi
VETERINARY SCIENCES
(2019)
Article
Parasitology
Maxwell W. Waema, Naomi W. Maina, Maina Ngotho, Simon M. Karanja, Beatrice M. Gachie, Dawn N. Maranga, John M. Kagira