The microstructural correlates of T1 in white matter

PurposeSeveral studies have shown strong correlations between myelin content and T-1 within the brain, and have even suggested that T-1 can be used to estimate myelin content. However, other micro-anatomical features such as compartment size are known to affect longitudinal relaxation rates, similar to compartment size effects in porous media. MethodsT(1) measurements were compared with measured or otherwise published axon size measurements in white matter tracts of the rat spinal cord, rat brain, and human brain. ResultsIn both ex vivo and in vivo studies, correlations were present between the relaxation rate 1/T-1 and axon size across regions of rat spinal cord with nearly equal myelin content. ConclusionWhile myelination is likely the dominant determinant of T-1 in white matter, variations in white matter microstructure, independent of myelin volume fraction, may also be reflected in T-1 differences between regions or subjects. Magn Reson Med 75:1341-1345, 2016. (c) 2015 Wiley Periodicals, Inc.