Article
Nanoscience & Nanotechnology
Qiuquan Cai, Jiahong Jiang, Hongjie Zhang, Pengfei Ge, Liu Yang, Weipu Zhu
Summary: A PTX-loaded nanodrug was prepared through self-assembly of PTX and an amphiphilic PEG derivative, showing good biocompatibility and selective drug release under intratumor reducing conditions. This nanodrug has potential for delivering hydrophobic drugs to treat malignant tumors with prolonged circulation time and excellent antitumor efficacy in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Wasana Nonkrathok, Tatiya Trongsatitkul, Nitinat Suppakarn
Summary: In this study, the shape memory properties of poly(lactic acid) (PLA)/poly(ethylene glycol) (PEG) blends were improved by adding maleic anhydride-grafted poly(lactic acid) (PLA-g-MA) as a compatibilizer. The PLA-g-MA improved interfacial adhesion between phases and promoted chain entanglement, leading to enhanced mechanical properties and shape fixity performance. The compatibilized blend containing 2 wt% PLA-g-MA exhibited the best shape fixity and recovery performance.
Article
Instruments & Instrumentation
Yi Wen, Zhimei Song, Hongmei Xu, Sijia Feng, Li Zhu, Fangfang Teng, Runliang Feng
Summary: The study prepared new polymeric micelles loaded with azithromycin to enhance its solubility and evaluate its antibacterial activity against Staphylococcus aureus. The micelles showed good in vitro and in vivo antibacterial effects, demonstrating their potential as a candidate for treating Staphylococcus aureus infections.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
Zhi-Rong Feng, Bao-Bo Wang, Hao Dong, Shun-Ping Zhao, Yu-Ping Wu, Qiao Qiao, Xiao-Ming Ren
Summary: In this study, three covalently grafted kaolinites were prepared by forming Al-O-C bonds between the OH groups of propanediol (PD)/butanediol (BD)/glycerol (GL) and the surface of kaolinite. The hybrids showed excellent chemical stability to water and exhibited ferroelectricity at room temperature.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Ekkachai Martwong, Yvette Tran
Summary: The study reports on the synthesis and temperature-responsive properties of poly(PEGMA) hydrogel thin films. Surface-attached poly(PEGMA) hydrogel films were synthesized using a simple, versatile, and well-controlled thiol-ene click reaction method, with the transition temperature finely tunable by adjusting the number of PEG units. The LCST properties of the hydrogel films are not sensitive to salt, holding promise for applications in biology such as injectable hydrogels, drug delivery systems, microfluidic valves, and flow switches for biotechnologies.
Article
Biochemistry & Molecular Biology
Pawika Towongphaichayonte, Rangrong Yoksan
Summary: This study successfully fabricated polyelectrolyte complexes from mPEG-g-CTS and ALG, which could form fibrous network macrogels or spherical nanoparticles with different physicochemical properties depending on the mPEG chain length and weight ratios. These complexes have potential applications as carriers for functional food additives, drugs, and bioactive compounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Corina Logigan, Christelle Delaite, Crina-Elena Tiron, Cristian Peptu, Marcel Popa, Catalina Anisoara Peptu
Summary: Chitosan hydrogels were prepared by chemical modification and double crosslinking in a water/oil emulsion. The modified chitosan showed better control of dimensional properties and morphology compared to neat chitosan. In addition, the modified hydrogels exhibited pH-dependent behavior and demonstrated excellent capacity for drug loading and release, making them suitable for controlled release applications in biomedicine.
Article
Biochemistry & Molecular Biology
Miao Zhang, Zhongxing Zhang, Xia Song, Jingling Zhu, Jing An Sng, Jun Li, Yuting Wen
Summary: In this study, an amphiphilic polymer composed of a hydrophobic palmitoyl group and a zwitterionic pMPC block was synthesized and characterized for applications in drug delivery systems. The polymer exhibited the ability to form stable micelles with enhanced drug loading capacity and cellular uptake efficiency. The DOX-loaded micelles showed a more efficient anticancer effect in multidrug-resistant cancer cells.
Article
Chemistry, Physical
Seungyeon Choi, Lane D. Yutzy, Yun Hee Ko, Jin-Kyun Lee, Jangwook P. Jung, Myungwoong Kim
Summary: We have developed a chemical approach to fabricate reactive organic thin films that are simple, clean, scalable, photopatternable, chemically adjustable, and versatile. These thin films exhibit effective biocompatibility, controlled reactivity, and processability on various surface types, making them suitable for defining surface activity for interfacing biological objects.
CHEMISTRY OF MATERIALS
(2023)
Article
Biochemical Research Methods
Sidra Kanwal, Muhammad Naveed, Ali Arshad, Azka Arshad, Farhat Firdous, Amir Faisal, Basit Yameen
Summary: Novel reduction-sensitive polymer-drug conjugate (PDC) nanoparticles with precise drug release control exhibit significant cytotoxicity against cancer cells in vitro, highlighting their potential in tumor therapy.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Dongdong Wang, Xiaoyi Zhang, Bingbing Xu
Summary: Efforts to design and develop advanced drug delivery systems for targeted cancer chemotherapy remain a major challenge. A reduction-responsive PEGylated doxorubicin prodrug was reported, which self-assembled into biodegradable micelles in solutions and exhibited enhanced therapeutic efficacy with low side effects for targeted tumors. The reduction-sensitive micelles could also encapsulate free DOX drug into polymer cargo, showing potential as an intelligent and multifunctional chemotherapeutic payload transporter for effective tumor therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yulia A. Kadina, Ekaterina V. Razuvaeva, Dmitry R. Streltsov, Nikita G. Sedush, Eleonora V. Shtykova, Alevtina I. Kulebyakina, Alexander A. Puchkov, Dmitry S. Volkov, Alexey A. Nazarov, Sergei N. Chvalun
Summary: Nanoparticles based on biocompatible mPEG(113)-b-P(D,L)LA(n) copolymers were prepared for the delivery of the anticancer agent oxaliplatin via a nanoprecipitation technique. It was found that an increase in the hydrophobic PLA block length resulted in larger nanoparticle size and decreased oxaliplatin loading content.
Article
Multidisciplinary Sciences
Sandu Cibotaru, Valentin Nastasa, Andreea-Isabela Sandu, Andra-Cristina Bostanaru, Mihai Mares, Luminita Marin
Summary: The study demonstrates the synergistic effect of phenothiazine and poly(ethylene glycol) structural building blocks in efficient antitumor drugs, inhibiting tumor cell proliferation and improving biocompatibility effectively.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Min Jeong Jo, Yu Jin Lee, Chun-Woong Park, Youn Bok Chung, Jin-Seok Kim, Mi Kyeong Lee, Dae Hwan Shin
Summary: The study encapsulated docetaxel and osthol in methoxy poly(ethylene glycol)-b-poly(caprolactone) to improve their bioavailability and solubility. The optimal drug ratio was found to be 1:4, with the micelles showing slow drug release and higher inhibitory effects compared to the solution form. The combination micelles demonstrated positive effects on the pharmacokinetics of the drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Chemical
Weijie Kou, Ruixin Lv, Shengwu Zuo, Zhihao Yang, Jiajia Huang, Wenjia Wu, Jingtao Wang
Summary: Poly (ethylene glycol) grafted polymer-like quantum dots (PPQDs) with an average diameter of around 2.5 nm were synthesized as nanofillers for hybrid polymer electrolytes, significantly enhancing ion conduction and stability. The efficient ion-conductive networks constructed by PPQDs and PEO showed a vertical Li+ conduction of 5.53 x 10(-5) S cm(-1) at 30 degrees C, 16 times higher than that of PEO electrolyte, demonstrating great potential for all-solid-state lithium batteries.
JOURNAL OF MEMBRANE SCIENCE
(2021)