Article
Chemistry, Analytical
Suyash Bhatt, Emily Masterson, Tianxiang Zhu, Jenna Eizadi, Judy George, Nesya Graupe, Adam Vareberg, Jack Phillips, Ilhan Bok, Matthew Dwyer, Alireza Ashtiani, Aviad Hai
Summary: Wireless brain technologies are advancing basic neuroscience and clinical neurology by providing new platforms that reduce invasiveness and expand possibilities in electrophysiological recording and stimulation. However, miniaturization is currently limited by the need for on-board power supply and large transmission circuitry. A new circuit design is presented here, which uses an ion-sensitive field effect transistor to sense ionic fluctuations in the brain and detune a radiofrequency resonator. The sensitivity and response of this sensor are validated through electromagnetic analysis and in vivo experiments.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Engineering, Electrical & Electronic
Xianghong Yang, Jiapei Ao, Xin Li, Long Hu, Weihua Liu, Chuanyu Han, Xiaoli Wang
Summary: Hydrogen ion sensors (pH sensors) with high sensitivity and stability have great potential in various fields. In this research, an ion-sensitive field-effect transistor (ISFET) based on SnO2 and paired with a high selectivity Al2O3 inorganic insulating film was used to enhance pH sensitivity. The study showed that the sensitivity of the ISFET-based pH sensor with an extended gate was significantly increased compared to a sensor without an extended gate, and the stability and response time were greatly improved.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2022)
Article
Materials Science, Multidisciplinary
Yash Pathak, Piyush Mishra, Megha Sharma, Shipra Solanki, Ved Varun Agarwal, Rishu Chaujar, Bansi Dhar Malhotra
Summary: In this work, the analog properties of the ion-sensitive field effect transistor (ISFET) and its circuit design for pH sensing were investigated theoretically and experimentally. The study found that molybdenum, with a work function of 4.75 eV, exhibited better threshold voltage, switching ratio, and leakage current characteristics compared to aluminum at 300 K. Additionally, the phenomenon of threshold voltage drift in ISFET was observed and verified by gradually increasing the pH value.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2024)
Article
Biophysics
Rhys Ashton, Callum D. Silver, Toby W. Bird, Ben Coulson, Andrew Pratt, Steven Johnson
Summary: This study demonstrates a dEGFET pH sensor based on an extended gate manufactured on PCB that is rendered pH sensitive through an electrodeposited IrOx film. By electrochemical polishing the extended gate electrode, the uniformity of the IrOx film can be enhanced, resulting in improved pH sensitivity of the dEGFET pH sensor. The sensor exhibits high sensitivity and repeatability, making it suitable for applications in healthcare and environmental monitoring.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Physical
M. Durga Prakash, Beulah Grace Nelam, Shaik Ahmadsaidulu, Alluri Navaneetha, Asisa Kumar Panigrahy
Summary: The article discusses the widespread use of Ion Sensitive Field Effect Transistors (ISFET) in medical applications and the design of a 2D-ISFET pH sensor. By comparing the sensitivity of the ISFET with different oxide layers and in different solutions, the best oxide material for designing the device is determined.
Article
Engineering, Electrical & Electronic
Yue He, Xiao Wang, Ji-Yu Zhou, Ting-Ting Wang, Meng-Ke Ren, Guo-Qiang Chen, Tao-Fei Pu, Xiao-Bo Li, Mao Jia, Yu-Yu Bu, Jin-Ping Ao
Summary: The sensitivity of AlGaN/GaN ISFETs as pH sensors was improved through gate recess process and ammonium hydroxide treatment. XPS analysis revealed that nitrogen vacancies introduced during the recess process led to a negative V-T shift, which could be improved by ammonium hydroxide treatment, resulting in enhanced current sensitivity of the pH sensor.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2021)
Article
Chemistry, Physical
Jiyu Zhou, Xiaobo Li, Taofei Pu, Yue He, Xiao Wang, Yuyu Bu, Liuan Li, Jin-Ping Ao
Summary: AlGaN/GaN ion-sensitive field-effect transistors (ISFETs) with stacked and high Al-content AlGaN barrier were fabricated as pH sensors, showing good sensitivity but degraded electrical performance after exposure to alkaline solution, due to surface etching and transformation of AlGaN into surface oxide.
APPLIED SURFACE SCIENCE
(2021)
Review
Chemistry, Physical
Arshak Poghossian, Michael J. Schoening
Summary: BioFEDs advantageously combine electronic field-effect functionality with the recognition ability of (bio)chemical receptors, enabling them to detect a wide range of biomolecules and bioparticles through a label-free sensing principle. Applications of BioFEDs include the electrical detection of clinically relevant protein biomarkers, DNA molecules, viruses, enzyme-substrate reactions, as well as monitoring cellular metabolic indicators and extracellular potentials.
CURRENT OPINION IN ELECTROCHEMISTRY
(2021)
Article
Chemistry, Applied
Mladena Glavas, Katarina Zlatic, Dijana Jadresko, Ivan Ljubic, Nikola Basaric
Summary: Two BODIPY phenolic esters with different spectral properties were synthesized and their stability under acid-catalyzed hydrolysis and esterase enzymatic conditions was demonstrated. The introduction of methyl groups on the BODIPY core resulted in higher fluorescence quantum yields. Solvents had minimal effect on the spectral properties, with solvent polarizability having a more significant impact than solvent polarity. Both BODIPY dyes showed pH responsive fluorescence in aqueous solution, making them suitable for intracellular pH measurements. The feasibility of the quenching mechanism in the protonated form of one of the dyes was confirmed through electrochemical measurements and density functional theory computations. The potential of these dyes as electron donors provides new opportunities for the design of fluorescent sensors. Confocal fluorescence microscopy confirmed the applicability of these dyes for intracellular measurements in H460 human cancer cells.
Article
Engineering, Electrical & Electronic
Soumendu Sinha, Tapas Pal, Prashant Sharma, Dheeraj Kharbanda, P. K. Khanna, Amit Tanwar, Rishi Sharma, Ravindra Mukhiya
Summary: The study focused on the fabrication, characterization, and electrochemical modeling of an Al2O3-gate ISFET-based pH sensor. The sensor, made using established MOS processes, demonstrated high sensitivity, low drift, and hysteresis properties. This was achieved through the deposition of Al2O3 sensing film and packaging technology, resulting in a capable pH sensor with superior performance.
JOURNAL OF ELECTRONIC MATERIALS
(2021)
Article
Multidisciplinary Sciences
Anyuan Liu, Xiaoshuai Huang, Wenting He, Fudong Xue, Yanrui Yang, Jiajia Liu, Liangyi Chen, Lin Yuan, Pingyong Xu
Summary: Researchers have developed a bright and photostable red pH-sensitive fluorescent protein, pHmScarlet, to visualize the docking and fusion events of exocytosis.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yizhe Sun, Lidong Gong, Yue Yin, Lei Zhang, Qiangming Sun, Kai Feng, Yimin Cui, Qiang Zhang, Xuehui Zhang, Xuliang Deng, Fuping You, Dan Lu, Zhiqiang Lin
Summary: Lipid-membrane-targeting strategies are promising for developing broad-spectrum antivirals. This study discovered that viral-encoded ion channels, called viroporins, can trigger membrane acidification in virus-infected cells. By using a library of gradient pH-sensitive nanoprobes, the researchers were able to measure the pH transitions in cellular membranes and selectively disrupt viral envelopes. In mouse models, this approach decreased viral titers and improved inflammatory damage.
ADVANCED MATERIALS
(2022)
Article
Engineering, Electrical & Electronic
Fahimul Islam Sakib, Md Azizul Hasan, Mainul Hossain
Summary: A nanoscale biosensor based on negative capacitance gate-all-around tunnel field-effect transistor (NC-GAA-TFET) is proposed for high sensitivity and label-free detection. The sensor shows significant improvement in current sensitivity compared to traditional devices, with the ability to detect biomolecules and pH changes while maintaining low power consumption and high signal-to-noise ratio.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2022)
Article
Plant Sciences
Rainer Waadt, Joerg Kudla, Hannes Kollist
Summary: Understanding plant physiology at the organismic scale involves analyzing biological processes down to the cellular and molecular levels. Fluorescent protein (FP) technology allows for direct monitoring of various cellular dynamics in plants, and multiplexing techniques enable simultaneous recording of multiple biological processes.
Article
Chemistry, Analytical
Hongxin Ren, Guowen Li, Xin Yue, Xiujin Chen, Cunzheng Zhang, Zhouping Wang, Chifang Peng
Summary: Nanomaterial based indicator displacement assays using fluorescent metal nanoclusters as receptors have been developed. In this study, GSH/CD-AuNCs were used as receptors and kaempferol/Al3+ complex as an indicator to fabricate a new nanomaterial based IDA. The fluorescence of GSH/CD-AuNCs was quenched by the KAE/Al3+ complex, but could be restored in the presence of chlorothalonil due to its higher affinity with beta-CD. Based on this principle, a novel fluorescent turn-on IDA-LFA for chlorothalonil was successfully constructed. This method has the advantages of rapid detection and high sensitivity.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Engineering, Biomedical
A. Mason, O. Korostynska, J. Louis, L. E. Cordova-Lopez, B. Abdullah, J. Greene, R. Connell, J. Hopkins
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2018)
Article
Water Resources
Ilaria Frau, Olga Korostynska, Alex Mason, Patrick Byrne
MINE WATER AND THE ENVIRONMENT
(2018)
Article
Engineering, Electrical & Electronic
Alex Mason, Matteo Soprani, Olga Korostynska, Abitami Amirthalingam, Jeff Cullen, Magomed Muradov, Estefania Nunez Carmona, Giorgio Sberveglieri, Veronica Sberveglieri, Ahmed Al-Shamma'a
JOURNAL OF SENSORS
(2018)
Article
Materials Science, Multidisciplinary
Ilaria Frau, Steve Wylie, Patrick Byrne, Jeff Cullen, Olga Korostynska, Alex Mason
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2019)
Article
Environmental Sciences
I Frau, S. R. Wylie, P. Byrne, J. D. Cullen, O. Korostynska, A. Mason
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2020)
Review
Chemistry, Analytical
Irina Yaroshenko, Dmitry Kirsanov, Monika Marjanovic, Peter A. Lieberzeit, Olga Korostynska, Alex Mason, Ilaria Frau, Andrey Legin
Article
Chemistry, Analytical
Ilaria Frau, Stephen Wylie, Patrick Byrne, Patrizia Onnis, Jeff Cullen, Alex Mason, Olga Korostynska
Summary: The study presents a novel technique based on microwave spectroscopy and planar sensors for in situ real-time water quality monitoring, successfully detecting the water pollution level in contaminated mining areas.
Article
Engineering, Biomedical
Hafiz Wajahat Hassan, Valeria Grasso, Olga Korostynska, Haroon Khan, Jithin Jose, Peyman Mirtaheri
Summary: Medical implants made of biodegradable materials are advantageous for short-term applications such as fracture fixation, as they degrade after healing without long-term side effects. Magnesium implants, in particular, can cause physiological changes in surrounding tissues, requiring both structural and functional assessment. Hybrid analysis incorporating Near Infrared Spectroscopy and photoacoustic imaging technology shows potential for monitoring the degradation process of Mg implants and tissue oxygenation.
MEDICAL ENGINEERING & PHYSICS
(2021)
Review
Engineering, Chemical
Dmytro Romanov, Olga Korostynska, Odd Ivar Lekang, Alex Mason
Summary: This article critically reviews the automation challenges in the meat industry and discusses the potential of human-robot collaboration to overcome these challenges. It highlights the benefits of customized robots in providing a flexible and cost-effective alternative to traditional machinery, but notes the lack of off-the-shelf solutions for all production steps in the red meat industry. The introduction of collaborative robots can improve food safety standards and working conditions, making automation more accessible for smaller production plants.
JOURNAL OF FOOD ENGINEERING
(2022)
Article
Engineering, Electrical & Electronic
A. Mason, D. Romanov, L. E. Cordova-Lopez, O. Korostynska
Summary: Automation is a crucial technology for the future of the meat industry, both in terms of productivity and work environment. This article introduces a smart knife as a tool that provides real-time feedback on contact status and cutting depth with meat, which can contribute to the development of new robotic technologies such as meat factory cells.
IEEE SENSORS JOURNAL
(2022)
Article
Chemistry, Analytical
Anna Mathew, Hafiz Wajahat Hassan, Olga Korostynska, Frank Westad, Eduarda Mota-Silva, Luca Menichetti, Peyman Mirtaheri
Summary: Biodegradable magnesium-based implants with mechanical properties similar to natural bone have advantages over nonbiodegradable metallic implants. However, monitoring the interaction between magnesium and tissue without interference is challenging. Optical near-infrared spectroscopy, a noninvasive method, can be used to monitor tissue properties. In this study, optical data was collected from cell culture medium and in vivo studies to study the effect of magnesium-based implant disks. Principal component analysis was used for data analysis. Results showed that the optical probe could detect variations in vivo and identify trends in the optical data over two weeks. The complexity of the implant interaction near the interface with the biological medium is the primary challenge of in vivo data analysis.
Article
Ethics
Martha Risnes, Olga Korostynska, Peyman Mirtaheri, Arild Berg
Summary: Wearable, non-invasive, brain-monitoring technologies have the potential to be used outside the laboratory to study the human brain in different and more relevant settings. This study focused on patient experiences with such devices in a rehabilitation context and found that the technology's impact varied depending on the role of the user (health professional, researcher, or patient). The findings emphasized the importance of understanding these differences when assessing the practical applications of novel technologies.
JOURNAL OF RESPONSIBLE INNOVATION
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Alex Mason, Olga Korostynska, Torunn Thauland Haseth, Ole Alvseike, Marianne Sundt Sodring
2019 13TH INTERNATIONAL CONFERENCE ON SENSING TECHNOLOGY (ICST)
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Ilaria Frau, Steve Wylie, Patrick Byrne, Jeff Cullen, Olga Korostynska, Alex Mason
2018 12TH INTERNATIONAL CONFERENCE ON SENSING TECHNOLOGY (ICST)
(2018)
Article
Environmental Sciences
Karin Brenda Moejes, Reshma Sulthana Rahiman Sherif, Simone Durr, Sheelagh Conlan, Alex Mason, Olga Korostynska