Article
Multidisciplinary Sciences
Qinpei Zhao, Jinhao Zhu, Xuan Shen, Chuwen Lin, Yinjia Zhang, Yuxiang Liang, Baige Cao, Jiangfeng Li, Xiang Liu, Weixiong Rao, Congrong Wang
Summary: To promote research in diabetes management, the ShanghaiT1DM and ShanghaiT2DM datasets have been developed and made publicly available. These datasets include clinical characteristics, laboratory measurements, medications, continuous glucose monitoring readings, and daily dietary information of 12 Type 1 and 100 Type 2 diabetic patients in Shanghai, China. They can contribute to the development of data-driven algorithms/models and diabetes monitoring/managing technologies.
Article
Pediatrics
Jesus Dominguez-Riscart, Nuria Buero-Fernandez, Ana Garcia-Zarzuela, Fernando A. Marmolejo-Franco, Ana C. Perez-Guerrero, Alfonso M. Lechuga-Sancho
Summary: The goal of therapy for type 1 diabetes is to maintain optimal glycemic control, with the most advanced devices being hybrid closed-loop systems. The latest international guidelines for diabetes management during surgery include specific adjustments to insulin therapy and continuous monitoring.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Helga Blauw, A. Joannet Onvlee, Michel Klaassen, Arianne C. van Bon, J. Hans DeVries
Summary: The study demonstrated that the bihormonal artificial pancreas provided superior glucose control in adults with type 1 diabetes compared to insulin pump therapy, without the need for meal or exercise announcements.
Review
Cardiac & Cardiovascular Systems
Keren Zhou, Diana Isaacs
Summary: This review discusses the development of closed-loop insulin pump systems and provides an overview of the currently approved systems and future technology. The findings show that these systems have demonstrated significant improvements in blood glucose control, hemoglobin A1c, and time spent in hypoglycemia. The newer systems also offer increased automation. However, there are notable differences in user experience between systems, and further research is required to achieve full automation without user input.
CURRENT CARDIOLOGY REPORTS
(2022)
Review
Endocrinology & Metabolism
Charlotte K. Boughton, Roman Hovorka
Summary: Advances in diabetes technologies have led to the development of automated closed-loop insulin delivery systems, which are changing the way type 1 diabetes is managed. This review examines the evidence supporting currently available closed-loop systems and those in development, including DIY systems, as well as the challenges and potential enhancements for clinical adoption.
Article
Endocrinology & Metabolism
Jennifer L. Sherr, Lutz Heinemann, G. Alexander Fleming, Richard M. Bergenstal, Daniela Bruttomesso, Helene Hanaire, Reinhard W. Holl, John R. Petrie, Anne L. Peters, Mark Evans
Summary: A technological solution for diabetes management in people requiring intensive insulin therapy has been sought for decades. Recent advancements in continuous glucose monitoring have allowed for modulation of insulin delivery through insulin pumps based on sensor glucose data. Automated insulin delivery systems have been granted regulatory approval and adopted in clinical care. This consensus report from the joint Diabetes Technology Working Group provides a review of the current landscape of these systems, with a focus on safety, and offers recommended actions. The development of these systems has been a collaborative effort between the European Association for the Study of Diabetes and the American Diabetes Association.
Article
Endocrinology & Metabolism
Julia Ware, Roman Hovorka
Summary: The introduction of glucose-responsive automated insulin delivery has revolutionized the management of type 1 diabetes. Multiple closed-loop systems are now available, and many more are in development. This review provides an overview of currently available and in-development closed-loop systems, as well as clinical evidence in different populations.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Review
Endocrinology & Metabolism
Viral N. Shah, Satish K. Garg
Summary: The study discusses the benefits of the HCL system in improving glycemic control and reducing hypoglycemia, highlighting the importance of standardized reporting for easy interpretation of data. It introduces the concept of an artificial pancreas (AP) Dashboard with seven components to aid providers and patients in understanding HCL data and improving glycemic outcomes.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Loic Olcomendy, Louis Cassany, Antoine Pirog, Roberto Franco, Emilie Puginier, Manon Jaffredo, David Gucik-Derigny, Hector Rios, Alejandra Ferreira de Loza, Julien Gaitan, Matthieu Raoux, Yannick Bornat, Bogdan Catargi, Jochen Lang, David Henry, Sylvie Renaud, Jerome Cieslak
Summary: This study focuses on diabetes treatment using continuous glucose monitoring and insulin delivery, and examines the limitations of glucose sensors and algorithms in blood glucose regulation. By using a computer model for simulation testing, the study evaluates the potential benefits of an islet-based biosensor and robust control theory in closed-loop insulin therapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Melissa-Rosina Pasqua, Adnan Jafar, Alessandra Kobayati, Michael A. Tsoukas, Ahmad Haidar
Summary: The objective of this study was to assess whether low doses of empagliflozin as adjunct to hybrid closed-loop therapy improve glycemia compared with placebo in adults with type 1 diabetes. The study found that adjunct use of 2.5 mg and 5 mg empagliflozin increased the time in range of blood glucose control by 11-13 percentage points. This study suggests that empagliflozin as adjunct therapy may help improve glycemic control in adults with type 1 diabetes.
Article
Endocrinology & Metabolism
Charlotte K. Boughton, Sara Hartnell, Hood Thabit, Tina Poettler, David Herzig, Malgorzata E. Wilinska, Nicole L. Ashcroft, Judy Sibayan, Nathan Cohen, Peter Calhoun, Lia Bally, Julia K. Mader, Mark Evans, Lalantha Leelarathna, Roman Hovorka
Summary: The study found that the use of Fiasp in the CamAPS FX closed-loop system may reduce hypoglycemia without compromising glucose control in adults with T1D.
DIABETES OBESITY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Sophie Templer
Summary: Closed-loop systems for automated insulin delivery have significantly advanced in recent years, from bulky, bedside technologies to miniaturized, wearable devices. These systems use interstitial glucose sensing, subcutaneous insulin pumps, and sophisticated algorithms. Future challenges include the development of fully closed-loop systems and the addition of glucagon to mitigate hypoglycemia risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Basak Ozaslan, Carol J. Levy, Yogish C. Kudva, Jordan E. Pinsker, Grenye O'Malley, Ravinder Jeet Kaur, Kristin Castorino, Camilla Levister, Mari Charisse Trinidad, Donna Desjardins, Mei Mei Church, Mitchell Plesser, Shelly McCrady-Spitzer, Selassie Ogyaadu, Kristen Nelson, Corey Reid, Sunil Deshpande, Walter K. Kremers, Francis J. Doyle, Barak Rosenn, Eyal Dassau
Summary: This study demonstrated the feasibility of closed-loop insulin delivery with a zone model predictive control algorithm for pregnant women with type 1 diabetes.
DIABETES TECHNOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Richard M. Bergenstal, Revital Nimri, Roy W. Beck, Amy Criego, Lori Laffel, Desmond Schatz, Tadej Battelino, Thomas Danne, Stuart A. Weinzimer, Judy Sibayan, Mary L. Johnson, Ryan J. Bailey, Peter Calhoun, Anders Carlson, Elvira Isganaitis, Rachel Bello, Anastasia Albanese-O'Neill, Klemen Dovc, Torben Biester, Kate Weyman, Korey Hood, Moshe Phillip
Summary: In adolescents and young adults with type 1 diabetes, the use of an investigational advanced hybrid closed-loop system was found to reduce hyperglycemia without increasing the occurrence of hypoglycemia compared to a commercially available MiniMed 670G system. Further testing of this technology in underserved populations and in individuals with impaired awareness of hypoglycemia could advance its effective use.
Review
Multidisciplinary Sciences
Bruce A. Perkins, Jennifer L. Sherr, Chantal Mathieu
Summary: Despite innovations in insulin therapy, most type 1 diabetes patients still struggle to achieve sufficient glycemic control. The future may lie in combining pharmacological solutions with automated insulin delivery methods, utilizing machine learning and other technologies to enhance effectiveness.