Article
Chemistry, Multidisciplinary
Mingyang Zhang, Hao Zhang, Lunqiang Jin, Hao Li, Simin Liu, Shuai Chang, Feng Liang
Summary: Enhanced guest-pair interactions in the CB[8] cavity were quantitatively determined using SMFS, showing how dynamic conformational changes can affect the rupture force of CB[8]-mediated heteroternary complexation. SMFS was also utilized for detecting methyl viologen based on competitive host-guest interactions in CB[8] or CB[7.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Ying Huang, Rui-Han Gao, Ming Liu, Li-Xia Chen, Xin-Long Ni, Xin Xiao, Hang Cong, Qian-Jiang Zhu, Kai Chen, Zhu Tao
Summary: This review summarizes various QSFs assembled via OSIQs, which can be classified as being assembled by self-induced OSIQ, anion-induced OSIQ, and aromatic-induced OSIQ. The design and construction of QSFs with novel structures and specific functional properties may establish a new research direction in Q[n] chemistry.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Miriam Colaco, Patricia Maximo, A. Jorge Parola, Nuno Basilio
Summary: The study focuses on the kinetics of a water-soluble host-guest system based on cucurbit[8]uril and two DTE photoswitches, demonstrating a method to control the binding kinetics in supramolecular systems using external stimuli. By modifying the structure of the DTE guest molecule, it is possible to significantly slow down the formation/dissociation rates of pseudorotaxane structures, leading to the emergence of a competitive metastable product with important impact on the overall binding kinetics. Additionally, the dissociation kinetics of the host-guest system can be controlled by approximately 100-fold by switching between closed and open DTE isomers.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Khaleel Assaf
Summary: The supramolecular complexation of doxepin with cucurbit[7]uril was investigated in aqueous solution, and a host-guest complex was formed. The partial encapsulation of doxepin led to the development of a supramolecular assembly at low concentration.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Suresh Moorthy, Alvaro Castillo Bonillo, Hugues Lambert, Elina Kalenius, Tung-Chun Lee
Summary: A new supramolecular approach has been reported to selectively deactivate the electrophilic alpha-carbon of phenyl diazonium ion through host-guest complexation, thus avoiding undesirable side reactions. This method holds great potential for the reactive chemistry of organic molecules in aqueous media.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Shuai-Peng Jin, Huai-Li Wu, Le-Ping Zhang, Guan-Yu Yang, Bo Yang
Summary: This article reports the fabrication of four new flexible 2D supramolecular organic frameworks (SOFs) utilizing a combination of hydrogen bonds, outer-surface interactions, and host-guest interactions with multiple types of cucurbit[n]urils. The work provides valuable information and a new strategy for designing more 2D supramolecular organic nanomaterials and macrocycle-based luminescent materials.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Biochemistry & Molecular Biology
Zhaoxi Sun, Qiaole He, Zhihao Gong, Payam Kalhor, Zhe Huai, Zhirong Liu
Summary: Atomic-level understanding of host-guest interactions is crucial in supramolecular chemistry. The remarkable guest binding behavior of Cucurbiturils makes them promising drug carriers. Computational investigations and comparisons of charge models and force fields provide guidelines for theoretical modeling of host-guest binding.
Article
Chemistry, Medicinal
Zhaoxi Sun, Zhe Huai, Qiaole He, Zhirong Liu
Summary: Describing, understanding, and designing complex interaction networks within macromolecular systems remain challenging in modern chemical research. Host-guest systems, despite their relative simplicity in both the structural feature and interaction patterns, still pose problems in theoretical modeling. The barrel-shaped supramolecular container cucurbit[8]uril (CB8) shows promising functionalities in various areas.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Chemistry, Multidisciplinary
Ming Liu, Yang Zhou, Lixia Chen, Bing Bian, Xin Xiao, Zhu Tao
Summary: The study investigates the interactions of cucurbit[6]uril with different sulfo-calix[n]arenes, and prepares solid fluorescent materials that exhibit selective responses to specific volatile organic compounds.
CHINESE CHEMICAL LETTERS
(2021)
Review
Chemistry, Inorganic & Nuclear
Kai Chen, Zi-Yi Hua, Jiang-Lin Zhao, Carl Redshaw, Zhu Tao
Summary: This article summarizes the supramolecular frameworks based on cucurbit[n]uril chemistry, including frameworks assembled through outer surface interactions and cucurbit[n]uril/metal ion complex-based frameworks, as well as Q[n]-based frameworks assembled using the structural characteristics associated with the cavity of Q[n]s through host-guest inclusion chemistry. The design and construction of these frameworks will enrich the research direction of Q[n] chemistry and lead to new applications.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Yang Luo, Wei Zhang, Jie Zhao, Mao-Xia Yang, Qian Ren, Carl Redshaw, Zhu Tao, Xin Xiao
Summary: The macrocyclic compounds pillararene and cucurbituril have attracted significant attention recently. However, there is limited research on the direct formation of supramolecular complexes with derivatized pillararenes and cucurbiturils. In this study, a novel naphthalene-derivatized pillararene NTP5 was synthesized and Q[10] was chosen as the host molecule. The encapsulation of 4-[2-(1-naphthalenyl)ethenyl]pyridine by Q[10] formed a host-guest complex in water-acetic acid solution, resulting in enhanced fluorescence and a morphological change in NTP5. Furthermore, the fluorescence of Q[10]-NTP5 could be quenched by the highly toxic pesticide paraquat through the formation of a new charge transfer ternary system. This work provides new insights into the supramolecular assemblies based on derivatized pillararenes and their potential applications.
CHINESE CHEMICAL LETTERS
(2023)
Review
Chemistry, Multidisciplinary
Shengke Li, Yan Gao, Yuanfu Ding, Anni Xu, Huaping Tan
Summary: Cucurbit[n]urils (CB[n]s) have emerged as promising building blocks for supramolecular nano drug delivery systems (SNDDS), showing stimuli responsiveness towards various stimuli for drug release. Recent breakthroughs in direct functionalization of CB[n]s have provided feasible methods for preparing superior derivatives for multifunctional SNDDS.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Xueyan Zhang, Shaolong Qi, Dahai Liu, Jianshi Du, Jingji Jin
Summary: Nanomedicines are crucial in cancer therapy, but the unsatisfactory efficacy and side effects caused by indiscriminate drug release limit their clinical applications. Utilizing a supramolecular strategy, researchers have designed targeted nanomedicines that enhance the efficiency of drugs, showing potential in precise cancer treatment and the development of sophisticated drug delivery systems.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Physical
Nanhang Zhu, Yujia Zhang, Jia Cheng, Yanchao Mao, Ke Kang, Guohao Li, Qiangying Yi, Yao Wu
Summary: Researchers have proposed an 1-ADA responsive immuno-affinitive supramolecular magnetic nanoparticle (ISM-NPs) system for efficient capture and release of sEVs. This system shows high capture efficiency and good release performance, providing potential applications in biomarker enrichment.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemical Research Methods
Carlos Redondo-Gomez, Soraya Padilla-Lopategui, Alvaro Mata, Helena S. Azevedo
Summary: The host-guest-mediated PA hydrogelation method relies on the formation of a host-guest homoternary complex with CB[8] and aromatic amino-acid-bearing PA nanofibers, resulting in hierarchical morphologies and increased stiffness compared to ion-based equivalents. This alternative cross-linking method can upgrade the design of PA materials and extend their biomedical applications, while maintaining similar biocompatibilities between the new and conventional hydrogels.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xiangyu Liang, Guangda Chen, Iek Man Lei, Pei Zhang, Zeyu Wang, Xingmei Chen, Mengze Lu, Jiajun Zhang, Zongbao Wang, Taolin Sun, Yang Lan, Ji Liu
Summary: By harnessing multi-length-scale structural hierarchy and using bidirectional freeze-casting and compression-annealing, a hierarchically structured hydrogel material has been developed. The engineered 2D lamellar structures, well-defined nanocrystalline domains, and robust interfacial interaction contribute to the hydrogel's high impact resistance, high water content, and superior softness, resulting in record-high ballistic energy absorption capability.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiangyu Liang, Guangda Chen, Iek Man Lei, Pei Zhang, Zeyu Wang, Xingmei Chen, Mengze Lu, Jiajun Zhang, Zongbao Wang, Taolin Sun, Yang Lan, Ji Liu
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Nannan Jian, Rui Guo, Lei Zuo, Yibo Sun, Yu Xue, Ji Liu, Kai Zhang
Summary: The production of natural materials involves bottom-up growth and adaptation to the environment, while synthetic materials are engineered and lack self-growing attributes. Replicating the self-growing characteristics of natural prototypes remains challenging. This study reports the fabrication of synthetic hydrogels with self-growing properties inspired by the self-growing behaviors of keratin proteins, broadening the potential applications of self-growing materials in actuation and soft robotics.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jiajun Zhang, Lulu Wang, Yu Xue, Iek Man Lei, Xingmei Chen, Pei Zhang, Chengcheng Cai, Xiangyu Liang, Yi Lu, Ji Liu
Summary: Coating conventional metallic electrodes with conducting polymers enables the bioelectrodes to have desirable characteristics for bioelectronics. However, the fragile interface between the conducting polymer and the electrode limits their utility and reliability. In this study, a reliable strategy for seamlessly connecting conventional electrodes with conducting hydrogel coatings is established, which improves the long-term robustness of the interface. Through in vivo implantation in mouse models, stable electrophysiological recording is achieved with a robust conducting hydrogel-electrode interface. This design strategy addresses technical challenges in bioelectrode engineering and opens up new avenues for diagnostic brain-machine interfaces.
ADVANCED MATERIALS
(2023)
Review
Cardiac & Cardiovascular Systems
Ruzhao Chen, Jiachen Xu, Yuge Wang, Benyue Jiang, Xiao Xu, Yang Lan, Jiang Wang, Xiufang Lin
Summary: This study found that sarcopenia has a high prevalence in patients with heart failure and is closely related to adverse clinical outcomes. The highest prevalence of sarcopenia in heart failure patients was observed in Asia, and patients with heart failure with reduced ejection fraction had a higher risk of poor outcomes from sarcopenia. Therefore, early identification and intervention for sarcopenia in heart failure patients are beneficial for improving prognosis.
CLINICAL CARDIOLOGY
(2023)
Article
Automation & Control Systems
Xingjuan Cai, Yang Lan, Zhixia Zhang, Jie Wen, Zhihua Cui, Wensheng Zhang
Summary: In this article, a skin cancer detection model based on federated learning integrated with deep generation model is proposed to address the problem of data insufficiency and data source privacy in healthcare IoT. The model utilizes dual generative adversarial networks and knee point-driven evolutionary algorithm to improve the quality of generated images and protect patient information privacy. Experimental results show high accuracy and area under the curve for the proposed model.
IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS
(2023)
Article
Multidisciplinary Sciences
Yuxuan Sun, Liu Wang, Yangyang Ni, Huajian Zhang, Xiang Cui, Jiahao Li, Yinbo Zhu, Ji Liu, Shiwu Zhang, Yong Chen, Mujun Li
Summary: The authors present an in situ dual heating strategy for the rapid 3D printing of thermosets with complex structures and diverse rheological properties. This strategy combines the direct ink writing (DIW) technique and a heating-accelerated in situ gelation mechanism, allowing for the printing of various thermosets with viscosities spanning five orders of magnitude, printed height over 100 mm, and high resolution of 50 μm.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Yang Lan, Yuma Morimoto, Ikuma Shimizu, Hideki Sugimoto, Shinobu Itoh
Summary: Structures, physicochemical properties, and reactivity of a whole series of mononuclear copper(II)-halide complexes supported by a TMG(3)tach tridentate ligand have been investigated. The results demonstrate the importance of the ligand structure in determining the spectroscopic and electronic features as well as the reactivity towards C-H bond activation reaction. The bulky and strongly electron-donating TMG substituents enforce a tetrahedral geometry for the copper(II) complexes, resulting in specific optical and chemical properties.
INORGANIC CHEMISTRY
(2023)
Article
Urology & Nephrology
Jiayang He, Mengchang Yang, Xiangming Quan, Jingyu Wen, Yang Lan, Hongji Yang, Gaoping Zhao, Yifu Hou, Jun Lu, Linfeng Xu, Liang Wei
Summary: This study identifies the characteristics of gut microbiome and fecal metabolites in renal transplant recipients (RTRs) with post-transplantation diabetes mellitus (PTDM). The species Dialister invisus is significantly associated with fasting plasma glucose (FPG). RTRs with PTDM show enhanced functions of tryptophan and phenylalanine biosynthesis, while fructose and butyric acid metabolism functions are reduced.
INTERNATIONAL JOURNAL OF UROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yuxuan Sun, Liu Wang, Zhengqing Zhu, Xingxiang Li, Hong Sun, Yong Zhao, Chenhui Peng, Ji Liu, Shiwu Zhang, Mujun Li
Summary: This study reports a ferromagnetic liquid crystal elastomer (magLCE) ink that allows independent programming of nematic order and magnetization via a customized 3D-printing platform. The 3D-printed magLCE offers designable shape morphing under different stimuli, making it promising for applications in wireless soft robots and intelligent devices.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yu Xue, Xingmei Chen, Fucheng Wang, Jingsen Lin, Ji Liu
Summary: Conducting polymer hydrogels are widely used as coatings for metallic electrodes to create mechanically compliant interfaces and reduce foreign body responses. However, concerns regarding fatigue crack propagation and delamination have limited their long-term viability. This study presents a method for achieving fatigue-resistant conducting polymer hydrogel coatings on metallic bioelectrodes by introducing nanocrystalline domains at the hydrogel-metal interface. The results show that this robust and biocompatible coating effectively reduces the required voltage for cardiac pacing and improves the long-term reliability of electric stimulation, indicating its potential for future bioelectronic interfaces.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Pengfei Yang, Linlin Xu, Panagiotis Trogadas, Marc-Olivier Coppens, Yang Lan
Summary: By incorporating cucurbit[n]urils (CB[n]) into sulfonated poly(ether ether ketone) (SPEEK) matrix, inspired by the proton conduction mechanism of bacteriorhodopsin, hybrid proton exchange membranes (PEMs) with enhanced proton conductivity are fabricated. The CB[n] carbonyl groups serve as proton-conducting sites, while the host-guest interaction between CB[n] and water molecules offers additional proton conducting pathways. The hybrid membranes exhibit significantly improved proton conductivity and superior fuel cell performance.
Article
Urology & Nephrology
Yang Lan, Duo Wang, Jiayang He, Hongji Yang, Yifu Hou, Wenjia Di, Hailian Wang, Xiangwei Luo, Liang Wei
Summary: This study integrated the analysis of gut microbiome and metabolites to identify the characteristics of Chronic Kidney Disease after transplantation (CKD-T). The results showed significant differences in gut microbiome diversity between CKD G1-2T group and CKD G3T group, with 8 flora including Akkermansia enriched in CKD G3T group. Compared to CKD G1-2T group, CKD G3T group had differential expression of amino acid metabolism, glycerophospholipid metabolism, amino acid biosynthesis, carbohydrate metabolism, and purine metabolism. Fecal metabolome analysis indicated a unique metabolite distribution characteristic in CKD G3T group.
Proceedings Paper
Engineering, Electrical & Electronic
Lixian Wang, Yang Lan, Manish Sharma, Xiaolei Peng, Zhiping Jiang
Summary: This research explores the physical counterpart to the traditional spectral hole burning effect in erbium-doped fiber amplifiers, known as inhomogeneous saturable absorption, through theoretical and experimental investigations. A cost-effective compensation method is proposed based on this effect.
2023 OPTICAL FIBER COMMUNICATIONS CONFERENCE AND EXHIBITION, OFC
(2023)
Article
Acoustics
Yeqing Ren, Haipeng Peng, Lixiang Li, Xiaopeng Xue, Yang Lan, Yixian Yang
Summary: This paper proposes a generalized voice spoofing detection method based on integral knowledge amalgamation to detect both synthetic attacks and replay attacks. Two amalgamation mechanisms, feature amalgamation and structure amalgamation, are utilized to incorporate high-level semantic knowledge and ensure global structure consistency. Experimental results demonstrate that the proposed method outperforms advanced generalized voice spoofing detection methods and achieves state-of-the-art detection capability in the logical access (LA) scenario.
IEEE-ACM TRANSACTIONS ON AUDIO SPEECH AND LANGUAGE PROCESSING
(2023)
