期刊
MACROMOLECULAR CHEMISTRY AND PHYSICS
卷 217, 期 6, 页码 735-747出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.201500339
关键词
aggregation processes; dynamic light scattering; RAFT polymerization; smart materials; stimuli-responsivity
资金
- Fonds der Chemischen Industrie (FCI)
Aqueous solutions of narrowly distributed poly[2-(N -morpholino)ethyl methacrylate], a biocompatible multiple stimuli-responsive polymer, show a peculiar three-step aggregation behavior upon heating, an effect which has hitherto barely been reported for other polymers. The phenomenon is discussed in terms of mesoglobule formation (first step) as well as by an unusual distinct disruption of hydrophobic hydration (second step) and hydrogen bonding to the hydrophilic aggregate surface (third step). Macroscopic precipitation only takes place after the third step, a behavior which resembles the denaturation and limited aggregation of proteins. Furthermore, the influence of different anions along the Hofmeister series is investigated, identifying salting-out (kosmotropic) and salting-in (chaotropic) effects. As an experimental tool to monitor the thermally induced aggregate growth, dynamic light scattering is used. The reported findings might lead to a more detailed understanding of both aggregation behavior of (biological) macromolecules and mechanistic processes involved in thermoresponsivity and salt-responsivity of water soluble polymers.
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