期刊
IEEE JOURNAL OF SOLID-STATE CIRCUITS
卷 47, 期 4, 页码 1056-1064出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSSC.2012.2185339
关键词
Biosensor; CMOS; magnetic bead; magnetic relaxation
资金
- trans-NIH Genes, Environment and Health Initiative
- Biological Response Indicators of Environmental Systems Center [U54 ES016115-01]
A compact and robust magnetic label detector for biomedical assays is implemented in 0.18-mu m CMOS. Detection relies on the magnetic relaxation signature of a microbead label for improved tolerance to environmental variations and relaxed dynamic range requirement, eliminating the need for baseline calibration and reference sensors. The device includes embedded electromagnets to eliminate external magnets and reduce power dissipation. Correlated double sampling combined with offset servo loops and magnetic field modulation, suppresses the detector offset to sub-mu T. Single 4.5-m magnetic beads are detected in 16 ms with a probability of error <0.1%.
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