期刊
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
卷 18, 期 4, 页码 1422-1433出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSTQE.2011.2180516
关键词
Biosensing; high throughput; interferometry; label free; nanoparticle; single virus
资金
- U.S. Army Research Laboratories [W911NF-06-2-0040]
- SmartLighting Engineering Research Center
- National Science Foundation [EEC-0812056]
- MITRE Corporation [79952, 80814, 81646]
- Center for Integration of Medicine & Innovative Technology
Label-free optical biosensors have shown promise in rapid and sensitive detection of viruses. Recently, we have demonstrated a technique termed interferometric reflectance imaging sensor (IRIS) capable of detecting viral antigens and single viruses in a high-throughput, quantitative, and label-free fashion. In this paper, we briefly review the current label-free optical methods that have demonstrated virus detection through ensemble measurements of viral antigen and emerging techniques that are capable of detecting individual viruses captured by the sensor. We then present the principle of single nanoparticle detection using IRIS and show proof-of-principle results on specific detection and shape analysis of individual viruses captured on the IRIS platform.
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