期刊
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
卷 16, 期 4, 页码 863-869出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSTQE.2009.2035362
关键词
Astigmatism; biopsy needle; interstitial imaging; optical coherence tomography (OCT); OCT needle
资金
- National Institutes of Health [R21 CA116442, R01 CA120480]
- National Science Foundation
- Alexander H. Steinkoler Pancreatic Cancer Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0940321] Funding Source: National Science Foundation
Fine optical coherence tomography (OCT) imaging needles that can be integrated with a standard biopsy needle have been developed with a new optics design to improve the optical quality and mechanical robustness, where a fiber-optic lens (that is spliced to a single-mode fiber) and a microreflector are encased within a microglass tube. The design also minimizes the cylindrical lens effect induced by the glass tube and eases the needle assembly process. Real-time cross-sectional OCT imaging of various tissue samples were performed ex vivo using the miniature-imaging needle along with a 1300-nm swept-source OCT system. The preliminary results demonstrate the improved mechanical and optical performance and suggest the potential of the fine OCT needle for minimally invasive interstitial imaging and image-guided biopsy.
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