Article
Biochemistry & Molecular Biology
Virginia Casas-Arrojo, Juan Decara, Maria de los Angeles Arrojo-Agudo, Claudia Perez-Manriquez, Roberto T. Abdala-Diaz
Summary: Porphyridium cruentum's sulfated polysaccharides exhibit strong immunomodulatory and cytotoxic effects, inducing IL-6 cytokines and TNF-alpha. They show potential as a valuable ingredient in nutraceutical products.
Article
Chemistry, Applied
Arnau Vilas-Franquesa, Christos Fryganas, Melania Casertano, Marco Montemurro, Vincenzo Fogliano
Summary: This study demonstrates a sequential processing strategy using enzymatic hydrolysis and fermentation to extract functional ingredients from mango peels, resulting in increased solubilization of oligosaccharides and recovery of phenolic aglycones.
Article
Chemistry, Medicinal
Gildacio Pereira Chaves Filho, Lucas Alighieri Neves Costa Batista, Silvia Regina Batistuzzo de Medeiros, Hugo Alexandre Oliveira Rocha, Susana Margarida Gomes Moreira
Summary: This study demonstrates the potential of sulfated glucan extracted from seaweeds in inhibiting adipogenesis and reducing lipid accumulation, highlighting its potential application in functional approaches to obesity management.
Article
Oncology
Hebatallah G. Hafez, Rafat M. Mohareb, Sohair M. Salem, Azza A. Matloub, Emad F. Eskander, Hanaa H. Ahmed
Summary: This study demonstrates the activity of Pterocladia capillacea and Corallina officinalis polysaccharides against Breast Cancer Stem Cells (BCSCs) and reveals their targeting mechanism through interference with signaling pathways.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Fahrul Nurkolis, Rudy Kurniawan, Isma Kurniatanty, Moon Nyeo Park, Myunghan Moon, Siti Fatimah, William Ben Gunawan, Reggie Surya, Nurpudji Astuti Taslim, Hangyul Song, Bonglee Kim
Summary: This study extracts sulfated polysaccharides (SPs) from two Indonesian ulvophyte green algae and evaluates their biological activities. The results show that SPCr exhibits strong antioxidant activity, while SPCl displays wide-ranging anticancer effects.
Article
Chemistry, Medicinal
Tian Fang, Xiaoqian Zhang, Shanshan Hu, Yanyan Yu, Xue Sun, Nianjun Xu
Summary: The study investigated the antioxidant activities of Gracilariopsis lemaneiformis polysaccharides after degradation, with GDP degraded by beta-dextranase showing the highest antioxidant activity. It was found that GDP can significantly improve oxidative damage and enhance antioxidant capacity.
Article
Biochemistry & Molecular Biology
Ioanna Stamogiannou, John Van Camp, Guy Smagghe, Davy Van de Walle, Koen Dewettinck, Katleen Raes
Summary: Different classes of phenolic compounds have distinct effects on the enzymatic hydrolysis of cellulose, acting as activators or inhibitors. The presence of the -OCH3 group is found to be crucial for the activating effect of phenolic compounds. Adsorption analysis and SEM images indicate that the activating or inhibiting action of phenolic compounds can lead to different adsorption modes, either on the enzyme or on the substrate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Celina Habryka, Robert Socha, Leslaw Juszczak
Summary: The study confirmed that enriching honey with bee pollen significantly increased the content of phenolic compounds, improving its antioxidant and antiradical activities, but resulting in a deterioration of its sensory properties.
Article
Plant Sciences
Natalia Cmikova, Lucia Galovicova, Michal Miskeje, Petra Borotova, Maciej Kluz, Miroslava Kacaniova
Summary: The aim of this research was to evaluate the antioxidant and antimicrobial activity of seaweed extracts, as well as to determine the chemical elements and heavy metals present. The results showed that kombu and arame exhibited the highest antioxidant activity, while the antimicrobial activity varied among different microorganisms. Additionally, arsenic, cadmium, and aluminum were found in the seaweed samples.
Article
Food Science & Technology
Zehong Chen, Yuxuan Liu, Dan Wang, Niuniu Wu, Kaiping Wang, Yu Zhang
Summary: In this study, sulfated modification was performed on Grifola frondosa polysaccharide (GFP) using the chlorosulfonic acid-pyridine method. The sulfated GFP (S-GFP) exhibited alpha-glucosidase inhibitory activity and changed the conformation of the enzyme. The results suggest that sulfation alters the structure and inhibitory mechanism of polysaccharides.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Xiaofeng Gao, Zeen Yang, Lingte Huang, Siying Zuo, Xinghan Li, Jia Li, Wen Jiang, Shuang Wang, Yongjun Zhang
Summary: Pumpkin polysaccharides (PPe) have the ability to reduce blood sugar and lipids. Our study found that hydrolysates derived from PPe (PPe-s) have stronger antioxidant capabilities than PPe. We used Caenorhabditis elegans and MIN6 cells as models to explore the potential mechanism of PPe-s. The results showed that PPe-s exhibited strong scavenging ability and increased the lifespan of C. elegans under oxidative stress, while also enhancing proliferation activity and insulin secretion in MIN6 cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Medicinal
Qiang Wei, Guoqiang Fu, Ke Wang, Qiong Yang, Jiarui Zhao, Yuan Wang, Kai Ji, Shuliang Song
Summary: This review focuses on the recent advances in antiviral research on sulfated polysaccharides from seaweeds, which are considered potential sources of bioactive compounds for drug development. These polysaccharides have shown broad-spectrum antiviral activity and can also improve the body's immunity. The findings of this review provide new ideas for the development of COVID-19 therapeutics and vaccines.
Article
Biochemistry & Molecular Biology
Sara Bautista-Exposito, Albert Vandenberg, Montserrat Duenas, Elena Penas, Juana Frias, Cristina Martinez-Villaluenga
Summary: This study characterized the chemical composition of red lentil hulls and explored their potential as a source of bioactive compounds. The hulls were found to be rich in dietary fiber and polyphenols, making them suitable for antioxidant and prebiotic applications. Enzymatic hydrolysis and microwave treatment were used to release oligosaccharides and phenolics from the hulls. Among the commercial enzyme preparations tested, Pectinex (R) Ultra Tropical showed the highest yields of oligosaccharides and free phenolics, significantly increasing the antioxidant activity. However, when combined with microwave treatment, the solubilization yield increased but the content of oligosaccharides and proanthocyanidins decreased, resulting in reduced antioxidant activity. Therefore, enzymatic hydrolysis alone was found to be more effective in producing lentil hull hydrolysates enriched in potential prebiotics and antioxidant compounds.
Review
Biotechnology & Applied Microbiology
Rajasri Yadavalli, Praharshita Valluru, Roshni Raj, C. Nagendranatha Reddy, Bishwambhar Mishra
Summary: Mycotoxins, including aflatoxins and Fusarium toxins, have harmful effects on both animals and humans. They can contaminate feed and food, leading to financial losses in the food and feed production industry. Biological detoxification, using algae and their compounds, offers an effective and eco-friendly method for mycotoxin decontamination. This study focuses on the potential utility of algal characteristics, particularly polysaccharides, in the detoxification of mycotoxins.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Agronomy
Mariangela Marrelli, Pasqualina Sprovieri, Filomena Conforti, Giancarlo Statti
Summary: The locally grown ancient wheat varieties Carosella and Majorca showed high polyphenol content and antioxidant activity. Whole wheat flour exhibited the highest antioxidant activity, indicating that these two wheat varieties could be potential sources of antioxidants with significant health benefits.
Review
Biotechnology & Applied Microbiology
Sherif Ashraf Fahmy, Mohamad Alawak, Jana Bruessler, Udo Bakowsky, Mayyada M. H. El Sayed
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Biochemistry & Molecular Biology
Nihal Abou El Azm, Daisy Fleita, Dalia Rifaat, Eric Zadok Mpingirika, Asma Amleh, Mayyada M. H. El-Sayed
Review
Pharmacology & Pharmacy
Sherif Ashraf Fahmy, Jana Bruessler, Mohamad Alawak, Mayyada M. H. El-Sayed, Udo Bakowsky, Tamer Shoeib
Article
Multidisciplinary Sciences
Omar S. Bayomie, Haitham Kandeel, Tamer Shoeib, Hu Yang, Noha Youssef, Mayyada M. H. El-Sayed
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Multidisciplinary
Hanaa L. Essa, Mohamed S. Abdelfattah, Alaa S. Marzouk, Hania A. Guirguis, Mayyada M. H. El-Sayed
APPLIED SCIENCES-BASEL
(2020)
Article
Multidisciplinary Sciences
Hanaa L. Essa, Mohamed S. Abdelfattah, Alaa S. Marzouk, Zeinab Shedeed, Hania A. Guirguis, Mayyada M. H. El-Sayed
Summary: Biogenic copper nanoparticles were synthesized using mangrove leaf extract and their impact on wheat seedling growth was dose-dependent. The nanoparticles promoted growth at lower concentration but inhibited it at higher concentration, affecting chlorophyll content in wheat leaves.
Article
Pharmacology & Pharmacy
Nada Mostafa Aboeita, Sherif Ashraf Fahmy, Mayyada M. H. El-Sayed, Hassan Mohamed El-Said Azzazy, Tamer Shoeib
Summary: This study optimized the ultrasound-assisted extraction technique to extract a highly antioxidant extract from red algae. The extract was then used for the synthesis of copper nanoparticles, which were loaded with nedaplatin to enhance its anticancer effect.
Article
Chemistry, Multidisciplinary
Naela Adel Mohammed Saleh, Rowan Bahaa El-din Abd El-bary, Eric Zadok Mpingirika, Hanaa L. Essa, Mayyada M. H. El-Sayed, Mirna Sarkis Sherbetjian, Hanin Fadel Elfandi, Muhammad Adel Abdel Wahed, Rami Arafeh, Asma Amleh
Summary: This study investigated the effects of Salvia triloba leaf extracts on cell viability, migration, and gene expression in osteosarcoma and ovarian cancer cells. The results showed that the extract had potential therapeutic compounds that inhibited cell proliferation and migration, and modulated genes involved in cancer progression.
APPLIED SCIENCES-BASEL
(2022)
Article
Environmental Sciences
Hebatullah H. Farghal, Marianne Nebsen, Mayyada M. H. El-Sayed
Summary: In this study, chitosan/xylan-coated magnetite (CsXM) nanoparticles were developed as eco-friendly efficient adsorbents for contaminant removal from water. The CsXM was successfully prepared with mesoporous structure, thermal stability, and neutral charge. Three representative pollutants, Pb(II), salicylic acid (SA), and congo red (CR), were effectively removed by CsXM, with Pb(II) and SA showing higher adsorption compared to CR. The adsorption followed the Freundlich isotherm model and the pseudo-second order kinetic model, and the binding mechanisms differed for different pollutants.
Article
Chemistry, Multidisciplinary
Jehan Abdel Salam, Amina A. Saleh, Toqa Taha El Nenaiey, Hu Yang, Tamer Shoeib, Mayyada M. H. El-Sayed
Summary: The study investigates the potential use of cape gooseberry husk as a biosorbent for removing pharmaceutical contaminants from water. The activated husk showed increased surface area, pore volume, and adsorption efficiency. It can be regenerated and reused for multiple cycles.
Article
Engineering, Chemical
Pan Hu, Yibei Sun, Pengwei Li, Wenxiao Ren, Jiachun Ren, Kexin Su, Jun Cai, Mayyada M. H. El-Sayed, Tamer Shoeib, Hu Yang
Summary: In this study, four starch-based coagulants were designed and fabricated, and their efficiency in removing nano-sized plastics from water was evaluated. The results showed that graft and partially hydrophobic starch-based coagulants exhibited better removal efficiency and produced more durable flocs compared to linear and hydrophilic coagulants. The findings highlight the importance of chain architecture and hydrophilicity in the design and selection of polymeric coagulants for efficient water treatment.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Polymer Science
Rasha E. Elsayed, Dina Hassanein, Mayyada M. H. El-Sayed, Tarek M. Madkour
Summary: A novel adsorbent-contaminant system consisting of bio-based crosslinked chitosan beads functionalized with poly(itaconic acid) side chains was investigated for removing diclofenac potassium from contaminated water. The polymeric microstructure of the adsorbent significantly influenced its adsorptive capacity, which was evaluated through various adsorbent samples prepared with different initiator and monomeric concentrations. The results showed that the grafted chitosan beads exhibited improved adsorption efficiencies compared to unfunctionalized chitosan beads, with adsorption mechanisms involving hydrogen bonding and stacking interaction. The study highlights the potential of grafted chitosan beads in removing emerging contaminants from water.
Article
Chemistry, Multidisciplinary
Hebatullah H. Farghal, Marianne Nebsen, Mayyada M. H. El-Sayed
Summary: A green approach was proposed to convert expired cellulose biopolymers into hydrochar adsorbents for removing pharmaceutical contaminants from water. The produced thermally stable hydrochar showed efficient removal of the contaminants, and a hydrochar/magnetite nanocomposite exhibited enhanced removal performance.
Article
Chemistry, Multidisciplinary
Amany A. Mostafa, Mayyada M. H. El-Sayed, Ahmed N. Emam, Ahmed A. Abd-Rabou, Reham M. Dawood, Hassane Oudadesse
Summary: This study investigated the bioactivity of novel silver-doped and gold-doped quaternary bioactive glasses. Silver doping enhanced phosphate uptake rate, while gold doping improved calcium and phosphate uptake rates and calcium uptake capacity. Gold-doped bioactive glasses were found to be favorable for enhancing calcium and phosphate uptake rates, while silver-doped glasses could be utilized for applications targeting rapid healing.
