Article
Medicine, General & Internal
Orlando Vieira Gomes, Leonardo Fernandes e Santana, Rita Marina Soares de Castro Duarte, Mateus de Sousa Rodrigues, Jandir Mendonca Nicacio, Dyego Jose de Araujo Brito, Monique Pereira Rego Muniz, Natalino Salgado-Filho, Precil Diego Miranda de Menezes Neves, Gyl Eanes Barros Silva
Summary: Lupus nephritis is a serious manifestation of systemic lupus erythematosus, primarily affecting the glomerulus, but can also present as an isolated tubular disease. Early diagnosis and treatment are crucial for patient outcomes.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Agneta Zickert, Klas Lannfelt, Jan Schmidt Mende, Birgitta Sundelin, Iva Gunnarsson
Summary: In patients with MLN, repeat renal biopsies showed increased resorption of immune complexes after RTX treatment, which was associated with clinical response. This phenomenon was not observed in patients treated with conventional therapies, suggesting that evaluation using electron microscopy findings may be useful for assessing treatment response in MLN.
Article
Rheumatology
Francesca Faustini, Helena Idborg, Enrico Fuzzi, Anders Larsson, Wen-Rong Lie, Sven Poetzsch, Shinji L. Okitsu, Elisabet Svenungsson, Iva Gunnarsson
Summary: This study investigated the role of urinary galectin-3 binding protein (u-Gal-3BP) as a candidate biomarker for renal disease in Lupus nephritis (LN). The results showed that u-Gal-3BP levels were higher in LN patients and correlated with the activity index in renal biopsies. After treatment, u-Gal-3BP levels decreased. Therefore, u-Gal-3BP shows promise as a non-invasive urinary biomarker to help detect and monitor renal involvement in Lupus erythematosus patients.
Review
Biochemistry & Molecular Biology
Marta Monticolo, Krzysztof Mucha, Bartosz Foroncewicz
Summary: Lupus nephritis is a common and serious complication of systemic lupus erythematosus, with genetic and environmental factors, including dysbiosis, playing a role in its development. The relationship between the human microbiome, genetic determinants, individual variability, and clinical consequences needs further investigation. Bacterial metabolites that mimic autoantigens and stimulate autoimmune responses may be a potential target for future interventions in Lupus nephritis.
Article
Rheumatology
Huihua Ding, Yiwei Shen, Cheng Lin, Ling Qin, Shijun He, Min Dai, Shinji L. Okitsu, Julie A. DeMartino, Qiang Guo, Nan Shen
Summary: Urinary G3BP levels are associated with renal disease activity in lupus nephritis patients and could serve as a non-invasive biomarker when renal biopsy is impractical.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Biology
Raouia Fakhfakh, Emna Bouallegui, Hana Houssaini, Nesrine Elloumi, Fatma Dhafouli, Olfa Abida, Hend Hachicha, Sameh Marzouk, Zouhir Bahloul, Khawla Kammoun, Tahia Boudawara, Hatem Masmoudi
Summary: Lupus nephritis (LN) is an immune complex glomerulonephritis, and the mechanisms of its pathogenesis are related to the expression and regulation of RNA-binding proteins (RBPs). Studying the differential expression of RBPs and their regulatory effects on target genes can help identify new therapeutic targets for LN.
Review
Medicine, Research & Experimental
Emily Capone, Stefano Iacobelli, Gianluca Sala
Summary: LGALS3BP, a secreted protein expressed in most human cells, has been identified as a potential therapeutic target for cancer treatment. Studies have shown that LGALS3BP plays a significant role in cancer, potentially impacting prognosis and functionality.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Camila Barbosa Oliveira, Camilla Albertina Dantas Lima, Gisele Vajgel, Paula Sandrin-Garcia
Summary: This review manuscript discusses the relationship between the NLRP3 inflammasome, SLE, and LN, emphasizing the impact of genetic susceptibility of NLRP3 polymorphisms on the disease and exploring NLRP3 inhibition mechanisms for the development of potential therapeutic drugs for LN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Allison C. Billi, Feiyang Ma, Olesya Plazyo, Mehrnaz Gharaee-Kermani, Rachael Wasikowski, Grace A. Hile, Xianying Xing, Christine M. Yee, Syed M. Rizvi, Mitra P. Maz, Celine C. Berthier, Fei Wen, Lam C. Tsoi, Matteo Pellegrini, Robert L. Modlin, Johann E. Gudjonsson, J. Michelle Kahlenberg
Summary: This study analyzed the skin and circulating immune cells of lupus patients using integrated single-cell RNA sequencing and spatial RNA sequencing. The findings reveal that the normal-appearing skin of patients with lupus is characterized by an interferon-rich environment and that CD16+ dendritic cells undergo interferon education in the skin, leading to proinflammatory phenotypes. These results provide important insights into the pathogenesis of cutaneous lupus erythematosus.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Rheumatology
Amany M. Ebaid, Nillie Ezzeldin, Enas Abdelhady, Heba A. Mohammed, Alshimaa L. Abdallah
Summary: This study evaluated the relationship between serum IGBP1 and SLE disease activity and renal activity, and found that serum IGBP1 is a valid biomarker for detecting active nephritis. Clinicians are recommended to monitor the serum IGBP1 levels of patients with SLE to detect LN.
Article
Rheumatology
A. S. R. Peretz, N. S. Rasmussen, S. Jacobsen, C. Sjowall, C. T. Nielsen
Summary: In patients with SLE, serum G3BP has been identified as a novel predictor of VTE. Further studies are necessary to better understand the role of G3BP in VTE and its clinical implications.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Immunology
Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai
Summary: This study investigated the alteration of oxylipins in the serum of systemic lupus erythematosus (SLE) patients and identified potential biomarkers for SLE classification. The results showed that certain oxylipins were correlated with lupus nephritis (LN) and SLE disease activity. Additionally, a combination of 5 oxylipins was found to have high accuracy in classifying SLE patients. The findings provide insights into the characteristics of SLE and the development of new tools for classification.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Marlene Pluess, Silvia Piantoni, Bjoern Tampe, Alfred H. J. Kim, Peter Korsten
Summary: Advances in the treatment and management of systemic lupus erythematosus have improved patient outcomes, but lupus nephritis remains a major complication. Belimumab has been shown to be superior as an add-on therapy for lupus nephritis, and personalized treatment options are expected with the development of new therapeutic agents.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Emil Carlsson, Alexandra Quist, Jennifer C. Davies, Angela Midgley, Eve M. D. Smith, Ian N. Bruce, Michael W. Beresford, Christian M. Hedrich
Summary: Approximately 30% of adult-onset systemic lupus erythematosus (SLE) patients develop lupus nephritis (LN). Current gold standard for LN detection, renal biopsies, is invasive and not suitable for routine monitoring. This study found that urinary proteins can be used to predict the activity of LN and support ongoing disease monitoring in adult-onset SLE patients. Further validation in larger cohorts is needed.
CLINICAL IMMUNOLOGY
(2022)
Article
Environmental Sciences
Heming Bai, Lei Jiang, Ting Li, Chong Liu, Xiaoxia Zuo, Yi Liu, Shaoxian Hu, Linyun Sun, Miaojia Zhang, Jin Lin, Weiguo Xiao, Qingwen Wang, Dongbao Zhao, Huaxiang Wu, Xiaodan Kong, Wenkang Gao, Wanxin Hou, Myeongsu Seong, Yuanpeng Zhang, Fangfang Chen, Sheng Chen, Xin Wu, Chunde Bao, Li Wang, Huji Xu
Summary: The study found that air pollutants PM2.5 and NO2 may be risk factors for lupus nephritis (LN), while short-term exposure to CO and O-3 does not generally have an association with LN. Furthermore, negative associations of LN with SO2 were observed for the entire region and east China.
ENVIRONMENTAL RESEARCH
(2021)
Letter
Rheumatology
Sindhu R. Johnson, Martin Aringer
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
George C. Drosos, Daisy Vedder, Eline Houben, Laura Boekel, Fabiola Atzeni, Sara Badreh, Dimitrios T. Boumpas, Nina Brodin, Ian N. Bruce, Miguel Angel Gonzalez-Gay, Soren Jacobsen, Gyorgy Kerekes, Francesca Marchiori, Chetan Mukhtyar, Manuel Ramos-Casals, Naveed Sattar, Karen Schreiber, Savino Sciascia, Elisabet Svenungsson, Zoltan Szekanecz, Anne-Kathrin Tausche, Alan Tyndall, Vokko van Halm, Alexandre Voskuyl, Gary J. Macfarlane, Michael M. Ward, Michael T. Nurmohamed, Maria G. Tektonidou
Summary: This study developed recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, emphasizing the importance of regular screening and management of modifiable CVR factors as well as patient education. The recommendations covered CVR prediction tools, interventions on traditional CVR factors, and interventions on disease-related CVR factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Sindhu R. Johnson, Dafna D. Gladman, Hermine Brunner, David Isenberg, Ann E. Clarke, Megan R. W. Barber, Laurent Arnaud, Paul R. Fortin, Marta Mosca, Alexandre E. Voskuyl, Susan Manzi, Cynthia Aranow, Anca Askanase, Graciela S. Alarcon, Sang-Cheol Bae, Nathalie Costedoat-Chalumeau, Jessica A. English, Guillermo J. Pons-Estel, Bernardo A. Pons-Estel, Rebecca Gilman, Ellen M. Ginzler, John G. Hanly, Soren Jacobsen, Kenneth Kalunian, Diane L. Kamen, Chynace Lambalgen, Alexandra Legge, S. Sam Lim, Anselm Mak, Eric F. Morand, Christine A. Peschken, Michelle Petri, Anisur Rahman, Rosalind Ramsey-Goldman, John A. Reynolds, Juanita Romero-Diaz, Guillermo Ruiz-Irastorza, Jorge Sanchez-Guerrero, Elisabet Svenungsson, Zahi Touma, Murray Urowitz, Evelyne Vinet, Ronald F. van Vollenhoven, Heather Waldhauser, Daniel J. Wallace, Asad Zoma, Ian N. Bruce
Summary: The SLICC, ACR, and Lupus Foundation of America are developing a revised SLE damage index (SDI) due to shifts in the concept of damage in SLE. A qualitative study was conducted to evaluate contemporary constructs in SLE damage and develop a conceptual framework for the revised SDI.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Biochemical Research Methods
Anders H. Kverneland, Ole Ostergaard, Kristina Bennet Emdal, Inge Marie Svane, Jesper Velgaard Olsen
Summary: This study demonstrates that enrichment of extracellular vesicles (EVs) by ultracentrifugation can significantly increase the depth of the plasma proteome analysis. By optimizing the workflow, over two thousand proteins can be quantified in a short time using label-free quantification and data independent acquisition (DIA), enabling high-throughput analysis of plasma samples and supporting potential biomarker discovery in the future.
Article
Medicine, Research & Experimental
Alexandros Mitropoulos, Carina Bostrom, Malin Mattsson, Evangelia Kouidi, Theodoros Dimitroulas, Sophie I. E. Liem, Theodora P. M. Vliet Vlieland, Jeska K. de Vries-Bouwstra, Soren Jacobsen, Giovanna Cuomo, Mohammed Akil, Markos Klonizakis
Summary: This study aims to explore the effects of a long-term, tailored exercise programme on pain, fatigue, quality of life, physical fitness, functional capacity, and vascular structure in patients with systemic sclerosis (SSc).
Article
Rheumatology
Ann E. Clarke, John G. Hanly, Murray B. Urowitz, Yvan St. Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. Van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, S. Sam Lim, Murat Inanc, Kenneth C. Kalunian, Soren Jacobsen, Christine A. Peschken, Diane L. Kamen, Anca Askanase, Vernon Farewell
Summary: The objective of this study was to estimate the costs associated with neuropsychiatric events in SLE. The study found that new/ongoing SLE or non-SLE NP events incurred higher direct and indirect costs. Indirect costs exceeded direct costs by 3.0 to 5.2 fold.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Renata Baronaite Hansen, Titilola Falasinnu, Mikkel Faurschou, Soren Jacobsen, Julia F. Simard
Summary: This study aimed to determine whether diabetes mellitus (DM) increases the risk of end-stage renal disease (ESRD) in patients with systemic lupus erythematosus (SLE). The findings show that SLE patients with DM have a 3 times higher risk of developing ESRD compared to SLE patients without DM.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
May Yee Choi, Irene Chen, Ann Elaine Clarke, Marvin J. Fritzler, Katherine A. Buhler, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Alan Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Kenneth Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, David Sontag, Karen H. Costenbader
Summary: A novel longitudinal clustering technique was used to analyze comprehensive autoantibody data from a large, well-characterised, multinational inception SLE cohort, in order to determine predictive profiles of clinical outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Clinical Neurology
Louise Pyndt Diederichsen, Line Vinderslev Iversen, Christoffer Tandrup Nielsen, Soren Jacobsen, Marie-Louise Hermansen, Nanna Witting, Rikke Cortes, Sine Sondergaard Korsholm, Markus Engebaek Krogager, Tina Friis
Summary: This study aimed to determine the prevalence and clinical associations of cN-1A autoantibodies in patients with connective tissue diseases. The results showed that cN-1A autoantibodies were predominantly found in patients with idiopathic inflammatory myopathies (IIM) and were associated with dysphagia in sporadic inclusion body myositis (sIBM) patients. Additionally, cN-1A positive non-IBM IIM patients had a milder disease course.
Article
Virology
Julie Knudsen, Nicole Hartwig Trier, Anette Holck Draborg, Christoffer Tandrup Nielsen, Soren Jacobsen, Peter Hojrup, Gunnar Houen
Summary: SLE and DIL are autoimmune diseases associated with EBV and CMV infections, but they differ in onset and clinical symptoms. This study found significantly elevated IgG titers to EBV and CMV antigens in serum samples from SLE and DIL patients, as well as reduced total IgG titers, which may be related to lymphocytopenia commonly seen in SLE.
Article
Microbiology
Rosa Maja Mohring Gynthersen, Mette Frimodt Hansen, Lukas Frans Ocias, Andreas Kjaer, Randi Fons Petersen, Sisse Rye Ostrowski, Lene Harritshoj, Soren Jacobsen, Ulrik Overgaard, Karen Angeliki Krogfelt, Anne-Mette Lebech, Helene Mens
Summary: The presence of N. mikurensis DNA was detected in immunocompromised patients in Denmark, highlighting the potential underdiagnosis of this bacterium in Danish patients.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2023)
Article
Medicine, General & Internal
Simon Jonck, Malte Lund Adamsen, Pil Hojgaard, Iben Elmerdahl Rasmussen, Helga Ellingsgaard, Morten Asp Vonsild Lund, Peter Godsk Jorgensen, Soren Jacobsen, Lars Kober, Niels Vejlstrup, Lene Dreyer, Bente Klarlund Pedersen, Ronan M. G. Berg, Regitse Hojgaard Christensen
Summary: The chronic inflammatory state in rheumatoid arthritis (RA) increases the risk of cardiovascular disease (CVD), with pro-inflammatory cytokines tumor necrosis factor (TNF) and interleukin 6 (IL-6) playing a vital role. Biological disease-modifying antirheumatic drugs (bDMARDs) may attenuate that risk. IL-6 is also a myokine, secreted from exercising skeletal muscles, where it exhibits anti-inflammatory effects that may mitigate the risk of CVD. We hypothesize that inhibiting IL-6 signaling will impair the cardiac and metabolic adaptations to exercise training compared to TNF inhibition in RA patients.
Article
Rheumatology
Yann Nguyen, Benoit Blanchet, Murray B. Urowitz, John G. Hanly, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Ann E. Clarke, Sasha Bernatsky, Daniel J. Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Joensen, Graciela S. Alarcon, Ronald F. Van Vollenhoven, Cynthia Aranow, Veronique Le Guern, Meggan Mackay, Guillermo Ruiz-Irastorza, S. Sam Lim, Murat Inanc, Kenneth C. Kalunian, Soren Jacobsen, Christine A. Peschken, Diane L. Kamen, Anca Askanase, Jill Buyon, Nathalie Costedoat-Chalumeau
Summary: The study aimed to assess the association between severe nonadherence to hydroxychloroquine (HCQ), analyzed by HCQ serum levels, and risks of systemic lupus erythematosus (SLE) flares, damage, and mortality rates. Severe nonadherence was found to be independently associated with increased risk of SLE flares, early damage, and five-year mortality.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
R. Talarico, G. A. Ramirez, S. C. Barreira, C. Cardamone, P. Triggianese, S. Aguilera, J. Andersen, T. Avcin, K. Benistan, G. Bertsias, A. Bortoluzzi, C. Bouillot, I. Bulina, G. R. Burmester, S. Callens, P. E. Carreira, R. Cervera, M. Cutolo, L. Damian, E. Della Torre, R. Faria, J. E. Fonseca, I. Galetti, E. Hachulla, L. Iaccarino, S. Jacobsen, N. Khmelinskii, M. Limper, D. Marinello, A. Meyer, G. Moroncini, G. Nagy, M. Olesinska, C. Pamfil, M. Pileckyte, M. Pistello, S. Rednic, C. Richez, V. C. Romao, M. Schneider, S. Sciascia, C. A. Scire, G. Simonini, V. Smith, A. Sulli, C. Tani, S. W. Tas, A. Tincani, M. C. Vonk, M. Tektonidou, M. Mosca
Summary: Recent studies have shown that immunocompromised individuals may inadvertently contribute to the mutations of the virus that lead to new variants. This aspect should be carefully considered as immunocompromised individuals remain at risk of COVID-19 despite vaccination, experience more severe disease, and can be contagious for longer. The European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ReCONNET) addressed this issue by forming a multidisciplinary Task Force to develop guidelines for treating immunocompromised patients with COVID-19. The final principles and points-to-consider were agreed upon by the Task Force.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Katrine A. Myhr, Amanda H. Zinglersen, Redi Pecini, Soren Jacobsen
Summary: This study aimed to investigate the prevalence and degree of myocardial fibrosis in SLE patients. The results showed that SLE patients displayed signs of myocardial fibrosis on CMR, which were associated with the presence of lupus anticoagulant (LAC).
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
