期刊
LUNG CANCER
卷 89, 期 2, 页码 115-120出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2015.05.019
关键词
Stereotactic body radiation therapy; Non-small cell lung cancer; PET
资金
- NIH [P30 CA008748]
Objectives: Glucose metabolic activity measured by [F-18]-fluoro-2-deoxy-glucose positron emission tomography (FOG-PET) has shown prognostic value in multiple malignancies, but results are often confounded by the inclusion of patients with various disease stages and undergoing various therapies. This study was designed to evaluate the prognostic value of tumor FOG uptake quantified by maximum standardized uptake value (SUVmax) in a large group of early-stage non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) using consistent treatment techniques. Materials and methods: Two hundred nineteen lesions in 211 patients treated with definitive SBRT for stage I NSCLC were analyzed after a median follow-up of 25.2 months. Cox regression was used to determine associations between SUVmax. and overall survival (OS), disease-specific survival (DSS), and freedom from local recurrence (FFLR) or distant metastasis (FFDM). Results: SUVmax >3.0 was associated with worse OS (p < 0.001), FFLR (p = 0.003) and FFDM (p = 0.003). On multivariate analysis, OS was associated with SUVmax (HR 1.89, p = 0.03), gross tumor volume (GTV) (HR 1.94,p = 0.005) and Karnofsky performance status (KPS) (HR 0.51,p = 0.008). DSS was associated only with SUVmax (HR 2.58, p = 0.04). Both LR (HR 11.47, p = 0.02) and DM (HR 3.75, p = 0.006) were also associated with higher SUVmax. Conclusion: In a large patient population, SUVmax >3.0 was associated with worse survival and a greater propensity for local recurrence and distant metastasis after SBRT for NSCLC. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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