Review
Biochemistry & Molecular Biology
Shizuya Yamashita, Manfredi Rizzo, Ta-Chen Su, Daisaku Masuda
Summary: Statins, ezetimibe, and PCSK9 inhibitors can lower LDL-C levels and reduce cardiovascular events, but residual risk factors like hypertriglyceridemia and low HDL-C still exist. Fibrates, nicotinic acids, and n-3 polyunsaturated fatty acids can be used to treat these risk factors.
Article
Ophthalmology
Pan Gao, Danna Jia, Pei Li, Yuwen Huang, Hualei Hu, Kui Sun, Yuexia Lv, Xiang Chen, Yunqiao Han, Zuxiao Zhang, Xiang Ren, Qing Wang, Fei Liu, Zhaohui Tang, Mugen Liu
Summary: A zebrafish model was generated to study the functional role of CYP4V2 in BCD development, revealing abnormal lipid metabolism in RPE cells as a direct consequence of CYP4V2 deficiency. Transcriptome analysis suggested dysregulation of the PPAR alpha pathway as a potential therapeutic target for BCD.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Miaomiao Xue, Pao Xu, Haibo Wen, Jianxiang Chen, Qingyong Wang, Jiyan He, Changchang He, Changxin Kong, Changyou Song, Hongxia Li
Summary: This study investigated the physiological changes and underlying mechanisms associated with lipid deposition in the liver of freshwater drums. The results showed that high-fat diets led to lipid deposition and affected fish health, causing metabolic disorders and inhibited antioxidant capacity. The study also identified specific molecular targets and pathways involved in lipid metabolism and oxidative stress, providing important insights for fatty liver control and prevention in aquatic animals.
Article
Biochemistry & Molecular Biology
Zhiyi Yuan, Xi Lu, Fan Lei, Hong Sun, Jingfei Jiang, Dongming Xing, Lijun Du
Summary: p-coumaric acid (p-CA) is a common plant phenolic acid with multiple bioactivities and a lipid-lowering effect. It has the potential to be used as a therapeutic drug or health care product for hyperlipidemia and fatty liver. However, the mechanism by which it regulates lipid metabolism is still unclear.
Article
Biochemistry & Molecular Biology
Sheng-Feng Tsai, Hao-Chang Hung, Monica Meng-Chun Shih, Fu-Chuan Chang, Bon-chu Chung, Chia-Yih Wang, Yu-Ling Lin, Yu-Min Kuo
Summary: This study aimed to investigate the causal relationship between chronic ingestion of a high-fat diet (HFD)-induced secretion of glucocorticoids (GCs) and the development of non-alcoholic fatty liver disease (NAFLD). The study found that the release of glucocorticoids induced by high-fat diet contributes to the development of NAFLD, and this process involves the upregulation of CD36 in the liver.
Article
Biochemistry & Molecular Biology
Yong Zhang, Jie Xu, Di Zhou, Tingting Ye, Puqing Zhou, Zuofeng Liu, Xinyuan Liu, Zinan Wang, Tianmiao Hua, Zhenghao Zhang, Qingyan Sun
Summary: This study demonstrates that swimming exercise can improve lipid metabolism in insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) through modulation of PPAR gamma signaling in the liver of mice.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zhen Chen, Rojeet Shrestha, Xiaoyue Yang, Xunzhi Wu, Jiaping Jia, Hitoshi Chiba, Shu-Ping Hui
Summary: This study investigated the chemical composition of lipid droplets (LDs) in human kidney cells under the influence of free fatty acids and oxidized lipoproteins. The results showed that both the fatty acids and oxidized lipoproteins significantly altered the lipid content and composition of LDs. The accumulation of oxidized lipids and dysregulation of lipid metabolism in LDs may be potential targets for the diagnosis and treatment of chronic kidney disease (CKD).
Article
Food Science & Technology
Yongshou Yang, Rikako Fukui, Huijuan Jia, Hisanori Kato
Summary: The study revealed that dietary supplementation with amaranth significantly reduced triglycerides, total cholesterol, and phospholipids levels in the liver, as well as downregulated the expression of lipogenesis-related genes. Amaranth supplementation also reversed the reduction in gut microbiota diversity and richness induced by a high-fat diet.
Review
Biochemistry & Molecular Biology
Ling Wang, Jiaye Liu, Zhijiang Miao, Qiuwei Pan, Wanlu Cao
Summary: Lipid droplets are cellular organelles used for lipid storage, existing as giant organelles in fat tissue and as small structures in hepatocytes, playing key roles in liver health and disease. They are involved in lipid metabolism, cell signaling, and interact with other organelles to regulate cellular biology.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Francisca S. Teixeira, Ligia L. Pimentel, Manuela E. Pintado, Luis M. Rodriguez-Alcala
Summary: The liver plays a crucial role in lipid metabolism and metabolic homeostasis. Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease worldwide and currently has no specific treatments. Lifestyle modifications such as weight loss, exercise, and dietary changes are recommended to reduce the risk factors associated with the disease. This publication provides an overview of the available research on lipid biomarkers linked to NAFLD and can guide the development of future pharmacological therapies.
Article
Endocrinology & Metabolism
Mikala M. Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E. Mead, Zachary A. Kipp, Evelyn A. Bates, Venkateshwari Varadharajan, Rakhee Banerjee, Se-Hyung Park, Nathan R. Shelman, Harrison A. Clarke, Tara R. Hawkinson, Terrymar Medina, Ramon C. Sun, Todd A. Lydic, Terry D. Hinds Jr, J. Mark Brown, Samir Softic, Gregory A. Graf, Robert N. Helsley
Summary: This study found that liver-specific deletion of CPT1a promotes sexually dimorphic steatotic liver disease (SLD) in mice, and new mechanisms by which females are protected from high-fat diet-induced liver injury were identified.
MOLECULAR METABOLISM
(2023)
Article
Food Science & Technology
Yiran Bu, Si Chen, Mengcheng Ruan, Libang Wu, Hualin Wang, Na Li, Xiuju Zhao, Xiaoli Yu, Zhiguo Liu
Summary: This study aimed to explore the effects of Per1/Per2 double knockout (DKO) on hepatic lipid metabolism in mice under HFD and HFD with DHA substitution. The results showed that Per1/Per2 played an important role in the circadian regulation of hepatic lipid metabolism, and DKO mice were more sensitive to HFD. DHA can improve circadian-related lipid metabolism disruption induced by HFD in mice.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Integrative & Complementary Medicine
Cui Shuang, Pan Xiao-Jie, Ge Chao-Liang, Guo Yi-Tong, Zhang Peng-Fei, Yan Ting-Ting, Zhou Ji-Yu, He Qing-Xian, Cheng Long-Hao, Wang Guang-Ji, Hao Hai-Ping, Wang Hong
Summary: Silymarin protects against NAFLD by activating PPARα to reduce lipid accumulation in mice, and it is not recommended to take silymarin and classical PPARα agonists simultaneously for NAFLD therapy.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Agriculture, Multidisciplinary
Huicui Liu, Tao Chen, Xiaoqing Xie, Xinlei Wang, Yiwen Luo, Nan Xu, Zhen Sa, Min Zhang, Zhifei Chen, Xinzhong Hu, Juxiu Li
Summary: The study demonstrates that BG from highland barley can significantly alleviate liver steatosis induced by NAFLD, by altering lipid metabolic patterns and regulating lipid metabolism-related genes. Additionally, the research also identified 13 differentially regulated lipid species that may serve as lipid biomarkers.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Wang Zhang, Jing-Ya Li, Xiao-Chen Wei, Qian Wang, Ji-Yang Yang, Huan Hou, Zi-Wei Du, Xin-An Wu
Summary: The study revealed that DBP can induce fatty liver disease by activating the PPAR alpha signaling pathway and inhibiting AMPK phosphorylation. The results indicated that DBP affects protein expression, leading to hyperlipidemia and abnormal liver function, which can be alleviated through the PPAR alpha/SREBP-1c/FAS/GPAT/AMPK signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Nutrition & Dietetics
Michael Hoppe, Alastair B. Ross, Cecilia Svelander, Ann-Sofie Sandberg, Lena Hulthen
EUROPEAN JOURNAL OF NUTRITION
(2019)
Article
Nutrition & Dietetics
Ulrika Andersson-Hall, Nils-Gunnar Carlsson, Ann-Sofie Sandberg, Agneta Holmang
Article
Nutrition & Dietetics
Malin Barman, Karin Jonsson, Agnes E. Wold, Ann-Sofie Sandberg
Article
Nutrition & Dietetics
Mia Stravik, Karin Jonsson, Olle Hartvigsson, Anna Sandin, Agnes E. Wold, Ann-Sofie Sandberg, Malin Barman
Article
Biochemistry & Molecular Biology
Nikul Soni, Alastair B. Ross, Nathalie Scheers, Intawat Nookaew, Britt G. Gabrielsson, Ann-Sofie Sandberg
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Food Science & Technology
Vanesa Castro-Alba, Claudia Eliana Lazarte, Daysi Perez-Rea, Ann-Sofie Sandberg, Nils-Gunnar Carlsson, Annette Almgren, Bjorn Bergenstahl, Yvonne Granfeldt
FOOD SCIENCE & NUTRITION
(2019)
Article
Multidisciplinary Sciences
Swarnim Gupta, Edwin Habeych, Nathalie Scheers, Sylvie Merinat, Brigitte Rey, Nicola Galaffu, Ann-Sofie Sandberg
SCIENTIFIC REPORTS
(2020)
Article
Nutrition & Dietetics
Malin Barman, Hardis Rabe, Bill Hesselmar, Susanne Johansen, Ann-Sofie Sandberg, Agnes E. Wold
Article
Nutrition & Dietetics
Mia Stravik, Malin Barman, Bill Hesselmar, Anna Sandin, Agnes E. Wold, Ann-Sofie Sandberg
Article
Obstetrics & Gynecology
Linda Englund Ogge, Fiona Murray, Dominika Modzelewska, Robert Lundqvist, Staffan Nilsson, Helena Carre, Maria Kippler, Agnes E. Wold, Ann-Sofie Sandberg, Anna Sandin, Bo Jacobsson, Malin Barman
Summary: This study investigates the potential bias due to self-selection in the NICE birth cohort in Sweden and finds that self-selection has minimal impact on the study's outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Malin Barman, Mia Stravik, Karin Broberg, Anna Sandin, Agnes E. Wold, Ann-Sofie Sandberg
Summary: Higher proportions of n-6 polyunsaturated fatty acids (including arachidonic acid) but lower proportions of n-3 polyunsaturated fatty acids (including DPA) in the infant's phospholipids at birth were associated with an increased risk of atopic eczema at 12 months of age. The n-6 and n-3 PUFAs were related to maternal intake of meat and fish, respectively. Our results suggest that prenatal exposure to unsaturated fatty acids is associated with eczema development in the infant. Maternal diet during pregnancy may partly explain the fatty acid profiles in utero.
Article
Biochemistry & Molecular Biology
Olle Hartvigsson, Malin Barman, Otto Savolainen, Alastair B. Ross, Anna Sandin, Bo Jacobsson, Agnes E. Wold, Ann-Sofie Sandberg, Carl Brunius
Summary: The proportion of arterial and venous cord blood affects the monitoring results of neonate health. Metabolomics analysis reveals differences in the metabolomes of arterial and venous blood, mainly related to amino acid and energy metabolism. Venous cord metabolites related to energy metabolism are positively associated with multiple pregnancies.
Article
Nutrition & Dietetics
Inger-Cecilia Mayer Labba, Michael Hoppe, Elisabeth Gramatkovski, Martin Hjellstrom, Mehdi Abdollahi, Ingrid Undeland, Lena Hulthen, Ann-Sofie Sandberg
Summary: This study compared the absorption of non-heme iron from meals containing texturized fava bean protein, beef protein, and cod protein. The results showed that iron absorption from fava bean protein meal was significantly lower compared to beef protein meal and cod protein meal. Therefore, a dietary shift from meat and fish protein to fava bean protein may increase the risk of iron deficiency.
Article
Environmental Sciences
Mia Stravik, Klara Gustin, Malin Barman, Michael Levi, Anna Sandin, Agnes E. Wold, Ann-Sofie Sandberg, Maria Kippler, Marie Vahter
Summary: This study assessed biomarkers in the blood and urine of 549 pregnant women to investigate the effects of fish and seafood intake on fetal development. The results showed that erythrocyte mercury and urinary arsenobetaine are reliable indicators of seafood intake.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Mariza Kampouri, Klara Gustin, Mia Stravik, Malin Barman, Anna Sandin, Ann-Sofie Sandberg, Agnes E. Wold, Marie Vahter, Maria Kippler
Summary: Studies suggest that early-life exposure to toxic metals and fluoride may affect the immune system and contribute to allergic diseases. This study investigated the relationship between exposure to these compounds in pregnant women and their infants with food allergy and atopic eczema. The results showed that gestational cadmium exposure was associated with an increased risk of food allergy in infants, while gestational and infant fluoride exposure had a weak association with atopic eczema. Further research is needed to establish causality.
ENVIRONMENT INTERNATIONAL
(2023)