Article
Health Care Sciences & Services
Dandan Chen, Hui Zhang, Jingjie Wu, Erxu Xue, Pingping Guo, Leiwen Tang, Jing Shao, Nianqi Cui, Xiyi Wang, Liying Chen, Zhihong Ye
Summary: Individualized mHealth-based intervention using the Behavior Change Wheel is effective in promoting diet and physical activity behaviors in patients with MetS.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Nutrition & Dietetics
Analie Nunes Couto, Hildegard Hedwig Pohl, Moises Evandro Bauer, Carla Helena Augustin Schwanke
Summary: This study verified the performance of the TyG index in predicting MetS in healthy individuals living in rural areas and estimated the cutoff points for different criteria. The results showed that the TyG index performed well in diagnosing MetS.
Article
Biochemistry & Molecular Biology
Amy Christensen, Christian J. J. Pike
Summary: A Western diet high in sugars and saturated fats can lead to metabolic and inflammatory impairments associated with age-related disorders. The APOE genotype, specifically APOE4, increases the risk for Alzheimer's disease and type 2 diabetes. In this study, female mice with APOE3 or APOE4 were given a control or Western diet for 13 weeks. APOE4 mice on the control diet had worse metabolic profiles, poorer cognitive performance, and higher expression of inflammatory genes compared to APOE3 mice. The Western diet had minimal effects on both genotypes, suggesting protective factors of female sex and young adult age.
Article
Endocrinology & Metabolism
Yaling Li, Rui Zheng, Shuting Li, Ruyi Cai, Feihua Ni, Huiyan Zheng, Ruying Hu, Ting Sun
Summary: This study aimed to investigate the association between anthropometric indexes and metabolic syndrome in American adults. The results showed that lipid accumulation products (LAP) was a better predictor for identifying individuals with metabolic syndrome in the American adult population.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Sang Wook Kang, Su Kang Kim, Young Sik Kim, Min-Su Park
Summary: The TyG index and five SNPs were found to be associated with the risk of MetS. The combination of TyG index and SNPs showed better diagnostic accuracy for MetS.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Ui-Jeong Kim, Eun-Jeong Choi, Hyunjin Park, Hye-Ah Lee, Bomi Park, Haesoon Kim, Youngsun Hong, Seungyoun Jung, Hyesook Park
Summary: This study classified and analyzed the health-related behavior of children and adolescents, and found both direct and indirect effects of these behaviors on the risk of metabolic syndrome mediated by inflammation. The results showed a significant association between inactive lifestyle and metabolic syndrome, with interleukin-6 acting as a mediating factor. Therefore, appropriate health behavior interventions during childhood and adolescence are important for preventing metabolic syndrome.
Article
Psychology, Multidisciplinary
Se Hee Min, Sharron L. Docherty, Eun-Ok Im, Qing Yang
Summary: This study aims to identify subgroups of midlife women with different health behavior profiles, examine their association with metabolic syndrome, and provide personalized guidance for healthy behaviors.
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Article
Nursing
Sungwon Park, Min Kyeong Jang, Chang Gi Park, Oi Saeng Hong
Summary: This study examined the factors influencing health promotion behaviors of workers at high risk of metabolic syndrome by applying the constructs of the Theory of Planned Behavior. The results showed that perceived behavioral control was a key predictor of health behaviors, and the theory constructs partially explained the behaviors. It was also found that participants with one risk factor more effectively managed their behaviors compared to those with two risk factors.
Article
Pharmacology & Pharmacy
Payel Kundu, Sarah Holden, Ines L. Paraiso, Reetesh Sudhakar, Chloe McQuesten, Jaewoo Choi, Cristobal L. Miranda, Claudia S. Maier, Gerd Bobe, Jan F. Stevens, Jacob Raber
Summary: Consumption of a high fat diet is associated with metabolic syndrome and cognitive impairments. The plant compound Xanthohumol (XN) has beneficial effects on cognition and metabolism. The effects of XN vary depending on sex and ApoE isoform.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nursing
Sungwon Park, Jiwon Lee, Jo Woon Seok, Chang Gi Park, Jin Jun
Summary: Comprehensive lifestyle modifications, including diet and exercise, can improve health behaviors and some clinical parameters among individuals with metabolic syndrome, but further research on the efficacy of interventions of varying durations is needed.
JOURNAL OF NURSING SCHOLARSHIP
(2023)
Article
Endocrinology & Metabolism
Asiyeh Sadat Zahedi, Mahdi Akbarzadeh, Bahareh Sedaghati-Khayat, Atefeh Seyedhamzehzadeh, Maryam S. Daneshpour
Summary: In this study, we consistently replicated the association of GCKR SNPs with higher triglyceride and lower fasting blood sugar levels in Iranian adults (p < 0.05). The CT genotype of the variants was associated with lower HDL-C levels. The proportional Cox adjusted model regression demonstrated that TT carriers of rs780094, rs780093, and rs1260326 were associated with 20%, 23%, and 21% excess risk of metabolic syndrome incidence, respectively (p < 0.05). High triglyceride levels showed the strongest association with the selected GCKR variants among the components of metabolic syndrome, indicating a potential risk factor for future incidence of metabolic syndrome for individuals carrying these T allele variants.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Medicine, General & Internal
Tomohiro Iwakura, Takanori Yasu, Takashi Tomoe, Asuka Ueno, Takushi Sugiyama, Naoyuki Otani, Shinya Kawamoto, Hiroyuki Nakajima
Summary: Pemafibrate treatment reduces triglyceride and remnant lipoprotein levels in patients with type 2 diabetes or metabolic syndrome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Lacramioara Ionela Butnariu, Eusebiu Vlad Gorduza, Elena Tarca, Monica-Cristina Panzaru, Setalia Popa, Simona Stoleriu, Vasile Valeriu Lupu, Ancuta Lupu, Elena Cojocaru, Laura Mihaela Trandafir, Stefana Maria Moisa, Andreea Florea, Laura Statescu, Minerva Codruta Badescu
Summary: Atherogenic dyslipidemia is a critical component of metabolic syndrome and is influenced by genetic factors. Genetic studies, including candidate gene-based association studies and genome-wide association studies, have revealed the genetic heterogeneity of atherogenic dyslipidemia. However, many genetic factors are still unknown. Future research should focus on identifying new genes and their molecular mechanisms, which can lead to the development of innovative therapies. Additionally, the use of polygenic risk scores and biomarkers can help identify individuals at risk and guide personalized preventive measures and therapy.
Article
Endocrinology & Metabolism
Chih-Ying Lin, Hui-Jung Hung, Chi-Jung Chung, Chia-Ti Huang, Trong-Neng Wu, Chiu-Ying Chen
Summary: The study found significant differences in metabolic syndrome, obesity, and health behaviors between the Tsou indigenous group and the Han nonindigenous group in Taiwan, despite similar age and sex distributions. The Tsou group had higher rates of metabolic syndrome, obesity, and unhealthy behaviors compared to the Han group. Ethnicity per se played a significant role in the development of metabolic syndrome, with the Tsou indigenous people having increased risks, possibly due to biological reasons rooted in their origins that need further exploration. Unhealthy behaviors may also indirectly affect the development of metabolic syndrome through their impact on obesity.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Review
Nutrition & Dietetics
Radu Sascau, Alexandra Clement, Rodica Radu, Cristina Prisacariu, Cristian Statescu
Summary: While targeting elevated levels of low-density lipoprotein cholesterol has been the main focus of atherosclerosis prevention and treatment for decades, the relationship between hypertriglyceridemia and atherosclerosis remains controversial. Recent studies suggest a complex interplay between triglycerides and atherosclerosis, warranting further research.
Article
Oncology
Seong-Woo Bae, Felix Berlth, Kyoung-Yun Jeong, Ji-Hyeon Park, Jong-Ho Choi, Shin-Hoo Park, Yun-Suhk Suh, Seong-Ho Kong, Do-Joong Park, Hyuk-Joon Lee, Charles Lee, Jong-Il Kim, Hyewon Youn, Hongyoon Choi, Gi Jeong Cheon, Keon Wook Kang, Han-Kwang Yang
Summary: This study developed a genetic signature, PETscore, to predict the metabolic activity of GC and identified five genes associated with [F-18]FDG uptake in GC. The PETscore was validated using human GC data and revealed associations between glucose uptake, tumor mutational burden, and genomic alterations in GC.
Article
Oncology
Bum-Sup Jang, Ji-Hyun Chang, Seung Hyuck Jeon, Myung Geun Song, Kyung-Hun Lee, Seock-Ah Im, Jong-Il Kim, Tae-You Kim, Eui Kyu Chie
Summary: The value of genomic profiling for predicting radiation therapy response was evaluated and a Bayesian network model was constructed. Alterations of DNA repair pathway and smoking somatic signature were associated with durable radiation response. The Bayesian network model provided helpful insights for high precision radiotherapy. However, further validation in prospective cohorts is needed for individualized treatment.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Gastroenterology & Hepatology
Eun Roh, Soon Young Hwang, Hye Jin Yoo, Sei Hyun Baik, Jin-Hee Lee, Sang Joon Son, Hyeon Ju Kim, Yong Soon Park, Sam-Gyu Lee, Be Long Cho, Hak Chul Jang, Bong Jo Kim, Miji Kim, Chang Won Won, Kyung Mook Choi
Summary: The study suggests that NAFLD predicts future risk of LMM and LMS, with a greater impact on LMS than on LMM.
HEPATOLOGY INTERNATIONAL
(2022)
Article
Primary Health Care
Song Yi Kim, Ji Young Kim, Gyeongsil Lee, Jae Moon Yun, BeLong Cho
Summary: This study discusses the appropriateness of admission criteria and prioritization of patients in residential treatment centers in South Korea during the COVID-19 pandemic. The results show that some clinical conditions of low-risk patients worsened, requiring transfer to other hospitals. It is recommended to prioritize elderly or patients with underlying diseases and provide necessary equipment for self-isolation of young patients in similar large-scale outbreaks.
KOREAN JOURNAL OF FAMILY MEDICINE
(2022)
Review
Medicine, General & Internal
Dong Wook Shin, Juhee Cho, Jae Hyun Park, BeLong Cho
Summary: Health screening is a crucial component of health promotion programs worldwide, aiming to prevent and manage common chronic diseases at an early stage. The General Health Screening Program (GHSP) in Korea, which initially targeted workers in the 1950s, has expanded to include the entire adult population. The program focuses on diseases like cerebrovascular and cardiovascular diseases, along with other conditions such as anemia, liver disease, and mental health disorders. The National Health Information Database, which includes GHSP information, is extensively utilized for clinical and public health research. However, there is a need to evaluate screening items systematically, reduce disparities in participation, and integrate GHSP with actual health promotion activities.
PRECISION AND FUTURE MEDICINE
(2022)
Article
Oncology
Jinyoung Shin, Dong Wook Shin, Jungkwon Lee, Jihye Hwang, Ji Eun Lee, Belong Cho, Yun-Mi Song
Summary: This study evaluated fear of cancer recurrence (FCR) and factors related to FCR in Korean stomach cancer survivors. The results showed that FCR was associated with social, psychological, and health-related quality of life factors, rather than demographic, socioeconomic, or cancer-related factors. This suggests the importance of addressing FCR and providing comprehensive survivorship care for stomach cancer survivors.
Article
Clinical Neurology
Hee-Kyung Joh, Hyuktae Kwon, Ki Young Son, Jae Moon Yun, Su Hwan Cho, Kyungdo Han, Jin-Ho Park, Belong Cho
Summary: This study examines the association between the allergic triad (asthma, allergic rhinitis, atopic dermatitis) and the risk of dementia. The results indicate that allergic diseases are positively associated with dementia risk, and the severity of allergic diseases has a dose-effect relationship with dementia risk.
ANNALS OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Youn Huh, Seo Hyeon Lee, Ki Young Son
Summary: This study investigated the association between physical activity and low muscle mass, focusing on the choice of diagnostic criterion. The results showed that physical inactivity was associated with an increased prevalence of weight-adjusted low muscle mass among elderly adults in Korea, while height-adjusted low muscle mass was not a useful indicator for women.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Health Care Sciences & Services
Junbok Lee, Yumi Oh, Meelim Kim, Belong Cho, Jaeyong Shin
Summary: This study investigated the willingness to use (WTU) and willingness to pay (WTP) for digital health interventions based on previous service experience, the content of the services, and individuals' health status. The results showed that public service users had a higher WTU and WTP for digital health interventions compared to nonusers and private service users. This highlights the importance of people's awareness and acceptance of digital health care in the expansion of such services.
JMIR MHEALTH AND UHEALTH
(2023)
Article
Geriatrics & Gerontology
Youn Huh, Ki Young Son, Ji Eun Lee, Kwang-Il Kim, Belong Cho, Chang Won Won
Summary: South Korea lacks official geriatric specialties and studies on unmet needs in geriatric health are scarce. Therefore, this study aimed to investigate the unmet needs regarding geriatric health problems among older Korean adults.
ANNALS OF GERIATRIC MEDICINE AND RESEARCH
(2023)
Article
Clinical Neurology
Jung-In Ko, Seok-Jin Choi, Shin Hye Yoo, Belong Cho, Min Sun Kim, Kyae Hyung Kim, Sun Young Lee
Summary: This study investigated the characteristics of ALS patients visiting the emergency department (ED). The results showed that 41.8% of patients arrived by ambulance and 27.7% spent more than 9 hours in the ED. After ED treatment, 57.4% were hospitalized, with 19.3% admitted to the intensive care unit (ICU) and 5.4% dying in the hospital. The primary reasons for ALS-related ED visits were dyspnea (35.2%), feeding tube problems (10.1%), fever (7.8%), and mental status changes (3.6%).
Article
Health Care Sciences & Services
In Young Hwang, Yohan Han, Min Sun Kim, Kyae Hyung Kim, Belong Cho, Wonho Choi, Yejin Kim, Shin Hye Yoo, Sun Young Lee
Summary: Respecting patients' preference for place of care is crucial in advance care planning for advanced cancer. This retrospective study in South Korea investigated adult cancer patients referred to a palliative care consultation team, recording their preference for place of care and demographic/clinical factors. Among the 891 patients referred, 23.6% preferred home discharge and only 53.8% of them were actually discharged home. Female patients had higher home discharge rates, while those with poor oral intake or dyspnea had lower rates. Additionally, 32.8% of patients discharged home had unintended hospital visits within 2 months. Individualized care planning considering relevant factors is necessary to meet patients' preferences for end-of-life care.
Article
Biochemistry & Molecular Biology
Dong Kyu Kim, Hyobin Jeong, Jingi Bae, Moon-Yong Cha, Moonkyung Kang, Dongjin Shin, Shinwon Ha, Seung Jae Hyeon, Hokeun Kim, Kyujin Suh, Mi-Sun Choi, Hoon Ryu, Seong-Woon Yu, Jong-Il Kim, Yeon-Soo Kim, Sang-Won Lee, Daehee Hwang, Inhee Mook-Jung
Summary: This study reveals the crucial role of mitochondria in neural progenitors and their association with the protein amyloid-beta, which is linked to Alzheimer's disease. Mitochondrial dysfunction inhibits neuronal differentiation, leading to deficits in adult hippocampal neurogenesis and cognitive function. The research suggests that lysine demethylase 5A epigenetically suppresses differentiation in response to mitochondrial damage.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Meeting Abstract
Obstetrics & Gynecology
Jaeyong Choi, Seung Mi Lee, Errol R. Norwitz, Ji Hoi Kim, Young Mi Jung, Chan-Wook Park, Jong Kwan Jun, Jong-Il Kim, Joong Shin Park
REPRODUCTIVE SCIENCES
(2022)
