Article
Oncology
Yu An, Gulimirerouzi Fnu, Changchun Xie, Georg F. F. Weber
Summary: This study conducted a comprehensive analysis of splice variants of Osteopontin and found that they have different expression patterns in various cancer patients, which are related to tumor grade, stage, and patient survival. However, there are still some discrepancies that need further investigation to clarify the diagnostic, prognostic, and potentially predictive potential of Osteopontin splice variants.
Article
Oncology
Se Ik Kim, Ji Hyun Kim, Sanghee Lee, Hyunsoon Cho, Willemien J. van Driel, Gabe S. Sonke, Robert E. Bristow, Sang-Yoon Park, Christina Fotopoulou, Myong Cheol Lim
Summary: This study systematically evaluated the value of hyperthermic intraperitoneal chemotherapy (HIPEC) in cytoreductive surgery (CRS) for epithelial ovarian cancer (EOC). The results showed that HIPEC improved progression-free survival (PFS) and overall survival (OS) in the recent chemotherapy exposure group, but had no significant effect in the non-recent chemotherapy exposure group.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
Klara Komici, Antonio Dello Iacono, Antonio De Luca, Fabio Perrotta, Leonardo Bencivenga, Giuseppe Rengo, Aldo Rocca, Germano Guerra
Summary: The study found that sarcopenia is linked to higher adiponectin levels, especially in Asian populations, with significant influence from female gender. However, caution is advised in interpreting these findings, and further longitudinal research is necessary for a better understanding of the topic.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Anne Macleod, Katharina M. Scheurlen, James F. Burton, Mary Alex Parks, Mst Sharmin Akter Sumy, Jeremy T. Gaskins, Susan Galandiuk
Summary: Obesity is a risk factor for colorectal cancer, and the adipokine adiponectin has an inverse relationship with obesity. This study conducted a systematic review and meta-analysis, finding that colorectal cancer patients generally have lower levels of systemic adiponectin, but the current evidence is insufficient to draw definitive conclusions.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Immunology
Xiaochun Lin, Kunpeng Lin, Chunxuan Lin, Taisheng Liu, Mingchen Ba, Yunqiang Tang, Jialang Wang, Lixia Zhou, Jiakang Wang, Congqin Xiao
Summary: High PD-L2 expression is associated with poor prognosis in lung cancer patients, especially in lung adenocarcinoma, and may serve as a potential biomarker for PD-1/PD-L1-targeted immunotherapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Yue Li, Jiahuan Xu, Pengchen Bao, Zhijing Wei, Lei Pan, Jiawei Zhou, Wei Wang
Summary: PYCR1 is highly expressed in various cancers and is associated with cancer volume and metastasis. Higher expression of PYCR1 is associated with poorer cancer prognosis. Molecular events and biological processes mediated by PYCR1 may be the underlying mechanisms for metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Apriliana E. R. Kartikasari, Emily Cassar, Mohammed A. M. Razqan, Crispin Szydzik, Cesar S. Huertas, Arnan Mitchell, Magdalena Plebanski
Summary: Circulating TNFR2 shows a correlation with various types of cancer, indicating its potential as a diagnostic biomarker.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Yuefeng Chen, Xinnan Pan, Baoming Tian, Yajun Hu
Summary: Polysaccharides have various biological activities, including tumor suppression by regulating the polarization of tumor-associated macrophages. In this study, the correlation between CD24 expression and colorectal cancer (CRC) was investigated. The results showed that CD24 expression was significantly correlated with advanced nuclear grade, lymph node metastasis, Duke's stage, and age of CRC patients.
FRONTIERS IN NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Xianglin Yang, Wen Tian, Shen Wang, Xiaotong Ji, Baosen Zhou
Summary: The study systematically evaluated the clinicopathological, diagnostic, and prognostic values of circRNAs in lung cancer. The results indicated that circRNAs could serve as important biomarkers for diagnosis, prognosis, and clinicopathological features in lung cancer.
Review
Oncology
Aino Niinivirta, Tuula Salo, Pirjo Astrom, Krista Juurikka, Maija Risteli
Summary: This study systematically evaluated the prognostic value of dysadherin in cancer and summarized the current knowledge on the subject. The results showed that high levels of tumoral FXYD5 are associated with increased risk of death, metastatic behavior of cancer, and inverse correlation with E-cadherin level.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Noor Bakour, Frank Moriarty, Gillian Moore, Tracy Robson, Stephanie L. Annett
Summary: High glucocorticoid receptor (GR) expression is associated with disease progression in gynaecological cancers and early stage, untreated triple negative breast cancers, but not prognostic in late stage, chemotherapy treated triple negative breast cancers. Additional studies are needed to elucidate the tumour specific function of the GR receptor for targeted therapy.
Review
Medicine, General & Internal
Xuhua Wang, Zhaoyuan Chen, Huaqiang Zhou, Wuyang Liu, Jiaquan Luo
Summary: LncRNA LOXL1-AS1 is overexpressed in cancer and is closely associated with shorter overall survival, lymph node metastasis, and distant metastasis.
Article
Medicine, General & Internal
Qian Yang, Lizhen Chen, Li Yang, Yuanshuai Huang
Summary: This meta-analysis demonstrated that circRNAs could be valuable biomarkers for diagnostic and prognostic purposes in lung cancer patients. CircRNAs showed good diagnostic performance in discriminating lung cancer patients from controls, and certain upregulated and downregulated circRNAs were associated with poor and favorable prognosis, respectively. High expression of specific circRNAs was also linked to unfavorable clinicopathological features.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Yuxiu Xie, Men Wang, Peng Xu, Yujiao Deng, Yi Zheng, Si Yang, Ying Wu, Zhen Zhai, Dai Zhang, Na Li, Nan Wang, Jing Cheng, Zhijun Dai
Summary: This study found that the use of BBs, CCBs, and diuretics is associated with an increased risk of breast cancer, while long-term use of RASIs may reduce this risk. It also suggests that diuretic users may have a higher risk of breast cancer-specific mortality.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Xuhua Wang, Zhaoyuan Chen, Huaqiang Zhou, Wuyang Liu, Jiaquan Luo
Summary: The lncRNA HEIH is overexpressed in various cancers and is associated with poor clinical outcomes. A meta-analysis found that high HEIH expression is correlated with shorter overall survival and advanced clinicopathological features in cancer patients.
Article
Biotechnology & Applied Microbiology
Yan Lin, Yufeng Lv, Rong Liang, Chunling Yuan, Jinyan Zhang, Dan He, Xiaowen Zheng, Jianfeng Zhang
ONCOTARGETS AND THERAPY
(2018)
Article
Cell Biology
Yan Lin, Rong Liang, Yufen Qiu, Yufeng Lv, Jinyan Zhang, Gang Qin, Chunling Yuan, Zhihui Liu, Yongqiang Li, Donghua Zou, Yingwei Mao
Article
Biochemistry & Molecular Biology
Jiaxiang Ye, Jinyan Zhang, Yufeng Lv, Jiazhang Wei, Xiaoyun Shen, Junqi Huang, Susu Wu, Xiaoling Luo
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Review
Oncology
Ziyu Liu, Yan Lin, Jinyan Zhang, Yumei Zhang, Yongqiang Li, Zhihui Liu, Qian Li, Ming Luo, Rong Liang, Jiazhou Ye
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Jiazhang Wei, Jiaxiang Ye, Yue Luo, Jingjin Weng, Qian He, Fei Liu, Min Li, Yan Lin, Yongqiang Li, Zhe Zhang, Shenhong Qu, Jinyan Zhang
Article
Oncology
Yue Luo, Jiaxiang Ye, Jiazhang Wei, Jinyan Zhang, Yongqiang Li
MOLECULAR MEDICINE REPORTS
(2020)
Article
Oncology
Rong Liang, Jinyan Zhang, Zhihui Liu, Ziyu Liu, Qian Li, Xiaoling Luo, Yongqiang Li, Jiazhou Ye, Yan Lin
Summary: RBM8A is abnormally overexpressed in hepatocellular carcinoma (HCC) and is involved in the development of drug resistance. It has the ability to regulate tumor-related signaling pathways, particularly through its interaction with histone deacetylase 9 (HDAC9). These findings suggest that RBM8A and its related pathways could serve as potential markers of oxaliplatin resistance and therapeutic targets in HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jiazhang Wei, Yayan Deng, Jiaxiang Ye, Yue Luo, Jingjin Weng, Qian He, Fei Liu, Min Li, Rong Liang, Yan Lin, Yongqiang Li, Jinyan Zhang, Jianrong Yang, Shenhong Qu
Summary: Recent studies have shown that alterations in SOCE play a critical role in tumor metastasis, with dysregulated expression of STIM/ORAI potentially serving as an indicator of poor prognosis. SOCE contributes significantly to EMT, tumor cell migration and invasion, and angiogenesis, suggesting it could be a feasible target for cancer treatment.
Article
Oncology
Yan Lin, Lei Wei, Beiquan Hu, Jinyan Zhang, Jiazhang Wei, Zhongrun Qian, Donghua Zou
Summary: The study revealed that RBM8A is up-regulated in GBM tissues and its higher expression is correlated with worse prognosis. RBM8A may promote GBM cell proliferation and migration by activating the Notch/STAT3 pathway, suggesting it as a potential therapeutic target for GBM treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Microbiology
Jiaxiang Ye, Jiazhang Wei, Yue Luo, Yayan Deng, Ting Que, Xiaojian Zhang, Fei Liu, Jinyan Zhang, Xiaoling Luo
Summary: The study found that Epstein-Barr virus promotes tumor angiogenesis in nasopharyngeal carcinoma through activating STIM1-dependent Ca2+ signaling. Knockdown of STIM1 can inhibit angiogenesis, suggesting that blocking this signaling may help in inhibiting EBV-promoted angiogenesis in NPC.
Article
Pharmacology & Pharmacy
Yan Lin, Xiaoli Liao, Yumei Zhang, Guobin Wu, Jiazhou Ye, Shanshan Luo, Xinxin He, Min Luo, Mingzhi Xie, Jinyan Zhang, Qian Li, Yu Huang, Sina Liao, Yongqiang Li, Rong Liang
Summary: This study suggests that the mutant type (HR-MUT) of the Homologous recombination (HR) pathway may impact the chemotherapy sensitivity and prognosis of colorectal cancer (CRC) patients. HR-MUT patients have a lower probability of tumor metastasis after chemotherapy, and HR-MUT can be used as an independent predictor of chemotherapy prognosis for CRC patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Yujuan Huang, Masamitsu Kanada, Jiaxiang Ye, Yayan Deng, Qian He, Zhengyang Lei, Yong Chen, Yongqiang Li, Peiwu Qin, Jinyan Zhang, Jiazhang Wei
Summary: This review summarizes the latest progress in the exploration of exosome-mediated cell-cell communication implicated in tumor microenvironment (TME) remodeling and underlying mechanisms. It focuses on the role of cell-cell interactions mediated by tumor cell-derived exosomes in promoting invasion and metastasis, and their potential as a therapeutic intervention target against distant metastasis. The clinical translational significance of tumor-derived exosomes for early diagnosis, efficacy, and progression evaluations is also discussed.
Article
Biochemistry & Molecular Biology
Yue Luo, Jiaxiang Ye, Yayan Deng, Yujuan Huang, Xue Liu, Qian He, Yong Chen, Qiuyun Li, Yan Lin, Rong Liang, Yongqiang Li, Jiazhang Wei, Jinyan Zhang
Summary: The miRNA-185-5p/STIM1 axis regulates the invasiveness of nasopharyngeal carcinoma (NPC) cell lines by affecting EGFR activation, making it a potential therapeutic target. Additionally, knocking down STIM1 inhibits migration ability and locoregional lymphatic invasion of NPC cells.
Review
Oncology
Xue Liu, Yayan Deng, Yujuan Huang, Jiaxiang Ye, Sifang Xie, Qian He, Yong Chen, Yan Lin, Rong Liang, Jiazhang Wei, Yongqiang Li, Jinyan Zhang
Summary: Genomic instability plays a crucial role in driving the evolution of malignancies, enhancing tumor cells' ability to adapt to the tumor microenvironment. Nasopharyngeal carcinoma progression is driven by genomic instability and persistent EBV infection, highlighting the importance of understanding and targeting genomic instability for effective treatment strategies.
Article
Oncology
Yan Lin, Jinyan Zhang, Junying Cai, Rong Liang, Guoying Chen, Gang Qin, Xueqiong Han, Chunling Yuan, Zhihui Liu, Yongqiang Li, Donghua Zou, Yingwei Mao