Review
Cardiac & Cardiovascular Systems
Qinyuan Pan, Yang Liu, Wenrui Ma, Rongsheng Kan, Hong Zhu, Dongye Li
Summary: Luteolin has cardioprotective effects against myocardial ischemia-reperfusion injury (MIRI) by reducing myocardial infarct size and improving intracardiac hemodynamics. It exerts anti-apoptosis, anti-oxidation, and anti-inflammation effects through different signaling pathways.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Guangyu Zhang, Xiaoding Wang, Chao Li, Qinfeng Li, Yu A. An, Xiang Luo, Yingfeng Deng, Thomas G. Gillette, Philipp E. Scherer, Zhao Wang
Summary: The study demonstrates the significant role of the ISR in myocardial ischemia/reperfusion injury by selectively suppressing mitochondrial protein synthesis and reducing oxidative stress to improve cell survival and mitigate reperfusion damage.
Article
Pharmacology & Pharmacy
Wen Jiang, Yuxiang Zhang, Wei Zhang, Xiaomei Pan, Jieyu Liu, Qiang Chen, Junhui Chen
Summary: Acute myocardial infarction (AMI) is the leading cause of death worldwide. Ischemia-reperfusion (I/R) injury is a common contributor to AMI. Hirsutine has been shown to protect cardiomyocytes against hypoxic injury. In this study, hirsutine pre-treatment improved myocardial I/R injury by reducing infarct size, enhancing cardiac function, inhibiting cell apoptosis, and balancing mitochondrial dynamics. Mechanistically, hirsutine inhibited mitochondrial-mediated apoptosis by blocking the AKT/ASK-1/p38 MAPK pathway. This study provides a promising therapeutic intervention for myocardial I/R injury.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Medicine, Research & Experimental
Jing Zhao, Jiwei Zhang, Qian Liu, Yingchao Wang, Yecheng Jin, Yingxin Yang, Cheng Ni, Ling Zhang
Summary: The study showed that HJT has protective effects against myocardial ischemia reperfusion injury by improving mitochondrial function and regulating autophagy to inhibit cell apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Lujing Jiang, Xiaojian Yin, Ya-Hui Chen, Yan Chen, Wei Jiang, Hao Zheng, Feng-Qing Huang, Baolin Liu, Wei Zhou, Lian-Wen Qi, Jia Li
Summary: Ginsenoside Rb1 attenuates cardiac ischemia/reperfusion (I/R) injury by inhibiting reactive oxygen species (ROS) production from mitochondrial complex I. It reduces myocardial infarct size, preserves cardiac function, and limits cardiac fibrosis. The mechanism involves inhibition of complex I-mediated ROS burst.
Article
Engineering, Biomedical
Xiaoping Zhang, Yage Sun, Rong Yang, Bo Liu, Yang Liu, Jianhai Yang, Wenguang Liu
Summary: In this study, a mitochondria-targeted nanomicelle was designed for the treatment of myocardial ischemia-reperfusion injury. The nanomicelle was encapsulated into a pH/ROS dual responsive injectable hydrogel for controllable drug delivery. The treatment effectively restored mitochondrial function and attenuated oxidative stress in a rat model.
Article
Biochemistry & Molecular Biology
Kun Zhang, Tao Wang, Gui-Feng Sun, Jin-Xing Xiao, Li-Ping Jiang, Fang-Fang Tou, Xin-Hui Qu, Xiao-Jian Han
Summary: This study aimed to evaluate the protective effect of metformin against retinal ischemia/reperfusion (I/R) injury and its underlying mechanism. The results showed that metformin could alleviate I/R-induced retinal injury through AMPK-mediated mitochondrial fusion and decreased generation of mitochondrial ROS.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chen Wang, Jian Chen, Mengxue Wang, Keiji Naruse, Ken Takahashi
Summary: Blocking the TRPM4 channel may protect the myocardium from oxidative stress by maintaining mitochondrial membrane potential and intracellular ATP levels, possibly through preventing aberrant increases in intracellular Ca2+ and ROS.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pathology
Juthipong Benjanuwattra, Nattayaporn Apaijai, Titikorn Chunchai, Kodchanan Singhanat, Busarin Arunsak, Kannaporn Intachai, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: In a model of myocardial ischemia/reperfusion injury, the timing of erythropoietin (EPO) administration was found to have varying effects on cardioprotection. EPO given during ischemia or reperfusion was shown to attenuate arrhythmia, improve cardiac function, reduce infarct size and apoptosis.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Yan Xue, Wenwen Fu, Ping Yu, Yuangeng Li, Xiaofeng Yu, Huali Xu, Dayun Sui
Summary: Myocardial ischemia-reperfusion (MI/R) injury occurs when coronary blood supply is impaired and then reestablished, leading to additional injury to the myocardial tissue, including mitochondria oxidative stress and apoptosis. Ginsenoside Rc, a main type of saponins, has been found to regulate mitochondrial functions. However, its potential benefits against MI/R injury have not been investigated. In this study, the protective effects of ginsenoside Rc were examined in an in vitro cell model and an in vivo rat model of MI/R injury. The results showed that ginsenoside Rc reduced oxidative stress and apoptosis through activating SIRT1, leading to cardioprotective effects.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xinhai Mo, Huijing Xiang, Lu Wei, Lianghua Xia, Xiaoying Chen, Yu Chen, Bo Zhang
Summary: Using self-assembly synthesis, allomelanin nanoparticles (AMNPs) show potential in treating myocardial I/R injury by providing antioxidative and anti-inflammatory effects, with targeted therapy at damaged cardiac sites.
Review
Biochemistry & Molecular Biology
Jolanta Laukaitiene, Greta Gujyte, Edmundas Kadusevicius
Summary: About 50 years ago, Eugene Braunwald, a father of modern cardiology, introduced the revolutionary belief that time is muscle, which has since driven efforts to protect the unaffected myocardium. However, understanding the metabolic changes in the ischemic myocardium after acute myocardial infarction (AMI) has proven challenging due to inconsistencies and dependencies on various factors. In recent years, the study of iron metabolism has emerged as a promising approach in the field of ischemic heart research, specifically focusing on a programmed cell death called ferroptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sen Zhang, Sijing Rao, Meiwen Yang, Chen Ma, Fengfang Hong, Shulong Yang
Summary: Hepatic ischemia-reperfusion injury is a major cause of post-operative hepatic dysfunction and liver failure after transplantation. Mitochondrial pathways play a crucial role in hepatic cell apoptosis, depending on multiple factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Engineering, Biomedical
Tianjiao Zhao, Wei Wu, Lihua Sui, Qiong Huang, Yayun Nan, Jianhua Liu, Kelong Ai
Summary: This article discusses the biology and molecular mechanisms of myocardial ischemia reperfusion injury, and summarizes the application of ROS-based nanoparticles, highlighting the latest advances in nanotechnology research for the treatment of myocardial ischemia reperfusion injury.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Xiaolei Sun, Rifeng Gao, Wenjia Li, Yongchao Zhao, Heng Yang, Hang Chen, Hao Jiang, Zhen Dong, Jingjing Hu, Jin Liu, Yunzeng Zou, Aijun Sun, Junbo Ge
Summary: ALDH2 activation in mitochondrial transplantation shows potential for treating myocardial I/R injury. Activation of ALDH2 and treatment with Alda-1 promote oxygen consumption rate and mechanical function of cardiomyocytes after mitochondrial transplantation. Mitochondrial transplantation inhibits cardiomyocyte apoptosis induced by hypoxia-reoxygenation, while promotion of mechanical function is observed only after mitochondrial Alda-1 treatment and transplantation.
BIOACTIVE MATERIALS
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.