Article
Medicine, General & Internal
Yoshihiro Nakamura, Hiroki Kobayashi, Sho Tanaka, Yoshinari Hatanaka, Yoshinobu Fuke, Noboru Fukuda, Masanori Abe
Summary: This study found a high prevalence of OSA among Japanese patients with PA, with severity of OSA significantly influenced by BMI. REI was significantly correlated with BMI.
Article
Orthopedics
Jian-Ming Zhao, Bi-Ying Wang, Jie-Feng Huang, Han-Sheng Xie, Meng-Lan Chen, Gong-Ping Chen
Summary: This study aimed to explore the relationship between bone mineral density (BMD) and obstructive sleep apnea (OSA) in young men. The results showed that moderate OSA patients had higher BMD at the lumbar spine compared to control and severe OSA groups. Further analysis revealed that LaSO2 and BMI were independent explanatory variables for BMD. These findings suggest a link between OSA and bone metabolism in younger men, with moderate OSA-related hypoxia positively affecting BMD. However, more research is needed to fully understand the effects of recurrent hypoxia on bone metabolism.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Health Care Sciences & Services
Valerio Brunetti, Elisa Testani, Anna Losurdo, Catello Vollono, Aldobrando Broccolini, Riccardo Di Iorio, Giovanni Frisullo, Fabio Pilato, Paolo Profice, Jessica Marotta, Eleonora Rollo, Irene Scala, Paolo Calabresi, Giacomo Della Marca
Summary: This study aimed to evaluate the association between obstructive sleep apnea (OSA) and atrial fibrillation (AF) in acute ischemic stroke. The results showed that OSA and AF are highly prevalent but not associated in acute stroke. Furthermore, OSA acts as an independent risk factor for stroke.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Chenyang Li, Yiqing Gao, Weijun Huang, Huajun Xu, Yupu Liu, Jianyin Zou, Huaming Zhu, Xinyi Li, Fangkai Han, Jingjing Liu, Kejia Wu, Hongliang Yi, Jian Guan, Shankai Yin
Summary: The study found that the sleep apnea-specific hypoxic burden (SASHB) can accurately predict and assess obstructive sleep apnea hypopnea syndrome (OSA) and its severity in Han Chinese individuals.
Article
Environmental Sciences
Junyi Wang, Wanzhou Wang, Wenlou Zhang, Jianli Wang, Yongwei Huang, Zixuan Hu, Yahong Chen, Xinbiao Guo, Furong Deng, Liqiang Zhang
Summary: This study aimed to assess the joint effect of multiple air pollutants on sleep disordered breathing parameters and identify the dominant pollutants. The results showed significant associations between air pollutants and sleep disordered breathing parameters in patients with obstructive sleep apnea (OSA), with PM10 and O3 being the dominant pollutants.
ENVIRONMENTAL RESEARCH
(2022)
Article
Respiratory System
Xueru Duan, Jun Huang, Murui Zheng, Wenjing Zhao, Lixian Lao, Haiyi Li, Zhiwei Wang, Jiahai Lu, Weiqing Chen, Hai Deng, Xudong Liu
Summary: This study investigates the effects of different lifestyle factors on the risk of obstructive sleep apnea (OSA) among Chinese adults. The study finds that not being exposed to secondhand smoke, having a healthy waist-hip ratio, and having a healthy mental status are associated with a reduced risk of OSA. Furthermore, a higher score on the healthy lifestyle scale is also associated with a lower risk of OSA.
BMC PULMONARY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Trygve M. Jonassen, Bjorn Bjorvatn, Ingvild W. Saxvig, Tomas M. L. Eagan, Sverre Lehmann
Summary: The study aims to identify predictors of severe obstructive sleep apnea (OSA) and suggests a prediction score based on simple and easily available data to prioritize patients for sleep studies. The study finds that age, sex, snoring, breathing cessations, BMI, hypertension, and myocardial infarction are positively associated with severe OSA. The prediction score, which includes factors such as age, snoring, breathing cessations, BMI, and self-reported hypertension, has high sensitivity and negative predictive value for severe OSA.
RESPIRATORY MEDICINE
(2022)
Article
Multidisciplinary Sciences
J. P. T. F. Ho, H. C. M. Donders, N. Zhou, K. Schipper, N. Su, J. de Lange
Summary: The study found that LSAT is significantly associated with COVID-19 severity, whereas AHI, ODI, RDI, and OSA treatment were not found to be risk factors for COVID-19 severity.
Article
Clinical Neurology
Meizhen Gu, Weijun Huang, Xinyi Li, Yupu Liu, Fan Wang, Chao Fang, Ting Chen
Summary: The study revealed a positive association between the Hypertriglyceridemic waist (HTGW) phenotype and obstructive sleep apnea (OSA) risk, which remained significant across different age, gender, and body mass index subgroups. Further longitudinal follow-up studies are required to establish the causal link and prognostic role of these metabolic factors.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Clinical Neurology
Kanitpong Phabphal, Monton Sripradit, F. Geater Alan, Krongthong Wongsritrang, Tabtim Chongsuvivatwong, Kanokrat Suwanlaong, Pasiri Sithinamsuwan
Summary: This study compares the performance characteristics of four common questionnaires for assessing the probability of obstructive sleep apnea (OSA) in patients with epilepsy. The results show that the NoSAS questionnaire has higher discriminatory ability at different AHI cutoffs.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Article
Endocrinology & Metabolism
Milina Tancic-Gajic, Miodrag Vukcevic, Miomira Ivovic, Ljiljana V. Marina, Zorana Arizanovic, Ivan Soldatovic, Milos Stojanovic, Aleksandar Dogo, Aleksandra Kendereski, Svetlana Vujovic
Summary: The study suggests that obstructive sleep apnea is associated with lower total and free testosterone levels in severely obese men. This finding indicates a potential impact of sleep disorders on sex hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Yuanyuan Xu, Ning Yang, Maoti Wei, Fenghua Wang, Kun Zhang, Leilei Shi, Hongda Chou, Yuming Li
Summary: The study aimed to analyze the association between obstructive sleep apnea (OSA) and endothelial function and heart structure in patients with hypertension. A cross-sectional study design was adopted, and 143 patients with hypertension were included and classified into two groups. The results showed that patients with OSA had thicker interventricular septal and left ventricular posterior wall, as well as decreased flow-mediated vasodilation. Logistic regression analyses identified gender and apnea-hypopnea index (AHI) as the factors associated with endothelial dysfunction, and flow-mediated vasodilation was associated with left ventricular mass index. In conclusion, OSA is associated with endothelial dysfunction and heart remodeling in patients with hypertension.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaoman Zhang, Weijun Huang, Huajun Xu, Xinyi Li, Fan Wang, Kejia Wu, Chenyang Li, Yupu Liu, Jianyin Zou, Huaming Zhu, Hongliang Yi, Jian Guan, Di Qian, Shankai Yin
Summary: This study found through a large cross-sectional study that low slow-wave sleep, excessive daytime sleepiness, and short sleep duration are risk factors for cardiovascular diseases in patients with obstructive sleep apnea (OSA). The impact of sleep on cardiovascular health should be paid more attention to.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Li-Ang Lee, Hai-Hua Chuang, Hui-Shan Hsieh, Chao-Yung Wang, Li-Pang Chuang, Hsueh-Yu Li, Tuan-Jen Fang, Yu-Shu Huang, Guo-She Lee, Albert C. Yang, Terry B. J. Kuo, Cheryl C. H. Yang
Summary: This retrospective case series investigated the effects of adenotonsillectomy on heart rate variability (HRV) indices in children with obstructive sleep apnea (OSA). The results showed that adenotonsillectomy improved HRV indices, indicating improvements in cardiac autonomic function in children with OSA.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Maria Leticia de Barros Massahud, Fabio Fernandes Borem Bruzinga, Silvana Alkmim de Miranda Diniz, Karolina Kristian de Aguilar Seraidarian, Regina de Magalhaes Lopes, Vinicius de Magalhaes Barros, Paulo Isaias Seraidarian
Summary: This cross-sectional study suggests an association between sleep bruxism (SB) and obstructive sleep apnea and hypopnea syndrome (OSAHS), particularly in its severe form. However, the relationship between the use of antidepressants and SB remains inconclusive.
JOURNAL OF ORAL REHABILITATION
(2022)
Article
Peripheral Vascular Disease
Mayu Higashioka, Satoko Sakata, Takanori Honda, Jun Hata, Mao Shibata, Daigo Yoshida, Kenichi Goto, Takanari Kitazono, Haruhiko Osawa, Toshiharu Ninomiya
Summary: The study investigated the association between serum small dense low-density lipoprotein (sdLDL) cholesterol level and development of coronary heart disease (CHD) in high cardiovascular risk subjects. Elevated sdLDL cholesterol was found to be significantly associated with increased risk of CHD, especially in patients with diabetes, CVD-related comorbidities, and high-risk category.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Article
Nutrition & Dietetics
Sanmei Chen, Takanori Honda, Jun Hata, Satoko Sakata, Yoshihiko Furuta, Daigo Yoshida, Mao Shibata, Tomoyuki Ohara, Yoichiro Hirakawa, Emi Oishi, Takanari Kitazono, Toshiharu Ninomiya
Summary: The study found that higher serum folate concentrations were associated with a lower risk of all-cause mortality in Japanese adults, while serum vitamin B-12 concentrations were not consistently associated with all-cause mortality risk.
JOURNAL OF NUTRITION
(2021)
Article
Urology & Nephrology
Takaya Sasaki, Emi Oishi, Takuya Nagata, Satoko Sakata, Sanmei Chen, Yoshihiko Furuta, Takanori Honda, Daigo Yoshida, Jun Hata, Nobuo Tsuboi, Takanari Kitazono, Takashi Yokoo, Toshiharu Ninomiya
Summary: The study found that higher serum NT-proBNP levels were associated with increased risks of developing chronic kidney disease (CKD) and a more rapid decline in estimated glomerular filtration rate (eGFR). In the general Japanese population, serum NT-proBNP could serve as a useful biomarker for assessing the future risk of CKD.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Jun Hata, Takuya Nagata, Satoko Sakata, Emi Oishi, Yoshihiko Furuta, Yoichiro Hirakawa, Takanori Honda, Daigo Yoshida, Takanari Kitazono, Toshiharu Ninomiya
Summary: A new risk prediction model for incident atrial fibrillation (AF) was developed using prospective longitudinal data from a general Japanese population, showing good discrimination and calibration for AF risk at 10 years. Common clinical parameters were included in the model for individual risk assessment of future AF onset in clinical settings, potentially reducing the risk of AF-related complications.
CIRCULATION JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Takaya Sasaki, Kensuke Izumaru, Jun Hata, Satoko Sakata, Emi Oishi, Takuya Nagata, Nobuo Tsuboi, Yoshinao Oda, Takanari Kitazono, Takashi Yokoo, Toshiharu Ninomiya
Summary: Elevated serum NT-proBNP levels were found to be positively correlated with myocardial fibrotic area in autopsied cases from a community, indicating a potential relationship between the two and their impact on prognosis.
JOURNAL OF CARDIOLOGY
(2021)
Review
Physiology
Kenichi Goto, Takanari Kitazono
Summary: Vascular endothelial cells regulate arterial tone through the release of nitric oxide and other diffusible factors, while myoendothelial gap junctions facilitate endothelium-dependent hyperpolarization for vasodilation. Increased intracellular Ca2+ concentration in endothelial cells is essential for the production of factors and generation of hyperpolarization, with TRPV4 ion channel playing a critical role. Dysregulation of endothelial TRPV4 channels is linked to endothelial dysfunction associated with cardiovascular disease risk factors, indicating potential for novel therapeutic strategies in CVD prevention.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Urology & Nephrology
Kenji Maki, Jun Hata, Satoko Sakata, Emi Oishi, Yoshihiko Furuta, Toshiaki Nakano, Yoshinao Oda, Takanari Kitazono, Toshiharu Ninomiya
Summary: Higher serum uric acid (SUA) levels were significantly associated with advanced glomerular sclerosis and advanced kidney arteriosclerosis, but not with advanced arteriolar hyalinosis.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Peripheral Vascular Disease
Takanori Honda, Yuki Ishida, Masaaki Oda, Kenichi Noguchi, Sanmei Chen, Satoko Sakata, Emi Oishi, Yoshihiko Furuta, Daigo Yoshida, Yoichiro Hirakawa, Jun Hata, Takanari Kitazono, Toshiharu Ninomiya
Summary: This study investigated the influence of weight change on predicted cardiovascular disease (CVD) risk and individual CVD risk factors. The findings demonstrated that losing weight in obese individuals and avoiding excessive weight gain in nonobese individuals were associated with a favorable global risk of future CVD and individual CVD risk factors in a real-world setting.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Endocrinology & Metabolism
Takanori Honda, Yoichiro Hirakawa, Jun Hata, Sanmei Chen, Mao Shibata, Satoko Sakata, Yoshihiko Furuta, Mayu Higashioka, Emi Oishi, Takanari Kitazono, Toshiharu Ninomiya
Summary: This study aimed to investigate the association between active commuting (cycling or walking to work) and the risk of diabetes in a cohort of community-dwelling adults in Japan. The results showed that active commuting, especially cycling or walking alone, was associated with a reduced risk of diabetes.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Takaya Sasaki, Satoko Sakata, Emi Oishi, Yoshihiko Furuta, Takanori Honda, Jun Hata, Nobuo Tsuboi, Takanari Kitazono, Takashi Yokoo, Toshiharu Ninomiya
Summary: The study found that increased day-to-day blood pressure variability is significantly associated with a higher risk of developing chronic kidney disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Biochemistry & Molecular Biology
Kenichi Goto, Takanari Kitazono
Summary: Blood pressure is determined by cardiac output and systemic vascular resistance. The upregulation of Ca2+-activated Cl- channel TMEM16A and the increased activity of NKCC1 in hypertension can increase vascular contractility and elevate blood pressure.
Editorial Material
Endocrinology & Metabolism
Kenichi Goto
Summary: Hypertension, especially obesity-related hypertension, is a major risk factor for cardiovascular disease globally. The presence of high triglycerides, a common comorbidity in obesity, has been shown to be an independent risk factor for new-onset hypertension.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Article
Public, Environmental & Occupational Health
Shoko Tomooka, Emi Oishi, Masako Asada, Satoko Sakata, Jun Hata, Sanmei Chen, Takanori Honda, Kosuke Suzuki, Hiroshi Watanabe, Norihito Murayama, Naohisa Wada, Takanari Kitazono, Toshiharu Ninomiya
Summary: In the general Japanese population, higher levels of serum LBP are associated with an increased risk of developing MetS.
JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Peripheral Vascular Disease
Yusuke Tomita, Satoko Sakata, Hisatomi Arima, Ikumi Yamato, Ai Ibaraki, Toshio Ohtsubo, Kiyoshi Matsumura, Masayo Fukuhara, Kenichi Goto, Takanari Kitazono
Summary: The study investigated the association between serum triglyceride levels and the risk of new-onset hypertension in Japanese workers. Results showed a positive correlation between increasing serum triglyceride levels and hypertension incidence rates, which remained significant even after adjusting for other risk factors. There were stronger associations between serum triglyceride levels and hypertension in participants under 40 years of age compared to those aged 40 or above.
JOURNAL OF HYPERTENSION
(2021)
Letter
Urology & Nephrology
Shunsuke Yamada, Hideaki Oka, Kenichi Goto, Toshiaki Nakano, Takanari Kitazono