Article
Peripheral Vascular Disease
Sarah C. Couch, Brian E. Saelens, Philip R. Khoury, Katherine B. Dart, Kelli Hinn, Mark M. Mitsnefes, Stephen R. Daniels, Elaine M. Urbina
Summary: This study found that the DASH intervention was more effective than routine care in improving systolic blood pressure, endothelial function, and diet quality in adolescents with elevated blood pressure and hypertension.
Article
Nutrition & Dietetics
Muzi Na, Yanxiu Wang, Xinyuan Zhang, Christopher Sarpong, Penny M. Kris-Etherton, Ming Gao, Aijun Xing, Shouling Wu, Xiang Gao
Summary: The DASH dietary pattern is associated with lower nighttime blood pressure variability in elderly adults, independent of sleep parameters and other factors.
JOURNAL OF NUTRITION
(2022)
Review
Multidisciplinary Sciences
Firoozeh Abbasian, Mohaddeseh Sadat Alavi, Ali Roohbakhsh
Summary: Hypertension is a major risk factor for cardiovascular diseases and premature death in older adults. Lifestyle improvements, including consuming high amounts of fruits and vegetables, can reduce the risk of high blood pressure. Carotenoids, natural pigments with high pharmacological potential and safety, have antihypertensive properties and provide additional benefits to the cardiovascular system.
Article
Multidisciplinary Sciences
Ruichao Li, Ansu Zhao, Xiaoyan Diao, Juhui Song, Chanjuan Wang, Yanhong Li, Xiaolan Qi, Zhizhong Guan, Ting Zhang, Yan He
Summary: This study found that the single nucleotide polymorphisms rs1808593 and rs7830 of the NOS3 gene are associated with essential hypertension in the Han, Miao, and Buyi populations in Guizhou, China.
Article
Nutrition & Dietetics
Joanna Popiolek-Kalisz, Piotr Blaszczak, Emilia Fornal
Summary: This study revealed a correlation between long-term dietary isorhamnetin intake and SBP values in coronary artery disease patients, especially in male participants. Specific food intake analysis indicated that consumption of onions, tomatoes, and blueberries could impact blood pressure values.
Article
Cardiac & Cardiovascular Systems
Andy W. C. Man, Yawen Zhou, Gisela Reifenberg, Alica Camp, Thomas Muenzel, Andreas Daiber, Ning Xia, Huige Li
Summary: This study aimed to investigate the significance of adipocyte NOS3 in vascular function and blood pressure control. Adipocyte-specific NOS3 knockout mice were fed a high-fat diet and exhibited increased blood pressure, vascular dysfunction, and remodelling, as well as increased expression of inflammation and hypoxia markers in perivascular adipose tissues. Moreover, a novel adipokine, chemerin, was upregulated in these mice. Treatment with a chemerin-neutralizing antibody normalized the expression of remodelling markers in cultured aorta segments from these mice. These findings suggest that dysfunction of adipocyte NOS3 contributes to obesity-induced vascular remodelling and hypertension.
CARDIOVASCULAR RESEARCH
(2023)
Article
Nutrition & Dietetics
Jinyoung Shon, Yerim Han, Yoon Jung Park
Summary: The study found that macronutrient intake patterns were associated with obesity susceptibility, and the associations differed depending on the circadian clock genotypes.
Article
Environmental Sciences
Siyue Wang, Mengying Wang, Hexiang Peng, Yaohua Tian, Huangda Guo, Jiating Wang, Huan Yu, Enci Xue, Xi Chen, Xueheng Wang, Meng Fan, Yi Zhang, Xiaochen Wang, Xueying Qin, Yiqun Wu, Jin Li, Ying Ye, Dafang Chen, Yonghua Hu, Tao Wu
Summary: Accumulating evidence suggests that instant exposure to particulate matter (PM) can increase blood pressure, possibly through the involvement of cell adhesion regulatory genes. However, few studies have investigated their interaction, and it is unclear if these genes modify the association. This study aimed to assess the association between instant PM exposure and blood pressure, and examine if SNPs in four cell adhesion regulatory genes modify the relationship.
Article
Peripheral Vascular Disease
Carolina Dalmasso, Jacqueline R. Leachman, Sundus Ghuneim, Nermin Ahmed, Eve R. Schneider, Olivier Thibault, Jeffrey L. Osborn, Analia S. Loria
Summary: The study found that obese male mice exposed to early life stress exhibit obesity-associated hypertension through hyperactivation of sensory nerve signals, leading to neuronal activation and increased blood pressure.
Review
Food Science & Technology
Wendong Fan, Houru Zong, Tong Zhao, Jianjun Deng, Haixia Yang
Summary: In this review, the effects of proanthocyanidins on blood pressure reduction and its related mechanisms were summarized. The results showed that proanthocyanidins have a significant antihypertensive effect, effectively preventing hypertension and reducing the occurrence of cardiovascular and cerebrovascular diseases. This effect may be attributed to the improvement of vascular function, reduction of oxidative stress and inflammation, and modulation of lipid metabolism.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Peripheral Vascular Disease
Michael A. Razavi, Lydia A. Bazzano, Jovia Nierenberg, Zhijie Huang, Camilo Fernandez, Alexander C. Razavi, Seamus P. Whelton, Jiang He, Tanika N. Kelly
Summary: The majority of US adults develop hypertension by age 40, raising the risk of atherosclerotic cardiovascular disease. Dietary sodium and potassium play a crucial role in hypertension pathophysiology, with individual variation in salt and potassium sensitivity affecting disease risk. Genomic characterization of these traits may be key in precision lifestyle approaches for hypertension prevention.
Review
Endocrinology & Metabolism
Joseph C. Watso, Ibra S. Fancher, Dulce H. Gomez, Zachary J. Hutchison, Orlando M. Gutierrez, Austin T. Robinson
Summary: Hypertension is a primary risk factor for cardiovascular disease, the leading cause of death worldwide. This review focuses on the interplay of obesity and excess dietary sodium from salt in contributing to hypertension. The independent and combined effects of obesity and dietary salt on various health issues, such as vascular dysfunction, autonomic cardiovascular dysregulation, kidney dysfunction, and insulin resistance, are discussed. The role of ultra-processed foods, accounting for nearly 60% of energy intake in America, as a major contributor to both obesity and salt overconsumption is highlighted. The article emphasizes the need to fill critical gaps in knowledge to inform prevention, management, treatment, and mitigation strategies for addressing these public health challenges.
Article
Cardiac & Cardiovascular Systems
Caroline Brand, Ana Paula Sehn, Camila Felin Fochesatto, Joao Francisco de Castro Silveira, Jorge Mota, David Martinez Gomez, Anelise Reis Gaya, Cezane Priscila Reuter, Jane Dagmar Pollo Renner
Summary: This study aims to investigate whether changes in cardiorespiratory fitness moderate the association between body fat percentage and arterial blood pressure in children and adolescents. The results showed that changes in cardiorespiratory fitness can attenuate the positive relationship between body fat percentage and systolic and diastolic blood pressure.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Nutrition & Dietetics
Avneet Oberoi, Caroline Giezenaar, Kylie Lange, Karen L. Jones, Michael Horowitz, Ian Chapman, Stijn Soenen
Summary: This study found that even with relatively low intake of whey protein, there is a risk of blood pressure decrease in older men.
Article
Peripheral Vascular Disease
Abu Mohd Naser, Feng J. He, Mahbubur Rahman, Norm R. C. Campbell
Summary: The study evaluated the relationship between estimated 24-hour urinary sodium excretion from different formulas and blood pressure, finding discrepancies between formula-estimated sodium levels and actual measurements. The formulas resulted in overestimation of sodium at lower levels and underestimation at higher levels, impacting the relationship with blood pressure.
Article
Oncology
Claire E. Thomas, Yi-Chuan Yu, Hung N. Luu, Renwei Wang, Pedram Paragomi, Jaideep Behari, Jian-Min Yuan
Summary: Higher blood neutrophil to lymphocyte ratio (NLR) and lower lymphocyte count are significantly associated with increased risk of hepatocellular carcinoma (HCC) in patients with non-alcoholic fatty liver disease (NAFLD). Further investigation is warranted to explore the immune response and surveillance in relation to HCC development in NAFLD patients.
Article
Oncology
Claire E. E. Thomas, Jennifer J. J. Adibi, Allison L. L. Kuipers, Brenda Diergaarde, Hung N. N. Luu, Aizhen Jin, Woon-Puay Koh, Yu-Tang Gao, Jennifer Adams-Haduch, Renwei Wang, Anna Lokshin, Jaideep Behari, Jian-Min Yuan
Summary: CD137 is associated with increased risk of hepatocellular carcinoma (HCC) and may serve as a long-term risk marker for HCC development.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Yi-Chuan Yu, Pedram Paragomi, Renwei Wang, Feiran Liang, Hung N. N. Luu, Jaideep Behari, Jian-Min Yuan
Summary: This study examined the association between serum magnesium levels and the risk of HCC among patients with NAFLD. The results showed that higher levels of serum magnesium were significantly associated with a decreased risk of HCC among patients with NAFLD.
Article
Oncology
Yi-Chuan Yu, Pedram Paragomi, Aizhen Jin, Renwei Wang, Robert E. Schoen, Woon-Puay Koh, Jian-Min Yuan, Hung N. Luu
Summary: This study analyzed the association between a low-carbohydrate diet and the risk of colorectal cancer, and found that high intake of animal protein and fat is moderately associated with an increased risk of colon cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Nutrition & Dietetics
Hung N. Luu, Chi Thi-Du Tran, Renwei Wang, Mai Vu-Tuyet Nguyen, Mo Thi Tran, Thuy Thi-Van Tuong, Quang Hong Tran, Linh Cu Le, Huong Thi-Thu Pham, Hien Huy Vu, Nam Chi Bui, Hien Thi-Thu Ha, Dung Tuan Trinh, Claire E. Thomas, Jennifer Adams-Haduch, Liudmilla Velikokhatnaya, Robert E. Schoen, Guoxiang Xie, Wei Jia, Paolo Boffetta, Jose C. Clemente, Jian-Min Yuan
Summary: The study found that colorectal advanced adenoma is associated with alterations in ileal juice bile acids. The concentrations of hyodeoxycholic acid (HCA) species in ileal juice were significantly higher in advanced adenoma patients compared to controls. The relative abundance of ursodeoxycholic acid (UDCA) in total bile acids was significantly reduced in cases than controls.
Article
Gastroenterology & Hepatology
Jaideep Behari, Amir Gougol, Renwei Wang, Hung N. Luu, Pedram Paragomi, Yi-Chuan Yu, Michele Molinari, Kapil Chopra, Shahid M. Malik, David Geller, Jian-Min Yuan
Summary: Patients with NAFLD without cirrhosis or advanced fibrosis have a low incidence of HCC, while those with cirrhosis have a higher risk. Stratifying the incidence of HCC in NAFLD patients based on the presence or absence of cirrhosis or advanced fibrosis can provide valuable information.
HEPATOLOGY COMMUNICATIONS
(2023)
Meeting Abstract
Oncology
Claire E. Thomas, Jennifer J. Adibi, Allison L. Kuipers, Brenda Diergaarde, Hung N. Luu, Aizhen Jin, Woon-Puay Koh, Yu-Tang Gao, Jennifer Adams-Haduch, Renwei Wang, Anna Lokshin, Jaideep Behari, Jian-Min Yuan
Meeting Abstract
Oncology
Yen Thi-Hai Pham, Aizhen Jin, Renwei Wang, Woon-Puay Koh, Jian-Min Yuan, Hung N. Luu
Meeting Abstract
Oncology
Yi-Chuan Yu, Pedram Paragomi, Aizhen Jin, Renwei Wang, Robert E. Schoen, Woon-Puay Koh, Jian-Min Yuan, Hung N. Luu
Meeting Abstract
Oncology
Jian-Min Yuan, Renwei Wang, Hung N. Luu, Jaideep Behari
Meeting Abstract
Oncology
Claire E. Thomas, Brenda Diergaarde, Allison L. Kuipers, Jennifer J. Adibi, Hung N. Luu, Xuling Chang, Rajkumar Dorajoo, Chew-Kiat Heng, Chiea-Chuen Khor, Renwei Wang, Aizhen Jin, Woon-Puay Koh, Jian-Min Yuan
Meeting Abstract
Oncology
Hung N. Luu, Pedram Paragomi, Yi-Chuan Yu, Aizhen Jin, Renwei Wang, Robert E. Schoen, Woon-Puay Koh, Jian-Min Yuan
Article
Oncology
Oanh Thi Bui, Huong Thanh Tran, Sang Minh Nguyen, Tu Van Dao, Quang Vinh Bui, Anh Tuan Pham, Martha J. Shrubsole, Qiuyin Cai, Fei Ye, Wei Zheng, Hung Nguyen Luu, Thuan Van Tran, Xiao-Ou Shu
Summary: This study conducted a retrospective case-control study among Vietnamese women to evaluate the association between menstrual and reproductive factors and the risk of breast cancer. The findings suggest that early age at menarche, late menopause, and higher parity are associated with an increased risk of breast cancer among Vietnamese women.
Article
Gastroenterology & Hepatology
Claire E. Thomas, Brenda Diergaarde, Allison L. Kuipers, Jennifer J. Adibi, Hung N. Luu, Xuling Chang, Rajkumar Dorajoo, Chew-Kiat Heng, Chiea-Chuen Khor, Renwei Wang, Aizhen Jin, Woon-Puay Koh, Jian-Min Yuan
Summary: Using data from the Singapore Chinese Health Study (SCHS), researchers found a strong correlation between a polygenic risk score (PRS) for hepatic fat (HFC-PRS) and nonalcoholic fatty liver disease (NAFLD), as well as an increased risk of hepatocellular carcinoma (HCC).
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Oncology
Chi Thi-Du Tran, Mai Vu-Tuyet Nguyen, Mo Thi Tran, Thuy Thi-Van Tuong, Quang Hong Tran, Linh Cu Le, Huong Thi-Thu Pham, Nam Chi Bui, Hien Huy Vu, Tu Thi-Cam Nguyen, Phuong Que Ta, Hien Thi-Thu Ha, Dung Tuan Trinh, Hanh Thi-My Bui, Dien Quang Trinh, Khanh Van Nguyen, Song Huu Le, Khien Van Vu, Thuan Van Tran, Huong Thi-Thanh Tran, Martha J. Shrubsole, Fei Ye, Qiuyin Cai, Wei Zheng, Paolo Boffetta, Xiao-Ou Shu, Hung N. Luu
Summary: A successful population-based colorectal cancer screening program was conducted in Vietnam, using immunochemical-fecal occult blood testing and subsequent colonoscopy. This provides a promising strategy for similar settings with limited resources.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2022)