Article
Medicine, General & Internal
Hertzel C. Gerstein, Naveed Sattar, Julio Rosenstock, Chinthanie Ramasundarahettige, Richard Pratley, Renato D. Lopes, Carolyn S. P. Lam, Nardev S. Khurmi, Laura Heenan, Stefano Del Prato, Leanne Dyal, Kelley Branch
Summary: The trial compared the cardiovascular and renal outcomes of weekly injections of efpeglenatide versus a placebo in participants with type 2 diabetes and a history of cardiovascular disease or current kidney disease. The study found that the risk of cardiovascular events was lower with efpeglenatide treatment, and a composite renal outcome event was also reduced.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Elisa Lazzaroni, Maria Elena Lunati, Laura Montefusco, Ida Pastore, Enrica Chebat, Vincenzo Cimino, Paola Silvia Morpurgo, Milena Muratori, Laura Plebani, Andrea Bolla, Antonio Rossi, Luciana Vallone, Alessandra Gandolfi, Camilla Tinari, Francesca D'Addio, Moufida Ben Nasr, Cristian Loretelli, Cristiana Scaranna, Rosalia Bellante, Roberto Manfrini, Fabrizio Muratori, Ivano Franzetti, Emanuela Orsi, Carmine Gazzaruso, Renata Ghelardi, Paolo Desenzani, Stefano Genovese, Angela Girelli, Franco Folli, Cesare Berra, Paolo Fiorina
Summary: This study aimed to investigate the acute effect of Dapagliflozin on kidney function in patients with type 2 diabetes. The results showed that after 6 months of treatment with Dapagliflozin, there were improvements in glycemic control, lipid profiles, blood pressure, and acute kidney function.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Environmental Sciences
Bin Wang, Heng Wan, Jing Cheng, Yingchao Chen, Yuying Wang, Yi Chen, Chi Chen, Wen Zhang, Fangzhen Xia, Ningjian Wang, Li Wang, Yingli Lu
Summary: Higher blood lead levels were associated with increased urinary albumin excretion in diabetic patients with vitamin D deficiency. However, this association was attenuated or non-significant in patients with sufficient vitamin D levels. The combination of high blood lead and low vitamin D levels corresponded to significantly higher urinary albumin-to-creatinine ratio. It was also found that the impact of blood lead levels on urinary albumin excretion was more pronounced in patients with reduced estimated glomerular filtration rate in the group with vitamin D deficiency.
ENVIRONMENTAL POLLUTION
(2021)
Article
Pharmacology & Pharmacy
Sjoukje van der Hoek, Douwe J. Mulder, Antoon T. M. Willemsen, Ton Visser, Andre Heeres, Riemer H. J. A. Slart, Philip H. Elsinga, Hiddo J. L. Heerspink, Jasper Stevens
Summary: This study reveals a relationship among interindividual differences in plasma exposure, kidney tissue distribution, angiotensin-1 receptor occupancy, and urinary-albumin-to-creatinine ratio (UACR) response after telmisartan administration.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Immunology
G. H. Dorflinger, P. H. Hoyem, E. Laugesen, J. A. ostergaard, K. L. Funck, R. Steffensen, P. L. Poulsen, T. K. Hansen, M. Bjerre
Summary: Contrary to T1D, T2D is not per se associated with increased MBL serum level for a given MBL genotype or with diabetes duration. Serum MBL was inversely correlated with body fat percentage, and T2D patients with the high MBL expression genotype presented with deterioration of renal function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Philip C. M. Au, Kathryn C. B. Tan, Bernard M. Y. Cheung, Ian C. K. Wong, Hang-Long Li, Ching-Lung Cheung
Summary: In a study conducted in Hong Kong, it was found that compared to dipeptidyl peptidase-4 inhibitors (DPP4is), the use of sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with type 2 diabetes was associated with a reduced risk of end-stage renal disease and acute renal failure, as well as a slower decline in estimated glomerular filtration rate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Katie M. Sullivan, James Scholey, Rahim Moineddin, Etienne Sochett, Brandy Wicklow, Yesmino Elia, Feng Xiao, Thalia Mederios, Pusha Sadi, Dylan Burger, Farid H. Mahmud, Alison B. Dart
Summary: The study found significant associations between podocyte MPE, blood glucose levels and eGFR in youth with type 1 diabetes, but not in those with type 2 diabetes, despite increased renal pathology in the type 2 diabetes cohort.
Article
Endocrinology & Metabolism
Jin Ook Chung, Seon-Young Park, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Summary: The study explores the relationship between plasma LRG1 level and urinary albumin excretion in patients with type 2 diabetes. The results show that there is a positive correlation between plasma LRG1 level and urinary albumin excretion, indicating that LRG1 may be associated with increased excretion of urinary albumin in the early stages of diabetic nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Qiaochu Xue, Xiang Li, Xuan Wang, Hao Ma, Yoriko Heianza, Lu Qi
Summary: Using a novel clustering algorithm, this study characterized and validated subtypes of type 2 diabetes (T2D) and assessed their associations with incident cardiovascular disease (CVD) risk. Five distinct T2D clusters were identified, with significantly different risks of CVD events. Patients with poor renal function had the highest risk of CVD events, followed by those with poor glycemic control and severe obesity.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Medicine, General & Internal
Arnaud D. Kaze, Bernard G. Jaar, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: The study found that increasing albuminuria and worsening stages of early CKD were independently associated with a higher risk of incident stroke in adults with type 2 diabetes.
Article
Endocrinology & Metabolism
Aziz Sener, Selin Yildiz, Gulce Kiren, Canan Topcuoglu
Summary: New inflammatory markers are useful in assessing albuminuria in T2DM patients, but not in assessing glycemic control.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Wai Kin Chan, Sung-Sheng Tsai, Yan-Rong Li, Wei-Yu Chou, Hsiao-Lien Chen, Szu-Tah Chen
Summary: The study investigated the association between serum bilirubin levels and albuminuria progression in type 2 diabetic Taiwanese, finding that higher levels of serum BIL were associated with a lower risk of albuminuria progression.
BIOMEDICAL JOURNAL
(2021)
Article
Endocrinology & Metabolism
Satomi Wakasugi, Tomoya Mita, Naoto Katakami, Yosuke Okada, Hidenori Yoshii, Takeshi Osonoi, Keiko Nishida, Toshihiko Shiraiwa, Keiichi Torimoto, Akira Kurozumi, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada
Summary: Continuous glucose monitoring-derived metrics related to intraday and interday glucose variability are significantly associated with the severity of diabetic retinopathy or albuminuria in patients with type 2 diabetes, possibly useful for risk assessment of diabetic microvascular complications.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Endocrinology & Metabolism
Yui Yamamoto, Ko Hanai, Tomomi Mori, Yoichi Yokoyama, Naoshi Yoshida, Hidekazu Murata, Tomohiro Shinozaki, Tetsuya Babazono
Summary: This study found that individuals with type 2 diabetes exhibiting non-albuminuric kidney insufficiency had a higher risk of kidney function decline, albuminuria, and all-cause mortality compared to those exhibiting preserved kidney function without albuminuria.
Editorial Material
Peripheral Vascular Disease
Ernesto L. Schiffrin, David A. Calhoun, John M. Flack, Sadayoshi Ito, R. Clinton Webb
AMERICAN JOURNAL OF HYPERTENSION
(2017)
Review
Gastroenterology & Hepatology
Takefumi Mori, Yusuke Ohsaki, Ikuko Oba-Yabana, Sadayoshi Ito
HEPATOLOGY RESEARCH
(2017)
Article
Endocrinology & Metabolism
Yuto Yamazaki, Yasuhiro Nakamura, Kei Omata, Kazue Ise, Yuta Tezuka, Yoshikiyo Ono, Ryo Morimoto, Yukinaga Nozawa, Celso E. Gomez-Sanchez, Scott A. Tomlins, William E. Rainey, Sadayoshi Ito, Fumitoshi Satoh, Hironobu Sasano
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2017)
Article
Peripheral Vascular Disease
Eikan Mishima, Takehiro Suzuki, Kazumasa Seiji, Yasutoshi Akiyama, Hideki Ota, Junichiro Hashimoto, Kei Takase, Takaaki Abe, Sadayoshi Ito
JOURNAL OF CLINICAL HYPERTENSION
(2017)
Article
Peripheral Vascular Disease
Junichiro Hashimoto, Sadayoshi Ito
JOURNAL OF HYPERTENSION
(2017)
Article
Urology & Nephrology
Masahiro Nezu, Tomokazu Souma, Lei Yu, Takafumi Suzuki, Daisuke Saigusa, Sadayoshi Ito, Norio Suzuki, Masayuki Yamamoto
KIDNEY INTERNATIONAL
(2017)
Article
Urology & Nephrology
Eikan Mishima, Shinji Fukuda, Chikahisa Mukawa, Akinori Yuri, Yoshitomi Kanemitsu, Yotaro Matsumoto, Yasutoshi Akiyama, Noriko N. Fukuda, Hiroki Tsukamoto, Kei Asaji, Hisato Shima, Koichi Kikuchi, Chitose Suzuki, Takehiro Suzuki, Yoshihisa Tomioka, Tomoyoshi Soga, Sadayoshi Ito, Takaaki Abe
KIDNEY INTERNATIONAL
(2017)
Article
Multidisciplinary Sciences
Masaaki Nakayama, Noritomo Itami, Hodaka Suzuki, Hiromi Hamada, Naoyuki Osaka, Ryo Yamamoto, Kazumasa Tsunoda, Hirofumi Nakano, Kimio Watanabe, Wan-Jun Zhu, Yukio Maruyama, Hiroyuki Terawaki, Shigeru Kabayama, Ryoichi Nakazawa, Mariko Miyazaki, Sadayoshi Ito
Article
Multidisciplinary Sciences
Dai Suzuki, Akiko Saito-Hakoda, Ryo Ito, Kyoko Shimizu, Rehana Parvin, Hiroki Shimada, Erika Noro, Susumu Suzuki, Ikuma Fujiwara, Hiroyuki Kagechika, William E. Rainey, Shigeo Kure, Sadayoshi Ito, Atsushi Yokoyama, Akira Sugawara
Article
Biochemistry & Molecular Biology
Masahiro Nezu, Tomokazu Souma, Lei Yu, Hiroki Sekine, Nobuyuki Takahashi, Andrew Zu-Sern Wei, Sadayoshi Ito, Akiyoshi Fukamizu, Zsuzsanna K. Zsengeller, Tomohiro Nakamura, Atsushi Hozawa, S. Ananth Karumanchi, Norio Suzuki, Masayuki Yamamoto
Article
Biochemistry & Molecular Biology
Emiko Sato, Yukako Tsunokuni, Manami Kaneko, Daisuke Saigusa, Ritsumi Saito, Shuichi Shimma, Akiyo Sekimoto, Yoshiko Kawana, Yuji Oe, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Hidekazu Shirai, Emiko Sato, Akiyo Sekimoto, Taeko Uchida, Yuji Oe, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Medicine, Research & Experimental
Sadayoshi Ito, Yasuyuki Okuda, Kotaro Sugimoto
Summary: This study examined factors associated with the antihypertensive effects of esaxerenone and the incidence of serum potassium elevation in patients with hypertension. Results showed that factors such as sex, weight, hypertension duration, prior antihypertensive treatment, plasma aldosterone concentration, urinary albumin-to-creatinine ratio, and smoking were associated with changes in blood pressure. Factors significantly associated with serum potassium elevation included baseline serum potassium, renal function, urinary albumin-to-creatinine ratio, blood pressure, and hypertension grade. The study concluded that esaxerenone is effective for patients with various backgrounds, but careful management is needed for those at risk of elevated serum potassium.
ADVANCES IN THERAPY
(2023)
Article
Urology & Nephrology
Kaori Narumi, Eikan Mishima, Yukako Akiyama, Tetsuro Matsuhashi, Takashi Nakamichi, Kiyomi Kisu, Shuhei Nishiyama, Hajime Ikenouchi, Akio Kikuchi, Rumiko Izumi, Mariko Miyazaki, Takaaki Abe, Hiroshi Sato, Sadayoshi Ito
Article
Urology & Nephrology
Toshiki Iwai, Mariko Miyazaki, Gen Yamada, Masaaki Nakayama, Tae Yamamoto, Michihiro Satoh, Hiroshi Sato, Sadayoshi Ito
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2018)