Article
Medicine, General & Internal
Marieta P. Theodorakopoulou, Artemios G. Karagiannidis, Maria-Eleni Alexandrou, Fotini Iatridi, Michalis Christodoulou, Theodoros Dimitroulas, Aikaterini Papagianni, Pantelis A. Sarafidis
Summary: This study examined the ambulatory central blood pressure and arterial stiffness parameters in patients with and without intradialytic hypertension (IDH). The results showed that IDH patients had higher levels of central blood pressure and arterial stiffness parameters compared to non-IDH patients. Additionally, the two groups displayed different trajectories over the 48-hour period, with IDH patients showing consistently high values. These findings suggest that increased arterial stiffness may be a significant factor associated with the high burden of cardiovascular disease in this population.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Juraj Jug, Didi Delalic, Valerija Bralic Lang, Tomislav Bulum, Ingrid Prkacin
Summary: This study aimed to compare the pulse wave velocity (PWV) values in subjects with prediabetes, non-dipper profile, and arterial hypertension with their values in healthy subjects. The results showed that subjects with prediabetes and non-dipping profiles had significantly higher PWV values. Age, blood pressure, nocturnal indices, and fasting plasma glucose were identified as independent predictors of PWV values. These findings highlight the importance of prediabetes and non-dipping hypertension as factors contributing to increased PWV.
Review
Medicine, General & Internal
Roman Jurik, Aleksandra Zebrowska, Petr Stastny
Summary: The systematic review examined the impact of resistance training on arterial stiffness, finding that low and moderate intensity resistance training is beneficial in reducing high arterial stiffness to prevent cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicole Bertin, Gianluca Colussi, Alessandro Cavarape, Leonardo A. Sechi, Cristiana Catena
Summary: The study found a significant association between plasma lipoprotein(a) (Lp(a)) levels and markers of vascular stiffening in hypertensive patients. This association may help predict cardiovascular risk and suggests that reducing Lp(a) levels could be beneficial for cardiovascular protection in hypertensive patients.
Review
Cardiac & Cardiovascular Systems
Alicia Saz-Lara, Rosa Maria Bruno, Ivan Cavero-Redondo, Celia Alvarez-Bueno, Blanca Notario-Pacheco, Vicente Martinez-Vizcaino
Summary: This systematic review and meta-analysis found that arterial stiffness, systolic blood pressure, and diastolic blood pressure are associated with incident hypertension. These findings are clinically important for the prevention of arterial hypertension and reducing cardiovascular morbidity and mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Andrew M. South, Joseph Rigdon, Saroja Voruganti, Jeanette M. Stafford, Dana Dabelea, Santica Marcovina, Amy K. Mottl, Cate Pihoker, Elaine M. Urbina, Elizabeth T. Jensen
Summary: This study investigated the association between uric acid levels and blood pressure and arterial stiffness in adolescents and young adults with type 1 diabetes. The results showed no significant relationship between uric acid and blood pressure or arterial stiffness in these patients. These findings support the results of clinical trials in older adults with diabetes, which show that lowering uric acid levels does not improve cardiovascular health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Ivan Cavero-Redondo, Alicia Saz-Lara, Cristina Lugones-Sanchez, Diana P. Pozuelo-Carrascosa, Leticia Gomez-Sanchez, Jose Francisco Lopez-Gil, Luis Garcia-Ortiz, Rosa Maria Bruno, Manuel Angel Gomez-Marcos
Summary: This study synthesized and evaluated scientific evidence on the efficacy of antihypertensive drugs on arterial stiffness in patients with hypertension. The findings suggest that thiazide diuretics, ACE inhibitors, ARBs, and their combinations can effectively reduce pulse wave velocity, while ACE inhibitors and ARBs can reduce augmentation index.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Hematology
Rajeev Malhotra, Christopher J. Nicholson, Dongyu Wang, Vijeta Bhambhani, Samantha Paniagua, Charles Slocum, Haakon H. Sigurslid, Christian L. Lino Cardenas, Rebecca Li, Sophie L. Boerboom, Yin-Ching Chen, Shih-Jen Hwang, Chen Yao, Fumito Ichinose, Donald B. Bloch, Mark E. Lindsay, Gregory D. Lewis, Jayashri R. Aragam, Udo Hoffmann, Gary F. Mitchell, Naomi M. Hamburg, Ramchandran S. Vasan, Emelia J. Benjamin, Martin G. Larson, Warren M. Zapol, Susan Cheng, Jason D. Roh, Christopher J. O'Donnell, Christopher Nguyen, Daniel Levy, Jennifer E. Ho
Summary: This study finds an association between ucMGP levels and arterial stiffness, as well as future HFpEF. Experimental studies using mice also support the link between Mgp heterozygosity and arterial stiffness. These findings suggest a potential role of therapeutic targeting MGP in HFpEF.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Laurence Guy Howes, Tanya Unni, Ameer Hamza, Jan B. Howes, Rohan Jayasinghe, Anna Kablak-Ziembicka, Mark Butlin
Summary: Antioxidants can reduce arterial stiffness, but the previous effects were weak. This study found that the combination therapy of sulfur-containing antioxidants with ascorbic acid had a significant effect on the stiffness index, which was stronger than previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Junli Zuo, Huijuan Chao, Biwen Tang, Alberto P. Avolio, Markus P. Schlaich, Janis Marc Nolde, Audrey Adji, Revathy Carnagarin
Summary: Females show a higher susceptibility to weight-related arterial stiffening and rise in blood pressure in obesity compared to males. The linear association between arterial stiffness and BMI remains significant in females but not in males, indicating gender differences in the impact of obesity on cardiovascular health. Our results suggest that female gender is associated with higher susceptibility of weight-related arterial stiffening and rise in blood pressure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Marieta Theodorakopoulou, Charalampos Loutradis, Athanasios Bikos, Elena Angeloudi, Manina Schoina, Vasileios Raptis, Vassilios Liakopoulos, Aikaterini Papagianni, Pantelis Sarafidis
Summary: The study found that treatment with nebivolol and irbesartan in hemodialysis patients with intradialytic hypertension can lower the 24-hour central blood pressure and pulse wave velocity, but not the augmentation index (AIx 75).
BLOOD PURIFICATION
(2021)
Article
Cardiac & Cardiovascular Systems
Jordana B. Cohen, Gary F. Mitchell, Dipender Gill, Stephen Burgess, Mahboob Rahman, Thomas Hanff, Vasan S. Ramachandran, Karen Mutalik, Raymond R. Townsend, Julio A. Chirinos
Summary: In this study, we used prospective cohort data and Mendelian randomization analyses to show that greater large artery stiffness (LAS) is associated with an increased risk of developing type 2 diabetes. LAS may play an important role in glucose homeostasis and could serve as a useful marker for future diabetes risk.
CIRCULATION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Keeron Stone, Simon Fryer, James Faulkner, Michelle L. Meyer, Kevin Heffernan, Anna Kucharska-Newton, Gabriel Zieff, Craig Paterson, Kunihiro Matsushita, Timothy M. Hughes, Hirofumi Tanaka, Lee Stoner
Summary: The study found no significant relationship between aortic-femoral arterial stiffness gradient (af-SG) and mean arterial pressure (MAP) in healthy older adults, as well as adults with hypertension and diabetes, indicating that af-SG may be considered as a MAP independent index of arterial health and cardiovascular disease (CVD) risk in older adults.
JOURNAL OF HYPERTENSION
(2021)
Article
Biochemistry & Molecular Biology
Zheng-Wei Chen, Chien-Ting Pan, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Yu-Li Lin, Vin-Cent Wu, Chi-Sheng Hung, Che-Wei Liao, Yen-Hung Lin
Summary: In this study involving 1006 PA patients and 983 EH patients, it was found that haPWV is more sensitive than baPWV in detecting aldosterone-induced arterial stiffness. Results indicated that PA patients had significantly higher baPWV compared to EH patients.
Article
Medicine, Research & Experimental
Vladiana Turi, Stela Iurciuc, Octavian Marius Cretu, Delia Mirela Tit, Simona Bungau, Adrian Apostol, Radu Dumitru Moleriu, Cristiana Bustea, Tapan Behl, Camelia Cristina Diaconu, Izabella Petre
Summary: The study revealed significant differences in hemodynamic and arterial stiffness parameters as well as heart rate between pregnant women with hypertension and those without. Arterial function parameters in women with pregnancy-induced hypertension differed long before the onset of high blood pressure, and body mass index had a deleterious effect, especially in pregnant women with hypertension. The assessment of arterial function parameters and BMI is important for predicting future blood pressure values and outcomes during pregnancy.
Review
Peripheral Vascular Disease
Rafael Bellotti Azevedo, Bruna Gopp Botelho, Joao Victor Goncalves de Hollanda, Leonardo Villa Leao Ferreira, Leticia Zarur Junqueira de Andrade, Stephanie Si Min Lilienwald Oei, Tomas de Souza Mello, Elizabeth Silaid Muxfeldt
Summary: In patients infected with COVID-19, cardiac injury is associated with higher morbimortality, and is characterized by inflammation response and multiple organ dysfunction syndrome caused by the virus. Hypertension and diabetes are common comorbidities, while cardiac injury is significantly related to inflammation biomarkers, hyperferritinemia, and leukocytosis.
JOURNAL OF HUMAN HYPERTENSION
(2021)
Article
Otorhinolaryngology
Flavia Rodrigues Ferreira, Thalyta Georgia Vieira Borges, Carla Rocha Muniz, Mariana Pinheiro Brendim, Elizabeth Silaid Muxfeldt
Summary: Resistant arterial hypertension patients with OSA exhibit significant swallowing characteristics such as piecemeal deglutition, spillage, and pharyngeal residue compared to those without OSA. The prevalence of swallow impairment is high in both groups, indicating the association between OSA and swallow dysfunction.
Article
Peripheral Vascular Disease
Christian Nejm Roderjan, Aline de Hollanda Cavalcanti, Arthur Fernandes Cortez, Bernardo Chedier, Fernanda Oliveira de Carvalho Carlos, Fabio de Souza, Elizabeth Silaid Muxfeldt
Summary: This study found an association between aortic stiffness and the severity of obstructive sleep apnea in patients with resistant hypertension. As the severity of apnea increased, arterial stiffness also increased, particularly in women, patients with true resistant hypertension, and those with adverse nocturnal blood pressure profiles.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Otorhinolaryngology
Mariana Pinheiro Brendim, Carla Rocha Muniz, Thalyta Georgia Vieira Borges, Flavia Rodrigues Ferreira, Elizabeth Silaid Muxfeldt
Summary: This study aimed to describe the prevalence and characteristics of oropharyngeal dysphagia (OD) in hypertensive patients with obstructive sleep apnea (OSA) through Fiberoptic Endoscopic Evaluation of Swallowing (FEES) and assess the sensitivity of the Eating Assessment Tool-10 (EAT-10) for detecting OD in this population. The results showed a high prevalence of dysphagia in this group, and the severity of dysphagia was associated with higher EAT-10 scores.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Rafael B. Azevedo, Debora C. R. Wandermurem, Flavia C. F. Liborio, Maira K. Machado, Natalia M. Ushijima, Ramon S. Narde, Inah Maria D. Pecly, Elizabeth S. Muxfeldt
Summary: Adverse cardiac metabolic profiles, particularly diabetes and obesity, are important risk factors for severe COVID-19. Patients with cardiovascular comorbidities are more likely to experience adverse clinical outcomes and increased severity of the disease.
CURRENT CARDIOLOGY REVIEWS
(2022)
Article
Peripheral Vascular Disease
Bernardo Chedier, Christian N. Roderjan, Aline H. Cavalcanti, Fabio de Souza, Elizabeth S. Muxfeldt
Summary: This study describes the prevalence of obstructive sleep apnea (OSA) and polysomnography (PSG) pattern in patients with refractory hypertension (RfHT). Patients with RfHT have similar OSA prevalence compared to patients with resistant hypertension, but they are younger and have a better sleep pattern.
JOURNAL OF HYPERTENSION
(2022)
Editorial Material
Urology & Nephrology
Cibele Isaac Saad Rodrigues, Rafael Bellotti Azevedo, Elizabeth Silaid Muxfeldt
JORNAL BRASILEIRO DE NEFROLOGIA
(2022)
Article
Otorhinolaryngology
Thalyta Georgia Vieira Borges, Carla Rocha Muniz, Flavia Rodrigues Ferreira, Mariana Pinheiro Brendim, Elizabeth Silaid Muxfeldt
Summary: This study aims to evaluate the rehabilitation effect of swallowing therapy program on oropharyngeal dysphagia in resistant hypertensive patients with obstructive sleep apnea (OSA), and to explore the association between clinical and anthropometric characteristics and the outcome. The results showed that patients with resistant hypertension and OSA exhibited improved swallowing performance after the therapy program.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Meeting Abstract
Peripheral Vascular Disease
Elizabeth Silaid Muxfeldt, Bernardo Chedier, Arthur Fernandes Cortez, Victor Margallo, Taissa Lorena Dos Santos
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Bernardo Chedier, Fabio de Souza, Bianca Viegas, Fernanda Oliveira C. Carlos, Taissa Lorena dos Santos, Hugo Farah Affonso Alves, Lucca Hiroshi de Sa Kimura, Carolina de Carvalho Fortes, Marcus Vinicius Serejo Borges V. da Silva, Camila Bello Nemer, Sofi A. Luz Botelho Lobo, Bianca Zattar de Mello Barreto, Vitor de Melo Nolasco, Joao Gabriell Bezerra da Silva, Joao Gabriel Rega do N. Vallaperde, Elizabeth Silaid Muxfeldt
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Bernardo Chedier, Fabio de Souza, Bianca Viegas, Fernanda Oliveira C. Carlos, Taissa Lorena dos Santos, Hugo Farah Affonso Alves, Lucca Hiroshi de Sa Kimura, Carolina de Carvalho Fortes, Marcus Vinicius Serejo Borges V. da Silva, Camila Bello Nemer, Sofia Luz Botelho Lobo, Bianca Zattar de Mello Barreto, Vitor de Melo Nolasco, Joao Gabriell Bezerra da Silva, Joao Gabriel Rega do N. Vallaperde, Elizabeth Silaid Muxfeldt
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Carolina de Carvalho Fortes, Bernardo Chedier, Christian Nejm Roderjan, Bianca Viegas, Fernanda O. Carvalho Carlos, Taissa Lorena dos Santos, Hugo Farah Affonso Alves, Camila Bello Nemer, Marcus Vinicius Serejo Borges V. da Silva, Lucca Hiroshi de Sa Kimura, Sofia Luz Coutinho Botelho Lobo, Bianca Zattar de M. Barreto, Vitor de Melo Nolasco, Joao Gabriell Bezerra da Silva, Joao Gabriel Rega do N. Vallaperde, Elizabeth Silaid Muxfeldt
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Carolina de Carvalho Fortes, Bernardo Chedier, Christian Nejm Roderjan, Bianca Viegas, Fernanda O. Carvalho Carlos, Taissa Lorena dos Santos, Hugo Farah Affonso Alves, Camila Bello Nemer, Marcus Vinicius Serejo Borges V. da Silva, Lucca Hiroshi de Sa Kimura, Sofia Luz Coutinho Botelho Lobo, Bianca Zattar de M. Barreto, Vitor de Melo Nolasco, Joao Gabriell Bezerra da Silva, Joao Gabriel Rega do N. Vallaperde, Elizabeth Silaid Muxfeldt
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Camila Bello Nemer, Bernardo Chedier, Aline de Hollanda Cavalcanti, Christian Nejm Roderjan, Bianca Viegas, Taissa Lorena dos Santos, Joao Carlos Moreno de Azevedo, Hugo Farah Affonso Alves, Lucca Hiroshi de Sa Kimura, Carolina de Carvalho Fortes, Marcus Vinicius Serejo Borges V. da Silva, Sofia Luz Coutinho Botelho Lobo, Fabio de Souza, Elizabeth Silaid Muxfeldt
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Christian Nejm Roderjan, Fabio de Souza, Bernardo Chedier, Aline de Hollanda Cavalcanti, Bianca Viegas, Fernanda Oliveira Carvalho Carlos, Taissa Lorena dos Santos, Joao Carlos Moreno de Azevedo, Carolina de Carvalho Fortes, Bianca Zattar de Jmello Barreto, Vitor de Melo Nolasco, Joao Gabriel do Nascimento Vallaperde, Joao Gabriell Bezerra da Silva, Elizabeth Silaid Muxfeldt
JOURNAL OF HYPERTENSION
(2022)