期刊
HYPERTENSION IN PREGNANCY
卷 33, 期 4, 页码 389-394出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/10641955.2014.915033
关键词
Matrix metalloproteinases; Meta analysis; Preeclampsia; Polymorphism
资金
- National Natural Science Foundation of China [81302822]
- Health industry specific research [200902008]
Studies investigating the association between matrix metalloproteinases (MMPs) gene polymorphisms and preeclampsia (PE) reported contradictory or non-conclusive results. We performed a meta-analysis of five studies that examined the relationship between PE and the MMP9-1562C>T polymorphism. The PubMed, Embase, and Google Scholar databases were searched to access the relevant genetic association studies up to September 2013. The meta-analysis revealed that there was no evidence for significant association between MMP9-1562C>T polymorphism and risk of PE. Large, multiethnic confirmatory, and well-designed studies are needed to further explore the relation between preeclampsia and polymorphisms of the MMPs gene.
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