期刊
HYPERTENSION IN PREGNANCY
卷 29, 期 4, 页码 375-384出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/10641950903242667
关键词
Preeclampsia; Screening test; Inositol phosphoglycan; Abnormal stimulus; Insulin resistance
Objective Hypertensive disorders represent the most common complications of human pregnancy with substantial impact on fetal and maternal outcomes Inositol phospho glycan P type has recently been identified as a novel marker of preeclampsia, the most severe form of hypertension during pregnancy, with a significant increase in urinary excretion preceding the clinical diagnosis Methods A prospective, longitudinal study was carried out to assess the potential of urinary levels of inositol phosphoglycan P type as a screening test for preeclampsia A specific ELISA based test was used to assess urinary levels of P IPG Results Nine patients out of 93 women recruited (496 urinary samples were collected) went on to develop preeclampsia in a cohort of women with high risk pregnancies A cut off value of urinary inositol phosphoglycan P type was identified by ROC analysis providing a sensitivity and specificity for the current protocol of 88 9% and 62 7%, respectively Twenty three women with healthy pregnancies had sporadic episodes of increased excretion of inositol phosphoglycan P type during preg nancy that consistently resolved back to normal baseline without development of preeclampsia There was no correlation of urine levels of inositol phosphoglycan P type and urine protein and patients with gestational hypertension had normal levels of urine inositol phosphoglycan P type Conclusions These findings suggest that, given the rapid raise of P IPG before the onset of the disease, multiple assessments may help at identifying women at risk of developing preeclampsia
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