Endoplasmic Reticulum Stress Sensor Protein Kinase R–Like Endoplasmic Reticulum Kinase (PERK) Protects Against Pressure Overload–Induced Heart Failure and Lung Remodeling

Double-Stranded RNA–Dependent Protein Kinase Deficiency Protects the Heart From Systolic Overload-Induced Congestive Heart Failure

(2014) Huan Wang et al.   CIRCULATION

Inhibition of Mammalian Target of Rapamycin With Rapamycin Reverses Hypertrophic Cardiomyopathy in Mice With Cardiomyocyte-Specific Knockout of PTEN

(2014) Xihui Xu et al.   HYPERTENSION

Loss of the Eukaryotic Initiation Factor 2α Kinase General Control Nonderepressible 2 Protects Mice From Pressure Overload–Induced Congestive Heart Failure Without Affecting Ventricular Hypertrophy

(2013) Zhongbing Lu et al.   HYPERTENSION

Macrophage Migration Inhibitory Factor Deletion Exacerbates Pressure Overload–Induced Cardiac Hypertrophy Through Mitigating Autophagy

(2013) Xihui Xu et al.   HYPERTENSION

Insulin Secretion and Ca2+Dynamics in β-Cells Are Regulated by PERK (EIF2AK3) in Concert with Calcineurin

(2013) Rong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tauroursodeoxycholic Acid Mitigates High Fat Diet-Induced Cardiomyocyte Contractile and Intracellular Ca2+ Anomalies

(2013) Subat Turdi et al.   PLoS One

Gene Therapy for Heart Failure

(2012) Lisa Tilemann et al.   CIRCULATION RESEARCH

Left Ventricular Failure Produces Profound Lung Remodeling and Pulmonary Hypertension in Mice

(2012) Yingjie Chen et al.   HYPERTENSION

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

(2011) A. Avivar-Valderas et al.   MOLECULAR AND CELLULAR BIOLOGY

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(2011) Wei Xin et al.   MOLECULAR MEDICINE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Endoplasmic-Reticulum Calcium Depletion and Disease

(2011) D. Mekahli et al.   Cold Spring Harbor Perspectives in Biology

Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis

(2010) Xiu Hua Liu et al.   CELL CALCIUM

Ablation of C/EBP Homologous Protein Attenuates Endoplasmic Reticulum–Mediated Apoptosis and Cardiac Dysfunction Induced by Pressure Overload

(2010) Hai Ying Fu et al.   CIRCULATION

Oxidative Stress Regulates Left Ventricular PDE5 Expression in the Failing Heart

(2010) Zhongbing Lu et al.   CIRCULATION

Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease

(2010) Tetsuo Minamino et al.   CIRCULATION RESEARCH

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Disruption of Sarcolemmal ATP-Sensitive Potassium Channel Activity Impairs the Cardiac Response to Systolic Overload

(2008) Xinli Hu et al.   CIRCULATION RESEARCH

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY