Article
Geriatrics & Gerontology
Yunli Xing, Ying Sun, Shan Wang, Feng Feng, Deqiang Zhang, Hongwei Li
Summary: Nocturnal blood pressure rise contributes to greater cognitive impairment in elderly patients, while cognitive impairment significantly increases the risk of all-cause mortality. Controlling blood pressure based on ambulatory monitoring is crucial for preventing cognitive dysfunction.
Article
Geriatrics & Gerontology
Sarah A. Gaussoin, Nicholas M. Pajewski, Gordon Chelune, Maryjo L. Cleveland, Michael G. Crowe, Lenore J. Launer, Alan J. Lerner, Jennifer Martindale-Adams, Linda O. Nichols, Paula K. Ogrocki, Bonnie C. Sachs, Kaycee M. Sink, Mark A. Supiano, Virginia G. Wadley, Valerie M. Wilson, Clinton B. Wright, Jeff D. Williamson, David M. Reboussin, Stephen R. Rapp
Summary: Intensive blood pressure control reduced the risk for amnestic and multi-domain subtypes of MCI. Adjudication of MCI was associated with an increased risk of progression to dementia and death.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Clinical Neurology
Gowsaly Mahalingam, Suraj Samtani, Ben Chun Pan Lam, Darren M. Lipnicki, Maria Fernanda Lima-Costa, Sergio Luis Blay, Erico Castro-Costa, Shifu Xiao, Maelenn Guerchet, Pierre-Marie Preux, Antoine Gbessemehlan, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary Yannakoulia, Themis Dardiotis, Ki-Woong Kim, Steffi Riedel-Heller, Susanne Roehr, Alexander Pabst, Suzana Shahar, Katya Numbers, Mary F. Ganguli, Tiffany Hughes, Chung-Chou H. Chang, Michael Crowe, Tze Pin Ng, Xinyi Gwee, Denise Qian Ling Chua, Joanna Rymaszewska, Karin Wolf-Ostermann, Anna-Karin Welmer, Jean Stafford, Rene Melis, Myrra Vernooij-Dassen, Yun-Hee Jeon, Perminder S. Sachdev, Henry Brodaty
Summary: Based on individual participant data from 13 longitudinal ageing studies, the study found that social connections are associated with lower risks of mild cognitive impairment, dementia, and mortality. Specifically, good social connection structure and quality are linked to lower risk of incident mild cognitive impairment, while social connection structure and function are related to lower risk of incident dementia and mortality. In Asian cohorts, being married/in a relationship is associated with reduced risk of dementia, and having a confidante is associated with reduced risk of dementia and mortality.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cardiac & Cardiovascular Systems
Adam de Havenon, Mohammad Anadani, Shyam Prabhakaran, Ka-Ho Wong, Shadi Yaghi, Natalia Rost
Summary: Increased systolic blood pressure variability was found to be associated with the development of probable dementia, even with excellent blood pressure control. Further research is needed to explore ways to reduce blood pressure variability and its potential impact on lowering the risk of cognitive impairment and dementia.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Hang Guo, Yi Tan, Zhizheng Yao, Zilu Zhang, Jiafu Yan, Xiaofeng Meng
Summary: High blood pressure variability and hypertension are risk factors for mild cognitive impairment and probable dementia. This study found that higher systolic blood pressure variability and pulse pressure variability were associated with an increased risk of probable dementia in the intensive group, while higher systolic blood pressure variability was associated with an increased risk of mild cognitive impairment in the intensive group. These findings emphasize the importance of monitoring blood pressure variability in intensive blood pressure treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Geriatrics & Gerontology
Elena Milanesi, Catalina Anca Cucos, Jordi A. Matias-Guiu, Gerard Pinol-Ripoll, Gina Manda, Maria Dobre, Antonio Cuadrado
Summary: Regulator of G protein signaling 2 (RGS2) is involved in neuronal plasticity and synaptic signaling, and its expression levels were found to be downregulated in the blood of Alzheimer's disease (AD) patients. Despite disease-specific therapy, RGS2 transcript levels continued to decrease at 1 year. These findings suggest that RGS2 may play a role in the pathology and progression of AD, serving as a potential blood biomarker for the disease.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Israel Martinez-Nicolas, Thide E. Llorente, Francisco Martinez-Sanchez, Juan J. G. Meilan
Summary: Through speech analysis, this study found that some speech parameters vary due to vascular pathologies, and can accurately predict the diagnosis probability of diabetes and hypertension over 95%, and hypercholesterolemia and heart disease over 80%. These findings may contribute to exploring the causes and developments of cognitive impairment diseases.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Xingyao Tang, Wei Zhao, Ming Lu, Xin Zhang, Ping Zhang, Zhong Xin, Ran Sun, Wei Tian, Marly Augusto Cardoso, Jinkui Yang, Rafael Sim, Jian-Bo Zhou, Coen D. A. Stehouwer
Summary: The study found a higher waist circumference to be associated with an increased risk of cognitive impairment and dementia, especially in individuals over the age of 65.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Geriatrics & Gerontology
Zihan Yin, Jun Zhou, Manze Xia, Zhenghong Chen, Yaqin Li, Xinyue Zhang, Xiang Li, Hang Yan, Lu Wang, Mingsheng Sun, Ling Zhao, Fanrong Liang, Ziwen Wang
Summary: Acupuncture has shown effectiveness in improving cognitive function in patients with mild cognitive impairment (MCI). However, previous studies have mainly focused on the cognitive effects and the neurological effects of acupuncture are relatively unclear. This systematic review summarized existing studies using different brain imaging techniques and found that acupuncture may induce brain alterations in MCI patients, particularly in the cingulate cortex, prefrontal cortex, and hippocampus. The effects of acupuncture on MCI may be associated with the regulation of the default mode network, central executive network, and salience network.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Chelsea Liu, Niranjani Nagarajan, Lama Assi, Kening Jiang, Danielle S. Powell, Emily Pedersen, Lori Rosman, Dillan Villavisanis, Michelle C. Carlson, Bonnielin K. Swenor, Jennifer A. Deal
Summary: There is variation in methods used to assess sensory impairment in studies measuring cognitive function among older adults. Standardized protocols are needed to ensure equitable inclusion of study participants.
ALZHEIMERS & DEMENTIA
(2022)
Article
Geriatrics & Gerontology
Xinyu Duan, Yusong Dang, Chenxi Kang, Peixi Rong, Mingxin Yan, Shutong Zhang, Jing Cui, Yaling Zhao, Fangyao Chen, Jing Zhou, Duolao Wang, Leilei Pei
Summary: This study aimed to investigate the relationship between long-term trajectories of changes in cardiovascular risk factors (CVRFs) and the risk of cognitive impairment among Chinese adults over 60 years old. The study found that lowered SBP, lowered PP, progressive obesity, and stable slim increased the risk for cognitive impairment in the Chinese elderly. Low stable DBP and elevated PP were protective against cognitive impairment among participants.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Knut Asbjorn Hestad, Knut Engedal, Geir Selbaek, Bjorn Heine Strand
Summary: In men, systolic blood pressure decreases linearly each year closer to death, without acceleration, while no such association is found in women. This trend is not influenced by age, year of diagnosis, or type of diagnosis.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Jong Hyeon Ahn, Min Chae Kang, Dongyoung Lee, Jin Whan Cho, Kyung-Ah Park, Jinyoung Youn
Summary: Orthostatic hypotension is a common non-motor symptom in Parkinson's disease that can cause cerebral and retinal hypoperfusion. Optical coherence tomography angiography (OCTA) is a non-invasive technology that can be used to detect microvascular damage in PD. This study found that PD patients had lower retinal capillary density and that blood pressure changes during a tilt test were negatively correlated with retinal vessel density.
NPJ PARKINSONS DISEASE
(2023)
Article
Peripheral Vascular Disease
Satoshi Hoshide, Masafumi Nishizawa, Hiroshi Kanegae, Kazuomi Kario
Summary: This study investigated the association between compliance with home blood pressure monitoring and cognitive impairment in elderly patients. The results showed that the number of days of home blood pressure measurement and compliance were independently associated with total cognitive assessment scores and the lowest quartile of cognitive assessment scores.
HYPERTENSION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Vinicius A. do Rosario, Zoe Fitzgerald, Samantha Broyd, Amelia Paterson, Steven Roodenrys, Susan Thomas, Vida Bliokas, Jan Potter, Karen Walton, Katrina Weston-Green, Maziar Youse, David Williams, Ian M. R. Wright, Karen Charlton
Summary: This study found that daily consumption of high dose fruit-based anthocyanins reduced TNF-alpha concentrations in older adults with MCI, but did not alter other inflammatory biomarkers, microvascular function, or blood pressure parameters. Further research with a larger sample size and longer follow-up is needed to determine the impact on CVD risk and cognitive decline progression.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Peripheral Vascular Disease
Shingo Nakayama, Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Yukako Tatsumi, Kei Asayama, Azusa Hara, Takuo Hirose, Megumi Tsubota-Utsugi, Masahiro Kikuya, Takefumi Mori, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo
Summary: This study investigated the association between ambulatory blood pressure and the risk of home hypertension in a normotensive population. The results showed that considering ambulatory blood pressure can improve the accuracy of the 10-year prediction model for home hypertension risk.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Editorial Material
Peripheral Vascular Disease
Kei Asayama
HYPERTENSION RESEARCH
(2023)
Review
Peripheral Vascular Disease
Chisa Matsumoto, Shigeru Shibata, Takuya Kishi, Satoshi Morimoto, Masaki Mogi, Koichi Yamamoto, Kazuo Kobayashi, Masami Tanaka, Kei Asayama, Eiichiro Yamamoto, Hironori Nakagami, Satoshi Hoshide, Masashi Mukoyama, Kazuomi Kario, Koichi Node, Hiromi Rakugi
Summary: COVID-19 can result in long-term symptoms, known as long COVID, which may have an impact on hypertension and cardiovascular diseases. This article summarizes the potential effects of long COVID on hypertension and related organs, and discusses the influence of age and sex on long COVID. Lastly, it explores areas of uncertainty and future directions for improved understanding and prognosis of clinical problems associated with COVID-19.
HYPERTENSION RESEARCH
(2023)
Review
Peripheral Vascular Disease
Shigeru Shibata, Kazuo Kobayashi, Masami Tanaka, Kei Asayama, Eiichiro Yamamoto, Hironori Nakagami, Satoshi Hoshide, Takuya Kishi, Chisa Matsumoto, Masaki Mogi, Satoshi Morimoto, Koichi Yamamoto, Masashi Mukoyama, Kazuomi Kario, Koichi Node, Hiromi Rakugi
Summary: The number of reported COVID-19 cases worldwide has exceeded 620 million, impacting people's health and daily lives since December 2019. The pandemic has affected blood pressure control in hypertensive patients due to restricted medical care access, psychological distress, and lifestyle changes.
HYPERTENSION RESEARCH
(2023)
Review
Peripheral Vascular Disease
Kei Asayama, Katarzyna Stolarz-Skrzypek, Wen-Yi Yang, Tine W. Hansen, Jana Brguljan-Hitij, Augustine N. Odili, Yan Li, Jan A. Staessen
Summary: The International Databases on Ambulatory (IDACO) and Home (IDHOCO) Blood Pressure in Relation to Cardiovascular Outcome conducted a meta-analysis which found that 24-hour and nighttime blood pressure levels are the best predictors of adverse health outcomes. They also established corresponding thresholds for home and ambulatory blood pressure. The study emphasized the importance of out-of-office blood pressure monitoring in tackling the hypertension pandemic.
HYPERTENSION RESEARCH
(2023)
Article
Psychiatry
Keiko Murakami, Aoi Noda, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama
Summary: This study investigates the association between maternal bonding disorder and developmental delays in children beyond 2 years of age. Data from 8380 mother-child pairs were analyzed, and it was found that bonding disorder is associated with developmental delays in children at 2 and 3.5 years of age.
ARCHIVES OF WOMENS MENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Yiwei Liu, Aya Hirata, Tomonori Okamura, Daisuke Sugiyama, Takumi Hirata, Aya Kadota, Keiko Kondo, Takayoshi Ohkubo, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
Summary: The impact of resting heart rate on cardiovascular disease mortality varies according to serum albumin levels in the general Japanese population.
JOURNAL OF EPIDEMIOLOGY
(2023)
Letter
Urology & Nephrology
Go Anan, Daisuke Kikuchi, Takuo Hirose, Kouji Okada, Takefumi Mori
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Meeting Abstract
Peripheral Vascular Disease
Risa Ishikawa, Katsuya Ishiyama, Ikuko Yabana, Takuo Hirose, Toshiyuki Sato, Keiji Matsumoto, Toshiko Kato, Ayaka Kamada, Hiroki Ito, Shingo Nakayama, Hideaki Hashimoto, Hanna Nakamura, Tomoyoshi Kimura, Takefumi Mori
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Hiroki Ito, Takuo Hirose, Shigemitsu Sato, Akari Endo, Ikuko Oba Yabana, Kazuhiro Takahashi, Takefumi Mori
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Shingo Nakayama, Michihiro Satoh, Hirohito Metoki, Takahisa Murakami, Yukako Tatsumi, Kei Asayama, Azusa Hara, Takuo Hirose, Megumi Tsubota Utsugi, Masahiro Kikuya, Takefumi Mori, Atsushi Hozawa, Yutaka Imai, Takayoshi Ohkubo
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Kei Asayama
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Narumi Eguchi, Kei Asayama, Tomohiro Katsuya, Yutaka Hatori, Masaaki Miyakawa, Mitsuhiko Noda
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Kayo Godai, Mio Kubo, Mai Kabayama, Arisa Wada, Michiko Kido, Sumiyo Hashimoto, Makiko Higashi, Hiromi Hatanaka, Takeshi Kikuchi, Takayuki Dodo, Yasuharu Tabara, Kei Asayama, Takayoshi Ohkubo, Hiromi Rakugi, Kei Kamide
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Arisa Wada, Mai Kabayama, Kayo Godai, Michiko Kido, Sumiyo Hashimoto, Makiko Higashi, Hiromi Hatanaka, Takeshi Kikuchi, Takayuki Dodo, Kei Asayama, Takayoshi Ohkubo, Hiromi Rakugi, Yasuharu Tabara, Kei Kamide
JOURNAL OF HYPERTENSION
(2023)