4.7 Letter

Response to Lack of Specificity of Commercial Antibodies Leads to Misidentification of Angiotensin Type-1 Receptor Protein

期刊

HYPERTENSION
卷 61, 期 4, 页码 E32-E32

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/HYPERTENSIONAHA.111.00982

关键词

-

资金

  1. NHLBI NIH HHS [K99 HL109167] Funding Source: Medline
  2. NIDDK NIH HHS [R01 DK069896] Funding Source: Medline

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Review Transplantation

An introduction and guide to becoming a social media savvy nephrologist

Natasha N. Dave, Matthew A. Sparks, Samira S. Farouk

Summary: The use of social media has increased significantly, with a growing number of medical professionals using it for professional purposes, including nephrologists. Harnessing social media professionally can have positive effects on career development and education. It is important for physicians to understand the basics, utilize available resources, and avoid potential pitfalls.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

Meeting Abstract Peripheral Vascular Disease

Angiotensin Ii Type 1a Receptor Expressed Insmooth Muscle Cells Is Required Forangiotensin Ii-induced Vascular Remodeling But Not For Cardiac Hypertrophy

Keisuke Okuno, Keiichi Torimoto, Stephanie Cicalese, Matthew A. Sparks, Satoru Eguchi

HYPERTENSION (2022)

Article Cardiac & Cardiovascular Systems

Cell-Specific Actions of the Prostaglandin E-Prostanoid Receptor 4 Attenuating Hypertension: A Dominant Role for Kidney Epithelial Cells Compared With Macrophages

Ting Yang, Chengcheng Song, Donna L. Ralph, Portia Andrews, Matthew A. Sparks, Beverly H. Koller, Alicia A. McDonough, Thomas M. Coffman

Summary: The expression of EP4R in kidney epithelial cells attenuates hypertension, potentially by reducing the activity of the epithelial sodium channel, leading to increased natriuresis.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

Article Peripheral Vascular Disease

Angiotensin II Type 1A Receptor Expressed in Smooth Muscle Cells is Required for Hypertensive Vascular Remodeling in Mice Infused With Angiotensin II

Keisuke Okuno, Keiichi Torimoto, Stephanie M. Cicalese, Kyle Preston, Victor Rizzo, Tomoki Hashimoto, Thomas M. Coffman, Matthew A. Sparks, Satoru Eguchi

Summary: Smooth muscle AT(1A) receptors mediate Ang II-induced vascular remodeling in both hypertensive and non-hypertensive conditions, contributing to medial hypertrophy and perivascular fibrosis. These findings indicate an independent etiology of blood pressure elevation and hypertensive vascular remodeling in response to Ang II.

HYPERTENSION (2023)

Article Urology & Nephrology

Trainee Love and Breakup Letters to NephSIM A Free, Mobile-Optimized, Nephrology Teaching Tool

Layla Fattah, David C. Thomas, Matthew A. Sparks, Samira S. Farouk

Summary: This study utilized the love and breakup letter methodology to evaluate a free open access medical education tool and analyzed the attitudes and needs of learners at different training stages through focus group discussions. The results showed that learners' attitudes and needs varied depending on the training stage, posing challenges in meeting their learning needs.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2023)

Article Urology & Nephrology

Engagement in Free Open Access Medical Education by US Nephrology Fellows

Dana M. Larsen, Christy K. Boscardin, Matthew A. Sparks

Summary: This study investigated the frequency, purpose, and type of free open access medical education (FOAMed) usage among nephrology fellows in the US. The results showed that 74% of fellows used FOAMed, and among them, 33% applied the knowledge gained from FOAMed resources in clinical practice. The purposes of FOAMed engagement varied, including accessing academic opinions, answering clinical questions, and staying up to date with the latest information.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2023)

Letter Cardiac & Cardiovascular Systems

Smooth muscle angiotensin II type 1A receptor is required for abdominal aortic aneurysm formation induced by angiotensin II plus β-aminopropionitrile

Keisuke Okuno, Keiichi Torimoto, Stephanie M. Cicalese, Tomoki Hashimoto, Matthew A. Sparks, Victor Rizzo, Satoru Eguchi

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2023)

Article Rheumatology

RheumMadness: Creating an Online Community of Inquiry in Rheumatology

Guy Katz, Didem Saygin, Allen Witt, Robert Harper, Lisa Criscione-Schreiber

Summary: This study evaluated the educational impact of RheumMadness, an online tournament of rheumatology concepts, using the community of inquiry (CoI) framework. The results showed that RheumMadness created an online community that fostered social constructivist learning about rheumatology.

ARTHRITIS CARE & RESEARCH (2023)

Article Nursing

Heterogeneity in Acute Kidney Injury Management in Critically Ill Patients: National Survey

Khaled Shawwa, Kwame Akuamoah-Boateng, Carrie Griffiths, Connor Nevin, Nicole Scherrer, Paul Mccarthy, Matthew A. Sparks, Kianoush Kashani, Javier A. Neyra, Ankit Sakhuja

Summary: A descriptive survey study was conducted to examine the heterogeneity in using tools for diagnosing acute kidney injury (AKI) in critical care settings. The results showed that 52% of respondents used point-of-care ultrasound, followed by 15% using novel biomarkers and 8% using formal kidney ultrasound imaging for diagnostic testing. Cystatin C was the most commonly used novel biomarker (72% of respondents). Only 6% used prediction models and an integrated clinical decision support system to identify patients at high-risk for developing AKI. The study confirmed the significant variation in the diagnosis of critically ill patients with AKI.

JNP- THE JOURNAL FOR NURSE PRACTITIONERS (2023)

Article Urology & Nephrology

Novel Concepts in Nephron Sodium Transport: A Physiological and Clinical Perspective

Justin P. Van Beusecum, Fitra Rianto, Jade Teakell, Valentina Kon, Matthew A. Sparks, Ewout J. Hoorn, Annet Kirabo, Nirupama Ramkumar

Summary: The kidneys are crucial for maintaining sodium balance in the body by utilizing multiple sodium transporters along the nephron. Imbalances in renal blood flow and glomerular filtration can lead to alterations in sodium transport, resulting in hypertension and Na+-retentive states. This article provides an overview of nephron sodium transport, discusses clinical syndromes and therapeutic agents affecting sodium transporter function, and highlights recent advancements in the field.

ADVANCES IN KIDNEY DISEASE AND HEALTH (2023)

Article Urology & Nephrology

Targeting Glomerular Hemodynamics for Kidney Protection

Solomiia Savedchuk, Deep Phachu, Mythri Shankar, Matthew A. Sparks, Lisa M. Harrison-Bernard

Summary: The kidney has a unique structure with two capillary beds in series: the glomerular and peritubular capillaries. The glomerular capillary bed is a high-pressure bed responsible for ultrafiltration and sodium/volume homeostasis. The regulation of resistance in the afferent and efferent arterioles, known as glomerular hemodynamics, determines the glomerular filtration rate (GFR) and renal blood flow. Medications targeting glomerular hemodynamics have shown effectiveness in kidney health. This review discusses tubuloglomerular feedback, disease states, and pharmacologic agents that alter glomerular hemodynamics.

ADVANCES IN KIDNEY DISEASE AND HEALTH (2023)

Meeting Abstract Urology & Nephrology

GESTATIONAL DIABETES INSIPIDUS-INDUCED REFRACTORY HYPOKALEMIA

Timothy Hopper, Matthew Sparks, John Middleton

AMERICAN JOURNAL OF KIDNEY DISEASES (2023)

Meeting Abstract Urology & Nephrology

SODIUM CORRECTION RATE AND CLINICAL PARAMETERS OF PATIENTS TREATED WITH PROACTIVE DDAVP CLAMP FOR HYPONATREMIA: A CASE SERIES

James Torain, Anjali Muraleedharan, Komal Safdar, Matthew Sparks

AMERICAN JOURNAL OF KIDNEY DISEASES (2023)

Meeting Abstract Urology & Nephrology

FROM SOIL TO THE PERITONEUM: FUNGAL PERITONITIS WITH PAECILOMYCES VARIOTII

Benjamin Catanese, Rasha Raslan, Matthew Sparks, Ruediger Lehrich

AMERICAN JOURNAL OF KIDNEY DISEASES (2023)

Article Urology & Nephrology

Sildenafil and Kidney Function in Heart Failure with Preserved Ejection Fraction

Daniel Edmonston, Matthew Sparks, Sudarshan Rajagopal, Myles Wolf

Summary: Background chronic kidney disease (CKD) worsens the prognosis for individuals with heart failure with preserved ejection fraction (HFpEF). In the RELAX trial, sildenafil decreased eGFR compared with placebo, but its long-term effects on kidney function in HFpEF are unclear. This study analyzed the influence of sildenafil on acute and chronic eGFR slopes in HFpEF patients. The results suggest that sildenafil induced an acute effect on eGFR without affecting the overall eGFR slope after 24 weeks, indicating that early reduction in eGFR after initiating sildenafil treatment does not pose a long-term risk.

KIDNEY360 (2023)

暂无数据