Article
Physiology
Mahmoud Abdelbary, Riyaz Mohamed, Ellen E. Gillis, Karl Diaz-Sanders, Babak Baban, Michael W. Brands, Jennifer C. Sullivan
Summary: Apoptosis was measured in various tissues of spontaneously hypertensive rats (SHR) to investigate its role in hypertension and T cell profile. The results showed that female SHR had higher renal and aortic apoptosis compared to males, but spleen apoptosis was comparable. However, treatment with the caspase inhibitor did not alter blood pressure or renal T cells in male or female SHR. This suggests that apoptosis does not contribute to hypertension or sex differences in renal T cells in SHR.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Kasey M. Belanger, Riyaz Mohamed, R. Clinton Webb, Jennifer C. Sullivan
Summary: Hypertension is a primary risk factor for cardiovascular disease, and there is increasing evidence supporting a role for the innate immune system in its development. TLR4 has been implicated in hypertension in male rats, but its role in females is not well understood. Male rats have higher TLR4 expression in the kidney than females, but TLR4 does not contribute to sex differences in blood pressure and renal T cell profile.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Yiting Wang, Jue Zhang, Junlin Zhang, Yucheng Wu, Rui Zhang, Honghong Ren, Mark E. Cooper, Fang Liu
Summary: The study found that female patients with DKD had higher levels of certain indicators (such as blood pressure, cholesterol levels) compared to male patients, but there was no significant association observed between sex differences and ESKD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Jenneffer Rayane Braga Tibaes, Maria Ines Barreto Silva, Bethany Wollin, Donna Vine, Sue Tsai, Caroline Richard
Summary: Understanding sex differences in immunological responses in the context of obesity is crucial for improving health outcomes. This systematic review found that females had lower systemic inflammation and a higher proportion of M2-like cells in adipose tissue compared with males in response to diet-induced obesity. However, there were no clear sex differences in immune function, and the mechanistic links between diet, obesity, and immune dysfunction remain unclear.
Review
Immunology
Henning Jacobsen, Sabra L. Klein
Summary: The ongoing COVID-19 pandemic has highlighted the sex-specific differences in immunity and outcomes following SARS-CoV-2 infection, with evidence suggesting a male bias in disease severity mediated by differential immune responses. While males are more susceptible to most viral infections, females possess immunological features that make them vulnerable to distinct immune-related disease outcomes. Sex chromosome complement, related genes, and sex steroids all play crucial roles in mediating these sex differences in immunity to viral infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Lynne A. Kelly, Aoife Branagan, Gergana Semova, Eleanor J. Molloy
Summary: Neonatal brain injury and associated inflammation are more common in males. Neurodevelopmental differences exist between males and females, with males having a higher incidence of developmental delay and learning difficulties. The underlying reasons for these sex differences may include genetic, immunological, and hormonal factors, but research on neonatal immune response is limited.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Toralf Melsom, Jon Viljar Norvik, Inger Therese Enoksen, Vidar Stefansson, Ulla Dorte Mathisen, Ole Martin Fuskevag, Trond G. Jenssen, Marit D. Solbu, Bjorn O. Eriksen
Summary: Among middle-aged and elderly individuals in the general population, the decline in mean GFR is slower in women compared to men, and it is independent of health status.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
Mita Varghese, Jeremy Clemente, Arianna Lerner, Simin Abrishami, Mohammed Islam, Perla Subbaiah, Kanakadurga Singer
Summary: This study reveals sexual dimorphism in adipose tissue macrophages (ATMs) in male and female mice under a high fat diet, using RNA-seq and chemotaxis assays. The findings suggest that sex hormones may play a role in regulating inflammatory responses associated with obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Shin Mei Chan, Gabe Weininger, John Langford, Daniel Jane-Wit, Alan Dardik
Summary: Vascular disorders present differently in women and men, with sex differences in AVF maturation and utilization. Inflammation plays a significant role in AVF maturation, suggesting potential for sex-specific vascular therapies to improve success rates.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Shan Cai, Jiajia Dang, Panliang Zhong, Ning Ma, Yunfei Liu, Di Shi, Zhiyong Zou, Yanhui Dong, Jun Ma, Yi Song
Summary: This study analyzed the sex differences in the prevalence of obesity phenotypes and their risk factors among children and adolescents in China. The results showed higher prevalence of obesity phenotypes in boys and identified various risk factors such as parental smoking, birth weight, and lifestyle factors. The findings highlight the importance of considering sex differences in managing obesity phenotypes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Florian Juszczak, Louise Pierre, Morgane Decarnoncle, Ines Jadot, Blanche Martin, Olivia Botton, Nathalie Caron, Jonas Dehairs, Johannes V. Swinnen, Anne-Emilie Decleves
Summary: This study found that female mice are naturally shielded from obesity-induced kidney damage and lipid accumulation in the kidneys. Obesity in males is associated with the presence of potentially toxic lipids and dysregulated renal metabolism. Understanding these sex-related differences in obesity-related complications could lead to better management and treatment of kidney problems in both men and women.
BIOLOGY OF SEX DIFFERENCES
(2023)
Review
Pharmacology & Pharmacy
Natalia Valdrighi, Juliana P. Vago, Arjen B. Blom, Fons A. J. van de Loo, Esmeralda N. Blaney Davidson
Summary: Osteoarthritis (OA) is a non-progressive disease with no current drugs available to halt or slow its progression, making symptom alleviation the main treatment option. Chronic pain is the main symptom that drives adults with OA to seek medical help. OA pathophysiology is closely linked to the innate immune system, which in turn is associated with joint pain. Sex differences in the biology of pain and the innate immune system have been observed, with OA being more prevalent in women and women experiencing worse outcomes despite similar levels of structural damage. This review aims to provide an overview of the role of innate immunity in OA pain and highlight the emerging evidence of sex differences in this context. The goal is to lay the scientific foundation for future research on pain relief therapies targeting innate immunity, with consideration of sex differences, in order to improve the treatment of pain in both women and men.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Natasha L. Pacheco, Nicole Noren Hooten, Yongqing Zhang, Calais S. Prince, Nicolle A. Mode, Ngozi Ezike, Kevin G. Becker, Alan B. Zonderman, Michele K. Evans
Summary: The study revealed sex-specific transcriptional changes in middle-aged frailty, aiding in the understanding of frailty progression and providing potential therapeutic targets for preventing frailty.
Review
Pharmacology & Pharmacy
Asad Shabbir, Krishnaraj Sinhji Rathod, Rayomand Syrus Khambata, Amrita Ahluwalia
Summary: Coordinated molecular responses are crucial for effective management of both acute and chronic inflammation. There are significant gender differences in the incidence and inflammatory mechanisms of vascular diseases. Regulation of host inflammation may be more effective than acute treatments.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021
(2021)
Article
Endocrinology & Metabolism
Benjamin C. Cossins, Inge van den Munckhof, Joost H. W. Rutten, Marinette van der Graaf, Rinke Stienstra, Leo A. B. Joosten, Mihai G. Netea, Yang Li, Niels P. Riksen
Summary: This study examined the association between adipocyte size, adipose tissue inflammation, systemic inflammation, and metabolic and atherosclerotic complications of obesity in a sex-specific manner. The results showed that inflammation in abdominal subcutaneous adipose tissue is more related to metabolic complications than atherosclerotic complications, and there are significant sex-specific differences in this association.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Letter
Psychiatry
Pasi J. Eskola, Juha P. Auvinen, Jari Jokelainen, Timo Liukkonen, Sylvain Sebert, Aimo Ruokonen, Katri Puukka, Markku Timonen, Sirkka Keinanen-Kiukaanniemi
Article
Endocrinology & Metabolism
Nina Rautio, Tuulia Varanka-Ruuska, Eeva Vaaramo, Saranya Palaniswamy, Rozenn Nedelec, Jouko Miettunen, Jaro Karppinen, Juha Auvinen, Marjo-Riitta Jarvelin, Sirkka Keinanen-Kiukaanniemi, Sylvain Sebert, Leena Ala-Mursula
PRIMARY CARE DIABETES
(2017)
Article
Nutrition & Dietetics
Jole Martino, Maria Teresa Segura, Luz Garcia-Valdes, M. C. Padilla, Ricardo Rueda, Harry J. McArdle, Helen Budge, Michael E. Symonds, Cristina Campoy
Review
Endocrinology & Metabolism
Michael E. Symonds, Grace Farhat, Peter Aldiss, Mark Pope, Helen Budge
Article
Nutrition & Dietetics
Peter Aldiss, Jo E. Lewis, David J. Boocock, Amanda K. Miles, Ian Bloor, Francis J. P. Ebling, Helen Budge, Michael E. Symonds
Article
Multidisciplinary Sciences
Ksenija Velickovic, Declan Wayne, Hilda Anaid Lugo Leija, Ian Bloor, David E. Morris, James Law, Helen Budge, Harold Sacks, Michael E. Symonds, Virginie Sottile
SCIENTIFIC REPORTS
(2019)
Article
Nutrition & Dietetics
Mousa Khalafi, Hamid Mohebbi, Michael E. Symonds, Pouran Karimi, Amir Akbari, Elma Tabari, Mehrsa Faridnia, Kamilia Moghaddami
Editorial Material
Physiology
Michael E. Symonds
EXPERIMENTAL PHYSIOLOGY
(2020)
Review
Sport Sciences
Mousa Khalafi, Michael E. Symonds
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2020)
Article
Cell Biology
Hilda Anaid Lugo Leija, Ksenija Velickovic, Ian Bloor, Harold Sacks, Michael E. Symonds, Virginie Sottile
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Endocrinology & Metabolism
James M. Law, David E. Morris, Lindsay Robinson, Tabitha Randell, Louise Denvir, Michael E. Symonds, Helen Budge
Summary: Type 1 diabetes affects the activity of brown adipose tissue, as shown by lower supraclavicular temperatures in children with diabetes compared to controls. Insulin delivery method may significantly impact the response of BAT to stimulation. Further research is needed to fully understand the glucose-insulin-BAT relationship.
PEDIATRIC DIABETES
(2021)
Article
Biochemistry & Molecular Biology
Peter Aldiss, Jo E. Lewis, Irene Lupini, Ian Bloor, Ramyar Chavoshinejad, David J. Boocock, Amanda K. Miles, Francis J. P. Ebling, Helen Budge, Michael E. Symonds
Summary: This study demonstrates that chronic suppression of adaptive thermogenesis leads to weight gain and increased fat mass in rodents. Living in a cool environment (20 degrees C) and treatment with a β3-adrenoreceptor agonist (YM-178) had minimal effects on metabolic health in obese rats raised at thermoneutrality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Multidisciplinary Sciences
Mousa Khalafi, Michael E. Symonds, Mohammad Hossein Sakhaei, Faeghe Ghasemi
Summary: The meta-analysis showed that exercise training reduces sICAM-1 but does not significantly affect sVCAM-1 in adults. Both aerobic and resistance training are effective in decreasing sICAM-1 in adults with metabolic disorders and cardiovascular diseases.
Article
Endocrinology & Metabolism
James M. Law, David E. Morris, Valerie Astle, Ellie Finn, Jose Joaquin Muros, Lindsay J. Robinson, Tabitha Randell, Louise Denvir, Michael E. Symonds, Helen Budge
JOURNAL OF THE ENDOCRINE SOCIETY
(2019)
Article
Obstetrics & Gynecology
M. H. Koot, I. J. Grooten, S. Sebert, M. Koiranen, M. R. Jarvelin, E. Kajantie, R. C. Painter, T. J. Roseboom
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2017)