Article
Cardiac & Cardiovascular Systems
Jinsong Gao, Xianghua Huang, Wen Di, Xiaojing Dong, Wenli Gou, Hong Shi, Zilian Wang, Angela Dietl, Sonja Grill, Martin Hund
Summary: This study demonstrates that the sFlt-1/PlGF ratio cutoff of 38 has high predictive performance for short-term prediction of preeclampsia in Chinese women, helping to reduce unnecessary hospitalization for low-risk women.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Obstetrics & Gynecology
Anne Dathan-Stumpf, Victoria Czarnowsky, Vicky Hein, Theresa Andraczek, Holger Stepan
Summary: This real-world data analysis found a correlation between the soluble fms-like tyrosine kinase-1 to placental growth factor ratio and the severity of preeclampsia and placental dysfunction, providing a useful tool for stratifying patients' outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jin Zhang, Wei Hua, Xinyuan Zhao, Fan Yang, Ting Guo, Jianhua Zhang, Xuerong Zheng, Wanqi Liang
Summary: This study confirmed the protective effects of paeoniflorin against preeclampsia-related endothelial damage by upregulating VEGFA to alleviate the injury caused by overexpression of sFlt-1 and sEng.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Xinwen Chang, Qizhi He, Mengtian Wei, Linyan Jia, Yingying Wei, Yiding Bian, Tao Duan, Kai Wang
Summary: Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) have beneficial effects on adverse birth outcomes in a preeclampsia mouse model induced by sFlt-1. They can decrease blood pressure, improve fetal birth weight, and restore placental vascular networks. In addition, HUCMSC-exos partially rescue sFlt-1-induced dysfunction of human umbilical vein endothelial cells.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Kazuya Mimura, Takuji Tomimatsu, Masayuki Endo, Tadashi Kimura
Summary: In early pregnancy, the sFlt-1/PlGF ratio may be used to differentiate between exacerbation of systemic lupus erythematosus and preeclampsia.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Physiology
Olivia K. Travis, Geilda A. Tardo, Chelsea Giachelli, Shani Siddiq, Henry T. Nguyen, Madison T. Crosby, Tyler D. Johnson, Andrea K. Brown, George W. Booz, Alex N. Smith, Jan Michael Williams, Denise C. Cornelius
Summary: In this study, neutralization of IFNy was found to reduce MAP, UARI, and placental ROS levels in RUPP recipients. However, fetal and placental weights in RUPP rats were not improved following anti-IFNy treatment. These findings suggest that IFNy may play a role in the pathophysiology of PE and could be a potential therapeutic target for improving maternal outcomes in PE.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Obstetrics & Gynecology
Fabienne Trottmann, Luigi Raio, Sofia Amylidi-Mohr, Beatrice Mosimann, Araceli Jarquin Campos, Franz H. Messerli, Lorenz Risch, Marc U. Baumann
Summary: In this study, pregnant women with AFLP had significantly higher sFlt-1 levels compared to those with HELLP syndrome. PlGF levels were also higher in AFLP patients. The sFlt-1 cutoff value of 31,100 pg/mL showed a sensitivity and specificity of 100% in distinguishing between AFLP and HELLP syndrome.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Biochemistry & Molecular Biology
Annika Schulz, Carolin C. Drost, Bettina Hesse, Katrin Beul, Goeran R. Boeckel, Alexander Lukasz, Hermann Pavenstaedt, Marcus Brand, Giovana S. Di Marco
Summary: In this study, it was found that excess sFlt-1 led to conformational changes in the endothelial glycocalyx (eGC), resulting in increased monocyte adhesion and vascular dysfunction. The eGC became flat and stiff under excess sFlt-1, while its structural components remained unchanged. Functionally, this conformation increased endothelial adhesiveness to THP-1 monocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Jakub Kornacki, Przemyslaw Wirstlein, Ewa Wender-Ozegowska
Summary: Evaluation of serum concentrations of HA in patients with PE was found to be more useful in the assessment of endothelial injury, compared to the assessment of SDC-1. The degree of EG damage was comparable in patients with early- and late-onset PE. The pathomechanism of the damage seems to be more sFlt-1 dependent in patients with early- onset PE than in the case of late-onset disease.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Jessica R. Zolton, Lindsey A. Sjaarda, Sunni L. Mumford, Elizabeth A. DeVilbiss, Keewan Kim, Kerry S. Flannagan, Jeannie G. Radoc, Neil J. Perkins, Robert M. Silver, Jean Wactawski-Wende, Micah J. Hill, Alan H. DeCherney, Enrique F. Schisterman
Summary: Circulating VEGF and sFLT-1 did not vary significantly across the menstrual cycle in normal ovulating women, and may not be useful as peripheral biomarkers of endometrial changes during the menstrual cycle. Plasma may be the preferred medium for measuring circulating VEGF in reproductive-age women, regardless of menstrual cycle phase.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Wanying Cheng, Lingling Wang, Xin Gao, Guangli Yin, Jujuan Wang, Yongqian Shu, Hongxia Qiu, Limin Duan
Summary: sFLt-1 is a reliable immune biomarker for predicting the inflammatory status and prognosis of secondary hemophagocytic lymphohistiocytosis (sHLH).
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Annika Schulz, Carolin Christina Drost, Bettina Hesse, Katrin Beul, Marcus Brand, Giovana Seno Di Marco
Summary: sFlt-1 has damaging effects on endothelial cell structure and function. Its levels are correlated with endothelial cell cortex stiffening, which is accompanied by cytoskeleton reorganization and changes in endothelial barrier function, mediated by p38 MAPK activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Ele Hanson, Kristiina Rull, Kaspar Ratnik, Pille Vaas, Pille Teesalu, Maris Laan
Summary: The study aimed to evaluate the value of screening for maternal serum sFlt-1/PlGF ratio in predicting the development of preeclampsia during the third trimester. The results showed that testing sFlt-1/PlGF ratio between 180-259 gestational days could detect approximately half of subsequent preeclampsia cases, with the highest detection rate observed at 225-238 gestational days.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Pablo Garcia-Manau, Manel Mendoza, Erika Bonacina, Carmen Garrido-Gimenez, Antoni Fernandez-Oliva, Julia Zanini, Marina Catalan, Helena Tur, Berta Serrano, Elena Carreras
Summary: This study aimed to compare sFlt-1/PlGF values and pregnancy outcomes among early-onset SGA/FGR stages, with results showing higher sFlt-1/PlGF ratios and increased frequency of adverse outcomes in FGR patients. There was a significant correlation between sFlt-1/PlGF values and gestational age at delivery, adverse pregnancy outcomes, etc.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Biochemistry & Molecular Biology
Qing Yong, Kyra L. Dijkstra, Carin van der Keur, Jan A. Bruijn, Michael Eikmans, Hans J. Baelde
Summary: Insufficient immune tolerance during pregnancy is associated with pathological conditions such as preeclampsia (PE). The expression of sFLT1 protein in human placenta is regulated by MIF during early pregnancy and preeclampsia. sFLT1 plays an important role in the modulation of inflammation in early pregnancy and preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Chantal Zevenbergen, Tim I. M. Korevaar, Andrea Schuette, Robin P. Peeters, Marco Medici, Theo J. Visser, Lutz Schomburg, W. Edward Visser
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2016)
Article
Endocrinology & Metabolism
E. T. Massolt, M. van der Windt, T. I. M. Korevaar, B. L. R. Kam, J. W. Burger, G. J. H. Franssen, I. Lehmphul, J. Koehrle, W. E. Visser, R. P. Peeters
CLINICAL ENDOCRINOLOGY
(2016)
Article
Endocrinology & Metabolism
Korcan Demir, Anja L. M. van Gucht, Muammer Buyukinan, Goenuel Catli, Yavuz Ayhan, Veysel Nijat Bas, Bumin Dundar, Behzat Ozkan, Marcel E. Meima, W. Edward Visser, Robin P. Peeters, Theo J. Visser
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2016)
Article
Cell Biology
Alies A. van Mullem, Anja L. M. van Gucht, W. Edward Visser, Marcel E. Meima, Robin P. Peeters, Theo J. Visser
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2016)
Article
Multidisciplinary Sciences
Elske T. Massolt, Grigoris Effraimidis, Tim I. M. Korevaar, Wilmar M. Wiersinga, W. Edward Visser, Robin P. Peeters, Hemmo A. Drexhage
Editorial Material
Endocrinology & Metabolism
W. Edward Visser, Heike Heuer, Theo J. Visser
Article
Endocrinology & Metabolism
Anja L. M. van Gucht, Marcel E. Meima, Nitash Zwaveling-Soonawala, W. Edward Visser, Eric Fliers, Johanna M. B. Wennink, Civile Henny, Theo J. Visser, Robin P. Peeters, A. S. Paul van Trotsenburg
Article
Genetics & Heredity
Francesca Novara, Stefan Groeneweg, Elena Freri, Margherita Estienne, Paolo Reho, Sara Matricardi, Barbara Castellotti, W. Edward Visser, Orsetta Zuffardi, Theo J. Visser
Article
Endocrinology & Metabolism
Carolien M. Beukhof, Leni van Doorn, Theo J. Visser, Sander Bins, W. Edward Visser, Ramona van Heerebeek, Folkert J. van Kemenade, Yolanda B. de Rijke, Wouter W. de Herder, Layal Chaker, Ron H. Mathijssen, Robin P. Peeters
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2017)
Article
Endocrinology & Metabolism
Anja L. M. van Gucht, Marcel E. Meima, Carla Moran, Maura Agostini, Anna Tylki-Szymanska, Malgorzata Krajewska-Walasek, Krystyna Chrzanowska, Alexandra Efthymiadou, Dionisios Chrysis, Korcan Demir, W. Edward Visser, Theo J. Visser, Krishna Chatterjee, Thamar B. van Dijk, Robin P. Peeters
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2017)
Review
Endocrinology & Metabolism
Stefan Groeneweg, Robin P. Peeters, Theo J. Visser, W. Edward Visser
JOURNAL OF ENDOCRINOLOGY
(2017)
Article
Cell Biology
Stefan Groeneweg, Robin P. Peeters, Theo J. Visser, W. Edward Visser
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2017)
Article
Endocrinology & Metabolism
Karn Wejaphikul, Stefan Groeneweg, Yvonne Hilhorst-Hofstee, V. Krishna Chatterjee, Robin P. Peeters, Marcel E. Meima, W. Edward Visser
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Review
Endocrinology & Metabolism
Stefan Groeneweg, Ferdy S. van Geest, Robin P. Peeters, Heike Heuer, W. Edward Visser
Article
Endocrinology & Metabolism
Stefan Groeneweg, W. Edward Visser, Theo J. Visser
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2017)
