Article
Peripheral Vascular Disease
Fang-Zheng Wang, Pei Qian, Mu-Yue Liu, Lei Ding, Hong-Yu Wang, Qian Wang, Zi-Yang Ding, Fei-Yu Jin, Rui-Gang Li, Ye-Bo Zhou
Summary: This study investigated the effects of nitric oxide (NO) and adrenomedullin (ADM) in the paraventricular nucleus (PVN) on the adipose afferent reflex (AAR) and sympathetic nerve activity (SNA) in obesity-related hypertension (OH) rats. The results showed that PVN ADM decreased basal SNA and attenuated the enhanced AAR in OH rats. Bilateral PVN microinjection of ADM increased NO and cGMP levels, as well as nNOS phosphorylation. Adeno-associated virus vectors encoding ADM transfection improved AAR, SNA, blood pressure, and vascular remodeling in OH rats.
JOURNAL OF HYPERTENSION
(2023)
Article
Multidisciplinary Sciences
Huanjuan Su, Zhichen Yang, Ying Zhang, Bihui Yang, Zhanmei Zhou, Cailing Su, Wei Cao
Summary: In mouse models of ureteral obstruction, an overactive central pathway driven by kidney afferent nerves activating angiotensin II signaling is identified as the cause of kidney fibrosis after relief of the obstruction. Manipulating these neural elements could be a potential treatment strategy. Similar evidence is found in human post-obstructed kidneys, suggesting the importance of targeting sympathetic nerve activity in fibrotic outcomes.
Article
Physiology
Yu Xu, Xuejie Fei, Hangjiang Fu, Aidong Chen, Xinrui Zhu, Feng Zhang, Ying Han
Summary: This study aimed to determine the roles of salusin-beta in the paraventricular nucleus (PVN) in modulating enhanced cardiac sympathetic afferent reflex (CSAR) and sympathetic hyperactivation in rats with chronic heart failure (CHF). The results showed that salusin-beta expression in the PVN was upregulated in CHF rats, and the injection of salusin-beta into the PVN increased blood pressure, renal sympathetic nerve activity, and CSAR. In addition, the use of anti-salusin-beta IgG produced opposite effects.
Article
Pharmacology & Pharmacy
Chunmei Xu, Jun Zhu, Guangyuan Gong, Li Guo, Ye Zhang, Ziyue Zhang, Chunlan Ma
Summary: This study found that anthocyanin can reduce salt-induced hypertension by inhibiting NLRP3-related inflammation and oxidative stress, and improving the expression and function of AT(1)R.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Biochemistry & Molecular Biology
Roberto B. Pontes, Erika E. Nishi, Renato O. Crajoinas, Maycon I. O. Milanez, Adriana C. C. Girardi, Ruy R. Campos, Cassia T. Bergamaschi
Summary: This study examined the effects of an acute increase in blood pressure and renal sympathetic nerve activity on sodium and water excretion and NHE3 activity. It was found that renal nerve stimulation independently decreased sodium and water excretion. However, when blood pressure was acutely increased during the stimulation, diuresis, natriuresis, and NHE3 activity inhibition were observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ana Luiza C. Sayegh, Jui-Lin Fan, Mathew Dawes, Julian F. R. Paton, James P. Fisher
Summary: The study found that central respiratory and sympathetic chemoreflex sensitivities are increased in hypertensive patients, suggesting that these reflexes may play a role in the development of hypertension.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biochemistry & Molecular Biology
Jing Wang, Linshan Sun, Jingjing You, Honghai Peng, Haijing Yan, Jiangong Wang, Fengjiao Sun, Minghu Cui, Sanwang Wang, Zheng Zhang, Xueli Fan, Dunjiang Liu, Cuilan Liu, Changyun Qiu, Chao Chen, Zhicheng Xu, Jinbo Chen, Wei Li, Bin Liu
Summary: Chronic stress induces depression and insulin resistance, and there is a bidirectional relationship between them. This study reveals the involvement of the hypothalamic paraventricular nucleus (PVN) in depression and insulin resistance induced by chronic stress. The activation of PVN neurons plays a role in increasing sympathetic innervation of adipose tissues, downregulating several adipokines, and leading to depression and insulin resistance.
Article
Physiology
Hong Zheng, Tapan A. Patel, Xuefei Liu, Kaushik P. Patel
Summary: In this study, the researchers found that C-type natriuretic peptide (CNP) may serve as a potential mediator of sympatho-inhibition within the hypothalamic paraventricular nucleus (PVN). Microinjection of CNP into the PVN significantly decreased renal sympathetic nerve activity, mean arterial pressure, and heart rate. The effects of CNP on PVN neurons projecting to the rostral ventrolateral medulla (RVLM) were mediated by the natriuretic peptide receptor type C (NPR-C).
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Physiology
Yuanyuan Fan, Enshe Jiang, Huanjia Gao, Jeremy Bigalke, Bojun Chen, Chunxiu Yu, Qinghui Chen, Zhiying Shan
Summary: The study showed that hyperactivity of the orexin system activates CaMKII expression in the PVN, leading to increased sympathetic nerve activity and blood pressure. Furthermore, orexin-A treatment increases CaMKII expression and phosphorylation in OX1R-expressing PC12 cells, as well as CaMKII activation in cultured hypothalamic neurons. Additionally, optogenetic excitation of PVN CaMKII-expressing neurons results in robust increases in RSNA and BP in SD rats.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Jean Faber, Maycon I. O. Milanez, Cristiano S. Simoes, Ruy R. Campos
Summary: This study aimed to investigate the specific spectral patterns of sympathetic vasomotor activation controlled by the PVN. The results showed that each nerve activity (renal and splanchnic) had its own electrophysiological pattern of frequency-coded rhythm. Furthermore, blockade of AT1 receptors had an impact on the spectral features of sympathetic nerve activity.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Ramon A. Pinol, Allison S. Mogul, Colleen K. Hadley, Atreyi Saha, Chia Li, Vojtech Skop, Haley S. Province, Cuiying Xiao, Oksana Gavrilova, Michael J. Krashes, Marc L. Reitman
Summary: The activation of POA(BRS3) neuronal populations increases body temperature, contributes to cold defense, and fine-tunes the feedback control of body temperature.
Article
Cell Biology
Jugang Chen, Yingjie Chu, Meng Gao, Xin Dai, Bin Li, Xiufen Qu, Dechun Yin
Summary: This study found that local cardiac sympathetic afferent ablation (LCSAA) can inhibit activated astrocytes in the hypothalamus paraventricular (PVN), thus reducing ventricular arrhythmia (VA) in rats with acute myocardial infarction (AMI). LCSAA can decrease the activation of astrocytes and neurons in the PVN, as well as sympathetic nerve activity, leading to a decrease in VA occurrence. Activated astrocytes may play an important role in the enhanced cardiac sympathetic afferent reflex (CSAR) in AMI.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Peripheral Vascular Disease
Seth W. Holwerda, Megan E. Gangwish, Rachel E. Luehrs, Virginia R. Nuckols, John P. Thyfault, John M. Miles, Gary L. Pierce
Summary: This study aimed to investigate the relationship between abdominal obesity and sympathetic nerve activity and blood pressure. The results showed that the transduction of sympathetic nerve activity to blood pressure was augmented in individuals with abdominal obesity and positively correlated with higher resting blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Integrative & Complementary Medicine
Jingya Wang, Qiumei Zhang, Lin Yao, Teng He, Xinyi Chen, Yang Su, Shengxuan Sun, Mengyue Fan, Jinglan Yan, Taiyi Wang, Meng Zhang, Feng Guo, Shiqing Mo, Manqi Lu, Meixia Zou, Liangjie Li, Qing Yuan, Huashan Pan, Yongjun Chen
Summary: This study found that electroacupuncture (EA) at the BL15 acupuncture point effectively prevented circulatory dysfunction in a rat model of atrial fibrillation. The treatment restored impaired vascular contraction and relaxation caused by atrial fibrillation and blocked abnormal activity of the autonomic nervous system. Importantly, excessive activation of PVN neurons diminished the protective effects of EA treatment on atrial fibrillation-induced circulatory dysfunction.
Article
Endocrinology & Metabolism
Zhigang Shi, Alyssa C. Bonillas, Jennifer Wong, Stephanie L. Padilla, Virginia L. Brooks
Summary: The study reveals that NPY in the hypothalamus suppresses sympathetic nerve activity in brown adipose tissue and influences heart rate and blood pressure via Y1R. Downstream pathways for BAT SNA may involve direct projections to the RPa and PVN.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Feng Zhang, Aidong Chen, Yan Pan, Xingxing Wang, Yu Xu, Ankit A. Desai, Haiyang Tang, Ying Han
Summary: PAH is a progressive disease with high mortality and complex etiology, leading to right heart failure. The renin-angiotensin system plays a critical role in maintaining cardiovascular homeostasis, with the ACE2-Ang-(1-7)-Mas axis potentially representing a novel target for PAH treatment.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Review
Chemistry, Multidisciplinary
Chao Ye, Fen Zheng, Nan Wu, Guo-qing Zhu, Xiu-zhen Li
Summary: Vascular remodeling plays a crucial role in the development of various vascular diseases and is closely associated with the release of extracellular vesicles (EVs). EVs impact vascular remodeling by affecting oxidative stress, inflammation, calcification, and lipid plaque formation. Therefore, EVs have the potential to be used as biomarkers for diagnosis and prognosis, as well as therapeutic targets for vascular remodeling and cardiovascular diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Yuan Xue, Sihan Hu, Chichi Chen, Jiachen He, Jie Sun, Yesheng Jin, Yuanshu Zhang, Guoqing Zhu, Qin Shi, Yongjun Rui
Summary: Irisin plays a regulatory role in bone homeostasis and promotes MSC-derived osteogenesis. Lack of Irisin leads to bone loss and enhanced bone resorption, while the presence of Irisin can promote osteogenesis by activating signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lu-Lu Wu, Yue Zhang, Xiu-Zhen Li, Xin-Li Du, Ying Gao, Jing-Xiao Wang, Xiao-Li Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Xiao Tan
Summary: Selective renal afferent denervation attenuated sympathetic activity, oxidative stress, vascular remodeling, and hypertension in spontaneously hypertensive rats (SHR).
Article
Cell Biology
Changlei Bao, Qian He, Hui Wang, Yanan Sun, Yahang Xu, Yan Pan, Yadan Hu, Shichuang Zheng, Shuxin Liang, Ang Luo, Tanzilan Nahar, Jiwang Chen, Haiyang Tang, Ying Han
Summary: The study found that artemisinin and its derivatives can be used to treat pulmonary arterial hypertension and improve the function and structure of pulmonary arteries, thereby attenuating disease progression. The therapeutic mechanism may involve reducing oxidative stress and increasing nitric oxide levels.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Medicine, Research & Experimental
Yan Pan, Aidong Chen, Xingxing Wang, Changlei Bao, Shuxin Liang, Haiyang Tang, Ying Han
Summary: This study investigated the effects of salusin-beta on endothelium-dependent vascular relaxation and the progression of PAH. The results showed that elevated salusin-beta levels in PAH rats led to reduced endothelium-dependent vasodilatation and participated in PAH progression by stimulating NAD(P)H oxidase-ROS production and inhibiting eNOS-NO release.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Bing Zhou, Nan Wu, Yuan Yan, Lu-Lu Wu, Guo-Qing Zhu, Xiao-Qing Xiong
Summary: This study demonstrates that the upregulation of miR-31-5p and the downregulation of FNDC5 contribute to Ang II-induced VSMC proliferation and migration.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Li Wang, Jing-Xiao Wang, Jun-Liu Chen, Wen-Yuan Hao, Wen-Zhou Xu, Zhi-Qin Xu, Yu-Tong Jiang, Pei-Qi Luo, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Xiu-Zhen Li
Summary: This study discovered that high expression of asprosin in the PVN increased sympathetic outflow and blood pressure via the cAMP-PKA signaling-mediated NADPH oxidase activation and subsequent superoxide production. These findings highlight the important role of asprosin in regulating sympathetic and cardiovascular function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xingxing Wang, Aidong Chen, Ruihua Hu, Feng Zhang, Shuxin Liang, Changlei Bao, Xuanxuan Liu, Haiyang Tang, Ying Han
Summary: This study investigates the effects of salusin-beta on the proliferation, migration, fibrosis, and calcification of pulmonary arterial smooth muscle cells (PASMCs). The results suggest that increased activity of salusin-beta contributes to vascular remodeling and the development of pulmonary arterial hypertension.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jing-Xiao Wang, Xiao-Li Wang, Zhi-Qin Xu, Yue Zhang, Dong Xue, Rong Zhu, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Xiao Tan
Summary: This study found that chemerin-9 in the PVN increases sympathetic activity and blood pressure through CMKLR1-dependent calcium influx, glutamate receptor-mediated NADPH oxidase activation, and subsequent superoxide production.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Changlei Bao, Shuxin Liang, Ying Han, Zi Yang, Shiyun Liu, Yanan Sun, Shichuang Zheng, Yuzhu Li, Ting Wang, Yali Gu, Kang Wu, Stephen M. Black, Jian Wang, Steffan T. Nawrocki, Jennifer S. Carew, Jason X. -J. Yuan, Haiyang Tang
Summary: ROC-325 is a promising agent for the treatment of pulmonary hypertension (PH) that inhibits autophagy, downregulates HIF levels, and increases nitric oxide production.
Article
Biochemistry & Molecular Biology
Jin-Hua Bo, Jing-Xiao Wang, Xiao-Li Wang, Yang Jiao, Ming Jiang, Jun-Liu Chen, Wen-Yuan Hao, Qi Chen, Yue-Hua Li, Zheng-Liang Ma, Guo-Qing Zhu
Summary: Research shows that the use of dexmedetomidine can attenuate sympathetic activity and inflammation in sepsis. The drug reduces NADPH oxidase-dependent superoxide production by inhibiting the adenylate cyclase-cAMP-PKA signaling pathway and activating GABA(A) receptors, thus alleviating sympathetic overactivity.
Article
Medicine, Research & Experimental
Fen Zheng, Chao Ye, Rui Ge, Yu Wang, Xiao-Lei Tian, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Bing Zhou
Summary: This study demonstrates the important roles of EVs-mediated miR21-3p transfer in promoting VSMC proliferation and migration in SHR and identifies SORBS2 as a target of miR-21-3p in this process.
Article
Medicine, Research & Experimental
Chao Ye, Fen Zheng, Tao Xu, Nan Wu, Ying Tong, Xiao-Qing Xiong, Ye-Bo Zhou, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Ying Han
Summary: This study reveals that NE promotes the release of small EVs and ACE transfer from AFs, leading to VSMCs proliferation in hypertension. Intervention of AFs-derived EVs release may be a potential therapeutic approach for vascular remodeling in hypertension related to excessive sympathetic activation.
