Review
Medicine, General & Internal
Gabrielle Bourque, Swapnil Hiremath
Summary: Resistant hypertension, a common condition, increases the risk of cardiovascular and renal events. This review provides an overview of the definition, diagnosis, evaluation, and management of resistant hypertension. The association between medication non-adherence and resistant hypertension, as well as non-pharmacological interventions, are discussed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Valentina Trimarco, Raffaele Izzo, Pasquale Mone, Maria Lembo, Maria Virginia Manzi, Daniela Pacella, Angela Falco, Paola Gallo, Giovanni Esposito, Carmine Morisco, Gaetano Santulli, Bruno Trimarco
Summary: Therapeutic concordance significantly improves the outcome of antihypertensive treatment in patients with therapy-resistant hypertension.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Peripheral Vascular Disease
Nicholas Chiu, Julie Lauffenburger, Jessica Franklin, Niteesh Choudhry
Summary: Research shows that patients with true resistant hypertension are at higher risk of cardiovascular and mortality events, especially among those who are black, have macroalbuminuria, chronic kidney disease, a history of stroke, higher baseline systolic blood pressure, and are taking more baseline antihypertensive medications.
HYPERTENSION RESEARCH
(2021)
Review
Medicine, General & Internal
Ryan J. Chan, Wryan Helmeczi, Swapnil S. Hiremath
Summary: Resistant hypertension refers to blood pressure that remains above guideline targets despite the use of three anti-hypertensives, including a diuretic, at optimal doses. It is estimated to affect 10-30% of hypertensive patients and is associated with increased risk of adverse cardiovascular outcomes. Proper diagnosis, exclusion of other conditions, and optimization of non-pharmacologic management are essential before considering additional treatment options. This review discusses the definitions of resistant hypertension, the importance of careful diagnosis and management strategies, and the need for new research and agents.
INTERNAL MEDICINE JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Elisabeta Badila, Cristina Japie, Emma Weiss, Ana-Maria Balahura, Daniela Barto, Alexandru Scafa Udriste
Summary: Resistant hypertension (R-HTN) is associated with higher mortality and morbidity compared to non-R-HTN, requiring a careful diagnostic approach to exclude other possible causes and adjust treatment accordingly. Current recommendations for managing R-HTN include optimizing drug regimens, adding new medications, and selecting appropriate drug combinations to achieve target blood pressure values.
Article
Medicine, General & Internal
Akshaya Srikanth Bhagavathula, Syed Mahboob Shah, Elhadi Husein Aburawi
Summary: The study found a high prevalence of TRH among newly treated hypertensive patients in the UAE, with suboptimal medication adherence and blood pressure control among participants, highlighting the urgent need for greater efforts to improve adherence to antihypertensive therapy and focus on TRH and blood pressure control.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Valentina Trimarco, Maria Virginia Manzi, Raffaele Izzo, Pasquale Mone, Maria Lembo, Daniela Pacella, Giovanni Esposito, Angela Falco, Carmine Morisco, Paola Gallo, Gaetano Santulli, Bruno Trimarco
Summary: This study investigates the impact of a therapeutic concordance approach on adverse drug reactions (ADRs) in patients with therapy-resistant hypertension (TRH). The results show that the therapeutic concordance approach significantly reduces the occurrence of ADRs in TRH patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Harpreet S. Bajaj, Richard M. Bergenstal, Andreas Christoffersen, Melanie J. Davies, Amoolya Gowda, Joakim Isendahl, Ildiko Lingvay, Peter A. Senior, Robert J. Silver, Roberto Trevisan, Julio Rosenstock
Summary: The study demonstrated that switching from daily basal insulin to once-weekly icodec was well tolerated and provided effective glycemic control. The use of a loading dose when switching to once-weekly icodec significantly increased the percent time in range during weeks 15 and 16 compared to once-daily IGlar U100, without increasing the risk of hypoglycemia.
Article
Cardiac & Cardiovascular Systems
Andrea Pio-Abreu, Fernanda Trani-Ferreira, Giovanio V. Silva, Luiz A. Bortolotto, Luciano F. Drager
Summary: Directly observed therapy (DOT) at hospital is helpful in confirming/excluding the phenotypes of resistant (RHTN) and refractory (RefHTN) hypertension, improving blood pressure control, and reducing the need for antihypertensive drugs after hospital discharge.
Article
Medicine, General & Internal
Alexander R. Zheutlin, Favel L. Mondesir, Catherine G. Derington, Jordan B. King, Chong Zhang, Jordana B. Cohen, Dan R. Berlowitz, D. Edmund Anstey, William C. Cushman, Tom H. Greene, Olugbenga Ogedegbe, Adam P. Bress
Summary: This study analyzed data from the SPRINT trial and found that the prevalence of therapeutic inertia was similar or lower for non-Hispanic Black and Hispanic participants compared to non-Hispanic White participants. These findings suggest that a standardized approach to blood pressure management, as used in the SPRINT trial, may help ensure equitable care and reduce disparities in hypertension.
Article
Peripheral Vascular Disease
Coralie M. G. Georges, Marco Pappaccogli, Elvira Fanelli, Geraldine Petit, Sabrina Ritscher, Marilucy Lopez-Sublet, Achille Bapolisi, Pierre Wallemacq, Franco Rabbia, Philippe de Timary, Stefan W. Toennes, Alexandre Persu
Summary: The aim of this study was to assess drug adherence and psychological factors in patients with apparently treatment-resistant hypertension (ATRH). The study found that poor drug adherence and altered psychological profiles play a major role in younger patients with ATRH devoid of cardiovascular complication. In contrast, in patients with ATRH and a history of cardio- or cerebrovascular complication, drug adherence and severity of hypertension were only associated with the number of yearly admissions to the emergency room and the total number of prescribed drugs.
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Ann-Kathrin Schaefer, Tim Kuczera, Rebecca Wurm-Kuczera, Dieter Mueller, Ellen Born, Mark Lipphardt, Marlene Pluess, Manuel Wallbach, Michael Koziolek
Summary: Uncontrolled hypertension is a key risk factor for cardiovascular morbidity, and baroreflex activation therapy (BAT) has been identified as an effective solution for true resistant hypertension. A study evaluating patients' eligibility for BAT found that only a small number eventually received a BAT system, largely due to treatable reasons for seemingly resistant hypertension. This underscores the importance of a thorough examination and careful consideration when determining suitability for interventional antihypertensive therapy.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Review
Biochemistry & Molecular Biology
Fabio Bioletto, Martina Bollati, Chiara Lopez, Stefano Arata, Matteo Procopio, Federico Ponzetto, Ezio Ghigo, Mauro Maccario, Mirko Parasiliti-Caprino
Summary: Primary aldosteronism is recognized as the most common cause of secondary hypertension, associated with high-risk phenotypes and increased cardiovascular morbidity. Excessive aldosterone secretion can contribute to the development of hypertension and drug resistance through various mechanisms and worsen end-organ damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
Gary Chun-Yun Kang
Summary: This study aimed to determine the efficacy of technology-based interventions in improving adherence to antihypertensive medications. The results showed that several interventions significantly improved adherence and had a positive impact on blood pressure control. However, randomized controlled trials on technological interventions in this area are still limited.
Article
Multidisciplinary Sciences
Sara Malo, Isabel Aguilar-Palacio, Cristina Feja, Maria Jesus Lallana, Javier Armesto, Maria Jose Rabanaque
Summary: This study analyzed patterns of antihypertensive drug use among new users in a Southern European population, identifying factors that influence persistence. The results showed that overall persistence with antihypertensive therapy was poor and influenced by sex, age, and type of therapy. Fixed combinations were found to be effective for initial therapy, especially for patients at higher risk of discontinuation.
Article
Obstetrics & Gynecology
Juhua Luo, Joann E. Manson, Michael Hendryx, Aladdin H. Shadyab, Karen C. Johnson, Paul C. Dinh, Scott B. Going, Rowan Chlebowski, Marcia L. Stefanick, Karen L. Margolis
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2019)
Article
Medicine, Research & Experimental
Beverly B. Green, Melissa L. Anderson, Jerry Campbell, Andrea J. Cook, Kelly Ehrlich, Sarah Evers, Yoshio N. Hall, Clarissa Hsu, Dwayne Joseph, Predrag Klasnja, Karen L. Margolis, Jennifer B. McClure, Sean A. Munson, Mathew J. Thompson
CONTEMPORARY CLINICAL TRIALS
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Paul Muntner, Paula T. Einhorn, William C. Cushman, Paul K. Whelton, Natalie A. Bello, Paul E. Drawz, Beverly B. Green, Daniel W. Jones, Stephen P. Juraschek, Karen L. Margolis, Edgar R. Miller, Ann Marie Navar, Yechiam Ostchega, Michael K. Rakotz, Bernard Rosner, Joseph E. Schwartz, Daichi Shimbo, George S. Stergiou, Raymond R. Townsend, Jeff D. Williamson, Jackson T. Wright, Lawrence J. Appel
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Geriatrics & Gerontology
Karen L. Margolis, David M. Buchner, Michael J. LaMonte, Yuzheng Zhang, Chongzhi Di, Eileen Rillamas-Sun, Julie Hunt, Farha Ikramuddin, Wenjun Li, Steve Marshall, Dori Rosenberg, Marcia L. Stefanick, Robert Wallace, Andrea Z. LaCroix
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2019)
Article
Public, Environmental & Occupational Health
Paul C. Dinh, Lauren A. Schrader, Catherine J. Svensson, Karen L. Margolis, Brian Silver, Juhua Luo
PREVENTIVE MEDICINE
(2019)
Correction
Geriatrics & Gerontology
John J. McNeil, Robyn L. Woods, Mark R. Nelson, Anne M. Murray, Christopher M. Reid, Brenda Kirpach, Elsdon Storey, Raj C. Shah, Rory S. Wolfe, Andrew M. Tonkin, Anne B. Newman, Jeff D. Williamson, Jessica E. Lockery, Karen L. Margolis, Michael E. Ernst, Walter P. Abhayaratna, Nigel Stocks, Sharyn M. Fitzgerald, Ruth E. Trevaks, Suzanne G. Orchard, Lawrence J. Beilin, Geoffrey A. Donnan, Peter Gibbs, Colin I. Johnston, Richard H. Grimm
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2019)
Article
Peripheral Vascular Disease
Elyse O. Kharbanda, Steve E. Asche, Steven P. Dehmer, Alan R. Sinaiko, Heidi L. Ekstrom, Nicole Trower, Patrick J. O'Connor
JOURNAL OF CLINICAL HYPERTENSION
(2019)
Article
Peripheral Vascular Disease
Karen L. Margolis, Steven P. Dehmer, JoAnn Sperl-Hillen, Patrick J. O'Connor, Stephen E. Asche, Anna R. Bergdall, Beverly B. Green, Rachel A. Nyboer, Pamala A. Pawloski, Nicole K. Trower, Michael V. Maciosek
Article
Cardiac & Cardiovascular Systems
Michael E. Ernst, Joanne Ryan, Enayet K. Chowdhury, Karen L. Margolis, Lawrence J. Beilin, Christopher M. Reid, Mark R. Nelson, Robyn L. Woods, Raj C. Shah, Suzanne G. Orchard, Rory Wolfe, Elsdon Storey, Andrew M. Tonkin, Amy Brodtmann, John J. McNeil, Anne M. Murray
Summary: This study found that high blood pressure variability in older adults, especially in men, is associated with increased risks of dementia and cognitive decline.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Rebecca C. Rossom, Stephanie A. Hooker, Patrick J. O'Connor, A. Lauren Crain, Joann M. Sperl-Hillen
Summary: This study compares the estimated 10-year and 30-year cardiovascular risk in primary care patients with and without serious mental illness (SMI). The results show that patients with SMI have significantly higher cardiovascular risk compared to those without SMI, even in young adults. The main contributing risk factors are elevated body mass index and smoking. Addressing uncontrolled major cardiovascular risk factors at an early age is crucial for individuals with SMI.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Peripheral Vascular Disease
Karen L. Margolis, Anna R. Bergdall, A. Lauren Crain, Meghan M. JaKa, Jeffrey P. Anderson, Leif Solberg, Joann Sperl-Hillen, MarySue Beran, Beverly B. Green, Patricia Haugen, Christine K. Norton, Amy J. Kodet, Rashmi Sharma, Deepika Appana, Nicole K. Trower, Pamala A. Pawloski, Daniel J. Rehrauer, Maria L. Simmons, Zeke J. McKinney, Thomas E. Kottke, Jeanette Y. Ziegenfuss, Rae Ann Williams, Patrick J. O'Connor
Summary: This study compared the effects of clinic-based care and telehealth care on reducing blood pressure and found that telehealth care can be an effective and safe alternative for improving patient-centered care for hypertension.
Article
Peripheral Vascular Disease
Sultana Monira Hussain, Michael E. Ernst, Anna L. Barker, Karen L. Margolis, Christopher M. Reid, Johannes T. Neumann, Andrew M. Tonkin, Thao Le Thi Phuong, Lawrence J. Beilin, Thao Pham, Enayet K. Chowdhury, Flavia M. Cicuttini, Julia F. M. Gilmartin-Thomas, Prudence R. Carr, John J. McNeil
Summary: Long-term variability in mean arterial pressure is associated with an increased risk of falls in frail or prefrail individuals taking antihypertensive medications. Beta-blocker monotherapy is associated with a higher risk of falls compared to calcium channel blockers.
Article
Medicine, Research & Experimental
Karen L. Margolis, A. Lauren Crain, Beverly B. Green, Patrick J. O'Connor, Leif Solberg, MarySue Beran, Anna R. Bergdall, Pamala A. Pawloski, Jeanette Y. Ziegenfuss, Meghan M. JaKa, Deepika Appana, Rashmi Sharma, Amy J. Kodet, Nicole K. Trower, Daniel J. Rehrauer, Zeke McKinney, Christine K. Norton, Patricia Haugen, Jeffrey P. Anderson, Benjamin F. Crabtree, Sarah K. Norman, Joann M. Sperl-Hillen
Summary: This study compared two trials and found that Hyperlink 1 was more explanatory while Hyperlink 3 was more pragmatic. The recruitment process and participant characteristics differed between the two trials, with Hyperlink 1 enrolling older, male, and White participants, and Hyperlink 3 enrolling younger, female, and non-White participants with lower socioeconomic indicators and more comorbidities.
Article
Health Care Sciences & Services
JoAnn M. Sperl-Hillen, Jeffrey P. Anderson, Karen L. Margolis, Rebecca C. Rossom, Kristen M. Kopski, Beth M. Averbeck, Jeanine A. Rosner, Heidi L. Ekstrom, Steven P. Dehmer, Patrick J. O'Connor
Summary: This study aimed to evaluate the impact of a shared decision-making system on factors influencing revenue generation in primary care clinics. The results showed that the use of the SDM system significantly increased the proportion of encounters assigned high-complexity (level 5) CPT codes.
JMIR FORMATIVE RESEARCH
(2022)