Review
Peripheral Vascular Disease
Mattias Brunstrom, Costas Thomopoulos, Bo Carlberg, Reinhold Kreutz, Giuseppe Mancia
Summary: This review provides an overview of important methodological considerations for systematic reviews and meta-analyses, particularly focusing on the effect of blood pressure-lowering on clinical outcomes. It also discusses the pros and cons of different analytical strategies.
Article
Peripheral Vascular Disease
Yue Deng, Wei Liu, Xinchun Yang, Zihong Guo, Juyan Zhang, Rongjie Huang, Xiaomin Yang, Chunli Yu, Jing Yu, Jun Cai
Summary: Intensive systolic blood pressure lowering can protect against the development of left ventricular hypertrophy in older hypertensive patients, but this favorable effect cannot fully account for the reduction in cardiovascular events associated with intensive systolic blood pressure lowering.
Article
Peripheral Vascular Disease
Jaejin An, Tiffany Luong, Lei Qian, Rong Wei, Ran Liu, Paul Muntner, Jeffrey Brettler, Marc G. Jaffe, Andrew E. Moran, Kristi Reynolds
Summary: The study found that patients who initiated ACEI-thiazide diuretic combination therapy were more likely to achieve BP goals compared with those who initiated monotherapy.
Article
Endocrinology & Metabolism
Tianzhichao Hou, Mian Li, Hong Lin, Zhiyun Zhao, Jieli Lu, Tiange Wang, Yu Xu, Weiqing Wang, Yufang Bi, Guang Ning, Min Xu
Summary: This study used mendelian randomization to investigate the causal effect of lowering systolic blood pressure on the risk of macrovascular and microvascular outcomes in diabetic patients. The results showed that lowering systolic blood pressure was associated with a decreased risk of diabetic coronary artery disease and nephropathy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Peripheral Vascular Disease
Seng Chan You, Harlan M. Krumholz, Marc A. Suchard, Martijn J. Schuemie, George Hripcsak, RuiJun Chen, Steven Shea, Jon Duke, Nicole Pratt, Christian G. Reich, David Madigan, Patrick B. Ryan, Rae Woong Park, Sungha Park
Summary: The study found no significant differences in the effectiveness and safety when comparing the third-generation beta-blockers with atenolol as first-line treatment for hypertension, but patients on third-generation beta-blockers had a higher risk of stroke compared to those on ACE inhibitors and thiazide diuretics.
Article
Peripheral Vascular Disease
Tao Yang, Xue Mei, Ethel Tackie-Yarboi, Millicent Tambari Akere, Jun Kyoung, Blair Mell, Ji-Youn Yeo, Xi Cheng, Jasenka Zubcevic, Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada, Isaac T. Schiefer, Bina Joe
Summary: This study reveals that gut microbiota can catabolize antihypertensive medications and compromise their blood pressure-lowering effects. Specifically, C. comes, a species in the bacterial genus Coprococcus, catabolizes ester ACE inhibitors through esterase activity, leading to reduced antihypertensive effects. This finding provides a new mechanistic explanation for the low efficacy of antihypertensive medications in hypertensive individuals.
Article
Cardiac & Cardiovascular Systems
Nathan K. Itoga, Daniel S. Taw, Maria E. Montez-Rath, Tara I. Chang
Summary: The study found that there are differences in the risk pattern of systolic blood pressure (SBP) and diastolic blood pressure (DBP) depending on clinical outcomes, with different SBP and DBP ranges associated with the lowest risk for different cardiovascular events. This suggests that individualization of blood pressure targets may be necessary based on the specific cardiovascular event for which a patient is most at risk.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Peripheral Vascular Disease
Nadia E. Bonekamp, Wilko Spiering, Hendrik M. Nathoe, L. Jaap Kappelle, Gert J. de Borst, Frank L. J. Visseren, Jan Westerink
Summary: The majority of real-world patients with CAD, PAD, or cerebrovascular disease would be eligible for landmark trials on blood pressure-lowering drugs. Patients with CAD ineligible for the EUROPA and PEACE trials are at higher adjusted mortality and major adverse cardiovascular event risks, which may limit applicability of their results to ineligible patients.
Article
Peripheral Vascular Disease
Zeinab Bidel, Milad Nazarzadeh, Dexter Canoy, Emma Copland, Eva Gerdts, Mark Woodward, Ajay K. Gupta, Christopher M. Reid, William C. Cushman, Kristian Wachtell, Koon Teo, Barry R. Davis, John Chalmers, Carl J. Pepine, Kazem Rahimi
Summary: The effects of blood pressure-lowering treatment on cardiovascular outcomes do not differ by sex, regardless of baseline blood pressure levels and age categories.
Article
Peripheral Vascular Disease
Rebecca J. Molsberry, Leah Rethy, Michael C. Wang, Rupal C. Mehta, Donald M. Lloyd-Jones, Hongyan Ning, Cora E. Lewis, Clyde W. Yancy, Sanjiv J. Shah, Sadiya S. Khan
Summary: The SPRINT trial found that intensive blood pressure lowering can reduce the risk of heart failure, especially in individuals at highest predicted HF risk. However, serious adverse events were more frequent in those undergoing intensive BP lowering. The study suggests that prioritizing intensive BP lowering in high-risk individuals may help reduce the burden of heart failure in the United States.
Article
Peripheral Vascular Disease
Douglas D. DeCarolis, Amy Gravely, Christine M. Olney, Areef Ishani
Summary: This analysis suggests that long-term exposure to thiazide-type diuretics and renin-angiotensin system blockers is associated with reduced adverse cardiovascular events, while long-term exposure to beta-blockers may increase the risk of cardiovascular events.
Article
Geriatrics & Gerontology
Son Nghiem, Clifford Afoakwah, Paul Scuffham, Joshua Byrnes
Summary: This study conducted a retrospective record-linkage cohort study of patients with diverse cardiovascular diseases in Queensland, Australia, using the hospital frailty risk score (HFRS) to measure frailty. The results showed that frail patients had worse health outcomes in terms of 30-day mortality, readmission, length of hospital stay, and hospital costs.
Article
Peripheral Vascular Disease
Jiachen Yu, Qirui Song, JingJing Bai, Shouling Wu, Peili Bu, YuFeng Li, Jun Cai
Summary: This study investigated the relationship between visit-to-visit blood pressure variability (BPV) and cardiovascular events in hypertensive patients. The results showed that visit-to-visit diastolic BPV was associated with adverse health outcomes in the standard treatment group, but not in the intensive treatment group.
Article
Peripheral Vascular Disease
Milad Nazarzadeh, Dexter Canoy, Zeinab Bidel, Emma Copland, Kazem Rahimi, Koon Teo, Barry R. Davis, John Chalmers, Carl J. Pepine, Mark Woodward
Summary: There is consistent epidemiological evidence that higher blood pressure increases the risk of cardiovascular diseases. However, there is limited randomized evidence on the role of blood pressure level at treatment initiation. The Blood Pressure Lowering Treatment Trialists' Collaboration provides a valuable resource for studying the efficacy and safety of antihypertensive therapy.
JOURNAL OF HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Giuseppe Mancia, Rita Facchetti, Fosca Quarti-Trevano, Guido Grassi
Summary: This study analyzed the effects of antihypertensive treatment on office and ambulatory blood pressure in patients with white-coat hypertension (WCH). The results showed that antihypertensive treatment effectively reduced office blood pressure in WCH patients, but had no effect on ambulatory blood pressure. These findings were consistent regardless of the type of treatment used.
JOURNAL OF HYPERTENSION
(2022)
Article
Endocrinology & Metabolism
Luisa Ojeda-Fernandez, Andreana Foresta, Giulia Macaluso, Pierluca Colacioppo, Mauro Tettamanti, Antonella Zambon, Stefano Genovese, Ida Fortino, Olivia Leoni, Maria Carla Roncaglioni, Marta Baviera
Summary: Metformin use was associated with lower risks of mortality, in-hospital mortality, hospitalization for COVID-19, and ICU admission in patients with diabetes, indicating its potential protective effect against severe COVID-19 outcomes, pending confirmation from randomized controlled trials. Hence, prescribing metformin to COVID-19 patients with diabetes is suggested until further evidence is available.
DIABETES OBESITY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Camilla Torlasco, Silvia Castelletti, Davide Soranna, Valentina Volpato, Stefano Figliozzi, Katia Menacho, Franco Cernigliaro, Antonella Zambon, Peter Kellman, James C. Moon, Luigi P. Badano, Gianfranco Parati
Summary: Tailored CMR and stress-CMR protocols including advanced tissue characterization are accurate and time-effective in diagnosing cardiomyopathies and ischemic heart disease. Compared to standard protocols, the average scan duration dropped by more than 30%, with a high proportion of impactful diagnostic and management changes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Ophthalmology
Paolo Milani, Marco Mazzola, Mario Cigada, Amedeo Massacesi, Marco Setaccioli, Stefania Moschini, Stefano Ciaccia, Fabrizio Scotti, Elena Mantovani, Davide Soranna, Antonella Zambon, Fulvio Bergamini
Summary: This study aims to propose an algorithm for the major and minor diagnostic criteria of macular myopic choroidal neovascularization (mCNV). By analyzing clinical and imaging parameters in a retrospective study, it was found that a combination of at least four clinical and biological markers yielded the highest positive- and negative-predictive values.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Rheumatology
Anna Zanetti, Garifallia Sakellariou, Antonella Zambon, Greta Carrara, Lisa Argnani, Lorenzo G. Mantovani, Paolo A. Cortesi, Serena Bugatti, Carlomaurizio Montecucco, Carlo A. Scire
Summary: Early diagnosis and tight control improve outcomes of rheumatoid arthritis. This study compared the effectiveness and costs of an early arthritis clinic (EAC) with the current standard of care. The results showed that despite higher costs, the EAC reduced the number and length of hospitalizations and had higher adherence to quality-of-care guidelines.
ARTHRITIS CARE & RESEARCH
(2023)
Correction
Cardiac & Cardiovascular Systems
Giuseppe Mascia, Lia Crotti, Antonella Groppelli, Marco Canepa, Andrea Carlo Merlo, Stefano Benenati, Paolo Di Donna, Roberta Della Bona, Davide Soranna, Antonella Zambon, Italo Porto, Iacopo Olivotto, Gianfranco Parati, Michele Brignole, Franco Cecchi
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Correction
Endocrinology & Metabolism
Raffaella Cancello, Amelia Brunani, Ettore Brenna, Davide Soranna, Simona Bertoli, Antonella Zambon, Henry C. Lukaski, Paolo Capodaglio
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Endocrinology & Metabolism
Raffaella Cancello, Amelia Brunani, Ettore Brenna, Davide Soranna, Simona Bertoli, Antonella Zambon, Henry C. Lukaski, Paolo Capodaglio
Summary: Phase angle (PhA) is a proposed marker of nutritional status in clinical conditions, but its use in obese patients raises concerns due to the variability of resistance and reactance measurements. Obesity is associated with various diseases that can affect PhA values. Improvement in clinical condition is related to positive changes in PhA.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Review
Respiratory System
Filippo Cattazzo, Martino F. Pengo, Alice Giontella, Davide Soranna, Grzegorz Bilo, Antonella Zambon, Janaka Karalliedde, Luigi Gnudi, Miguel angel Martinez-Garcia, Pietro Minuz, Carolina Lombardi, Gianfranco Parati, Cristiano Fava
Summary: This meta-analysis aimed to investigate whether Continuous Positive Airway Pressure (CPAP) could improve glucose and lipid metabolism in patients with obstructive sleep apnoea (OSA). The findings revealed that CPAP modestly improved insulin sensitivity and total cholesterol levels, but with low effect size. The study suggests that CPAP does not substantially improve metabolic dysregulation in an unselected OSA population, but may have a higher effect in specific subgroups of patients.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Multidisciplinary Sciences
Elisa Perger, Paolo Castiglioni, Andrea Faini, Davide Soranna, Antonella Zambon, Debora Rosa, Stefano Vicini, Paolo Meriggi, Laura Pini, Claudia Baratto, Sergio Caravita, Ali Azarbarzin, Gianfranco Parati, Carolina Lombardi
Summary: The combination of noradrenergic and antimuscarinic drugs can reduce the severity of obstructive sleep apnea. However, there is no data on its effects on cardiac autonomic modulation. This study aimed to evaluate the impact of 1-week treatment with this drug on cardiovascular autonomic control in OSA patients.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Claudia Baratto, Sergio Caravita, Giorgia Corbetta, Davide Soranna, Antonella Zambon, Celine Dewachter, Mara Gavazzoni, Francesca Heilbron, Michele Tomaselli, Noela Radu, Francesco Paolo Perelli, Giovanni Battista Perego, Jean-Luc Vachiery, Gianfranco Parati, Luigi P. Badano, Denisa Muraru
Summary: This study aimed to explore the impact of secondary tricuspid regurgitation (STR) on exercise hemodynamics and cardiorespiratory adaptation in heart failure with preserved ejection fraction (HFpEF) patients. The results showed that HFpEF patients with severe STR had higher right atrial pressure and pulmonary artery wedge pressure, and lower left ventricular transmural pressure and cardiac output compared to HFpEF patients without STR. This impairment in SV and CO reserve in HFpEF-STR led to pulmonary vascular de-recruitment and relative left heart underfilling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Antonella Groppelli, Martina Rafanelli, Giuseppe Dario Testa, Samuele Agusto, Giulia Rivasi, Erika Carbone, Davide Soranna, Antonella Zambon, Paolo Castiglioni, Andrea Ungar, Michele Brignole, Gianfranco Parati
Summary: Compared with conventional methods, the study found that RootiRx (R) was unable to detect rapid drops in blood pressure occurring during impending reflex syncope, and thus cannot be used as a diagnostic tool for hypotensive syncope. However, the RRI mean values and LF/HF power ratios obtained with RootiRx (R) were consistent with those obtained using conventional methods.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Claudia Baratto, Celine Dewachter, Sergio Caravita, Antonella Zambon, Antoine Bondue, Gianfranco Parati, Jean-Luc Vachiery
Summary: The COVID-19 lockdown had a negative impact on the exercise capacity of pulmonary arterial hypertension patients, despite their clinical stability and the absence of disease progression.
PULMONARY CIRCULATION
(2022)
Article
Endocrinology & Metabolism
Biagio Cangiano, Emanuele Giusti, Caterina Premoli, Davide Soranna, Giovanni Vitale, Silvia Grottoli, Valeria Cambria, Giovanna Mantovani, Roberta Mungari, Pietro Maffei, Francesca Dassie, Antonella Giampietro, Sabrina Chiloiro, Maria Laura Tanda, Silvia Ippolito, Salvatore Cannavo, Marta Ragonese, Antonella Zambon, Luca Persani, Letizia Maria Fatti, Massimo Scacchi
Summary: This study found a high prevalence of depression in patients with acromegaly, which is associated with female gender and arthropathy. Both depression and arthropathy independently and strongly contribute to the impaired quality of life in patients.
Article
Geriatrics & Gerontology
Chiara Sidoli, Antonella Zambon, Elena Tassistro, Emanuela Rossi, Enrico Mossello, Marco Inzitari, Antonio Cherubini, Alessandra Marengoni, Alessandro Morandi, Giuseppe Bellelli
Summary: This study investigated the prevalence, features, and motor subtypes of delirium in older patients admitted to rehabilitation facilities. The results showed that delirium was relatively common during rehabilitation, with mixed delirium being the most prevalent subtype. Delirium was associated with factors such as dementia, disability, medications, and physical restraints.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Letter
Cardiac & Cardiovascular Systems
Martino F. Pengo, Fabio Albini, Giulia Guglielmi, Chiara Mollica, Davide Soranna, Gaia Zambra, Antonella Zambon, Grzegorz Bilo, Gianfranco Parati
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)