Review
Cardiac & Cardiovascular Systems
Danielle L. Kirkman, Austin T. Robinson, Matthew J. Rossman, Douglas R. Seals, David G. Edwards
Summary: Cardiovascular disease is a leading cause of death in America, with advancing age being a major risk factor. Vascular dysfunction, characterized by endothelial dysfunction and large elastic artery stiffening, is associated with an increased CVD risk. Mitochondria play a crucial role in maintaining vascular homeostasis, and age- and disease-related impairments in mitochondrial function contribute to vascular dysfunction and increase CVD risk.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jiong Hu, Marco Sisignano, Roman Brecht, Natarajan Perumal, Carlo Angioni, Iris-Sofia Bibli, Beate Fisslthaler, Hartmut Kleinert, Norbert Pfeiffer, Ingrid Fleming, Caroline Manicam
Summary: The Cyp2c44-derived EETs in VSMC are shown to mediate vasoconstriction of the ophthalmic artery, as evidenced by experimental studies.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Geoffrey Van den Bergh, Astrid Van den Branden, Britt Opdebeeck, Paul Fransen, Ellen Neven, Guido De Meyer, Patrick C. D'Haese, Anja Verhulst
Summary: Arterial media calcification is an active cell process, and endothelial dysfunction may play a significant role in disease progression.
Article
Cardiac & Cardiovascular Systems
Xiangyu Zheng, Jennifer Berg Sen, Zhuoxin Li, Mostafa Sabouri, Luaye Samarah, Christina S. Deacon, Joseph Bernardo, Daniel R. Machin
Summary: Excessive salt consumption leads to hypertension and arterial dysfunction in humans, but this phenotype is not observed in genetically identical mouse strains. In this study, researchers investigated the effects of a high-salt diet on blood pressure and arterial function in genetically diverse UM-HET3 mice. Results showed that high-salt diet increased systolic blood pressure and aortic stiffness, while impairing endothelium-dependent dilation. These findings suggest that genetically diverse mice may offer insights into arterial adaptations in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ragini D. D. Singh, Avadhesh Avadhesh, Gaurav Sharma, Sagar Dholariya, Rima B. B. Shah, Bela Goyal, Subash Chandra Gupta
Summary: Targeted cancer therapy using CYP as drug target has shown promise, but there are still challenges including drug resistance and limited therapeutic index. Recent advances in molecular tools and structure-activity relationship understanding have helped in the development of CYP-based drugs with better efficacy. Future directions involve the development of more selective tools to understand molecular alterations and develop specific CYP inhibitors/inducers.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Cardiac & Cardiovascular Systems
Sander Craps, Jore Van Wauwe, Sofie De Moudt, Dorien De Munck, Arthur J. A. Leloup, Bram Boeckx, Tim Vervliet, Wouter Dheedene, Nathan Criem, Carla Geeroms, Elizabeth A. Jones, An Zwijsen, Diether Lambrechts, Paul Fransen, Manu Beerens, Aernout Luttun
Summary: Prdm16 plays a critical role in arterial flow recovery by maintaining endothelial function, making it a potential target for therapeutic strategies in peripheral artery disease patients ineligible for revascularization.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Wen-Tao Sun, Hai-Tao Hou, Huan-Xin Chen, Hong-Mei Xue, Jun Wang, Guo-Wei He, Qin Yang
Summary: The study investigated the expression and contribution of calcium-activated potassium channels in commonly used coronary artery bypass grafts, finding that BKCa subtype plays a significant role in vasodilatation in the internal thoracic artery. Differences were observed in the distribution of KCa channel subtypes between the two types of grafts.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Transplantation
Geoffrey van den Bergh, Britt Opdebeeck, Cedric Neutel, Pieter-Jan Guns, Guido De Meyer, Patrick D'Haese, Anja Verhulst
Summary: Cardiovascular disease is a major cause of death in CKD patients, and we aimed to investigate the early stage of disease progression in AMC etiology. Male Wistar rats were fed an adenine diet to induce AMC, and the results showed a time-dependent increase in aortic calcium and arterial stiffness. The study also revealed early alterations in biomechanics/cellular functionality and a progressive loss in basal NO levels in CKD rats.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel S. Gaul, Natacha Calatayud, Jurgen Pahla, Nicole R. Bonetti, Yu-Jen Wang, Julien Weber, Samuele Ambrosini, Luca Liberale, Sarah Costantino, Shafeeq A. Mohammed, Simon Kraler, Lambertus J. Van Tits, Lisa Pasterk, Daria Vdovenko, Alexander Akhmedov, Frank Ruschitzka, Francesco Paneni, Thomas F. Luscher, Giovanni G. Camici, Christian M. Matter
Summary: Deletion of endothelial SIRT6 gene accelerates arterial thrombosis in mice, and silencing of SIRT6 enhances TF expression and activates inflammatory pathways in cultured human aortic endothelial cells.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Claudia Regina Da Silva Araujo, Juliana Fernandes, Debora Sidronio Caetano, Ana Eugenia Vasconcelos do Rego Barros, Juliana Andrade Ferreira De Souza, Maria da Gloria Rodrigues Machado, Maria Ines Remigio de Aguiar, Simone Cristina Soares Brandao, Shirley Lima Campos, Armele de Fatima Dornelas de Andrade, Daniella Cunha Brandao
Summary: This study aimed to assess the prevalence of endothelial dysfunction, arterial stiffness, and altered heart rate variability (HRV) in patients with pre-existing cardiovascular diseases (CVD) hospitalized due to COVID-19. The study found that 51.8% of patients presented endothelial dysfunction and enhancement in the high-frequency component of HRV. There was a high prevalence of endothelial dysfunction, especially in patients with chronic heart failure.
Article
Hematology
Julian Leberzammer, Stijn M. Agten, Xavier Blanchet, Rundan Duan, Hans Ippel, Remco T. A. Megens, Christian Schulz, Maria Aslani, Johan Duchene, Yvonne Doring, Natalie J. Jooss, Pengyu Zhang, Richard Brandl, Konstantin Stark, Wolfgang Siess, Kerstin Jurk, Johan W. M. Heemskerk, Tilman M. Hackeng, Kevin H. Mayo, Christian Weber, Philipp von Hundelshausen
Summary: The study explored the molecular mechanisms of CXCL12 in arterial thrombosis, revealing that inhibition of CXCR4 can attenuate platelet aggregation and limit arterial thrombosis. Mechanistically, CXCL12 activates Btk leading to platelet aggregation, while the interaction between CXCL12 and CCL5 can inhibit this process. A novel peptide was found to inhibit CXCL12-induced platelet aggregation without prolonging bleeding time.
Article
Multidisciplinary Sciences
Shun-Ku Lin, Hsin Hsiu, Hsi-Sheng Chen, Chang-Jen Yang
Summary: This study used arterial pulse-wave measurements and MLP analysis to effectively distinguish between AD patients and control subjects. The results showed significant differences in BPW indices between AD patients and control subjects, as well as significant intergroup differences among mild, moderate, and severe AD.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Xiao-Ling Zhu, Tao Li, Yu Cao, Qing-Ping Yao, Xing Liu, Ying Li, Yang-Yang Guan, Ji-Jun Deng, Rui Jiang, Jun Jiang
Summary: tRFs and tiRNAs are generated from specific cleavage of tRNAs or their precursors, regulating gene expression in stressful cellular conditions. This study showed that tRF(GlnCTG) is overexpressed in injured arteries and negatively regulates FAS gene expression, promoting vascular smooth muscle cell proliferation. Investigating the roles of tRFs/tiRNAs is crucial for understanding intimal hyperplasia mechanisms and potential treatments.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Biochemistry & Molecular Biology
Roberto Castelli, Antonio Gidaro, Gavino Casu, Pierluigi Merella, Nicia I. Profili, Mattia Donadoni, Margherita Maioli, Alessandro P. Delitala
Summary: Aging leads to significant changes in the structural proprieties of the arterial wall, such as loss of elasticity and reduced compliance. Arterial hypertension, diabetes mellitus, and chronic kidney disease are major factors contributing to these changes. Arterial stiffness, evaluated by non-invasive methods like pulse wave velocity, is crucial in assessing vessel elasticity. Early assessment of stiffness is important as it can precede clinical signs of cardiovascular disease. While there is no specific pharmacological target for arterial stiffness, managing its risk factors can improve arterial wall elasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Satomi Wakasugi, Tomoya Mita, Naoto Katakami, Yosuke Okada, Hidenori Yoshii, Takeshi Osonoi, Nobuichi Kuribayashi, Yoshinobu Taneda, Yuichi Kojima, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada
Summary: This study found that some CGM-derived metrics are significantly associated with arterial stiffness in patients with type 2 diabetes, potentially useful for identifying high-risk patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Nutrition & Dietetics
Jeremy Bellien, Erwan Bozec, Frederic Bounoure, Hakim Khettab, Julie Malloizel-Delaunay, Mohamed Skiba, Michele Iacob, Nathalie Donnadieu, Aude Coquard, Beatrice Morio, Brigitte Laillet, Jean-Paul Rigaudiere, Jean-Michel Chardigny, Christelle Monteil, Cathy Vendeville, Alain Mercier, Anne-Francoise Cailleux, Anne Blanchard, Jacques Amar, Leopold K. Fezeu, Bruno Pannier, Alessandra Bura-Riviere, Pierre Boutouyrie, Robinson Joannides
Summary: This study assessed the cardiovascular and metabolic effects of camelina oil in hypertensive patients with metabolic syndrome. The results showed that camelina oil supplementation did not improve vascular function but adversely affected glucose metabolism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Regis Bordet, Jean-Christophe Dantonel, Eric Vacaresse, Claire Le Jeunne, Nora Benhabiles, Alain Beretz, Christian Boitard, Stephanie Debette, Gilles Duluc, Philippe Froguel, Benedicte Garbil, Stanislas Lyonnet, Abderrahim Mahfoudi, Pierre Marquet, Franck Mouthon, Olivier Rascol, Vincent Richard, Emmanuelle Simon, Nathalie Varoqueaux, Herve Watiert, Marie Zinsu
Summary: This article explores the impact of the Investments for the Future programme on health research and innovation, identifying five key factors for future development in healthcare innovation.
Article
Cardiac & Cardiovascular Systems
Frederic Roca, Michele Iacob, Thomas Duflot, Nathalie Donnadieu, Caroline Thill, Jeremy Bellien, Robinson Joannides
Summary: Heart rate reduction may increase arterial wall energy dissipation, but this effect may be influenced by age. Older individuals have poorer arterial stiffness and cardiovascular coupling, and lower energy dissipation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Paul Billoir, Perrine Lepretre, Caroline Thill, Jeremy Bellien, Veronique Le Cam Duchez, Jean Selim, Fabienne Tamion, Thomas Clavier, Emmanuel Besnier
Summary: This study found that coagulation disorders are common in COVID-19 patients, and immature platelets are early predictors of severe worsening. It suggests the key role of thrombopoiesis in the adaptation to SARS-CoV-2 infection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Matthieu Leuillier, Thomas Duflot, Severine Menoret, Hind Messaoudi, Zoubir Djerada, Deborah Groussard, Raphael G. P. Denis, Laurence Chevalier, Ahmed Karoui, Baptiste Panthu, Pierre-Alain Thiebaut, Isabelle Schmitz-Afonso, Severine Nobis, Cynthia Campart, Tiphaine Henry, Camille Sautreuil, Serge H. Luquet, Olivia Beseme, Catherine Feliu, Helene Peyret, Lionel Nicol, Jean-Paul Henry, Sylvanie Renet, Paul Mulder, Debin Wan, Laurent Tesson, Jean-Marie Heslan, Angeline Duche, Sebastien Jacques, Frederic Ziegler, Valery Brunel, Gilles J. P. Rautureau, Christelle Monteil, Jean-Luc do Rego, Jean-Claude do Rego, Carlos Afonso, Bruce Hammock, Anne-Marie Madec, Florence Pinet, Vincent Richard, Ignacio Anegon, Christophe Guignabert, Christophe Morisseau, Jeremy Bellien
Summary: The physiological role of the N-terminal phosphatase activity (sEH-P) of soluble epoxide hydrolase (sEH-H) was investigated using CRISPR/Cas9 to generate a knock-in (KI) rat line lacking sEH-P activity. The study found that sEH-P KI rats exhibited decreased metabolism of lysophosphatidic acids, decreased weight and fat mass gain, and increased insulin sensitivity. Moreover, sEH-P KI rats showed increased lipolysis and enhanced energy expenditure, which potentiated brown adipose thermogenesis. Additionally, sEH-P KI rats fed a high-fat diet did not experience weight gain, fat mass accumulation, insulin resistance, or hepatic steatosis, and they also exhibited enhanced cardiac mitochondrial activity and protection against ischemia-reperfusion injury. Overall, the findings highlight the importance of sEH-P in energy and fat metabolism and its potential therapeutic significance in the management of obesity and cardiac complications.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Laurence Chevalier, Jean Selim, Celia Castro, Fabien Cuvilly, Jean-Marc Baste, Vincent Richard, Philippe Pareige, Jeremy Bellien
Summary: Glycocalyx is a layer of structure on the cell membrane composed of glycosaminoglycans and proteoglycans. It interacts with various proteins, contributing to vascular permeability and modulation of local inflammatory processes. This study developed innovative electron microscopy approaches to visualize the glycocalyx at the subcellular scale.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Emmanuel Besnier, Valery Brunel, Caroline Thill, Perrine Lepretre, Jeremy Bellien, Zoe Demailly, Sylvanie Renet, Fabienne Tamion, Thomas Clavier
Summary: sRAGE levels in plasma can be used to identify patients at risk of developing a critical form of COVID-19 pneumonia, and can help in correctly referring patients to the appropriate healthcare facility.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jean Selim, Mouad Hamzaoui, Antoine Ghemired, Zoubir Djerada, Laurence Chevalier, Nicolas Piton, Emmanuel Besnier, Thomas Clavier, Anais Dumesnil, Sylvanie Renet, Paul Mulder, Fabien Doguet, Fabienne Tamion, Benoit Veber, Jeremy Bellien, Vincent Richard, Jean-Marc Baste
Summary: The use of human albumin and hypertonic sodium lactate as priming agents during mechanical circulatory support in lung transplantation can reduce pulmonary endothelial dysfunction. However, hypertonic sodium lactate may lead to the development of pulmonary edema.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Pharmacology & Pharmacy
Jean-Luc Cracowski, Vincent Richard, Mathieu Molimard
Article
Biochemistry & Molecular Biology
Guillaume Feugray, Tony Pereira, Michele Iacob, Lucile Moreau-Grange, Gaetan Prevost, Valery Brunel, Robinson Joannides, Jeremy Bellien, Thomas Duflot
Summary: This study found that there were no significant differences in ARA metabolite levels between T2D patients and healthy volunteers, but HTN patients showed alterations in ARA metabolite correlation patterns with increased 20-, 19-, 15-, and 8-HETE. Additionally, a decrease in 20-HETE was observed during both hyperglycemic and hyperinsulinemic clamps, suggesting a potential link to glucose tolerance and insulin signaling regulation.
Article
Surgery
Mickael Palmier, Emlyn Cornet, Sylvanie Renet, Anais Dumesnil, Nicolas Perzo, Quentin Cohen, Vincent Richard, Didier Plissonnier
Summary: This study investigated the lung injury induced by supraceliac aortic cross clamping through an inflammatory ischemia-reperfusion trigger and analyzed the role of glycocalyx (GCX), a component of the endothelial membrane, in remote lung injury. The results showed that plasma levels of GCX products (Sdc-1 and HS), TNF-α, and IL-10 reached peak levels at different time points during reperfusion. The levels were significantly higher in the clamping groups compared to the sham group. Lung levels of TNF-α and IL-10 also reached peak levels at 6 hours, and were significantly higher than the sham group. Histopathologic scores and pulmonary gravimetry showed more severe lung injury and pulmonary edema in the clamping groups compared to the sham group at different time points. In conclusion, supraceliac aortic clamping causes early lung injury associated with a systemic inflammatory response and altered GCX structure.
ANNALS OF VASCULAR SURGERY
(2023)
Article
Medicine, General & Internal
Hind Messaoudi, Thomas Levesque, Nicolas Perzo, Elodie Berg, Guillaume Feugray, Anais Dumesnil, Valery Brunel, Dominique Guerrot, Helene Eltchaninoff, Vincent Richard, Said Kamel, Eric Durand, Youssef Bennis, Jeremy Bellien
Summary: This study demonstrates that subtotal nephrectomy associated with a high-phosphorus diet in rats can mimic the cardiovascular consequences of chronic kidney disease (CKD) including calcified aortic valve disease (CAVD). This animal model can be used to investigate the mechanisms involved in the development of aortic stenosis and test new therapeutic strategies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Matthieu Leuillier, Valentin Platel, Ly Tu, Guillaume Feugray, Raphael Thuillet, Deborah Groussard, Hind Messaoudi, Mina Ottaviani, Mustapha Chelgham, Lionel Nicol, Paul Mulder, Marc Humbert, Vincent Richard, Christophe Morisseau, Valery Brunel, Thomas Duflot, Christophe Guignabert, Jeremy Bellien
Summary: Inhibitors of soluble epoxide hydrolase (sEH) present an opportunity for developing oral drugs for cardiovascular and inflammatory diseases. However, the administration of sEH inhibitors may lead to the development of pulmonary hypertension (PH). This study evaluated the impact of chronic oral administration of the sEH inhibitor TPPU on hemodynamics and pulmonary vascular remodeling in rats. The results showed that TPPU did not induce or aggravate PH and RV dysfunction, and may have a potential beneficial effect against pulmonary artery remodeling in humans.