Article
Endocrinology & Metabolism
Katelyn E. Senkus, Kristi M. Crowe-White, Anneliese C. Bolland, Julie L. Locher, Jamy D. Ard
Summary: This study examined the relationship between the adiponectin:leptin (AL) ratio and cardiometabolic health in older adults with obesity, as well as the effects of a 12-month exercise and diet intervention on changes in the AL ratio. The results suggest that the AL ratio can be used as a measure of adipose tissue dysfunction among older adults and that exercise and diet intervention can improve the AL ratio.
NUTRITION & DIABETES
(2022)
Review
Biochemistry & Molecular Biology
Carlos Jimenez-Cortegana, Lourdes Hontecillas-Prieto, Daniel J. Garcia-Dominguez, Fernando Zapata, Natalia Palazon-Carrion, Maria L. Sanchez-Leon, Malika Tami, Antonio Perez-Perez, Flora Sanchez-Jimenez, Teresa Vilarino-Garcia, Luis De la Cruz-Merino, Victor Sanchez-Margalet
Summary: Obesity is considered a pandemic and a risk factor for various types of cancers, including lymphoma, due to its promotion of an inflammatory state. Leptin, as a key adipokine, has been studied for its potential role in connecting obesity and lymphomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Bo Li, Cong Hou, Lianxia Li, Ming Li, Shan Gao
Summary: This study aimed to assess the associations between hypertension and four adipokine levels in Chinese youth, and to examine the extent to which these associations are mediated by insulin resistance (IR). The results showed that youth with hypertension had lower adiponectin and higher leptin, FGF21, and RBP4 levels. The coexistence of multiple abnormal adipokine levels increased the risk of hypertension, and the associations between adipokines and hypertension were mediated by IR.
HYPERTENSION RESEARCH
(2023)
Article
Nutrition & Dietetics
A. K. Miroslawska, P. F. Gjessing, M. D. Solbu, J. V. Norvik, O. M. Fuskevag, T. A. Hanssen, T. K. Steigen
Summary: This study found that two years after renal denervation, patients did not show improvement in insulin resistance, adiponectin, and leptin levels. Baseline insulin sensitivity was not correlated with blood pressure response.
CLINICAL NUTRITION
(2021)
Article
Neurosciences
M. H. Vickers
Summary: Changes in early life nutrition can have significant effects on the risk of obesity and metabolic disorders in later life, which can be passed on to future generations. This process, known as developmental programming, plays a role in the origins of health and disease. Early nutritional compromise can lead to adverse health outcomes in offspring, with the potential for exacerbation by a poor postnatal nutrition environment. The mechanisms underlying programming are not yet fully understood, but altered neuroendocrine circuits that regulate satiety and energy balance have been identified as a common feature in preclinical models.
Article
Chemistry, Multidisciplinary
Marcelina Sperling, Teresa Grzelak, Marta Pelczynska, Pawel Bogdanski, Krystyna Czyzewska, Dorota Formanowicz
Summary: Adipolin, neprilysin, and chemerin have pleiotropic properties that can influence health complications associated with obesity. This study aimed to investigate the relationship between adipokine levels and anthropometric and metabolic parameters, as well as blood pressure values, while considering gender and age. The results showed correlations between chemerin concentration and glucose levels in obese women, adipolin concentration and LDL-C serum concentration in obese individuals with normal glucose tolerance, and chemerin concentration and triglyceride levels in men. High chemerin levels were also associated with elevated triglyceride levels in men. Furthermore, age was found to affect the frequency of high plasma adipolin concentrations, but only in individuals with a BMI less than 30 kg/m(2). The study also revealed interrelationships between the concentrations of the studied adipokines.
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Andong He, Xiaofeng Yang, Yuzhen Ding, Lu Sun, Meiting Shi, Ruiman Li
Summary: This study found a positive correlation between serum ferritin and diastolic blood pressure in adult women, suggesting a potential role of serum ferritin in blood pressure regulation. However, the association with systolic blood pressure was weak and varied across different population subgroups.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Review
Immunology
Olga Sierawska, Paulina Niedzwiedzka-Rystwej
Summary: It is increasingly believed that diabetes in cats may belong to both metabolic and autoimmune diseases due to the involvement of the immune system and secretion of adipokines. Risk factors include age, sex, breed, obesity, and insulin resistance. Diagnosis of diabetes in cats is more complicated than in humans.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Xin Wang, Carrie A. Karvonen-Gutierrez, Bhramar Mukherjee, William H. Herman, Sung Kyun Park
Summary: The study found that urinary molybdenum was positively associated with adipokine levels, while cadmium, cesium, and lead were negatively associated with adipokine levels.
ENVIRONMENTAL RESEARCH
(2021)
Article
Peripheral Vascular Disease
Lanfranco D'Elia, Alfonso Giaquinto, Giovanni de Simone, Roberto Iacone, Ornella Russo, Pasquale Strazzullo, Ferruccio Galletti
Summary: The study demonstrated a positive association between higher leptin (LPT) levels and cardiometabolic risk as well as incidence of left ventricular hypertrophy (LVH) in adult men. The results suggest a potential predictive role of LPT on cardiac remodelling, independently of changes in body weight and blood pressure over time.
JOURNAL OF HYPERTENSION
(2021)
Review
Biochemistry & Molecular Biology
Kajetan Kielbowski, Estera Bakinowska, Piotr Ostrowski, Bartlomiej Pala, Ewa Gromowska, Klaudia Gurazda, Pawel Dec, Andrzej Modrzejewski, Andrzej Pawlik
Summary: Psoriasis is a chronic skin condition mediated by the immune system, characterized by inflammation and excessive skin cell growth. Dendritic cells, T lymphocytes, and keratinocytes play key roles in the development of psoriasis, while the IL-23/IL-17 pathway contributes to disease progression. Adipokines secreted by adipose tissue, such as adiponectin, leptin, visfatin, and resistin, have immunomodulatory effects and may influence the progression or suppression of psoriasis. Understanding the relationship between psoriasis and adipokines could lead to new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
John R. Koethe, Carlee Moser, Todd T. Brown, James H. Stein, Theodoros Kelesidis, Michael Dube, Judith Currier, Grace A. McComsey
Summary: In persons with HIV initiating antiretroviral therapy, higher circulating leptin levels are associated with increased insulin resistance and systemic inflammation, independent of fat depot size. This suggests that adipocyte lipid content may contribute to impaired glucose tolerance and systemic inflammation in this population. Serum leptin level is a stronger determinant of insulin resistance and systemic inflammation compared to measurements of regional adiposity.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Genetics & Heredity
Sadia Afrin, Gregory W. Kirschen, Mostafa A. Borahay
Summary: This study aims to determine how adipocytes and adipocyte-secreted factors affect changes in myometrial stem cells (MSCs) in a manner that promotes the growth of uterine leiomyomas. The results showed that co-culture of MSCs with adipocytes increased proliferation and extracellular matrix (ECM) deposition, and adipocyte-secreted factors induced oxidative damage and DNA damage in MSCs. These findings suggest that obesity may mediate the initiation of tumorigenesis in MSCs, leading to the development of leiomyomas.
Article
Oncology
Emanuele Vita, Alessio Stefani, Geny Piro, Luca Mastrantoni, Marco Cintoni, Giuseppe Cicchetti, Ileana Sparagna, Federico Monaca, Guido Horn, Jacopo Russo, Diletta Barone, Mariantonietta Di Salvatore, Rocco Trisolini, Filippo Lococo, Ciro Mazzarella, Alessandra Cancellieri, Carmine Carbone, Anna Rita Larici, Maria Cristina Mele, Sara Pilotto, Michele Milella, Giampaolo Tortora, Emilio Bria
Summary: Leptin may play a crucial role in the effectiveness of immunotherapy in lung adenocarcinoma, and is associated with metabolic immune dysfunctions.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Medicine, General & Internal
Felipe Mattioni Maturana, Rebecca Rolf, Simone Schweda, Max Reimer, Manuel Widmann, Christof Burgstahler, Andreas M. Niess, Inga Krauss, Barbara Munz
Summary: Physical exercise has positive effects on chronic conditions, and leptin may serve as a suitable biomarker in exercise-based lifestyle intervention programs for subjects with multimorbidity.
JOURNAL OF CLINICAL MEDICINE
(2023)