Review
Biochemistry & Molecular Biology
Jan Modzelewski, Iga Siarkowska, Justyna Pajurek-Dudek, Stepan Feduniw, Katarzyna Muzyka-Placzynska, Arkadiusz Baran, Anna Kajdy, Magdalena Bednarek-Jedrzejek, Aneta Cymbaluk-Ploska, Ewa Kwiatkowska, Sebastian Kwiatkowski
Summary: This systematic review collected evidence on preeclampsia occurring before the 20th week of gestation and investigated the role of PLGF and sFlt-1 in its development. In the analyzed cases, all pregnancies with preeclampsia before the 20th week resulted in intrauterine fetal demise, and elevated SFlt-1/PLGF ratios were observed in all women. The review identified 37 reported cases worldwide, emphasizing the need for further research to establish revised definitions or new ones for this very early onset preeclampsia, which is rare but possible.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Medicine, Research & Experimental
Jessica L. Faulkner, Jennifer C. Sullivan
Summary: MicroRNAs (miRNA) are small non-coding RNA molecules involved in regulating target genes after transcription. They have been found to be associated with the development and progression of various cardiovascular diseases, including hypertension. Researchers are exploring the potential of using miRNA as biomarkers for diagnosing and treating hypertension and hypertension-related end-organ damage.
Article
Endocrinology & Metabolism
Nicoline Callesen Do, Marianne Vestgaard, Bjorg Asbjornsdottir, Lise Lotte Torvin Andersen, Dorte Moller Jensen, Lene Ringholm, Peter Damm, Elisabeth Reinhardt Mathiesen
Summary: In women with preexisting diabetes, both home blood pressure and office blood pressure are positively associated with the development of preeclampsia, and their predictive abilities are comparable. Home blood pressure is lower than office blood pressure in both early and late pregnancy, and the difference increases with increasing office blood pressure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Gajewska, Marzena Laskowska, Agostinho Almeida, Edgar Pinto, Katarzyna Skorzynska-Dziduszko, Anna Blazewicz
Summary: The study compared blood lead levels in preeclamptic women with healthy pregnant women, finding significantly higher BLL in the PE group. Furthermore, BLL showed a significant positive relationship with the presence of PE.
Article
Peripheral Vascular Disease
Laura A. Magee, Jeffrey Bone, Salwa Banoo Owasil, Joel Singer, Terry Lee, Mrutunjaya B. Bellad, Shivaprasad S. Goudar, Alexander G. Logan, Salesio E. Macuacua, Ashalata A. Mallapur, Hannah L. Nathan, Rahat N. Qureshi, Esperanca Sevene, Andrew H. Shennan, Anifa Vala, Marianne Vidler, Zulfiqar A. Bhutta, Peter von Dadelszen
Summary: In pregnancy, higher blood pressure levels and visit-to-visit variability are associated with adverse pregnancy outcomes, with each 5 mm Hg increase in blood pressure levels leading to increased odds of the composite outcome. Increased blood pressure visit-to-visit variability is also associated with increased odds of hypertension and adverse pregnancy outcomes.
Article
Neurosciences
Serena B. Gumusoglu, Michaela D. Kiel, Aleigha Gugel, Brandon M. Schickling, Kaylee R. Weaver, Marisol C. Lauffer, Hannah R. Sullivan, Kaylie J. Coulter, Brianna M. Blaine, Mushroor Kamal, Yuping Zhang, Eric J. Devor, Donna A. Santillan, Stephanie C. Gantz, Mark K. Santillan
Summary: This study found that Rgs2 KO mice exhibited anxiety, depression, and hedonic behaviors, as well as changes in cortical vascular density and vessel length. The expression of serotonergic genes and angiogenic genes showed sex-specific changes. Dorsal raphe serotonin neurons were also affected. These results provide new clues for further investigating the shared mechanisms of psychiatric and obstetric diseases.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Bei Gan, Xiuyan Wu, Lin Lu, Xuemei Li, Jianhua Li
Summary: The study shows that there is a relationship between systolic blood pressure in the early pregnancy stage in patients with preeclampsia and the development of severe eclampsia and birth weight. Higher systolic blood pressure in early pregnancy can predict low birth weight and severe preeclampsia.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Shi Fang, M. Christine Livergood, Pablo Nakagawa, Jing Wu, Curt D. Sigmund
Summary: This review focuses on the mechanisms by which nuclear receptors mediate transcriptional responses, with a specific emphasis on the role of PPARγ in regulating blood pressure. Genetic and clinical trial data demonstrate the importance of PPARγ in hypertension, and the tissue- and cell-specific molecular mechanisms by which PPARs modulate blood pressure and related phenotypes are detailed. The role of placental PPARs in preeclampsia is also discussed, along with future research directions and implications for novel therapies.
CIRCULATION RESEARCH
(2021)
Review
Medicine, General & Internal
Margaux Van Wynsberghe, Joanne Flejeo, Hamza Sakhi, Mario Ollero, Dil Sahali, Hassan Izzedine, Carole Henique
Summary: This review examines the use of VEGF/VEGFR2 signaling inhibitors in cancer treatment, focusing on their impact on kidney physiology and the emergence of adverse nephrotoxic effects. The paper also discusses the pathophysiological mechanisms of common renal diseases and outlines cellular damage associated with these therapies.
Article
Peripheral Vascular Disease
Anna Kivioja, Elli Toivonen, Jaakko Tyrmi, Sanni Ruotsalainen, Samuli Ripatti, Heini Huhtala, Tiina Jaaskelainen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Tanja Saarela, Hannele Laivuori
Summary: The study found that the polygenic risk score for blood pressure (BP-PRS) is associated with an increased risk of preeclampsia and its severe subtypes, with women with high BP-PRS presenting higher blood pressure values during pregnancy.
Article
Peripheral Vascular Disease
Joana Lopes Perdigao, Jennifer Lewey, Adi Hirshberg, Nathanael Koelper, Sindhu K. Srinivas, Michal A. Elovitz, Lisa D. Levine
Summary: This study suggests that a short course of postpartum furosemide significantly improves blood pressure control in women with hypertensive disorders of pregnancy, particularly among those without severe disease. The use of furosemide reduced the risk of persistent hypertension at 7 days postpartum and shortened the days to resolution of hypertension, without significant differences in readmissions or need for additional antihypertensive medication between groups.
Review
Nutrition & Dietetics
Baris Afsar, Rengin Elsurer Afsar
Summary: Preeclampsia is a disorder characterized by hypertension and end organ damage after 20 weeks of gestation. There are two main types: early-onset, associated with placental dysfunction, and late-onset, related to obesity, diabetes, and cardiovascular abnormalities. The role of sodium intake in preeclampsia is not well-understood, with conflicting results from previous studies.
Article
Cardiac & Cardiovascular Systems
Julia Binder, Pilar Palmrich, Erkan Kalafat, Petra Pateisky, Ebru Oeztuerk, Johanna Mittelberger, Asma Khalil
Summary: This study evaluated the predictive value of the sFlt-1/PlGF ratio in women with chronic hypertension for delivery due to superimposed preeclampsia, finding that angiogenic imbalance can predict delivery related to superimposed preeclampsia and is associated with a significantly shorter time to delivery interval.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cell Biology
Yike Yang, Huili Jin, Yuhan Qiu, Yamin Liu, Li Wen, Yong Fu, Hongbo Qi, Philip N. Baker, Chao Tong
Summary: Moderate levels of reactive oxygen species (ROS) are crucial for placental angiogenesis, and reducing ROS with potent antioxidants may increase the risk of preeclampsia.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Obstetrics & Gynecology
Sunitha Suresh, Easha Patel, Ariel Mueller, Jessica Morgan, Whitney Lynn Lewandowski, Stefan Verlohren, Peter von Dadelszen, Laura A. Magee, Sarosh Rana
Summary: Hypertension complicates a significant percentage of pregnancies and is a leading cause of maternal and perinatal morbidity and mortality. This study aimed to evaluate the prognostic value of the soluble fms-like tyrosine kinase-1/placental growth factor ratio in women with suspected preeclampsia who have already met the diagnostic criteria. The findings suggest that this ratio is associated with an increased risk of developing preeclampsia with severe features.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Obstetrics & Gynecology
S. Ananth Karumanchi, Towia Libermann
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Peripheral Vascular Disease
Vesna D. Garovic, Ralf Dechend, Thomas Easterling, Ananth Karumanchi, Suzanne McMurtry Baird, Laura A. Magee, Sarosh Rana, Jane V. Vermunt, Phyllis August, Vice Chair
Summary: Hypertensive disorders of pregnancy (HDP) are a major cause of morbidity and mortality for both mothers and fetuses worldwide. This report reviews the current literature on HDP, including epidemiology, pathophysiology, treatment guidelines, and associated complications.
Article
Public, Environmental & Occupational Health
Katherine M. Johnson, Aaron J. Specht, Jessica M. Hart, Saira Salahuddin, Adrienne L. Erlinger, Michele R. Hacker, Alan D. Woolf, Marissa Hauptman, S. Ananth Karumanchi, Karen O'Brien, Blair J. Wylie
Summary: Prenatal risk-factor based lead screening is underutilized and does not effectively distinguish between individuals with and without elevated blood levels. Further exploration is needed to assess the benefit and cost-effectiveness of universal lead testing.
MATERNAL AND CHILD HEALTH JOURNAL
(2022)
Article
Immunology
Richard M. Burwick, Gabriela Dellapiana, Rachel A. Newman, Sarah D. Smithson, Mariam Naqvi, John Williams, Melissa S. Wong, Martha Bautista, Anna Gaden, Shamsah D. Kazani, Derek A. Dunn, Mark H. Ma, Sanjay Mitter, Jonathan P. R. Monteleone, Stephan R. Ortiz, Sara Ghandehari, Noah Merin, Mark Zakowski, S. Ananth Karumanchi
Summary: The study evaluated the use of eculizumab in pregnant and postpartum individuals with severe COVID-19. Results showed that all participants survived at Day 15 and remained alive and free of mechanical ventilation at Day 29. The treatment was found to be safe with no serious adverse events.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Adelene Y. Tan, Ken Kearney, Courtney Jenkins, S. Ananth Karumanchi, Walter Bee, Paul Kussie
Summary: Placental growth factor (PlGF) has acute vasodilatory effects on human resistance arteries and can decrease blood pressure when administered to male Guinea Pigs, leading to compensatory increase in heart rate.
HYPERTENSION IN PREGNANCY
(2022)
Review
Obstetrics & Gynecology
Stefan Verlohren, Shaun P. Brennecke, Alberto Galindo, S. Ananth Karumanchi, Ljiljana B. Mirkovic, Dietmar Schlembach, Holger Stepan, Manu Vatish, Harald Zeisler, Sarosh Rana
Summary: Preeclampsia poses significant morbidity and mortality risks for both mother and baby. The discovery of circulating angiogenic factors in preeclampsia pathogenesis has advanced diagnosis and prognosis, but there is currently no consensus or clear guidance on their practical use in routine clinical practice.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Obstetrics & Gynecology
Laura A. Magee, Mark A. Brown, David R. Hall, Sanjay Gupte, Annemarie Hennessy, S. Ananth Karumanchi, Louise C. Kenny, Fergus McCarthy, Jenny Myers, Liona C. Poon, Sarosh Rana, Shigeru Saito, Anne Cathrine Staff, Eleni Tsigas, Peter von Dadelszen
Summary: Uniform departmental management protocols should be maintained for managing hypertensive pregnant women, and regular audits of maternal and fetal outcomes should be conducted. The cause and optimal clinical management of pre-eclampsia and hypertensive disorders of pregnancy remain uncertain, therefore, it is recommended that every hypertensive pregnant woman be given the opportunity to participate in research, clinical trials, and follow-up studies.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Zolt Arany, Denise Hilfiker-Kleiner, S. Ananth Karumanchi
Summary: Cardiovascular complications during pregnancy, such as preeclampsia and peripartum cardiomyopathy, have become a major cause of maternal mortality and have long-term effects on maternal cardiovascular health. However, the causes and mechanisms underlying these complications are not well understood, and treatment options are limited. Preclinical models have played an important role in advancing our understanding of these diseases.
CIRCULATION RESEARCH
(2022)
Editorial Material
Medical Laboratory Technology
Kathryn J. Gray, Martin Hemberg, S. Ananth Karumanchi
CLINICAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Sarah M. Davis, Vignesh N. Hariharan, Agnes Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa, Nicholas McHugh, Annabelle Biscans, Julia F. Alterman, S. Ananth Karumanchi, Melissa J. Moore, Anastasia Khvorova
Summary: Preeclampsia is a potentially lethal pregnancy complication driven by overexpression of placental soluble fms-like tyrosine kinase 1 (sFLT1). Researchers have found that injecting specific siRNA can reduce placental sFLT1 and improve symptoms. They also discovered that modifying siRNA chemically can enhance its effectiveness and safety, providing a framework for further development of this therapeutic approach.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Endocrinology & Metabolism
Mengyao Tang, Anders Berg, Eugene P. Rhee, Andrew S. Allegretti, Sagar Nigwekar, S. Ananth Karumanchi, James P. Lash, Sahir Kalim
Summary: The impact of glycated hemoglobin (HbA(1c)) on renal outcomes in patients with diabetes and chronic kidney disease (CKD) is modified by carbamylation and anemia.
Review
Peripheral Vascular Disease
Takahiko Nakagawa, Ana Andres-Hernando, Tomoki G. Kosugi, Laura Sanchez-Lozada, Peter Stenvinkel, Karolina Kublickiene, S. Ananth Karumanchi, Duk-Hee Kang, Hideto Kojima, Bernardo R. Rodriguez-Iturbe, Dean A. Tolan, Miguel J. Lanaspa, Richard Johnson
Summary: Preeclampsia is a hypertensive disorder of pregnancy caused by abnormal placentation. Fructose, which plays a critical role in fetal growth, is produced in the placenta during early pregnancy to assist fetal survival in a hypoxic environment. Impaired placentation leads to excessive fructose production, which drives various pathological features of preeclampsia. In addition, dietary fructose intake has been identified as an independent risk factor for preeclampsia.
HYPERTENSION RESEARCH
(2023)
Article
Urology & Nephrology
Sahir Kalim, Sophia Zhao, Mengyao Tang, Eugene P. Rhee, Andrew S. Allegretti, Sagar Nigwekar, S. Ananth Karumanchi, James P. Lash, Anders H. Berg
Summary: Protein carbamylation, driven by elevated blood urea levels, is associated with adverse outcomes in ESKD. However, its relationship to clinical outcomes in earlier stages of CKD is not well understood.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lauren A. Biwer, Qing Lu, Jaime Ibarrola, Alec Stepanian, Joshua J. Man, Brigett V. Carvajal, Nicholas D. Camarda, Zsuzsanna Zsengeller, Geraldine Skurnik, Ellen W. Seely, S. Ananth Karumanchi, Iris Z. Jaffe
Summary: Preeclampsia is associated with hypertension and end organ damage, and women exposed to preeclampsia have an increased risk of hypertension after pregnancy. This study found that exposure to sFlt1 during pregnancy leads to enhanced responsiveness of smooth muscle cell mineralocorticoid receptors (SMC-MR) to hypertensive stimuli, contributing to postpartum hypertension. These findings suggest that targeting SMC-MR could be a potential intervention to mitigate cardiovascular risk in women after preeclampsia.
CIRCULATION RESEARCH
(2023)
Article
Obstetrics & Gynecology
Eynav Accortt, James Mirocha, Dongsheng Zhang, Sarah J. Kilpatrick, Towia Libermann, S. Ananth Karumanchi
Summary: This study aimed to determine if a panel of novel third-trimester plasma protein biomarkers in pregnant women can be used to identify those who have a high predisposed risk for perinatal mood and anxiety disorders. The results showed that participants with perinatal mood and anxiety disorders had a unique and distinct plasma protein signature that regulated a variety of neuronal signaling and proinflammatory pathways. Further validation studies with larger sample sizes are needed to determine the potential use of these molecules for early detection of perinatal mood and anxiety disorders when combined with traditional risk factors.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
