Review
Biochemistry & Molecular Biology
Iveta Fizikova, Jozef Dragasek, Peter Racay
Summary: The complexity of the brain can lead to the development of serious neuropsychiatric disorders, such as schizophrenia. The etiopathogenesis of schizophrenia involves multiple mechanisms, highlighting its complexity and providing a new perspective for studying this disorder. This review focuses on the contribution of mitochondria, particularly oxidative damage, ROS, and energy metabolism. It also discusses the role of redox imbalance and lactate in oxidative stress, lipid peroxidation, and cognitive functions in schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Fanghui Liang, Jian Jiang, Xinyue Yang, Guoyang Zhang, Jiaying Zhou, Jiahao Han, Yujie Geng, Zhuo Wang
Summary: Neuroinflammation leads to oxidative stress in the brain and is linked to various neurological disorders. A fluorescent probe, SiR-FH, was developed for detecting HClO. This probe demonstrated high selectivity, rapid response, and sensitivity, successfully detecting endogenous and exogenous HClO in living cells. Real-time monitoring of HClO flux in the brains of mice with LPS-induced neuroinflammation was achieved using SiR-FH, providing a practical tool for studying oxidative stress related to neuroinflammation.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Atsushi Kawase, Momoko Hatanaka, Naoya Matsuda, Hiroaki Shimada, Masahiro Iwaki
Summary: This study demonstrates the alterations in Slc25a39/40 expression in mice with cholestasis-associated renal injury and LPS-induced inflammation, providing insights into the regulation of this protein expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Zafer Yonden, Farzaneh Bonyadi, Yavar Yousefi, Amin Daemi, Seyyedeh Touran Hosseini, Sana Moshari
Summary: This study reveals that chronic and high-dose nano-micelle curcumin (NMC) can suppress the redox capacity and stimulate mitophagy signaling in the testicles.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Takayuki Kobayashi, Hiroyuki Uchino, Eskil Elmer, Yukihiko Ogihara, Hidetoshi Fujita, Shusuke Sekine, Yusuke Ishida, Iwao Saiki, Shoichiro Shibata, Aya Kawachi
Summary: In this study, a SAE model was established using CypD KO mice, and metabolomic analysis showed that the GSH levels were maintained in the KO animals following CLP. This suggests that CypD may play a role in the pathogenesis of SAE by inhibiting MPTP induction and protecting mitochondrial and cellular function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ling Wei, Zhicai Zuo, Zhuangzhi Yang, Heng Yin, Yue Yang, Jing Fang, Hengmin Cui, Zongjun Du, Ping Ouyang, Xia Chen, Jian Chen, Yi Geng, Yanqiu Zhu, Zhengli Chen, Chao Huang, Fengyuan Wang, Hongrui Guo
Summary: This study found that nickel chloride treatment may induce liver damage through mitochondrial damage and ferroptosis.
Article
Biochemistry & Molecular Biology
Saadet Turkseven, Cristian Turato, Gianmarco Villano, Mariagrazia Ruvoletto, Maria Guido, Massimo Bolognesi, Patrizia Pontisso, Marco Di Pascoli
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease that can progress to non-alcoholic steatohepatitis (NASH) and eventually cirrhosis. Inflammation and oxidative stress, caused by mitochondrial dysfunction, are crucial in the development of NASH. This study evaluated the potential of acetylsalicylic acid (ASA) and mitoquinone, an antioxidant, to inhibit the progression of NASH. The results showed that both ASA and mitoquinone reduced liver steatosis and inflammation, restored anti-inflammatory factors, and increased antioxidant expression.
Article
Biochemistry & Molecular Biology
Junjie Du, Dongmin Yu, Jinghang Li, Linjie Si, Dawei Zhu, Ben Li, Yizhou Gao, Lifu Sun, Xufeng Wang, Xiaowei Wang
Summary: Through mouse experiments and in vitro cell experiments, it was found that Asiatic acid (AA) enhances the survival of cardiomyocytes and alleviates cardiac dysfunction by protecting mitochondrial structure, reducing oxidative stress, inhibiting mitochondrial-dependent apoptosis pathway, and inhibiting the activation of the JNK pathway, which highlights its potential therapeutic value in chronic pressure overload-induced heart failure and oxidative stress-induced cardiomyocyte apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Biyi Chen, Nastaran Daneshgar, Hsiang-Chun Lee, Long-Sheng Song, Dao-Fu Dai
Summary: Mitochondrial oxidative stress plays a role in aging and various cardiovascular diseases. Its involvement in bradyarrhythmia is less understood. In a mouse model of Leigh Syndrome (LS), mitochondrial antioxidant treatment improved bradyarrhythmia and extended lifespan. Increased reactive oxygen species (ROS) in the LS heart were observed and abolished by mitochondrial antioxidant treatment. This study suggests the direct mechanistic roles of mitochondrial ROS in bradyarrhythmia and highlights the potential clinical application of mitochondrial-targeted antioxidants in LS patients.
Review
Pharmacology & Pharmacy
Etelka Poestyeni, Alma Ganczer, Andrea Kovacs-Valasek, Robert Gabriel
Summary: The presence of neuropeptides in the mammalian retina has significant effects on normal retinal processes and physiology, and they play a crucial role in fighting various retinal pathologies. Genetically manipulated mouse models have helped to better understand the molecular background of retinal diseases. Neuropeptides have been found to be important in diabetic retinopathy and ischemia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physiology
Jingqing Chen, Xihong Zhou, Hai Jia, Zhenlong Wu
Summary: Serine administration can alleviate doxorubicin-induced oxidative damage in skeletal muscle of mice by enhancing NRF2/CAR signaling pathway.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Hideyuki Torikai, Mei-Hua Chen, Li Jin, Jiang He, John F. Angle, Weibin Shi
Summary: Apoe(-/-) and Ldlr(-/-) mice are common animal models for studying hypercholesterolemia and atherosclerosis. This study found that C3H-Ldlr(-/-) mice developed larger atherosclerotic lesions compared to C3H-Apoe(-/-) mice in the aortic root, but neither knockout showed any lesions in the carotid artery. After ligation, the common carotid artery in both knockouts developed intimal lesions, with C3H-Ldlr(-/-) mice having larger lesions than C3H-Apoe(-/-) mice. These findings suggest that small dense LDL may play a more significant role in the susceptibility to atherosclerosis in these mouse models compared to inflammation and oxidative stress.
Article
Biochemistry & Molecular Biology
Marta Medina-Carbonero, Arabela Sanz-Alcazar, Elena Britti, Fabien Delaspre, Elisa Cabiscol, Joaquim Ros, Jordi Tamarit
Summary: Friedreich Ataxia is a rare neuro-cardiodegenerative disease caused by mutations in the frataxin gene. The most common mutation is a GAA expansion in the first intron of the gene, resulting in decreased frataxin expression. By introducing a specific mutation into the murine Fxn gene, researchers have analyzed the consequences of this mutation in vivo. They found that mice with this mutation displayed low frataxin levels in all tissues, neurological deficits resembling those in FA patients, and mitochondrial alterations. The researchers concluded that the primary pathological mechanism underlying this mutation is frataxin deficiency, suggesting frataxin replacement therapies may benefit patients with this mutation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Environmental Sciences
Xiaoxia Yu, Fei Meng, Ju Huang, Weidong Li, Jiaming Zhang, Shen Yin, Liangran Zhang, Shunxin Wang
Summary: This study demonstrated that exposure to 1-NP disrupts mouse oocyte maturation by affecting meiotic spindle assembly, chromosome alignment, first polar body extrusion, fertilization capability, mitochondrial function, intracellular redox balance, and gene expression related to antioxidant enzymes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Geriatrics & Gerontology
Hyunjung Lee, Tae Youl Ha, Chang Hwa Jung, Farida Sukma Nirmala, So-Young Park, Yang Hoon Huh, Jiyun Ahn
Summary: The study revealed that acute insulin resistance coincides with mitochondrial dysfunction in skeletal muscle, leading to impaired mitochondrial function and the development of acute insulin resistance. Improving mitochondrial function has significant potential in treating acute insulin resistance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Peripheral Vascular Disease
Celine Baron-Menguy, Valerie Domenga-Denier, Lamia Ghezali, Frank M. Faraci, Anne Joutel
Article
Behavioral Sciences
R. J. Taugher, Y. Lu, R. Fan, A. Ghobbeh, C. J. Kreple, F. M. Faraci, J. A. Wemmie
GENES BRAIN AND BEHAVIOR
(2017)
Article
Peripheral Vascular Disease
T. Michael De Silva, Chunyan Hu, Dale A. Kinzenbaw, Mary L. Modrick, Curt D. Sigmund, Frank M. Faraci
Editorial Material
Cardiac & Cardiovascular Systems
Frank M. Faraci
CIRCULATION RESEARCH
(2018)
Article
Peripheral Vascular Disease
T. Michael De Silva, Mary L. Modrick, Fabrice Dabertrand, Frank M. Faraci
Article
Peripheral Vascular Disease
T. Michael De Silva, Ying Li, Dale A. Kinzenbaw, Curt D. Sigmund, Frank M. Faraci
Article
Cardiac & Cardiovascular Systems
Frank M. Faraci, Rebecca J. Taugher, Cynthia Lynch, Rong Fan, Subhash Gupta, John A. Wemmie
CIRCULATION RESEARCH
(2019)
Review
Physiology
T. Michael De Silva, Frank M. Faraci
ANNUAL REVIEW OF PHYSIOLOGY, VOL 82
(2020)
Editorial Material
Neurosciences
Frank M. Faraci
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Clinical Neurology
T. Michael De Silva, Mary L. Modrick, Justin L. Grobe, Frank M. Faraci
Summary: The activation of central and cerebrovascular RAS impairs endothelial signaling in the brain through AT1R expression and activation, leading to impaired cerebral artery function and showing sex-dependent effects.
Article
Physiology
Dale A. Kinzenbaw, Lucy Langmack, Frank M. Faraci
Summary: The renin-angiotensin system plays a role in vascular disease, but the impact of Ang II on endothelial function is not well understood. This study found that Ang II impairs endothelial function and ROCK2 may contribute to this effect.
PHYSIOLOGICAL REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Rasna Sabharwal, Mark W. Chapleau, Thomas D. Gerhold, Gary L. Baumbach, Frank M. Faraci
Summary: Changes in vascular structure, such as arteriolar wall thickness, diameter, wall-to-lumen ratio, and biological stiffness, rapidly change during hypertension and recover with blood pressure. However, inward remodeling develops slowly and does not recover. This lack of recovery of arteriolar diameter has implications for the long-term impact of hypertension on vascular determinants of brain health.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Editorial Material
Hematology
Frank M. Faraci
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Martin Dichgans, Frank M. Faraci, Christer Betsholtz, Elizabeth Hillman, Anne Joutel, Mark Nelson, Dominik Paquet, BRENDA Network
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaoming Hu, T. Michael De Silva, Jun Chen, Frank M. Faraci
CIRCULATION RESEARCH
(2017)