Article
Medicine, Research & Experimental
Claudio Borghi, Pathiyil Balagopalan Jayagopal, Alexandra Konradi, Luiz Aparecido Bortolotto, Luca Degli Esposti, Valentina Perrone, Jacques R. Snyman
Summary: This retrospective observational analysis examined the change in medication adherence when treatment was switched from PER/IND + AML to PER/IND/AML single-pill combination. The results showed a significant increase in adherence and decrease in non-adherence with PER/IND/AML single-pill combination. Therefore, switching to a triple single-pill combination may improve adherence to antihypertensive treatment.
ADVANCES IN THERAPY
(2023)
Article
Peripheral Vascular Disease
Khalid M. Bashir, Tammy Burns, Samuel J. Pirruccello, Sarah J. Aurit, Daniel E. Hilleman
Summary: Chlorthalidone may be more effective than hydrochlorothiazide in reducing adverse cardiovascular events in hypertensive patients, possibly due to its antiplatelet effects. However, this study found that neither chlorthalidone nor hydrochlorothiazide had antiplatelet effects.
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Article
Pharmacology & Pharmacy
Rana Said, Basel Arafat, Tawfiq Arafat, Eyad Mallah
Summary: A sensitive LC-MS/MS method was developed for simultaneous quantification of amlodipine, valsartan, and hydrochlorothiazide in human plasma. The method was successfully applied in a bioequivalence study for the treatment of hypertension, showing stability and efficiency in quantifying the drugs.
CURRENT PHARMACEUTICAL ANALYSIS
(2021)
Article
Environmental Sciences
Gizem Tiris, Mohammad Mehmandoust, Hayam M. Lotfy, Nevin Erk, Sang-Woo Joo, Elena-Niculina Dragoi, Yasser Vasseghian
Summary: A novel RP-HPLC method was developed for the quantification of TLM and HYD in a ternary mixture of synthetic laboratory mixture. A new spectrophotometric method was also applied for simultaneous determination of active substances.
Article
Pharmacology & Pharmacy
Bo Qiu, Haojing Song, Congyang Ding, Xue Sun, Runxuan Du, Haotian Yang, Wanjun Bai, Zhanjun Dong
Summary: This study demonstrates the bioequivalence of test and reference valsartan/amlodipine formulations under fasting and postprandial conditions through a clinical trial. The participants were randomly divided into three sequences and underwent crossover administration. The average bioequivalence and reference-scaled average bioequivalence methods were used to evaluate the pharmacokinetic parameters.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Jaewon Oh, Wonho Kim, Gee-Hee Kim, Hack-Lyoung Kim, Sang-Don Park, Kyung Wan Min, Dongkeun Hyun, Jun Hwa Hong, Soo Lim, Jinho Shin
Summary: This study assessed the real-world safety and effectiveness of an SPC containing olmesartan, amlodipine, and hydrochlorothiazide in South Korean patients with hypertension and cardiovascular risk factors. The results showed that the therapy led to a significant reduction in blood pressure and had a high control rate.
ADVANCES IN THERAPY
(2023)
Article
Pharmacology & Pharmacy
Rosmery Merma Leon, Michele Georges Issa, Marcelo Dutra Duque, Josiane Souza Pereira Daniel, Humberto Gomes Ferraz
Summary: This study developed a method to evaluate the dissolution profile of tablets containing Hydrochlorothiazide and Valsartan using in silico tools. In vitro dissolution tests and statistical analysis were conducted to determine the final dissolution conditions and assess the effectiveness of the method.
Article
Pharmacology & Pharmacy
Pervaiz Akhtar Shah, Haider Abbas Zaidi, Haroon Khalid Syed, Huma Ishfaq, Rao M. Altaf, Areeba Pervaiz, Salah-Ud-Din Khan, Muhammad Shahid Iqbal, Javed Khan
Summary: A triple layered tablet containing various excipients and new combination of APIs was successfully developed through wet granulation. Different formulations with varying concentrations of disintegrant were prepared and results showed that the change in disintegrant concentration did not significantly affect the flow ability of granules. In vitro drug release studies indicated that all formulations exhibited zero order release.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Integrative & Complementary Medicine
Fengting Su, Qing Xia
Summary: Diabetic nephropathy is the leading cause of chronic renal and end-stage kidney disease in China, and it often coexists with hypertension. Hypertension affects two-thirds of individuals with type 2 diabetes and increases the risk of cardiovascular complications. This study aimed to investigate the effects of a combination of valsartan, amlodipine, and alpha-lipoic acid on total antioxidant capacity and inflammatory markers in patients with diabetic nephropathy. The findings showed that this combination had a significant effect in improving the condition of the patients.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Nutrition & Dietetics
Chu-Lin Chou, Ching-Hao Li, Te-Chao Fang
Summary: High fructose intake is associated with obesity and metabolic syndrome, but the blockers of renin-angiotensin system and calcium channel can reduce triacylglycerol storage in fructose-induced adiposity by inhibiting PU.1 activation.
Article
Nutrition & Dietetics
Somin Lee, Cheolmin Jo, Ho-Young Choi, Kyungjin Lee
Summary: The combined administration of curcumin and amlodipine showed a stronger vasorelaxant effect than amlodipine alone, but did not significantly reduce systolic and diastolic blood pressure compared to amlodipine alone.
Article
Medicine, General & Internal
Caroline Foch, Jan Feifel, Ulrike Gottwald-Hostalek
Summary: This study compared the effects of a low-dose combination of amlodipine and bisoprolol with up titration to maximum dose of amlodipine on blood pressure in hypertensive patients. The findings showed a greater decrease in diastolic blood pressure with the low-dose combination therapy.
CURRENT MEDICAL RESEARCH AND OPINION
(2022)
Article
Biochemistry & Molecular Biology
Paula Soria-Chacartegui, Pablo Zubiaur, Dolores Ochoa, Marcos Navares-Gomez, Houwaida Abbes, Gonzalo Villapalos-Garcia, Alejandro de Miguel, Eva Gonzalez-Iglesias, Andrea Rodriguez-Lopez, Gina Mejia-Abril, Samuel Martin-Vilchez, Sergio Luquero-Bueno, Manuel Roman, Francisco Abad-Santos
Summary: Drug combination therapy is a common strategy for managing hypertension, but there are currently no pharmacogenetic biomarkers available for guiding hypertension pharmacotherapy. This study analyzed the association between genetic variants and pharmacokinetic parameters, adverse drug reactions, and blood pressure measurements in volunteers. The results showed that certain genetic variants were associated with differences in drug metabolism and the incidence of adverse reactions. Additionally, sex influenced the pharmacokinetics of certain drugs, with lower exposure observed in women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yu Wang, Zhen Hua, Wenjing Chen, Yushuo Zhu, Yunlun Li
Summary: This study aims to evaluate the efficacy and safety of the Chinese herbal extract Tengfu Jiangya tablet (TJT) combined with Valsartan/Amlodipine in treating stage 2 hypertension. The study uses a randomized double-blind, placebo-controlled, multicenter trial design and will observe the changes in mean sitting systolic and diastolic blood pressure from baseline to week 4. This study may provide evidence-based recommendations for complementary preventive measures for stage 2 hypertension.
Article
Electrochemistry
Somayeh Mohammadi, Mohammad Ali Taher, Hadi Beitollahi
Summary: A single-stage hydrothermal method was used to synthesize MoS2 NSs-G hybrid nanostructures, with MoS2 nanosheets tightly attached to the surface of graphene. The MoS2 NSs-G modified electrode exhibited superior electrocatalytic activity for the oxidation of amlodipine, with a LOD of 0.0012 mu M and a linear range of 0.04-400.0 mu M. Additionally, it showed favorable results for concurrent measurement of amlodipine and hydrochlorothiazide, making it a promising sensor for clinical assays.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)