Article
Nutrition & Dietetics
Inaki Robles-Vera, Nestor de la Visitacion, Marta Toral, Manuel Sanchez, Miguel Romero, Manuel Gomez-Guzman, Felix Vargas, Juan Duarte, Rosario Jimenez
Summary: The study showed that DOX can reduce blood pressure, improve endothelial dysfunction, and decrease oxidative stress and inflammation in DOCA-salt hypertensive rats. Additionally, DOX can modulate gut microbiota composition, enhance intestinal barrier integrity, and maintain normal levels of endotoxemia and noradrenaline.
Article
Biochemistry & Molecular Biology
Edina da Luz Abreu, Camila Rodrigues Moro, Samia Hassan Husein Kanaan, Ricardo Bernardino de Paula, Camila Teixeira Herrera, Pedro Henrique Dorneles Costa, Franck Maciel Pecanha, Dalton Valentim Vassallo, Luciana Venturini Rossoni, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: This study aimed to evaluate the potential antihypertensive effect of egg white hydrolysate (EWH) and its beneficial effects on blood vessels in rats with severe hypertension. The results showed that EWH significantly reduced blood pressure and improved vascular function. This effect may be attributed to the antioxidant and anti-inflammatory properties of EWH.
Article
Physiology
Carolina S. Cerrudo, Susana Cavallero, Martin Rodriguez Fermepin, German E. Gonzalez, Martin Donato, Nicolas M. Kouyoumdzian, Ricardo J. Gelpi, Cecilia M. Hertig, Marcelo R. Choi, Belisario E. Fernandez
Summary: The study found that natriuretic peptides play an important role in the hypertrophic remodeling transition caused by chronic hemodynamic overload. Results showed that cardiac hypertrophy and left ventricular ANP gene expression were more pronounced in volume overload model, while BNP gene expression was positively correlated with left ventricular hypertrophy only in pressure overload model. The combined models exhibited intermediate values between those of single groups.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Estrellita Uijl, Liwei Ren, Katrina M. Mirabito Colafella, Richard van Veghel, Ingrid M. Garrelds, Oliver Domenig, Marko Poglitsch, Ivan Zlatev, Jae B. Kim, Stephen Huang, Lauren Melton, Ewout J. Hoorn, Don Foster, A. H. Jan Danser
Summary: The study found that brain angiotensin II depends on circulating angiotensinogen in DOCA-salt hypertension model. Spironolactone normalized blood pressure, restored brain angiotensin II, and lowered blood pressure, indicating that DOCA-salt hypertension is not mediated by brain RAS activation.
Article
Food Science & Technology
Yueh-Min Lin, Khan Farheen Badrealam, Wei-Wen Kuo, Pei Fang Lai, William Shao-Tsu Chen, Cecilia Hsuan Day, Tsung-Jung Ho, Vijaya Padma Viswanadha, Marthandam Asokan Shibu, Chih-Yang Huang
Summary: Nerolidol has been shown to ameliorate hypertension-induced cardiac injuries by targeting the TLR4/NF-kappa B signaling pathway, leading to reduced inflammation and oxidative stress, and providing effective cardioprotection. Echocardiography analysis demonstrated improved cardiac functional characteristics in hypertensive rats treated with nerolidol, highlighting its potential as a cardio-protective agent against hypertension-induced cardiac remodeling.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Adrien Flahault, Mathilde Keck, Pierre-Emmanuel Girault-Sotias, Lucie Esteoulle, Nadia De Mota, Dominique Bonnet, Catherine Llorens-Cortes
Summary: LIT01-196 is a stable apelin-17 analog that acts as a full agonist for the apelin receptor, effectively reducing arterial blood pressure in both normotensive and hypertensive rats via a nitric oxide-dependent mechanism. It maintains its blood pressure-lowering effect in hypertensive rats for over 7 hours, with no significant impact on plasma sodium and potassium levels or kidney function after repeated administration.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Li Zeng, Zerong Liu, Luxin Zhou, Meng Chen, Xuewei Zheng, Pengfei Yang, Xinrui Zhao, Zhongmin Tian
Summary: The study found that protein-rich almond supplementation can prevent salt-induced hypertension by regulating amino acid metabolism, increasing nitric oxide content, and alleviating oxidative stress.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Peripheral Vascular Disease
Takahiro Miura, Akihiro Sakuyama, Lusi Xu, Jiahe Qiu, Asako Namai-Takahashi, Yoshiko Ogawa, Masahiro Kohzuki, Osamu Ito
Summary: This study aimed to investigate the mechanisms behind the antihypertensive and renal protective effects of the xanthine oxidoreductase inhibitor febuxostat. The results showed that febuxostat attenuated high salt diet-induced hypertension and renal damage in Dahl salt-sensitive rats by reducing renal oxidative stress. The antihypertensive effect of febuxostat may be partly mediated by its diuretic and natriuretic actions.
JOURNAL OF HYPERTENSION
(2022)
Article
Cell Biology
Lok Chun Chan, Yuqi Zhang, Xiaoqing Kuang, Mohamad Koohi-Moghadam, Haicui Wu, Theo Yu Chung Lam, Jiachi Chiou, Chunyi Wen
Summary: This study investigated the alteration of gut microbiota in a DOCA-induced hypertensive rat model and found that gut microbiota dysbiosis may contribute to chondrocyte senescence induced by DOCA. Captopril can alleviate joint damage and exert its effects by modulating specific bacterial genera levels in the gut microbiota.
Article
Biochemistry & Molecular Biology
Pauline Robert, Phuc Minh Chau Nguyen, Alexis Richard, Celine Grenier, Arnaud Chevrollier, Mathilde Munier, Linda Grimaud, Coralyne Proux, Tristan Champin, Eric Lelievre, Emmanuelle Sarzi, Emilie Vessieres, Samir Henni, Delphine Prunier, Pascal Reynier, Guys Lenaers, Celine Fassot, Daniel Henrion, Laurent Loufrani
Summary: The study found that mitochondrial fusion plays a protective role in hypertension by reducing oxidative stress. Defects in mitochondrial fusion worsen hypertension. Additionally, increased mitochondrial ROS production leads to apoptosis in vascular cells and decreased proliferation of VSMCs.
Article
Chemistry, Medicinal
Pei Qian, Qian Wang, Fang-Zheng Wang, Hang-Bing Dai, Hong-Yu Wang, Qing Gao, Hong Zhou, Ye-Bo Zhou
Summary: This study aimed to investigate the protective role of adrenomedullin (ADM) in cardiac remodeling and function in obesity-related hypertension (OH) rats. The results showed that ADM improved systemic inflammation and oxidative stress in OH rats, and had inhibitory effects on cardiac inflammation and oxidative stress. ADM also improved cardiac remodeling and function in OH rats.
Article
Pharmacology & Pharmacy
Yifang Li, Matthew Shen, Dorota Ferens, Brad R. S. Broughton, Padma Murthi, Sheetal Saini, Robert E. Widdop, Sharon D. Ricardo, Anita A. Pinar, Chrishan S. Samuel
Summary: Combining BM-MSCs and serelaxin provided broader renoprotection than either therapy alone or perindopril, suggesting a potential novel treatment for hypertensive CKD.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jiameng Hao, Liping Chang, Dandong Wang, Chuanyuan Ji, Shaolan Zhang, Yunlong Hou, Yiling Wu
Summary: This study found that Periplocin has significant effects on improving cardiac structure and function in DOCA-induced heart failure rats, possibly by inhibiting the recruitment of inflammatory and immune cells. Periplocin also has the effect of improving cardiomyocyte contractility and calcium transient amplitude.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
David Mondaca-Ruff, Patricio Araos, Cristian E. Yanez, Ulises F. Novoa, Italo G. Mora, Maria Paz Ocaranza, Jorge E. Jalil
Summary: The study demonstrated that hydrochlorothiazide can reduce pathological left ventricular hypertrophy (LVH) in hypertension patients by decreasing myocardial ROCK activation, controlling blood pressure, hypertrophy, and myocardial fibrosis. This suggests that thiazides may have preventive outcomes on LVH regression and incident heart failure in hypertension.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Andres Garcia-Sanchez, Luis Gomez-Hermosillo, Jorge Casillas-Moreno, Fermin Pacheco-Moises, Tannia Isabel Campos-Bayardo, Daniel Roman-Rojas, Alejandra Guillermina Miranda-Diaz
Summary: Obesity and hypertension are increasing health problems in developed countries. The relationship between obesity and hypertension is not fully understood, but oxidative stress and mitochondrial dysfunction may have a role. A cross-sectional study was conducted on 175 subjects with normal weight, overweight, or obesity to assess their mitochondrial function and hypertension status. The study found that obese subjects had lower ATP hydrolysis activity and increased oxidative stress compared to normal weight and overweight subjects. Subjects with hypertension also showed increased oxidative stress and inflammation markers. These findings suggest that obesity-related hypertension may involve impaired mitochondrial function and increased oxidative stress.