Article
Cell Biology
Julieth Daniela Buell-Acosta, Maria Fernanda Garces, Arturo Jose Parada-Banos, Edith Angel-Muller, Maria Carolina Paez, Javier Eslava-Schmalbach, Franklin Escobar-Cordoba, Sofia Alexandra Caminos-Cepeda, Ezequiel Lacunza, Justo P. Castano, Ruben Nogueiras, Carlos Dieguez, Ariel Ivan Ruiz-Parra, Jorge Eduardo Caminos
Summary: This study investigated the serum FGF-21 levels in healthy and mild preeclamptic pregnant women at different stages of pregnancy. The results showed that FGF-21 levels were highest in the third trimester of healthy pregnancy and higher throughout the entire pregnancy in preeclamptic women. FGF-21 may play a critical role in protecting against the negative effects of high concentrations of NEFA and hypertensive disorder, as well as in reproductive function during the menstrual cycle in healthy women.
Article
Respiratory System
Grayson L. Baird, Thomas Walsh, Jason Aliotta, Melissa Allahua, Ruth Andrew, Ghada Bourjeily, Alexander S. Brodsky, Nina Denver, Mark Dooner, Elizabeth O. Harrington, James R. Klinger, Margaret R. MacLean, Christopher J. Mullin, Mandy Pereira, Athena Poppas, Mary Whittenhall, Corey E. Ventetuolo
Summary: In this study, fluctuations in cardiopulmonary function during menstruation in women with PAH were found to be driven by E2 and DHEA-S. These sex hormones influence transcription of extracellular vesicle miRNAs implicated in the pathobiology of pulmonary vascular disease and cancer, and are associated with clinical markers such as 6-minute walk distance and NT-proBNP levels.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Cardiac & Cardiovascular Systems
Maria M. Pereira, Juan Torrado, Claudio Sosa, Alejandro Diaz, Daniel Bia, Yanina Zocalo
Summary: Non-pregnant women have a progressive increase in arterial stiffness from central-to-peripheral arteries (stiffness gradient, SG), and it remains unclear the status of the SG in women with healthy pregnancies (HP) and pregnancy-associated hypertension (PAH). This study aims to determine if HP and PAH are associated with changes in SG and potential differences between subgroups of PAH.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Elzbieta Poniedzialek-Czajkowska, Radzislaw Mierzynski, Dominik Dluski, Bozena Leszczynska-Gorzelak
Summary: Hypertensive disorders of pregnancy, such as preeclampsia, pose significant risks to both mother and fetus. Aspirin is currently the only recommended pharmacological agent for prevention in high-risk groups, while metformin shows potential as an interesting option for prophylaxis, although further research is needed to clarify its effectiveness.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Eva G. Mulder, Chahinda Ghossein-Doha, Ella Cauffman, Veronica A. Lopes van Balen, Veronique M. M. M. Schiffer, Robert-Jan Alers, Jolien Oben, Luc Smits, Sander M. J. van Kuijk, Marc E. A. Spaanderman
Summary: Tailored circulatory normalization of nonphysiological hemodynamic changes during pregnancy can reduce the risk of recurrent preeclampsia in high-risk populations. This simple and innovative treatment strategy shows no adverse effects on offspring outcomes.
Article
Peripheral Vascular Disease
Anna Kivioja, Elli Toivonen, Jaakko Tyrmi, Sanni Ruotsalainen, Samuli Ripatti, Heini Huhtala, Tiina Jaaskelainen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Tanja Saarela, Hannele Laivuori
Summary: The study found that the polygenic risk score for blood pressure (BP-PRS) is associated with an increased risk of preeclampsia and its severe subtypes, with women with high BP-PRS presenting higher blood pressure values during pregnancy.
Review
Pharmacology & Pharmacy
Christos Anthoulakis, Apostolos Mamopoulos, David Rousso, Asterios Karagiannis, Apostolos Athanasiadis, Grigoris Grimbizis, Vasilios Athyros
Summary: Arterial stiffness (AS) is a predictor of cardiovascular morbidity and mortality, particularly in pregnant women with preeclampsia (PE). Current clinical practice only uses low-dose aspirin for PE prevention, which does not protect against term PE. AS assessment may serve as a promising predictive marker for PE development.
CURRENT VASCULAR PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Amelie Paquin, Ana Werlang, Thais Coutinho
Summary: This study evaluates the impact of persistent hypertension on arterial health in women after preeclampsia. The findings suggest that women with persistent hypertension after preeclampsia may have a higher cardiovascular risk and may benefit from targeted prevention strategies.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Review
Physiology
Francisco J. Valenzuela-Melgarejo, Constanza Lagunas, Fabiola Carmona-Pasten, Kevins Jara-Medina, Gustavo Delgado
Summary: Disruption of factors in blood pressure regulation can lead to hypertension, with melatonin playing a crucial role during pregnancy in modulating physiological functions. Supplementation of melatonin can reduce blood pressure, prevent oxidative stress, and repair endothelial damage at the placental level.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michalina Bralewska, Tadeusz Pietrucha, Agata Sakowicz
Summary: Preeclampsia is a dangerous complication of pregnancy, with high risks of mortality and morbidity for both mother and fetus. The placenta, which produces hormones such as chromogranin A (CgA), is believed to play a central role in this condition. This study investigated the influence of the preeclamptic environment on CgA production in trophoblastic cell lines and tested the secretion of CgA-derived peptide catestatin (CST) as well as its correlation with apoptosis. The findings suggest that both CgA and CST may have roles in the complex pathogenesis of preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Charles DeCarlo, Laura T. Boitano, Rose L. Molina, Ido Weinberg, Mark F. Conrad, Matthew J. Eagleton, Anahita Dua
Summary: This study followed a large number of women for 22 years and found that pregnancy and preeclampsia were significantly associated with acute peripheral arterial events.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Health Care Sciences & Services
Junjun Chen, Yuelong Ji, Tao Su, Ma Jin, Zhichao Yuan, Yuanzhou Peng, Shuang Zhou, Heling Bao, Shusheng Luo, Hui Wang, Jue Liu, Na Han, Hai-Jun Wang
Summary: Prediction models developed through machine learning statistics can help identify high-risk patients with de novo hypertensive disorder of pregnancy, enabling timely intervention and care.
Review
Endocrinology & Metabolism
Erin B. Taylor, Eric M. George
Summary: Preeclampsia is a common pregnancy disorder caused by antiangiogenic and inflammatory factors produced by the hypoxic placenta. Effective treatments for preeclampsia are currently limited, but preclinical animal models have facilitated the development of new therapeutics.
Article
Obstetrics & Gynecology
Daimin Wei, Yaxin Su, Peter C. K. Leung, Yan Li, Zi-Jiang Chen
Summary: This review summarizes the current knowledge on the pathophysiological roles of BMPs and their underlying molecular mechanisms in regulating human endometrial proliferation and decidualization, aiming to promote the development of innovative strategies for diagnosing, treating, and preventing infertility and adverse pregnancy complications associated with dysregulated human endometrial remodeling.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Obstetrics & Gynecology
Zainab Mahmoud, Ikechukwu A. Orji, Gabriel L. Shedul, Kasarachi Aluka-Omitiran, Nanna Ripiye, Blessing Akor, Helen Eze, Tunde Ojo, Guhan Iyer, Abigail S. Baldridge, Lisa R. Hirschhorn, Mark D. Huffman, Dike B. Ojji
Summary: Despite receiving care in primary health care facilities, pregnant women with hypertension in Nigeria experience significant gaps in care and important areas for improvement. This study highlights the need to address the quality of care and outcomes for pregnant women with hypertension, considering Nigeria's high burden of maternal mortality.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Letter
Cardiac & Cardiovascular Systems
Anda Bularga, Kuan Ken Lee, Anoop S. V. Shah, Atul Anand, Andrew R. Chapman, Chris Tuck, David E. Newby, Sarah Jenks, Nicholas L. Mills, Dorien M. Kimenai
Review
Cardiac & Cardiovascular Systems
Beth Whittington, Evangelos Tzolos, Michelle C. Williams, Marc R. Dweck, David E. Newby
Summary: The identification of intracoronary thrombus and atherothrombosis is crucial for diagnosing acute myocardial infarction. Invasive coronary angiography remains the primary imaging modality, but more recent non-invasive angiographic techniques like CT and MRI have improved visualisation of coronary artery disease. Invasive intravascular imaging approaches, such as angioscopy, intravascular ultrasound, and optical coherence tomography, provide direct visualisation of coronary atheroma and better thrombus detection. Non-invasive detection of intracoronary thrombus using radiotracers holds promise but has not been widely implemented in routine clinical practice.
Article
Cardiac & Cardiovascular Systems
Mohammed N. Meah, Ryan Wereski, Anda Bularga, Edwin J. R. van Beek, Marc R. Dweck, Nicholas L. Mills, David E. Newby, Damini Dey, Michelle Claire Williams, Kuan Ken Lee
Summary: In patients with acute chest pain, plasma cardiac troponin I concentrations >= 5 ng/L, even without myocardial infarction, are associated with a higher burden of low-attenuation coronary plaque. This suggests that cardiac troponin may be indicative of future adverse cardiovascular events in these patients.
Article
Cardiac & Cardiovascular Systems
Praveen Thokala, Steve Goodacre, Katherine Oatey, Rachel O'Brien, David E. Newby, Alasdair Gray
Summary: This study aimed to estimate the cost-effectiveness of early CT coronary angiography (CTCA) for intermediate risk patients with suspected acute coronary syndrome (ACS), compared with standard care. The results showed that within the trial, there were no significant differences in costs or QALYs between early CTCA and standard care. Long-term economic analysis suggested higher long-term costs with CTCA and uncertain effect on long-term QALYs, making routine use of CTCA for suspected ACS unlikely to be a cost-effective use of NHS resources.
Article
Biochemistry & Molecular Biology
Dimitrios M. Doudesis, Kuan Ken Lee, Jasper Boeddinghaus, Anda Bularga, Amy E. Ferry, Chris D. Tuck, Matthew T. H. Lowry, Pedro Lopez-Ayala, Thomas Nestelberger, Luca E. Koechlin, Miguel Bernabeu, Lis Neubeck, Atul Anand, Karen Schulz, Fred Apple, William J. Parsonage, Jaimi Greenslade, Louise Cullen, John Pickering, Martin O. Than, Alasdair Gray, Christian W. Mueller, Nicholas Mills, CoDE-ACS Investigators
Summary: A clinical decision support system using machine learning models and high-sensitivity troponin measurements outperforms clinical guidelines that use fixed cardiac troponin thresholds for myocardial infarction diagnosis. The system integrates cardiac troponin concentrations and clinical features to calculate CoDE-ACS score, which corresponds to an individual's probability of myocardial infarction. It has excellent discrimination for myocardial infarction, identifies more low probability cases and reduces cardiac death rate.
Article
Multidisciplinary Sciences
Claire E. Hastie, David J. Lowe, Andrew McAuley, Nicholas L. Mills, Andrew J. Winter, Corri Black, Janet T. Scott, Catherine A. O'Donnell, David N. Blane, Susan Browne, Tracy R. Ibbotson, Jill P. Pell
Summary: Previous studies on long-COVID have been limited, and without comparison groups, it is difficult to differentiate disease progression from symptoms caused by other factors. The Long-COVID in Scotland Study (Long-CISS) conducted a cohort study in Scotland, comparing adults with laboratory-confirmed SARS-CoV-2 infection to PCR-negative adults. The study found that individuals with previous symptomatic infection had a higher prevalence of symptoms compared to those who were never infected, with altered taste, smell, and confusion improving over time, and late onset dry and productive cough, and hearing problems being more likely following SARS-CoV-2 infection.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Hamish J. C. McAuley, Rachael A. Evans, Charlotte E. Bolton, Christopher E. Brightling, James D. Chalmers, Annemarie B. Docherty, Omer Elneima, Paul L. Greenhaff, Ayushman Gupta, Victoria C. Harris, Ewen M. Harrison, Ling-Pei Ho, Alex Horsley, Linzy Houchen-Wolloff, Caroline J. Jolley, Olivia C. Leavy, Nazir I. Lone, William D. C. Man, Michael Marks, Dhruv Parekh, Krisnah Poinasamy, Jennifer K. Quint, Betty Raman, Matthew Richardson, Ruth M. Saunders, Marco Sereno, Aarti Shikotra, Amisha Singapuri, Sally J. Singh, Michael Steiner, Ai Lyn Tan, Louise Wain, Carly Welch, Julie Whitney, Miles D. Witham, Janet Lord, Neil J. Greening, HOSP-COVID Study Collaborat Grp
Summary: This study recruited COVID-19 survivors in the UK and objectively measured frailty using FFP. The results showed that frailty and pre-frailty are common after hospitalization with COVID-19, and comprehensive assessment and interventions targeting frailty are needed beyond the initial illness.
Article
Hematology
Beth Whittington, Evangelos Tzolos, Rong Bing, Jack Andrews, Christophe Lucatelli, Mark G. Macaskill, Adriana A. S. Tavares, Tim Clark, Nicholas L. Mills, Jennifer Nash, Damini Dey, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Edwin J. R. van Beek, Colin Smith, Marc R. Dweck, Michelle C. Williams, William Whiteley, Joanna M. Wardlaw, David E. Newby
Summary: Using F-18-GP1 positron emission tomography and computed tomography angiography, it is possible to identify activated platelets and thrombus noninvasively, which has potential clinical application in establishing the role and origin of thrombus in ischemic stroke.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ziwen Li, Mairi Brittan, Nicholas L. Mills
Summary: Ischaemic heart disease is a global healthcare challenge with high morbidity and mortality. Early revascularisation in acute myocardial infarction has improved survival; however, limited regenerative capacity and microvascular dysfunction often lead to impaired function and the development of heart failure. New mechanistic insights are required to identify robust targets for the development of novel strategies to promote regeneration.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Bertil Lindahl, Nicholas L. Mills
Summary: Proposed an alternative clinical classification for myocardial infarction and called for international consensus to reduce diagnostic uncertainty in practice and research.
Review
Medical Laboratory Technology
Kristin M. Aakre, Fred S. Apple, Nicolas L. Mills, Steven J. R. Meex, Paul O. Collinson
Summary: Cardiac troponin measurements are crucial for the diagnosis of myocardial infarction and long-term risk prediction of cardiovascular disease. However, the accuracy of these measurements at low concentrations and the potential misclassification of patients are still debated.
CLINICAL CHEMISTRY
(2023)
Letter
Cardiac & Cardiovascular Systems
Marie de Bakker, Atul Anand, Nicholas L. Mills, Dorien M. Kimenai