Article
Biology
Sonia Mota-Zamorano, Nicolas R. Robles, Juan Lopez-Gomez, Barbara Cancho, Luz M. Gonzalez, Guadalupe Garcia-Pino, Maria Luisa Navarro-Perez, Guillermo Gervasini
Summary: Preclinical studies suggest that AA-derived eicosanoids may be involved in DKD pathogenesis. Plasma and urinary levels of DHETs and 20-HETE were examined in 334 subjects, showing lower concentrations in DKD patients compared to non-diabetic individuals, indicating a potential role of these compounds in DKD.
Article
Biochemistry & Molecular Biology
Agnieszka Kij, Anna Bar, Kamil Przyborowski, Bartosz Proniewski, Lukasz Mateuszuk, Agnieszka Jasztal, Anna Kieronska-Rudek, Brygida Marczyk, Karolina Matyjaszczyk-Gwarda, Anna Tworzydlo, Camilla Enggaard, Pernille B. Laerkegaard Hansen, Boye Jensen, Maria Walczak, Stefan Chlopicki
Summary: Inhibition of thrombin activity in Ang II-induced hypertension in mice improves the NO-dependent function of vascular endothelium and normalises the 20-HETE-dependent pathway without affecting blood pressure and vascular remodelling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Agnieszka Walkowska, Ludek Cervenka, John D. Imig, John R. Falck, Janusz Sadowski, Elzbieta Kompanowska-Jezierska
Summary: The study demonstrated that in spontaneously hypertensive rats, both EET-A and AAA induced renal vasodilation but did not show additive effects. Both agents have a definite therapeutic potential for hypertension and deserve further experimental and clinical testing for novel antihypertensive therapy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Rahele A. Farahani, Mohsen Afarideh, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Christopher M. Ferguson, Amir Lerman, Stephen C. Textor, Lilach O. Lerman, Alfonso Eirin
Summary: Percutaneous transluminal renal angioplasty (PTRA) may alleviate mitochondrial damage caused by renal artery stenosis and metabolic syndrome, improving renal function and reducing injury in the poststenotic kidney.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nirupama Ramkumar, Deborah Stuart, Caitlin S. Peterson, Chunyan Hu, William Wheatley, Jae Min Cho, J. David Symons, Donald E. Kohan
Summary: Loss of sPRR reduces baseline blood pressure, decreases Ang II-induced hypertension and renal injury, and is associated with greater endothelium-dependent vasorelaxation of resistance-sized arteries.
CIRCULATION RESEARCH
(2021)
Review
Biology
Lukasz Dobrek
Summary: Renal artery stenosis (RAS) is mainly caused by fibromuscular dysplasia or atherosclerosis, leading to various pathophysiological mechanisms like endothelin, resulting in kidney injury and chronic kidney disease.
Article
Radiology, Nuclear Medicine & Medical Imaging
Benny Drieghe, Gunther van Loon, Annelies Decloedt, Sabrina Stuyvaert, Marc L. De Buyzere, Thierry Bove, Tine De Backer
Summary: The study aimed to investigate the relationship between renal pressure-flow and renin release. The results demonstrated that in a unilateral graded renal artery stenosis animal model, a 25% decrease in distal renal perfusion pressure led to a significant decrease in renal flow, accompanied by upregulation of renin secretion.
ACADEMIC RADIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Supaporn Kulthinee, Adis Tasanarong, Martha Franco, Luis Gabriel Navar
Summary: In angiotensin II (Ang II)-dependent hypertension, both angiotensin II type 1 receptors (AT1R) and purinergic P2X receptors (P2XR) are involved in maintaining renal vasoconstriction. The interaction between AT1R and P2XR activation is regulated by the release of adenosine triphosphate (ATP). P2XR exerts a dominant influence that can abrogate the actions of AT1R on renal afferent arterioles in Ang II-dependent hypertension. This finding has important clinical implications for the treatment of kidney function impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Lin Zhao, Jinhong Xue, Yi Zhou, Xueqi Dong, Fang Luo, Xiongjing Jiang, Xinping Du, Xianliang Zhou, Xu Meng
Summary: A study found that the prevalence of coexisting primary aldosteronism (PA) and renal artery stenosis (RAS) among PA patients was 6.9%, with a higher prevalence of resistant hypertension in the severe RAS group. Treatment with standard methods significantly decreased the prevalence of resistant hypertension when both PA and RAS were treated.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Asmaa A. Ahmed, Shimaa K. Mohamed, Shahira Nofal, Engy M. El Morsy, Amany A. E. Ahmed
Summary: This study investigated the modulation of AMPK signaling pathways by bempedoic acid and its antihypertensive and antifibrotic effects in a rat model of hypertension. The results showed that bempedoic acid can activate the AMPK pathway, inhibit oxidative stress, reverse endoplasmic reticulum stress, and inhibit the ERK/TGF-β fibrotic pathway to maintain vascular integrity and prevent vascular remodeling.
Article
Surgery
Dawn M. Coleman, Amer Heider, David Gordon, Santhi K. Ganesh, Jonathan L. Eliason, James C. Stanley
Summary: This study examined 33 stenotic renal arteries from 28 children, with stenoses mainly occurring in the proximal-ostial renal arteries. Ostial stenoses commonly exhibited intimal tissue hyperplasia and elastic lamina disruptions, while central and distal stenoses often showed fibrodysplasia of the media and adventitia.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Shiju Ye, He Huang, Yun Xiao, Xue Han, Fengjie Shi, Wu Luo, Jiawen Chen, Yang Ye, Xia Zhao, Weijian Huang, Yi Wang, Dongwu Lai, Guang Liang, Guosheng Fu
Summary: Macrophage activation is essential in renal fibrosis and dysfunction in hypertensive chronic kidney disease. Dectin-1, a pattern recognition receptor, is involved in chronic noninfectious diseases. In this study, we found that Dectin-1 expression on CD68+ macrophages was elevated in the kidney after Ang II infusion. Using Dectin-1-deficient mice, we observed that renal dysfunction, interstitial fibrosis, and immune activation induced by Ang II were attenuated.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Peripheral Vascular Disease
Cesare Cuspidi, Marijana Tadic, Carla Sala, Fosca Quarti-Trevano, Elisa Gherbesi, Giuseppe Mancia, Guido Grassi
Summary: This meta-analysis indicates that renal artery revascularization combined with antihypertensive therapy has a positive impact on LV structure, leading to a decrease in LV mass index and a lower risk of LVH.
JOURNAL OF HYPERTENSION
(2021)
Article
Medicine, Research & Experimental
Nisita Chaihongsa, Putcharawipa Maneesai, Weerapon Sangartit, Siwayu Rattanakanokchai, Prapassorn Potue, Juthamas Khamseekaew, Sarawoot Bunbupha, Poungrat Pakdeechote
Summary: This study found that galangin can reduce blood pressure, cardiac dysfunction, and hypertrophy in hypertensive rats. It can also decrease the activity of angiotensin converting enzyme and the concentration of angiotensin II, and reduce the overexpression of certain proteins in cardiac tissue. Furthermore, galangin can attenuate kidney damage and oxidative stress, while increasing antioxidant enzyme activity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Iwona Baranowska, Olga Gawrys, Agnieszka Walkowska, Krzysztof H. Olszynski, Ludek Cervenka, John R. Falck, Adeniyi M. Adebesin, John D. Imig, Elzbieta Kompanowska-Jezierska
Summary: Numerous studies have shown that metabolites of arachidonic acid, specifically epoxyeicosatrienoic acids (EETs) and 20-Hydroxyeicosatetraenoic acid (20-HETE), play important roles in blood pressure regulation, vascular tone, and renal function control. In this study, the researchers tested the effectiveness of EET-A and AAA in treating spontaneously hypertensive rats (SHR) and found that the combination treatment not only reduced blood pressure but also increased nitric oxide levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Sara Consalvi, Giovanna Poce, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Paola Patrignani, Annalisa Bruno, Maurizio Anzini, Vincenzo Calderone, Alma Martelli, Lara Testai, Antonio Giordani, Mariangela Biava
Summary: This review discusses the rational for further studies of COX-2 inhibitors-NO releaser hybrids (NO-Coxibs) in the pharmacological treatment of airway inflammation in Cystic Fibrosis (CF), indicating that previous research results may provide suitable candidates for the treatment of CF.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Michele Bevilacqua, Paolo De Togni, Filippo Cattazzo, Davide Dell'Atti, Andrea Dalbeni, Fulvia Mazzaferri, Evelina Tacconelli, Afshin Farzaneh-Far, Cristiano Fava, Pietro Minuz, Simone Romano
Summary: Evidence shows that the cardiovascular system is involved in patients with COVID-19. Evaluating subclinical cardiac involvement is crucial for risk stratification. Left ventricular global longitudinal strain (LVGLS) can help identify high-risk patients and guide early treatment.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Filippo Cattazzo, Francesco Inglese, Andrea Dalbeni, Salvatore Piano, Martino Francesco Pengo, Martina Montagnana, Davide Dell'Atti, Francesco Soliani, Andrea Cascella, Stefano Vicini, Carmine Gambino, Pietro Minuz, Roberto Vettor, Gianfranco Parati, Paolo Angeli, Cristiano Fava
Summary: This study evaluated the performance of two non-invasive respiratory function indices in predicting a clinically relevant composite outcome in COVID-19 pneumonia patients. The ROX index and the SatO2/FiO2 ratio showed comparable accuracy to the traditional PaO2/FiO2 ratio in predicting intubation or death for patients admitted to medical wards.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Review
Cell Biology
Gianenrico Rovati, Annalisa Contursi, Annalisa Bruno, Stefania Tacconelli, Patrizia Ballerini, Paola Patrignani
Summary: Platelets play a crucial role in supporting metastasis through various mechanisms beyond their roles in hemostasis, leukocyte trafficking, and vessel stability. They interact directly with cancer cells to promote a disseminating phenotype and release molecules that drive metastatic signaling pathways in cancer cells. Agents affecting platelet activation could potentially inhibit these prometastatic mechanisms.
Review
Pharmacology & Pharmacy
Patrizia Ballerini, Annalisa Contursi, Annalisa Bruno, Matteo Mucci, Stefania Tacconelli, Paola Patrignani
Summary: Colorectal and hepatocellular carcinoma are associated with chronic inflammation, and there is a need for sensitive and specific noninvasive biomarkers for monitoring. Platelets play a role in intestinal and liver inflammation, and antiplatelet agents like Aspirin can reduce the incidence and mortality of these cancers. Platelet-mediated drug delivery systems could improve the efficacy and reduce the toxicity of anti-inflammatory agents.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Davide Serrano, Paola Patrignani, Vittoria Stigliano, Daniela Turchetti, Stefania Sciallero, Franco Roviello, Alessandro D'Arpino, Ignazio Grattagliano, Salvo Testa, Cristina Oliani, Lucio Bertario, Bernardo Bonanni
Summary: Cancer prevention in the era of precision medicine should consider integrated therapeutic approaches. Low-dose aspirin has been proven to reduce the risk of colorectal cancer in Lynch syndrome carriers and is recommended for CRC prevention.
Article
Endocrinology & Metabolism
Alice Giontella, Luca A. Lotta, Aris Baras, Pietro Minuz, Dipender Gill, Olle Melander, Cristiano Fava
Summary: This study found a direct association between genetically predicted calcium level and diastolic blood pressure, and a weaker association with systolic blood pressure. No clear association was found for genetically predicted calciotropic hormone levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Health Care Sciences & Services
Maria-Chiara Ambrosetti, Giulia Battocchio, Stefania Montemezzi, Filippo Cattazzo, Tissjana Bejko, Evelina Tacconelli, Pietro Minuz, Ernesto Crisafulli, Cristiano Fava, Giancarlo Mansueto
Summary: This study shows for the first time that COVID-19 patients have significantly enlarged segmental and subsegmental vessel calibers in the lungs, indicating distinct pathophysiology compared to other inflammatory and thromboembolic diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Annalisa Contursi, Rosa Fullone, Paulina Szklanna-Koszalinska, Simone Marcone, Paola Lanuti, Francesco Taus, Alessandra Meneguzzi, Giulia Turri, Melania Dovizio, Annalisa Bruno, Corrado Pedrazzani, Stefania Tacconelli, Marco Marchisio, Patrizia Ballerini, Pietro Minuz, Patricia Maguire, Paola Patrignani
Summary: This study aimed to investigate the release of EVs from activated platelets in CRC patients and healthy controls and their effect on gene expression and lipid mediator synthesis. The protein content of thrombin-stimulated mEVs was found to be modulated in CRC and could potentially serve as a noninvasive tool to discriminate patients from healthy subjects. Furthermore, the interaction between platelet mEVs and cancer cells may provide valuable prognostic information and aid in the development of targeted anticancer strategies.
Article
Endocrinology & Metabolism
Anita Morandi, Claudia Piona, Massimiliano Corradi, Marco Marigliano, Alice Giontella, Silvia Orsi, Federica Emiliani, Angela Tagetti, Denise Marcon, Cristiano Fava, Claudio Maffeis
Summary: This study aimed to assess the association between overall oxidative stress, oxidized lipoproteins, and glycemic variability with early macro-vascular damage in type 1 diabetes (T1D), in addition to traditional risk factors. The results showed that oxidative stress, gender, insulin dose, diabetes duration, and changes in lipids and blood pressure contributed to the variance of early vascular damage in young patients with T1D.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Oncology
Angel Lanas, Stefania Tacconelli, Annalisa Contursi, Elena Piazuelo, Annalisa Bruno, Maurizio Ronci, Simone Marcone, Melania Dovizio, Federico Sopena, Lorenza Falcone, Cristina Milillo, Matteo Mucci, Patrizia Ballerini, Paola Patrignani
Summary: This study conducted a clinical study on eight FAP patients treated with low-dose Aspirin, and found that although it appropriately inhibited platelet production, there was still high synthesis of TXA(2) and PGE(2) in normal colon tissues and adenomas, indicating the need for other treatment methods to block the effects of these substances.
Article
Medicine, General & Internal
Simone Romano, Denise Marcon, Lorella Branz, Angela Tagetti, Giada Monami, Alice Giontella, Francesca Malesani, Luca Pecoraro, Pietro Minuz, Milena Brugnara, Cristiano Fava
Summary: Subclinical cardiovascular damage, including increased RWT and high cIMT, is already present in children with ADPKD. RWT is significantly correlated with cDC and PWV, indicating an association between vascular stiffening and cardiac remodeling. It is noteworthy that subclinical cardiovascular damage may occur before a decline in glomerular filtration rate, even in the absence of renal function abnormalities.
MEDICINA-LITHUANIA
(2023)
Meeting Abstract
Peripheral Vascular Disease
Stefano Bortolotti, Angela Tagetti, Alice Giontella, Lorella Branz, Denise Marcon, Pietro Minuz, Franco Antoniazzi, Cristiano Fava
JOURNAL OF HYPERTENSION
(2021)