Review
Cell Biology
Jirong Lv, Xue Xiao, Mingxia Bi, Tingting Tang, Deao Kong, Meining Diao, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jiang
Summary: ATP-sensitive potassium channels (KATP channels) play a crucial role in linking the electrical activity of the cell membrane with cell metabolism. They have been found to be expressed in various cells and play important roles in neurodegenerative diseases. The KATP channel openers and inhibitors have protective effects on neurons by regulating neuronal excitability and neurotransmitter release, reducing abnormal protein aggregation and Ca2+ overload, and decreasing reactive oxygen species (ROS) production and microglia activation. However, KATP channels also exhibit dual effects in some cases.
AGEING RESEARCH REVIEWS
(2022)
Editorial Material
Plant Sciences
Guangyuan Xu, Xiangzong Meng, Daolong Dou
Summary: BIK1 plays a central role in plant immunity, with its ubiquitination state determining the strength of immune signaling.
TRENDS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Robin Frobom, Erik Berglund, Craig A. Aspinwall, Weng-Onn Lui, Inga-Lena Nilsson, Catharina Larsson, Robert Branstrom
Summary: The study investigated the effects of three clinically established TKIs (imatinib, sunitinib, nilotinib) on KATP channel activity, revealing that these drugs can decrease KATP channel activity by interacting with the ATP-binding site on the channel. This interaction may contribute to some of the side effects associated with TKIs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Editorial Material
Biochemistry & Molecular Biology
Marta Bjornson, Cyril Zipfel
Summary: Plant immunity has traditionally been divided into two tiers, but recent research shows that both cell-surface and intracellular immune receptors are needed for maximum immune response.
Article
Neurosciences
Paulo S. Strazza, Daniela V. F. de Siqueira, Ricardo M. Leao
Summary: Cartwheel neurons in the dorsal cochlear nucleus are glycinergic interneurons that provide inhibition to fusiform neurons. Most of these neurons exhibit spontaneous firing, while a small fraction are quiet neurons. The quiet neurons have an outward conductance sensitive to tolbutamide, while active neurons can be affected by the K-ATP agonist diazoxide. The role of K-ATP channels in controlling the spontaneous firing of these neurons is revealed.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Environmental Sciences
Benliang Deng, Jing Zhao, Yumeng Zhang, Yipu Fan, Shan Tian
Summary: The role of exogenous ATP in regulating antioxidant response and Cd accumulation in maize seedlings under heavy metal stress was investigated. The results showed that ATP alleviated Cd toxicity, enhanced antioxidant defense ability, and promoted Cd accumulation. This study provides new insights into enhancing heavy metal tolerance in plants through exogenous ATP application.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
Mark J. Specterman, Qadeer Aziz, Yiwen Li, Naomi A. Anderson, Leona Ojake, Keat-Eng Ng, Alison M. Thomas, Malcolm C. Finlay, Richard J. Schilling, Pier D. Lambiase, Andrew Tinker
Summary: This study investigated the effects of hypoxia on atrial electrophysiology in mice with global deletion of the K-ATP pore-forming subunits. The results showed that K-ATP blockade or absence resulted in atrial electrophysiological modifications at the cellular and tissue level. Furthermore, the global knockout of Kir6.2 prevented hypoxia-induced atrial path length shortening and arrhythmogenicity, suggesting a potential translational approach for treating ischemically driven atrial arrhythmia.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Iskra Cruz-Cruz, German Bernate-Obando, Carlos Larque, Rene Escalona, Rodolfo Pinto-Almazan, Myrian Velasco
Summary: Metabolic syndrome (MS) is a cluster of metabolic signs that increases the risk of developing type 2 diabetes and cardiovascular diseases. In the early stage of MS, a high-sugar diet can affect the pharmacological properties of K-ATP channels involved in insulin secretion.
Article
Endocrinology & Metabolism
Casey J. Bauchle, Kristen E. Rohli, Cierra K. Boyer, Vidhant Pal, Jonathan V. Rocheleau, Siming Liu, Yumi Imai, Eric B. Taylor, Samuel B. Stephens
Summary: This study demonstrates that mitochondrial CIC is not essential for glucose-stimulated insulin secretion, and there are additional complexities in the role of Idh1 and NADPH in regulating beta-cell function.
Article
Oncology
Evan K. Noch, Laura N. Palma, Isaiah Yim, Nayah Bullen, Yuqing Qiu, Hiranmayi Ravichandran, Junbum Kim, Andre Rendeiro, Melissa B. Davis, Olivier Elemento, David J. Pisapia, Kevin Zhai, Hongbiao Carl LeKaye, Jason A. Koutcher, Patrick Y. Wen, Keith L. Ligon, Lewis C. Cantley
Summary: This study investigated the critical role of insulin feedback in the poor clinical efficacy of phosphatidylinositol 3-kinase (PI3K) inhibition in cancer and the independent association between hyperglycemia and poor prognosis in glioblastoma (GBM). It was found that combining anti-hyperglycemic therapy with PI3K inhibition improved treatment efficacy in a GBM mouse model. Analysis of clinical trial data revealed that hyperglycemia was independently associated with poor progression-free survival in GBM patients.
Article
Multidisciplinary Sciences
Bo-Hyun Lee, Jose J. De Jesus Perez, Vera Moiseenkova-Bell, Tibor Rohacs
Summary: Long-chain acyl-Coenzyme A (LC-CoA) is an important signaling molecule that activates TRPV5 and TRPV6 ion channels. The researchers discovered that LC-CoA and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) have the same mechanism in maintaining channel activity. By utilizing cryo-electron microscopy, the authors determined the structure of LC-CoA-bound TRPV5, providing insights into the regulation of ion channels by metabolic signaling molecules.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Abidullahl, Shujaat Ahmadi, Niaz Ali, Feras Almarshad, Muhammad Nabi, Shafiq Ur Rahman, Shakir Ullah, Jahangir Khan, Haya Hussain, Syeda Hajira Bukhari
Summary: The study found that Moxifloxacin and Gemifloxacin exert their relaxant effects on isolated rabbits' jejunal preparations possibly through activation of ATP-sensitive potassium channels (K-ATP). They relaxed low potassium-induced contractions and had EC50 values of 2.83 and 1.11 µg/mL for spontaneous contractions.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Meng-Ting Wang, Hsueh-Yi Pan, Ya-Ling Huang, Li-Wei Wu, Pin-Chun Wang, Yu-Juei Hsu, Tzu-Chieh Lin, Chenwei Lin, Jyun-Heng Lai, Chien-Hsing Lee
Summary: In patients with type 2 diabetes receiving metformin, the use of high-affinity sulfonylureas for blocking mitoKATP channels is associated with an increased risk of major adverse cardiovascular events, myocardial infarction, all-cause mortality, and severe hypoglycemia compared to low-affinity sulfonylureas.
Review
Pharmacology & Pharmacy
Zhicheng Wang, Weikang Bian, Yufeng Yan, Dai-Min Zhang
Summary: ATP-sensitive potassium channels (K-ATP channels) play important roles in cellular excitability and metabolism. Activation of K-ATP channels can repolarize the membrane potential and reduce the occurrence of arrhythmias. Under severe and prolonged anoxia, K-ATP channels open to decrease cellular excitability and prevent action potential generation. Small active molecules can enhance the opening of K-ATP channels, leading to membrane repolarization and decreased malignant arrhythmias. Mutations in K-ATP channels worsen the regulatory roles in mutation-related diseases. However, efficient treatments for patients with K-ATP channel mutations are still lacking.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anja Hofmann, Frieda Frank, Steffen Wolk, Albert Busch, Anna Klimova, Pamela Sabarstinski, Michael Gerlach, Dmitry Egorov, Irakli Kopaliani, Sonke Weinert, Bianca Hamann, David M. Poitz, Coy Brunssen, Henning Morawietz, Katrin Schroder, Christian Reeps
Summary: The study found that low NOX4 mRNA expression is associated with an increased risk for symptomatic carotid artery stenosis and reduced plaque stabilizing mechanisms, suggesting protective effects of NOX4 in human advanced atherosclerosis.
Article
Anesthesiology
Keiko Hama-Tomioka, Hiroyuki Kinoshita, Toshiharu Azma, Katsutoshi Nakahata, Naoyuki Matsuda, Noboru Hatakeyama, Hirosato Kikuchi, Yoshio Hatano
ANESTHESIA AND ANALGESIA
(2009)
Article
Anesthesiology
Shinji Kawahito, Takashi Kawano, Hiroshi Kitahata, Jun Oto, Akira Takahashi, Kazumi Takaishi, Nagakatsu Harada, Tadahiko Nakagawa, Hiroyuki Kinoshita, Toshiharu Azma, Yutaka Nakaya, Shuzo Oshita
ANESTHESIA AND ANALGESIA
(2011)
Article
Anesthesiology
Hiroyuki Kinoshita, Naoyuki Matsuda, Hiroshi Iranami, Koji Ogawa, Noboru Hatakeyama, Toshiharu Azma, Shinji Kawahito, Mitsuaki Yamazaki
ANESTHESIA AND ANALGESIA
(2012)
Article
Anesthesiology
Masanori Haba, Hiroyuki Kinoshita, Naoyuki Matsuda, Toshiharu Azma, Keiko Hama-Tomioka, Noboru Hatakeyama, Mitsuaki Yamazaki, Yoshio Hatano
Article
Anesthesiology
K. Hama-Tomioka, H. Kinoshita, K. Nakahata, T. Kondo, T. Azma, S. Kawahito, N. Hatakeyama, N. Matsuda
BRITISH JOURNAL OF ANAESTHESIA
(2012)
Letter
Anesthesiology
Toshiyuki Minonishi, Hiroyuki Kinoshita, Kazuaki Tange, Noboru Hatakeyama, Naoyuki Matsuda, Toshiharu Azma, Yoshio Hatano
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2010)
Article
Pharmacology & Pharmacy
Toshiharu Azma, Florin Tuluc, Taishin Ito, Chikako Aoyama-Mani, Shinji Kawahito, Hiroyuki Kinoshita
CURRENT PHARMACEUTICAL DESIGN
(2014)
Article
Pharmacology & Pharmacy
Shinji Kawahito, Katsutoshi Nakahata, Toshiharu Azma, Yasuhiro Kuroda, David J. Cook, Hiroyuki Kinoshita
CURRENT PHARMACEUTICAL DESIGN
(2014)
Article
Anesthesiology
Toshiyuki Minonishi, Hiroyuki Kinoshita, Michiko Hirayama, Shinji Kawahito, Toshiharu Azma, Noboru Hatakeyama, Yoshihiro Fujiwara
JOURNAL OF CLINICAL ANESTHESIA
(2013)
Article
Pharmacology & Pharmacy
Masanori Haba, Noboru Hatakeyama, Hiroyuki Kinoshita, Hiroki Teramae, Toshiharu Azma, Yoshio Hatano, Naoyuki Matsuda
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2010)
Article
Cardiac & Cardiovascular Systems
Toshiharu Azma, Yuki Matsubara, Hiroyuki Kinoshita, Ikuhiro Hidaka, Seiji Shiraishi, Masakazu Nakao, Masashi Kawamoto, Osafumi Yuge, Yoshio Hatano
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2009)
Article
Cardiac & Cardiovascular Systems
Toshiharu Azma, Yuki Sugimoto, Hiroyuki Kinoshita, Taishin Ito, Masanori Tsukamoto, Hiroshi Hoshijima, Masakazu Nakao, Hirosato Kikuchi
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2012)
Article
Multidisciplinary Sciences
Hiroyuki Kinoshita, Kazushi Watanabe, Toshiharu Azma, Guo-Gang Feng, Takahiko Akahori, Hisaki Hayashi, Motohiko Sato, Yoshihiro Fujiwara, Akihiko Wakatsuki
Article
Medicine, Research & Experimental
Yoko Sakai, Shinji Kawahito, Kazumi Takaishi, Naoji Mita, Hiroyuki Kinoshita, Noboru Hatakeyama, Toshiharu Azma, Yutaka Nakaya, Hiroshi Kitahata
JOURNAL OF MEDICAL INVESTIGATION
(2014)