Article
Physiology
Andre L. Teixeira, Jordan B. B. Lee, Massimo Nardone, Jamie F. F. Burr, Philip J. J. Millar
Summary: The sympathetic nervous system plays a crucial role in cardiovascular regulation, particularly in response to acute stress. The relationship between renal and leg vasoconstriction at rest or during sympathetic stressors is not yet known. This study aimed to investigate the relationships between muscle sympathetic nerve activity (MSNA), leg vascular conductance (LVC), and renal vascular conductance (RVC) in young healthy adults, both at rest and during laboratory-based stressors. The findings revealed differential control of regional sympathetic vasoconstriction at rest and during stress in young healthy humans.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Marat Fudim, Piotr P. Ponikowski, Daniel Burkhoff, Mark E. Dunlap, Paul A. Sobotka, Jeroen Molinger, Manesh R. Patel, G. Michael Felker, Adrian F. Hernandez, Sheldon E. Litwin, Barry A. Borlaug, Anisha Bapna, Horst Sievert, Vivek Y. Reddy, Zoar J. Engelman, Sanjiv J. Shah
Summary: Volume recruitment from the splanchnic compartment is a crucial physiological response to stressors such as physical activity and blood loss. Excess fluid redistribution from this compartment in heart failure patients can lead to increased cardiac filling pressures and reduced exercise capacity. Blocking neural activity of the greater splanchnic nerve may provide significant benefits in some heart failure patients, but the long-term safety of splanchnic nerve modulation therapy remains unknown.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Peripheral Vascular Disease
Ailsa F. Ralph, Celine Grenier, Hannah M. Costello, Kevin Stewart, Jessica R. Ivy, Neeraj Dhaun, Matthew A. Bailey
Summary: High salt intake leads to hypertension, affecting renal and vascular function in C57BL6/J mice, with a rapid increase in blood pressure observed in male mice within 4 days of dietary switch. The high-salt diet also increases renal artery sensitivity and urinary excretion of adrenaline in these mice.
Review
Biochemistry & Molecular Biology
Alex Cleber Improta-Caria, Marcela Gordilho Aras, Luca Nascimento, Ricardo Augusto Leoni De Sousa, Roque Aras-Junior, Bruno Solano de Freitas Souza
Summary: MicroRNAs are small non-coding RNAs that regulate gene and protein expression, playing important roles in various cellular processes. In diseases such as hypertension, microRNAs are involved in regulating physiological processes, but the specific mechanisms need further study.
Article
Peripheral Vascular Disease
Seth W. Holwerda, Megan E. Gangwish, Rachel E. Luehrs, Virginia R. Nuckols, John P. Thyfault, John M. Miles, Gary L. Pierce
Summary: This study aimed to investigate the relationship between abdominal obesity and sympathetic nerve activity and blood pressure. The results showed that the transduction of sympathetic nerve activity to blood pressure was augmented in individuals with abdominal obesity and positively correlated with higher resting blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Yifei Zhu, Yuan Chu, Sheng Wang, Junjian Tang, Hu Li, Lei Feng, Fan Yu, Xin Ma
Summary: Smooth muscle cell TRPV4 plays a significant role in vascular contraction and blood pressure regulation, and its expression level may be associated with obesity. The study found that TRPV4(SMC) has different effects on vasomotor tone regulation compared to endothelial TRPV4, and the loss of TRPV4(SMC) can protect obese mice from vasoconstriction and hypertension.
Review
Endocrinology & Metabolism
Jacqueline K. Limberg, Rogerio N. Soares, Jaume Padilla
Summary: This review summarizes recent advances in understanding the role of the autonomic nervous system in controlling blood flow and blood pressure during hyperinsulinemia. It emphasizes the need for further exploration on the translation of findings to chronic conditions such as obesity, insulin resistance, and type 2 diabetes. The findings suggest that, in insulin-sensitive adults, increased muscle sympathetic nerve activity during hyperinsulinemia does not lead to greater sympathetic vasoconstriction in the peripheral circulation. Instead, the attenuated alpha-adrenergic receptor constriction and enhanced beta-adrenergic vasodilation likely explain the observed results. The increase in blood pressure in insulin-sensitive individuals is primarily supported by an increase in cardiac output, as there is no increase in sympathetically mediated restraint of peripheral vasodilation during hyperinsulinemia. These findings highlight the complex interplay between central and peripheral mechanisms in regulating sympathetic nervous system activity and maintaining blood pressure during hyperinsulinemia. Further exploration is needed to determine if these results are applicable to insulin-resistant conditions and their long-term implications for cardiovascular regulation.
CURRENT DIABETES REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Qin Tang, Qinhui Liu, Xuping Yang, Tong Wu, Cuiyuan Huang, Jinhang Zhang, Zijing Zhang, Guorong Zhang, Yingnan Zhao, Jian Zhou, Hui Huang, Yan Xia, Jiamin Yan, Yanping Li, Jinhan He
Summary: Overexpression of Sirt6 in hypothalamic POMC neurons exacerbates diet-induced obesity and metabolic disorders, leading to increased adiposity and decreased energy expenditure.
Article
Cardiac & Cardiovascular Systems
Andrew W. D'Souza, Sarah L. Hissen, Kazumasa Manabe, Ryosuke Takeda, Takuro Washio, Geoff B. Coombs, Belinda Sanchez, Qi Fu, J. Kevin Shoemaker
Summary: Sympathetic vascular transduction is attenuated in older adults compared to young adults, and there is an inverse relationship between the central and peripheral arcs of the baroreflex. Age and sex have independent and interactive effects on sympathetic vascular transduction and sympathetic neurohemodynamic balance in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yuhong Wang, Wanli Jiang, Hu Chen, Huixin Zhou, Zhihao Liu, Zihan Liu, Zhihao Liu, Yuyang Zhou, Xiaoya Zhou, Lilei Yu, Hong Jiang
Summary: Circadian disruption may facilitate cardiac remodeling after myocardial infarction by activating the sympathetic nervous system, leading to reduced cardiac function, increased left ventricular volume, and exacerbated cardiac fibrosis. Modulating sympathetic activity through designer receptors exclusively activated by designer drugs technique can alleviate the disruption-related cardiac dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Peripheral Vascular Disease
Baojian Xue, Alan Kim Johnson
Summary: Hypertension affects over 1 billion individuals worldwide, and the cause is largely unknown. Increased sympathetic nervous system activity is common in hypertensive patients, but the root cause is still unclear. Recent research has found that the neural network controlling sympathetic drive becomes more reactive after exposure to mild challenges, leading to a sensitized hypertensive response. Plasticity in the neural network and the involvement of various factors are necessary for the induction and maintenance of this state. This review discusses the induction and expression of this sensitized hypertensive response in adult animals and the offspring of mothers with prenatal obesity/overnutrition or maternal gestational hypertension, as well as interventions to reverse the effects of stressor-induced sensitization.
Article
Peripheral Vascular Disease
Yusuke Sata, Sandra L. Burke, Nina Eikelis, Anna M. D. Watson, Cindy Gueguen, Kristy L. Jackson, Gavin W. Lambert, Kyungjoon Lim, Kate M. Denton, Markus P. Schlaich, Geoffrey A. Head
Summary: Renal denervation, whether total or afferent, can effectively reduce hypertension and sympathetic activity in chronic kidney disease (CKD) rabbits, suggesting that renal afferents play a significant role in driving elevated blood pressure in this model.
Article
Chemistry, Analytical
Robert Chen-Hao Chang, Chia-Yu Wang, Wei-Ting Chen, Cheng-Di Chiu
Summary: Accidents caused by fatigue are common, and a drowsiness detection system is proposed to assess the driver's condition using heart rate variability and eyelid closure percentage. The system utilizes an algorithm to accurately and reliably determine the driver's state, and incorporates a near-infrared webcam for non-contact measurement.
Review
Immunology
Yumiko Mizuno, Yoshimitsu Nakanishi, Atsushi Kumanogoh
Summary: Upon exposure to external stressors, the body activates the sympathetic nervous system (SNS) to maintain homeostasis, which also regulates immune responses. Overactivation of the SNS can lead to inflammatory diseases. This review focuses on the role of semaphorins, axon guidance cues, in the crosstalk between the SNS and immune system.
INFLAMMATION AND REGENERATION
(2023)
Review
Medicine, General & Internal
Johannes Raphael Kupka, Keyvan Sagheb, Bilal Al-Nawas, Eik Schiegnitz
Summary: The sympathetic nervous system plays an important role in regulation mechanisms, including the fight-or-flight response and external stress processing. It also influences bone metabolism, which is crucial for dental implant success. This review summarizes the current literature on this topic and explores future research perspectives.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Abbi D. Lane-Cordova, Graziela Z. Kalil, Christopher J. Wagner, Amy L. Sindler, Jess G. Fiedorowicz, Tiwaloluwa Ajibewa, William G. Haynes, Gary L. Pierce
HYPERTENSION RESEARCH
(2018)
Article
Endocrinology & Metabolism
Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G. Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann
MOLECULAR METABOLISM
(2018)
Article
Multidisciplinary Sciences
Sophie Bauer, Charlotte Wennberg Huldt, Kajsa P. Kanebratt, Isabell Durieux, Daniela Gunne, Shalini Andersson, Lorna Ewart, William G. Haynes, Ilka Maschmeyer, Annika Winter, Carina Ammala, Uwe Marx, Tommy B. Andersson
SCIENTIFIC REPORTS
(2017)
Article
Endocrinology & Metabolism
Yan-Ling He, William Haynes, Charles D. Meyers, Ahmed Amer, Yiming Zhang, Ping Mahling, Anisha E. Mendonza, Shenglin Ma, William Chutkow, Eric Bachman
DIABETES OBESITY & METABOLISM
(2019)
Article
Endocrinology & Metabolism
Young Do Koo, Ji Seon Lee, Seung-Ah Lee, Paula G. F. Quaresma, Ratan Bhat, William G. Haynes, Young Joo Park, Young-Bum Kim, Sung Soo Chung, Kyong Soo Park
METABOLISM-CLINICAL AND EXPERIMENTAL
(2019)
Article
Endocrinology & Metabolism
Daniel Linden, Andrea Ahnmark, Piero Pingitore, Ester Ciociola, Ingela Ahlstedt, Anne-Christine Andreasson, Kavitha Sasidharan, Katja Madeyski-Bengtson, Magdalena Zurek, Rosellina M. Mancina, Anna Lindblom, Mikael Bjursell, Gerhard Bottcher, Marcus Stahlman, Mohammad Bohlooly-Y, William G. Haynes, Bjorn Carlsson, Mark Graham, Richard Lee, Sue Murray, Luca Valenti, Sanjay Bhanot, Peter Akerblad, Stefano Romeo
MOLECULAR METABOLISM
(2019)
Article
Medicine, General & Internal
Yangbo Sun, Buyun Liu, Jessica K. Smith, Marcelo L. G. Correia, Dana L. Jones, Zhanyong Zhu, Adeyinka Taiwo, Lisa L. Morselli, Katie Robinson, Alexander A. Hart, Linda G. Snetselaar, Wei Bao
Article
Endocrinology & Metabolism
Ville Karhunen, Iyas Daghlas, Verena Zuber, Marijana Vujkovic, Anette K. Olsen, Lotte Bjerre Knudsen, William G. Haynes, Joanna M. M. Howson, Dipender Gill
Summary: By leveraging human genetic data, this study found that GIP signaling plays a beneficial role in improving cardiometabolic health, with genetic associations at GIP and GIPR genes in relation to type 2 diabetes liability co-localizing with some cardiometabolic outcomes. Mendelian randomisation analyses further supported the association of genetically proxied GIP signaling with improved metabolic outcomes.
Review
Peripheral Vascular Disease
Elham Shams, Vijayvardhan Kamalumpundi, Joshua Peterson, Ronaldo Altenburg Gismondi, Wille Oigman, Marcelo Lima de Gusmao Correia
Summary: The prevalence of obesity has increased significantly from 1975 to 2015, with a strong link to hypertension. Excessive weight gain, especially when associated with visceral fat accumulation, accounts for a substantial portion of the risk of developing hypertension. Exercise and bariatric/metabolic surgery can lower blood pressure, while weight gain increases it, establishing a clear connection between these two factors. The mechanisms underlying obesity-related hypertension are complex and multifaceted.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Review
Endocrinology & Metabolism
Grant J. Herrington, Joshua J. Peterson, Linhai Cheng, Benjamin M. Allington, Renato D. Jensen, Heather S. Healy, Marcelo L. G. Correia
Summary: This scoping review synthesizes existing research on the use of very low-calorie diets (VLCDs) in subjects with nonalcoholic fatty liver disease (NAFLD) and end-stage liver disease (ESLD). The findings suggest that treatment based on VLCD in subjects with NAFLD seems to be safe and tolerable, but may result in mild adverse effects. Overall, VLCD may be effective in inducing weight loss and acutely reducing hepatosteatosis in patients with obesity complicated with NAFLD and potentially in ESLD.
OBESITY SCIENCE & PRACTICE
(2022)
Article
Surgery
Alexander Hart, Yangbo Sun, Tyler J. Titcomb, Buyun Liu, Jessica K. Smith, Marcelo L. G. Correia, Linda G. Snetselaar, Zhanyong Zhu, Wei Bao
Summary: The study found that preoperative hypoalbuminemia is associated with negative 30-day postoperative outcomes of bariatric surgery, with severe hypoalbuminemia showing worse outcomes compared to marginal hypoalbuminemia.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Editorial Material
Peripheral Vascular Disease
Linhai Cheng, Marcelo Lima de Gusmao Correia
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Correction
Pharmacology & Pharmacy
Vijayvardhan Kamalumpundi, Elham Shams, Cally Tucker, Linhai Cheng, Joshua Peterson, Sanmati Thangavel, Oloigbe Ofori, Marcelo Correia
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Vijayvardhan Kamalumpundi, Elham Shams, Cally Tucker, Linhai Cheng, Joshua Peterson, Sanmati Thangavel, Oloigbe Ofori, Marcelo Correia
Summary: Type 2 diabetes often overlaps with hypertension due to genetic, physiological, and environmental factors. There are several metabolic abnormalities that contribute to the coexistence. While diet and exercise are early treatment options, long-term strategies are needed. Novel medications can prevent long-term complications. Understanding the common causes and consequences allows for proactive prevention and treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Elham Shams, Vijayvardhan Kamalumpundi, Linhai Cheng, Adeyinka Taiwo, Amal Shibli-Rahhal, Ayotunde O. Dokun, Marcelo L. G. Correia
Summary: A study found that COVID-19 patients with overweight/obesity-related hypertension who were prescribed ARB/ACEI before admission to the hospital had lower mortality and less severe COVID-19 compared to those who were not taking ARB/ACEI.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)