Article
Multidisciplinary Sciences
Richard Perryman, Alexander Renziehausen, Hamidreza Shaye, Androniki D. Kostagianni, Antonis D. Tsiailanis, Thomas Thorne, Maria Chatziathanasiadou, Gregory B. Sivolapenko, Mohamed Ahmed El Mubarak, Gye Won Han, Barbara Zarzycka, Vsevolod Katritch, Guillaume Lebon, Cristiana Lo Nigro, Laura Lattanzio, Sophie Morse, James J. Choi, Kevin O'Neill, Zoi Kanaki, Apostolos Klinakis, Tim Crook, Vadim Cherezov, Andreas G. Tzakos, Nelofer Syed
Summary: This study reveals that AT(2)R is a therapeutic target for GBM and AngII promotes proliferation through this receptor. EMA401 and its derivative A3E can inhibit the proliferation and invasiveness of GBM, and show enhanced penetration in the CNS.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Letter
Medicine, General & Internal
Robert C. Speth
Summary: The article does not differentiate between ACE inhibitor therapy and ARB therapy in advanced CKD. The mechanisms of action of ACE inhibitors and ARBs differ substantially, with varying effects on renal function.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Hematology
Jeff Z. Chen, Hisashi Sawada, Dien Ye, Yuriko Katsumata, Masayoshi Kukida, Satoko Ohno-Urabe, Jessica J. Moorleghen, Michael K. Franklin, Deborah A. Howatt, Mary B. Sheppard, Adam E. Mullick, Hong S. Lu, Alan Daugherty
Summary: Deletion of AT1aR and inhibition of Ang II production had similar effects in attenuating pathologies in the proximal thoracic aorta of male Fbn1(C1041G/+) mice. Inhibition of the renin-angiotensin system attenuated dysregulation of genes within the aorta related to pathology of Fbn1(C1041G/+) mice.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shuang Zheng, Weijiang Tan, Xiang Li, Lijing Wang, Caiyi Zhu, W. Glen Pyle, Jianxin Chen, Jian Wu, Xuecong Ren, Honghua Chen, Yunzeng Zou, Peter H. Backx, Feng Hua Yang
Summary: This study investigates the protective effects of n-3 polyunsaturated fatty acids (PUFAs) on cardiac ischemia-reperfusion (IR) injury and the underlying regulatory mechanisms. The results show that n-3 PUFAs can protect against post-IR injury and preserve cardiac contractile function through the inhibition of APLNR. This inhibition synchronizes the PI3K-AKT-mTOR axis, suppresses detrimental phosphorylation signaling, and restores or increases myofilament phosphorylation in post-IR hearts.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Maksymilian Ziaja, Kinga Anna Urbanek, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The renin-angiotensin system (RAS) is not only involved in regulating cardiovascular function, but also plays a complex role in various processes such as memory and cancer. Maintaining the balance between individual elements of the RAS system is crucial for achieving homeostasis, and any disturbance in their expression or activity can lead to pathological processes.
Article
Pharmacology & Pharmacy
Daniel Fernandes, Leticia Kramer Pacheco, Regina Sordi, Karin Scheschowitsch, Gustavo Campos Ramos, Jamil Assreuy
Summary: A study found that early and partial blockade of the AT 1 receptor with a low dose of losartan can counteract sepsis-induced refractoriness to vasoconstrictors, providing an opportunity to improve the outcome of this condition.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Daniel E. Leisman, Jamie R. Privratsky, Jake R. Lehman, Mabel N. Abraham, Omar Y. Yaipan, Mariana R. Brewer, Ana Nedeljkovic-Kurepa, Christine C. Capone, Tiago D. Fernandes, Robert Griffiths, William J. Stein, Marcia B. Goldberg, Steven D. Crowley, Rinaldo Bellomo, Clifford S. Deutschman, Matthew D. Taylor
Summary: Angiotensin-II treatment in sepsis can enhance the innate immune response and reduce bacterial infection, making it a potential treatment to augment immune responses in sepsis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Endocrinology & Metabolism
Yuanyuan Liu, Haomeng Hao, Tingting Lan, Rui Jia, Mingya Cao, Liang Zhou, Zhiming Zhao, Wensen Pan
Summary: The local Renin-Angiotensin System (RAS) plays a role in the female reproductive system, regulating follicle development and physiological functions of the placenta and uterus. Ang II and Ang-(1-7) have similar functions in this system and can influence the occurrence and development of diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Moudhi Almutlaq, Fatmah A. Mansour, Jahad Alghamdi, Yassen Alhendi, Abir Abdullah Alamro, Amani Ahmed Alghamdi, Hassan S. Alamri, Fayhan Alroqi, Tlili Barhoumi
Summary: This study demonstrates that angiotensin II (Ang II) exacerbates the T-cell response to SARS-CoV-2 in recovered COVID-19 patients. The presence of Ang II increases the phosphorylation levels of proteins involved in cardiovascular diseases, inflammation, and viral infection. These findings suggest that Ang II may worsen the inflammatory response and alter the immune response to a more inflammatory profile against SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Amanda da Silva Chaves, Nathalia Santos Magalhaes, Daniella Bianchi Reis Insuela, Patricia Machado Rodrigues E Silva, Marco Aurelio Martins, Vinicius Frias Carvalho
Summary: This study investigates the role of the renin-angiotensin system (RAS) in the overproduction of corticosterone in diabetic mice. The results suggest that inhibition of angiotensin synthesis and AT(1) receptor activity can reduce corticosterone levels in diabetic mice. Furthermore, the protective effect of Olmesartan on corticosterone overproduction in diabetic mice depends on both AT(1) receptor blockade and AT(2) receptor activation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Plant Sciences
Yan Wu, Xin Yang, Yuanyuan Ju, Fei Zhao
Summary: This study found that fraxinol has significant therapeutic effects in the treatment of acute lung injury (ALI). It works by balancing the ACE-Ang II-AT1R and ACE2-Ang (1-7)-Mas axis and inhibiting the activation of NLRP3 inflammasome.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dominga Lapi, Maurizio Cammalleri, Massimo Dal Monte, Martina Di Maro, Mariarosaria Santillo, Anna Belfiore, Gilda Nasti, Simona Damiano, Rossella Trio, Martina Chiurazzi, Barbara De Conno, Nicola Serao, Paolo Mondola, Antonio Colantuoni, Bruna Guida
Summary: The study found that Ang II and Ang 1-7 trigger different mechanisms through different receptors to affect cerebral microvascular injury in rats. Ang II exacerbates damage, while Ang 1-7 protects the microcirculation and can be regulated by specific receptor antagonists and activators.
Article
Peripheral Vascular Disease
Yuchen Shen, Zhenfeng Wang, Lixin Su, Lianzhou Zheng, Yifeng Han, Xiaohui Jiao, Xindong Fan, Deming Wang
Summary: This study aimed to investigate the preventive effect of losartan on acute elevation of pulmonary arterial pressure (AEPAP) induced by endovascular ethanol injection and explore its underlying mechanisms. The results showed that losartan failed to completely inhibit AEPAP and only partially reversed ethanol-induced pulmonary artery remodeling. The elevation of AEPAP was mainly caused by the activation of the renin-angiotensin system (RAS) and P38 MAPK signaling. Losartan partially prevented AEPAP and vascular remodeling by promoting NADPH oxidase (NOX) activity, which was independent of RAS.
HYPERTENSION RESEARCH
(2023)
Article
Biology
Ehsan Tabatabai, Majid Khazaei, Fereshteh Asgharzadeh, Seyedeh Elnaz Nazari, Neda Shakour, Hamid Fiuji, Aghigh Ziaeemehr, Asma Mostafapour, Mohammad Reza Parizadeh, Mohammad Nouri, Seyed Mahdi Hassanian, Farzin Hadizadeh, Gordon A. Ferns, Mohammad Rahmati, Farzad Rahmani, Amir Avan
Summary: Colorectal cancer is a significant cause of cancer-related mortality, and aberrant activation of the renin-angiotensin system has been linked to poor clinical outcomes in CRC patients. This study investigated the anti-tumor effects of the angiotensin receptor blocker Candesartan, either alone or in combination with 5-FU, in CRC models. Candesartan suppressed tumor cell proliferation and migration by modulating various genes and markers, and its combination with 5-FU reduced tumor growth by inhibiting fibrosis and inducing oxidative stress.
Article
Biochemistry & Molecular Biology
Xiuying Liang, Haijing Guan, Jingwen Sun, Yan Qi, Wenjuan Yao
Summary: This study identified novel proteins associated with Ang II infusion and showed that Ang II could regulate lipid metabolism, transportation, and adipocyte differentiation in PVAT. Key pathways involved fatty acid biosynthesis and various protein signaling cascades. These findings provide insights into the relationship between local RAS activation and PVAT dysfunction.
Article
Peripheral Vascular Disease
Till Schuette, Sarah M. Kedziora, Nadine Haase, Florian Herse, Andreas Busjahn, Anna Birukov, Natalia Alenina, Dominik N. Mueller, Michael Bader, Michael Schupp, Ralf Dechend, Kristin Kraeker, Michaela Golic
Summary: A study conducted on a rat model found that maternal diabetes during pregnancy without obesity did not have a negative impact on the metabolic health of male offspring. There were no significant differences in blood glucose control between offspring exposed to maternal hyperglycemia and those from control pregnancies. Intrauterine exposure to hyperglycemia and hyperinsulinemia without obesity did not lead to fetal programming of diabetes and obesity in this particular model.
Article
Cardiac & Cardiovascular Systems
Ellen G. Avery, Hendrik Bartolomaeus, Andras Maifeld, Lajos Marko, Helge Wiig, Nicola Wilck, Stephan P. Rosshart, Sofia K. Forslund, Dominik N. Mueller
Summary: The pathogenesis of hypertension involves multiple factors including genetic, environmental, hormonal, hemodynamic, and inflammatory forces. There is increasing evidence that the gut microbiome plays a significant role in hypertension. Lifestyle factors such as dietary fiber consumption and fasting can impact hypertension through modulation of the microbiome.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sarah M. Kedziora, Kristin Kraker, Lajos Marko, Julia Binder, Meryam Sugulle, Martin Gauster, Dominik N. Muller, Ralf Dechend, Nadine Haase, Florian Herse
Summary: Preeclampsia is associated with renal injuries during pregnancy, but most of these pathologies often recover postpartum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Gemma Chiva-Blanch, Dominik N. Mueller
CARDIOVASCULAR RESEARCH
(2021)
Article
Endocrinology & Metabolism
Till Schuette, Sarah M. Kedziora, Nadine Haase, Florian Herse, Natalia Alenina, Dominik N. Mueller, Michael Bader, Michael Schupp, Ralf Dechend, Michaela Golic, Kristin Kraeker
Summary: Research revealed that diabetic pregnancy affects the cardiac health of rat offspring, particularly under high-fat diet conditions. Offspring of diabetic pregnancies showed cardiac dysfunction and changes in cardiomyocytes after consuming a high-fat diet, highlighting the importance of diet in the development of heart dysfunction in offspring of diabetic pregnancies.
Article
Biochemistry & Molecular Biology
Talita Guerreiro Rodrigues Hungaro, Marcos F. Gregnani, Thais Alves-Silva, Florian Herse, Natalia Alenina, Michael Bader, Ronaldo C. Araujo
Summary: During pregnancy, changes in cortisol levels can have significant effects on trophoblastic cells and the development of the embryo. Continuous and intermittent exposure to cortisol both repressed the expression of inflammatory genes, but only continuous exposure repressed the expression of angiogenic genes, indicating that sustained increase in cortisol levels may be more harmful than short-term increases.
Letter
Peripheral Vascular Disease
Lajos Marko, Anne Dorr, Peter Linz, Anton H. van den Meiracker, Ingrid M. Garrelds, Titus Kuehne, Ralf Dechend, A. H. Jan Danser, Anne Floercken, Dominik N. Mueller
Editorial Material
Cardiac & Cardiovascular Systems
Friedrich C. Luft
EUROPEAN HEART JOURNAL
(2022)
Correction
Multidisciplinary Sciences
Julia Schewe, Eric Seidel, Sofia Forslund, Lajos Marko, Jorg Peters, Dominik N. Muller, Christoph Fahlke, Gabriel Stolting, Ute Scholl
NATURE COMMUNICATIONS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Friedrich C. Luft
Article
Peripheral Vascular Disease
Irene Matre Thowsen, Tore Reikvam, Trude Skogstrand, Anne-Maj Samuelsson, Dominik N. Muller, Olav Tenstad, Kari Alitalo, Tine Karlsen, Helge Wiig
Summary: Our results suggest that dermal lymphatic vessels are not involved in salt storage or blood pressure regulation in these mouse models of salt-sensitive hypertension.
Article
Biochemistry & Molecular Biology
Sarah M. Kedziora, Benedikt Obermayer, Meryam Sugulle, Florian Herse, Kristin Kraeker, Nadine Haase, Immaculate M. Langmia, Dominik N. Muller, Anne Cathrine Staff, Dieter Beule, Ralf Dechend
Summary: The placenta is a temporary organ with a unique structure and function to ensure healthy fetal development. Placental dysfunction caused by diabetes affects placental metabolism, inflammation, and weight, but the main driver of gene expression differences in the placenta is fetal sex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Anne-Maj Samuelsson, Theda Ulrike Patricia Bartolomaeus, Harithaa Anandakumar, Irene Thowsen, Elham Nikpey, Jianhua Han, Lajos Marko, Kenneth Finne, Olav Tenstad, Johannes Eckstein, Nikolaus Berndt, Titus Kuehne, Sarah Kedziora, Ibrahim Sultan, Trude Skogstrand, Tine Karlsen, Harri Nurmi, Sofia K. Forslund, Entela Bollano, Kari Alitalo, Dominik N. Muller, Helge Wiig
Summary: This study investigates the role of VEGF-B in cardiac proteomic and metabolic adaptation in heart failure, and finds that VEGF-B TG accelerates metabolic maladaptation, leading to structural cardiomyopathy and systolic heart failure.
CARDIOVASCULAR RESEARCH
(2023)