Article
Physiology
Nancy J. Hong, Agustin Gonzalez-Vicente, Fara Saez, Jeffrey L. Garvin
Summary: The study showed that impaired flow-induced NO production in the thick ascending limbs of Dahl salt-sensitive rats is mainly due to NOS3 uncoupling and diminished NOS3 expression, rather than simple scavenging. The difference between strains was enhanced on a high-salt diet, further elucidating the pathogenesis of salt-sensitive hypertension.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Anna D. Manis, Oleg Palygin, Elena Isaeva, Vladislav Levchenko, Peter S. LaViolette, Tengis S. Pavlov, Matthew R. Hodges, Alexander Staruschenko
Summary: The K(ir)5.1 channel plays a crucial role in the brain, and its knockout leads to seizures and mortality. SSKcnj16-/- rats showed increased light sensitivity and reproducible audiogenic seizures, highlighting a distinct role for K(ir)5.1 channels in the brain.
Article
Biochemistry & Molecular Biology
Kathleen Lukaszewicz, John R. R. Falck, Julian Lombard
Summary: In Dahl salt-sensitive rats, impaired vascular relaxation can be restored by restoring physiological levels of angiotensin II, inhibiting 20-HETE production, or introducing a normally functioning renin allele. However, chronically low angiotensin II levels in SS rats were found to upregulate cytochrome P450-4A and increase the production of the vasoconstrictor 20-HETE. The renin-angiotensin system and the CYP4A/20-HETE pathway both contribute to vascular dysfunction in the Dahl SS rat, but they are independent of each other.
Article
Chemistry, Multidisciplinary
Xilan Li, Yun Liu, Xiaowei Qi, Shilin Xiao, Zhongsheng Xu, Zhixian Yuan, Qi Liu, Haisheng Li, Siyuan Ma, Tengfei Liu, Yong Huang, Xiaorong Zhang, Xiao Zhang, Zhengwei Mao, Gaoxing Luo, Jun Deng
Summary: A novel nanotheranostic agent, TMSN@PM, coated with platelet membrane and mesoporous silica nanoparticles, was developed for targeted imaging and treatment of inflammatory diseases. The agent can scavenge excess reactive oxygen species and enhance magnetic resonance imaging under inflammatory conditions. This non-invasive imaging-based strategy provides early prediction of therapeutic outcomes in inflammatory therapy.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Usman M. Ashraf, Blair Mell, Pedro A. Jose, Sivarajan Kumarasamy
Summary: Disruption of the Resp18 gene in the SS rat is associated with symptoms such as hypertension and renal fibrosis, as well as altered renal transcriptomic response to high salt diet. RNA sequencing and qRT-PCR confirmed the upregulation of renal Ren in Resp18(mutant) rats, indicating a significant increase in circulating renin activity after 7 days on high salt diet.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Luiz F. Ferrari, Charles Rey, Anna Ramirez, Adam Dziuba, Jacqueline Zickella, Michael Zickella, Hershel Raff, Norman E. Taylor
Summary: Animal models are important for studying chronic pain disorders and new therapies. However, current models lack the ability to accurately predict the effectiveness of new drugs. This study identifies the Dahl salt-sensitive rat strain as the first rodent model of inherited widespread hyperalgesia. The model exhibits physiological phenotypes related to chronic pain and can be used to identify biomarkers for diagnosis and treatment.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Multidisciplinary
Li Zeng, Zerong Liu, Luxin Zhou, Meng Chen, Xuewei Zheng, Pengfei Yang, Xinrui Zhao, Zhongmin Tian
Summary: The study found that protein-rich almond supplementation can prevent salt-induced hypertension by regulating amino acid metabolism, increasing nitric oxide content, and alleviating oxidative stress.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Multidisciplinary Sciences
Smriti Murali Krishna, Jiaze Li, Yutang Wang, Corey S. Moran, Alexandra Trollope, Pacific Huynh, Roby Jose, Erik Biros, Jianxing Ma, Jonathan Golledge
Summary: In this study, the role of KAL in inhibiting the development of AAA through reducing inflammation, oxidative stress, and vascular smooth muscle cell apoptosis was investigated using experimental mouse models and patient studies. The results suggest that upregulating KAL may be a novel therapeutic strategy for AAA by limiting aortic wall remodeling and aneurysm development through reductions in oxidative stress and vascular smooth muscle cell apoptosis.
SCIENTIFIC REPORTS
(2021)
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Integrative & Complementary Medicine
Jiye Chen, Yongjian Zhang, Yongcheng Wang, Ping Jiang, Guofeng Zhou, Zhaoyu Li, Jinlong Yang, Xiao Li
Summary: This study revealed that the potential mechanisms and therapeutic effects of Guizhi decoction on hypertension may be attributed to the regulation of cardiac inflammation and fibrosis.
Article
Biochemistry & Molecular Biology
Shengwei Li, Zhibing Li, Ran Yin, Jungang Nie, Yongnan Fu, Ru Ying
Summary: The study showed that DUOX1-induced ROS production and pyroptosis play a crucial role in the development of cardiac fibrosis, with high levels of ROS and pyroptosis being associated with cardiac fibrosis. Interventions targeting DUOX1 can effectively inhibit the development of fibrosis in cardiomyocytes.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Nutrition & Dietetics
Ryoya Kawata, Yuji Hotta, Kotomi Maeda, Tomoya Kataoka, Kazunori Kimura
Summary: High salt intake may lead to urinary storage symptoms through abnormalities in detrusor muscle contraction and enhanced cholinergic signals. Excessive salt intake should be avoided to preserve bladder function.
Article
Pharmacology & Pharmacy
Lili He, Sai Ma, Qingjuan Zuo, Guorui Zhang, Zhongli Wang, Tingting Zhang, Jianlong Zhai, Yifang Guo
Summary: This study investigated the protective effect of canagliflozin on myocardial metabolism and heart under stress overload. Canagliflozin showed improvement in cardiac hypertrophy, fibrosis, and left ventricular diastolic dysfunction induced by hypertension. The activation of the AMPK/SIRT1/PGC-1α pathway by canagliflozin was suggested to regulate energy metabolism and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jeanne A. Ishimwe, Melanie B. Baker, Michael R. Garrett, Jennifer M. Sasser
Summary: This study investigated the use of 1,3-butanediol in preventing preeclampsia in a rat model. The results showed that 1,3-butanediol significantly lowered blood pressure and improved uterine artery resistance in treated dams, with no adverse fetal effects observed. Physiological ketosis via 1,3-butanediol may be a potential therapeutic approach for managing hypertension and mitigating adverse pregnancy outcomes.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Physiology
Ubong S. Ekperikpe, Sautan Mandal, Stephen J. Holt, Jacori K. Daniels, Tyler D. Johnson, Jonita S. Cooper, Sarah M. Safir, Denise C. Cornelius, Jan M. Williams
Summary: Childhood/prepubertal obesity is a public health concern and a major risk factor for renal injury. This study examines the relationship between insulin resistance and renal injury in obese children and explores the potential therapeutic use of metformin in managing renal injury during prepubertal obesity.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)