Article
Medicine, General & Internal
Ping Liu, Rob R. Quinn, Ngan N. Lam, Huda Al-Wahsh, Manish M. Sood, Navdeep Tangri, Marcello Tonelli, Pietro Ravani
Summary: This study found that with advancing age, CKD regression and death were more likely than CKD progression or kidney failure. These findings have important implications for patient care and for assessing the potential effect of population aging on the burden of CKD.
Article
Medicine, General & Internal
Maggie Wang, Samson S. Peter, Chi D. Chu, Delphine S. Tuot, Jonathan H. Chen
Summary: The findings of this study suggest that nearly half of patients with CKD at high risk of progressing to kidney failure do not have a nephrologist visit within 1 year of established risk.
Article
Transplantation
Yuko Katayama, Jun Sugama, Tomohisa Suzuki, Yoshimasa Ishimura, Akihiro Kobayashi, Yusuke Moritoh, Masanori Watanabe
Summary: The study found that the enteropeptidase inhibitor SCO-792 had significant therapeutic effects on chronic kidney disease in rats, preventing declines in glomerular filtration rate, albuminuria, and kidney fibrosis. Furthermore, it increased hydrogen sulphide production capacity, suggesting potential for CKD treatment.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Raphaelle Corremans, Patrick C. D'Haese, Benjamin A. Vervaet, Anja Verhulst
Summary: The study successfully developed a rat model of DKD by combining STZ/NAD and oral L-NAME, inducing diabetes, hypertension, and characteristic features of DKD, providing a new animal model for DKD research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wataru Fujii, Shigeru Shibata
Summary: This article reviews the extensive research conducted over the past 80 years on the regulation and action of the mineralocorticoid receptor (MR). It highlights the role of MR and the steroid hormone aldosterone in integrating responses of tubular cells and maintaining fluid homeostasis, as well as their dysregulation in kidney diseases. Experimental studies have shown the pathological consequences of MR overactivity and the mechanisms of enhanced MR signaling, while clinical studies have demonstrated the renoprotective effects of MR blockade. The article also discusses future areas of investigation, including the use of non-steroidal MR antagonists in non-diabetic kidney disease patients and the search for downstream mediators of renoprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Hye-Yeon Kim, Sun-Seog Kweon, Young-Hoon Lee, So-Yeon Ryu, Hae-Sung Nam, Min-Ho Shin, Kyeong-Soo Park, Seong-Woo Choi
Summary: The study found independent associations between estimated glomerular filtration rate (eGFR) and albumin to creatinine ratio (ACR) with all-cause and cardiovascular mortality in Korean adults aged >= 50 years. When comparing eGFR performance, eGFR(cys) showed superior predictive accuracy for all-cause mortality compared to eGFR(MDRD) and eGFR(CKD-EPI).
Article
Engineering, Biomedical
Kang Zhang, Xiaohong Liu, Jie Xu, Jin Yuan, Wenjia Cai, Ting Chen, Kai Wang, Yuanxu Gao, Sheng Nie, Xiaodong Xu, Xiaoqi Qin, Yuandong Su, Wenqin Xu, Andrea Olvera, Kanmin Xue, Zhihuan Li, Meixia Zhang, Xiaoxi Zeng, Charlotte L. Zhang, Oulan Li, Edward E. Zhang, Jie Zhu, Yiming Xu, Daniel Kermany, Kaixin Zhou, Ying Pan, Shaoyun Li, Iat Fan Lai, Ying Chi, Changuang Wang, Michelle Pei, Guangxi Zang, Qi Zhang, Johnson Lau, Dennis Lam, Xiaoguang Zou, Aizezi Wumaier, Jianquan Wang, Yin Shen, Fan Fan Hou, Ping Zhang, Tao Xu, Yong Zhou, Guangyu Wang
Summary: Deep-learning models trained on retinal fundus images can accurately identify chronic kidney disease and type 2 diabetes, as well as predict disease progression risk. These models demonstrate high accuracy in training and validation, providing reliable predictions for blood glucose and glomerular filtration rate.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Environmental Sciences
Habyeong Kang, Jung Pyo Lee, Kyungho Choi
Summary: Exposure to consumer chemicals has been found to have inconsistent associations with estimated glomerular filtration rate (eGFR) when adjusted by different methods, but novel covariate-adjusted creatinine standardization revealed significant inverse associations. Phthalate metabolites, DEHP, and BPA were identified as major drivers of the association with eGFR or ACR in mixture exposure models using weighted quantile sum regression. The study suggests that exposure to specific chemicals may lead to declined eGFR and increased ACR in the general adult population.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Tarak Srivastava, Robert E. Garola, Jianping Zhou, Varun C. Boinpelly, Lakshmi Priya, Mohammed Farhan Ali, Mohammad H. Rezaiekhaligh, Daniel P. Heruth, Jan Novak, Uri S. Alon, Trupti Joshi, Yuexu Jiang, Ellen T. McCarthy, Virginia J. Savin, Mark L. Johnson, Ram Sharma, Mukut Sharma
Summary: Increased fluid-flow shear stress can contribute to the progression of chronic kidney disease. Modulating the expression of EP2 and EP4 receptors, as well as their signaling pathways, may provide a novel approach to mitigate kidney injury.
Article
Biochemistry & Molecular Biology
Ramzi Khalil, Margien G. S. Boels, Palga Group, Bernard M. van den Berg, Jan A. Bruijn, Ton J. Rabelink, Pancras C. W. Hogendoorn, Hans J. Baelde
Summary: This study investigates the effect of heterozygous germline mutations in the EXT1 and EXT2 genes on the glomerular barrier function and the endothelial glycocalyx in humans. The results show that these mutations do not lead to (micro)albuminuria, specific renal phenotype or changes to the endothelial glycocalyx in humans. These findings contribute to the understanding of the role of EXT1 and EXT2 genes in pathophysiology.
MOLECULAR GENETICS AND GENOMICS
(2022)
Article
Environmental Sciences
Maria Grau-Perez, Arce Domingo-Relloso, Tamara Garcia-Barrera, Jose L. Gomez-Ariza, Montserrat Leon-Latre, Belen Moreno-Franco, Martin Laclaustra, Eliseo Guallar, Ana Navas-Acien, Roberto Pastor-Barriuso, Josep Redon, Maria Tellez-Plaza
Summary: This study assessed the association between metal exposures and changes in renal endpoints, finding that zinc, arsenic, chromium, and tungsten may have nephrotoxic effects at low exposure levels, and other metals may also be associated with renal disease.
ENVIRONMENTAL POLLUTION
(2023)
Article
Medicine, General & Internal
Rihwa Choi, Sang Gon Lee, Eun Hee Lee
Summary: This retrospective study reviewed the estimated glomerular filtration rates (eGFR) calculated by three equations and investigated the changes in prevalence of chronic kidney diseases. The study found that the prevalence of decreased eGFR increased with age and that the equation based on CKD-EPI 2021 had a lower prevalence compared to the other equations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Zelai Xu, Pengtao Yue, James J. Feng
Summary: Albuminuria occurs when albumin leaks into the urine, and the mechanism behind it is not well understood. A gel-compression hypothesis suggests that compression of the glomerular basement membrane (GBM) acts as a barrier, but it fails to explain the reduction in filtration flux and thickening of the GBM. A second mechanism involving constriction of flow area at the slit diaphragm must also be considered. By combining these two mechanisms, the poroelastic model validates the hypothesis and explains the in vivo features of albuminuria.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Neurosciences
Erin L. Richard, Linda K. McEvoy, Eyal Oren, John E. Alcaraz, Gail A. Laughlin, Andrea Z. LaCroix, Rany M. Salem
Summary: In older men, albuminuria and hyperuricemia are associated with cognitive decline. However, no such associations were detected in women. eGFR showed no significant association with cognitive performance in either sex.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, General & Internal
Antonia Schuster, Louisa Steines, Karolina Mueller, Florian Zeman, Peter Findeisen, Bernhard Banas, Tobias Bergler
Summary: Evidence of tubular atrophy and interstitial fibrosis is prognostically unfavorable and associated with a premature graft loss after kidney transplantation. Recently, Dickkopf 3 (DKK3), a profibrotic glycoprotein released by stressed tubular epithelial cells, has been identified to cause IF/TA by regulating the Wnt/beta-catenin signaling and seems to engage a T-cell response. The aim of our study was to determine if a correlation between DKK3 and graft function exists and if DKK3 could be a new indicator to identify patients at risk for a deterioration in graft function. Patients, transplanted between 2016 and 2018, were analyzed with regard to DKK3 in the urine and graft function (creatinine, eGFR, albuminuria). Multivariable analyzes were used including known factors influencing graft function (PRA, donor age) to stress robustness of DKK3. The 3 and 12 month DKK3 values were significant predictors for subsequent graft function up to 36 months. An increase of DKK3 from month 3 to 12 of >= 25% showed a higher risk of an impaired graft function, with, e.g., a reduction in eGFR of about 9-10 ml/min in contrast to patients without intensified DKK3 increase. Induction therapy has an influence on DKK3 as patients induced with a T-cell depleting therapy showed a trend toward lower DKK3 values. In summary, our study is the first investigation of DKK3 in kidney transplant recipients and was able to show that DKK3 could forecast graft function. It is recommended to investigate the potential of DKK3 as a predictor of kidney function after transplantation in further studies.
FRONTIERS IN MEDICINE
(2022)
Article
Peripheral Vascular Disease
Tomohisa Yamashita, Sarfaraz Ahmad, Kendra N. Wright, Drew J. Roberts, Jessica L. VonCannon, Hao Wang, Leanne Groban, Louis J. Dell'Italia, Carlos M. Ferrario
Article
Peripheral Vascular Disease
Carlos M. Ferrario, Seethalakshmi R. Iyer, John C. Burnett, Sarfaraz Ahmad, Kendra N. Wright, Jessica L. VonCannon, Amit Saha, Leanne Groban
Summary: The study identified the presence of Ang (1-12) in the blood of both normotensive subjects and patients with hypertension, regardless of age or sex, suggesting its role as a potential source for Ang II production in the blood. Higher plasma Ang (1-12) concentrations in hypertensive patients were correlated with certain indicators.
Editorial Material
Medicine, Research & Experimental
Carlos M. Ferrario
Summary: The study reviewed the anticontractile response of perivascular adipose tissue in experimental heart failure induced in rats by occlusion of a coronary artery.
Review
Anesthesiology
Hao Wang, Amit K. Saha, Xuming Sun, Neal D. Kon, Carlos M. Ferrario, Leanne Groban
Summary: Hospitalizations for COVID-19 increase with age, likely due to increased fragility in biological repair systems and weakened immune systems. Changes in cardiac ACE2 expression related to cardiac diseases and pharmaceutical regimens may influence susceptibility to SARs-CoV-2 in older adults.
CURRENT OPINION IN ANESTHESIOLOGY
(2021)
Letter
Medicine, Research & Experimental
Carlos M. Ferrario, Leanne Groban, Hao Wang, Sarfaraz Ahmad
Article
Gastroenterology & Hepatology
Enis Kostallari, Bo Wei, Delphine Sicard, Jiahui Li, Shawna A. Cooper, Jinhang Gao, Mrunal Dehankar, Ying Li, Sheng Cao, Meng Yin, Daniel J. Tschumperlin, Vijay H. Shah
Summary: The wound-healing response in liver increases stiffness, which in turn amplifies fibrogenesis. This study reveals heterogeneous distribution of stiffness in fibrotic liver at macroscopic and microscopic levels and its impact on hepatic stellate cell heterogeneity. Stiffness in high-density extracellular matrix areas is mainly responsible for high liver stiffness. Moreover, a specific protein, FHL2, is found to be upregulated in a stiffness-sensitive subpopulation of hepatic stellate cells, promoting extracellular matrix production.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carlos M. Ferrario, Jessica L. VonCannon, Jie Zhang, Jorge P. Figueroa, Kendra N. Wright, Leanne Groban, Amit Saha, J. Wayne Meredith, Sarfaraz Ahmad
Summary: The engineered monoclonal antibody showed high specificity in neutralizing angiotensin II formation from h-Ang-(1-12) and effectively suppressed the vasoconstrictor activity of h-Ang-(1-12) both in hypertensive rats and in carotid artery strips. This antibody can potentially be explored for the treatment of hypertension.
Review
Urology & Nephrology
Carlos M. Ferrario, Leanne Groban, Hao Wang, Xuming Sun, Jessica L. VonCannon, Kendra N. Wright, Sarfaraz Ahmad
Summary: This paper addresses the limitations of current therapeutic approaches based on renin-angiotensin system blockade for hypertension and cardiovascular disease, and highlights the need for further understanding and enhancement of available treatments.
KIDNEY INTERNATIONAL SUPPLEMENTS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Tiffany Wu, Shawna A. Cooper, Vijay H. Shah
Summary: The new technologies enable noninvasive detection and staging of asymptomatic alcohol-associated liver disease, potentially improving patient outcomes through better clinical management.
Review
Peripheral Vascular Disease
Carlos M. Ferrario, Amit Saha, Jessica L. VonCannon, Wayne J. Meredith, Sarfaraz Ahmad
Summary: To address contemporary hypertension challenges, it is necessary to reexamine therapeutic accomplishments using angiotensin converting enzyme inhibitors and angiotensin II receptor blockers, and to better appreciate the evidence-based shortcomings from randomized clinical trials.
CURRENT HYPERTENSION REPORTS
(2022)
Article
Oncology
Shawna A. Cooper, Christopher J. Dick, Pinaki Misra, Nelson Leung, Carrie A. Schinstock, Marina Ramirez-Alvarado
Summary: This study evaluates the use of urinary extracellular vesicles (uEVs) as analytical diagnostic tools for AL amyloidosis. The findings suggest that uEVs can provide important tools for patient management, and the detection of LC oligomers from non-invasive urine samples can reduce patient burden and healthcare costs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao Ma, Seethalakshmi R. Iyer, Xiaoyu Ma, Shawn H. Reginauld, Yang Chen, Shuchong Pan, Ye Zheng, Dante G. Moroni, Yue Yu, Lianwen Zhang, Valentina Cannone, Horng H. Chen, Carlos M. Ferrario, S. Jeson Sangaralingham, John C. Burnett Jr
Summary: This study investigated the interaction between angiotensin II (ANGII) and the natriuretic peptide system (NPS) and found an inverse relationship between ANGII and natriuretic peptides. The results demonstrated that ANGII suppresses cGMP generation mediated by natriuretic peptides through an AT(1)/PKC dependent mechanism. This study highlights the importance of targeting both the renin-angiotensin-aldosterone system (RAAS) and NPS for cardiovascular protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Kenneth C. C. Riley Jr, Alaa Koleilat, Joseph A. Dugdale, Shawna A. Cooper, Trace A. Christensen, Lisa A. Schimmenti
Summary: Our understanding of inner ear hair cell ultrastructure has been expanded by using serial block-face scanning electron microscopy (SBFSEM) to evaluate hair cells in myo7aa(-/-) null zebrafish compared to wild-type zebrafish. We found that myo7aa(-/-) mutant ribbon synapses are smaller in volume and surface area, but similar in other measurements. This suggests that therapeutic intervention may be feasible for myo7aa(-/-) mutant ribbons.
Article
Chemistry, Multidisciplinary
Md Abdullah Shamim, Ayaz Shahid, Pabitra K. Sardar, Steven Yeung, Jeremiah Reyes, Jenny Kim, Cyrus Parsa, Robert Orlando, Jeffrey Wang, Kristen M. Kelly, Frank L. Meyskens, Bradley T. Andresen, Ying Huang
Summary: The R-carvedilol enantiomer, which does not bind to beta-adrenergic receptors, exhibits skin cancer preventive activity. Transfersomes loaded with R-carvedilol were prepared and characterized. These transfersomes showed slower drug release but significantly enhanced skin drug permeation and retention compared to the free drug.
Editorial Material
Pharmacology & Pharmacy
Bradley T. Andresen
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)