Article
Peripheral Vascular Disease
Michihiro Satoh, Takuo Hirose, Hironori Satoh, Shingo Nakayama, Taku Obara, Takahisa Murakami, Tomoko Muroya, Kei Asayama, Masahiro Kikuya, Takefumi Mori, Yutaka Imai, Takayoshi Ohkubo, Hirohito Metoki
Summary: This observational retrospective cohort study investigates the effects of ARBs and dCCBs monotherapy on renal function. The results show that ARBs can be recommended for kidney protection in a primary care setting, while dCCB treatment initially increases estimated glomerular filtration rate (eGFR) with no adverse effects on proteinuria.
JOURNAL OF HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Misaki Yamamoto, Fumi Takahashi-Yanaga, Masaki Arioka, Kazunobu Igawa, Katsuhiko Tomooka, Ken Yamaura, Toshiyuki Sasaguri
Summary: The study demonstrates that DM-celecoxib can prevent cardiac remodeling and kidney injury, reduce urinary albumin excretion, and provide protective effects by inhibiting the Wnt/β-catenin signaling pathway.
JOURNAL OF HYPERTENSION
(2021)
Review
Biochemistry & Molecular Biology
Luisa Petri Correa, Felipe Rodrigues Gatto, Guilherme Yanq Sen Bressani, Katharina Lanza, Ana Cristina Simoes e Silva
Summary: Premature newborns have impaired kidney development and function, making the diagnosis and management of kidney injury challenging. Current biomarkers for kidney function are inconsistent, highlighting the need for further research and standardization.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Obstetrics & Gynecology
Liang Chen, Jing Yue, Shulin Zhou, Yali Hu, Juan Li
Summary: Maternal malnutrition leads to intrauterine growth restriction and increases the risk of hypertension and renal dysfunction in offspring; administration of ouabain during pregnancy can partially restore nephron number, normalize blood pressure, and reduce urinary protein excretion; feeding a high-salt diet exacerbates these effects, but ouabain treatment can partially ameliorate them.
REPRODUCTIVE SCIENCES
(2021)
Article
Physiology
Kristina Rodionova, Martin Hindermann, Karl Hilgers, Christian Ott, Roland E. Schmieder, Mario Schiffer, Kerstin Amann, Roland Veelken, Tilmann Ditting
Summary: The study showed that low doses of an Ang II inhibitor candesartan in congestive heart failure rats can have similar effects on tubular sodium and water reabsorption as renal denervation. Additionally, decreases in renal sympathetic nerve activity induced by volume expansion were impaired in congestive heart failure rats but unaffected by candesartan.
KIDNEY & BLOOD PRESSURE RESEARCH
(2021)
Article
Oncology
Chie Masaki, Kiminori Sugino, Sakiko Kobayashi, Yoshie Hosoi, Reiko Ono, Haruhiko Yamazaki, Junko Akaishi, Kiyomi Y. Hames, Chisato Tomoda, Akifumi Suzuki, Kenichi Matsuzu, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Koichi Ito
Summary: The study indicates that long-term administration of lenvatinib in DTC patients leads to a sustained decline in renal function, particularly after a treatment duration of more than 2 years. Proteinuria is identified as a risk factor for declining eGFR. Patients with better baseline renal function exhibit renal reserve capacity, which prolongs clinical outcomes. Decision-making protocols should carefully weigh the benefits of continued lenvatinib treatment against potential risks.
Review
Medicine, General & Internal
Verdiana Ravarotto, Giovanni Bertoldi, Matteo Rigato, Elisa Pagnin, Laura Gobbi, Paul A. Davis, Lorenzo A. Calo
Summary: Adverse changes in cardiovascular and renal systems are major contributors to overall morbidity and mortality. This review compares the effects and activity of various systems in hypertension and Gitelman's and Bart-ter's syndromes, providing insights into the control mechanisms and health status reflection of the cardiovascular and renal systems.
Article
Cardiac & Cardiovascular Systems
Nirupama Ramkumar, Deborah Stuart, Caitlin S. Peterson, Chunyan Hu, William Wheatley, Jae Min Cho, J. David Symons, Donald E. Kohan
Summary: Loss of sPRR reduces baseline blood pressure, decreases Ang II-induced hypertension and renal injury, and is associated with greater endothelium-dependent vasorelaxation of resistance-sized arteries.
CIRCULATION RESEARCH
(2021)
Article
Physiology
Acaris Benetti, Flavia Leticia Martins, Leticia Barros Sene, Maria Heloisa M. Shimizu, Antonio C. Seguro, Weverton M. Luchi, Adriana C. C. Girardi
Summary: The study found that DPP4 inhibition can alleviate proteinuria in rats with chronic kidney disease and prevent the reduction of important protein expression. Furthermore, the urinary DPP4 activity may serve as a biomarker for renal disease and progression.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Pediatrics
Tomas Seeman, Friederike Weigel, Kveta Blahova, Filip Fencl, Stepanka Pruhova, Katharina Hermes, Richard Klaus, Barbel Lange-Sperandio, Veit Grote, Ulrike John-Kroegel
Summary: The study found that high blood pressure is present in 22% of children with RCAD syndrome and ambulatory hypertension in 14% of them.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Ke Lin, Wu Luo, Na Yang, Lan Su, Hao Zhou, Xiang Hu, Yi Wang, Zia A. Khan, Weijian Huang, Gaojun Wu, Guang Liang
Summary: The study reveals that Ang II induces inflammation and fibrosis in renal tubular epithelial cells through MyD88. Inhibition of MyD88 decreases these adverse effects and protects renal function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fenglin Wang, Jenny Ngo, Yuwen Li, Hongbing Liu, Chao-Hui Chen, Zubaida Saifudeen, Maria Luisa S. Sequeira-Lopez, Samir S. El-Dahr
Summary: Dot1, an epigenetic regulator, plays crucial roles in organismal development and homoeostasis by regulating telomeric silencing, genomic integrity, and homoeotic gene expression. Studies in fruit flies and mice have shown that Dot1 functions differently in various cell lineages, particularly in the development of the kidney. The link between H3K79me and renal developmental pathways highlights the importance of chromatin-based mechanisms in organogenesis.
Review
Biochemistry & Molecular Biology
Supaporn Kulthinee, Adis Tasanarong, Martha Franco, Luis Gabriel Navar
Summary: In angiotensin II (Ang II)-dependent hypertension, both angiotensin II type 1 receptors (AT1R) and purinergic P2X receptors (P2XR) are involved in maintaining renal vasoconstriction. The interaction between AT1R and P2XR activation is regulated by the release of adenosine triphosphate (ATP). P2XR exerts a dominant influence that can abrogate the actions of AT1R on renal afferent arterioles in Ang II-dependent hypertension. This finding has important clinical implications for the treatment of kidney function impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Chun Gan, Xindi Zhou, Dan Chen, Huan Chi, Jiawen Qiu, Hui You, Yaxi Chen, Mo Wang, Haiping Yang, Wei Jiang, Qiu Li
Summary: In this study, the researchers found that different mutation types after the vitamin B12-binding domain of Cubilin (encoded by CUBN) uncouple proteinuria from glomerular filtration barrier, which may be a common benign condition in humans and may not require any treatment or renal biopsy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Physiology
Xiaohua Huang, Shereen M. Hamza, Wenqing Zhuang, William A. Cupples, Branko Braam
Summary: Increasing RVP can lead to reduced renal blood flow and glomerular filtration rate, but inhibiting or clamping ANG II levels may attenuate renal vasoconstriction without affecting systemic blood pressure or heart rate. RBF autoregulation remains intact during venous congestion, suggesting a potential role in mitigating vasoconstriction.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Virginia Reverte, Venkateswara R. Gogulamudi, Carla B. Rosales, Diego C. Musial, Sabrina R. Gonsalez, Alberto J. Parra-Vitela, Michelle Galeas-Pena, Venkata N. Sure, Bruna Visniauskas, Sarah H. Lindsey, Prasad V. G. Katakam, Minolfa C. Prieto
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2020)
Article
Developmental Biology
L. Oltra, V. Reverte, B. Garces, G. Li Volti, J. M. Moreno, F. J. Salazar, M. T. Llinas
Meeting Abstract
Endocrinology & Metabolism
Chad Schwartzkopf, Virginia Reverte Ribo, Francisca Rodriguez, Lidia Oltra, Juan Manuel Moreno Ayuso, M. Teresa Llinas, Alejandro S. Nicolas, Courtney Shea, Mark Currie, Juli E. Jones, Emmanuel S. Buys, Jaime Masferrer, Francisco Javier Salazar Aparicio
Article
Multidisciplinary Sciences
Lidia Oltra, Virginia Reverte, Antonio Tapia, Juan M. Moreno, Francisco J. Salazar, Maria T. Llinas
Article
Biochemistry & Molecular Biology
Juan M. Moreno, Carlos M. Martinez, Carlos de Jodar, Virginia Reverte, Antonio Bernabe, F. Javier Salazar, Maria T. Llinas
Summary: The mechanisms involved in renal dysfunction induced by high-fat diet in subjects with altered renal development are not well-studied. This study found that there are sex-dependent differences in the hypertension and deterioration of renal function in rats with prolonged HFD and ARDev. The deterioration of renal function induced by HFD in rats with ARDev is Ang II-dependent and mediated by increments in oxidative stress and immune system activation, which may contribute to sex-dependent increments in oxidative stress and glomerular damage.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Virginia Reverte, Francisca Rodriguez, Lidia Oltra, Juan M. Moreno, Maria T. Llinas, Courtney M. Shea, Chad D. Schwartzkopf, Emmanuel S. Buys, Jaime L. Masferrer, F. Javier Salazar
Summary: The combined treatment of an SGLT2 inhibitor and an sGC stimulator improves cardiovascular, renal, and metabolic dysfunction in hypertensive rats with altered renal development and prolonged exposure to a high-fat diet. The effects of the simultaneous treatment may be related to a greater reduction in the inflammatory status.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Bruna Visniauskas, Virginia Reverte, Caleb M. Abshire, Benard O. Ogola, Carla B. Rosales, Michelle Galeas-Pena, Venkata N. Sure, Siva S. V. P. Sakamuri, Nicholas R. Harris, Isabella Kilanowski-Doroh, Alexandra B. Mcnally, Alec C. Horton, Margaret Zimmerman, Prasad V. G. Katakam, Sarah H. Lindsey, Minolfa C. Prieto
Summary: Plasma soluble prorenin receptor (sPRR) displays sexual dimorphism and is higher in women with type 2 diabetes mellitus (T2DM). This study investigates if plasma sPRR contributes to sex differences in the activation of the systemic renin-angiotensin-aldosterone system (RAAS) and vascular damage in a high-fat diet (HFD)-induced T2DM model.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jean Michell Santoyo, Jose Antonio Noguera, Francisco Aviles, Trinidad Hernandez-Caselles, Catalina de Paco-Matallana, Juan Luis Delgado, Santiago Cuevas, M. Teresa Llinas, Isabel Hernandez
Summary: This study aimed to assess the effects of pravastatin on the generation of circulating extracellular vesicles in women at high risk of term preeclampsia. The results showed that pravastatin can reduce the levels of cell-derived membrane vesicles in the circulation of high-risk preeclampsia patients, which may help reduce the characteristics of endothelial dysfunction, inflammation, and other features of the disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Physiology
Nancy J. Hong, Agustin Gonzalez-Vicente, Fara Saez, Jeffrey L. Garvin
Summary: The study showed that impaired flow-induced NO production in the thick ascending limbs of Dahl salt-sensitive rats is mainly due to NOS3 uncoupling and diminished NOS3 expression, rather than simple scavenging. The difference between strains was enhanced on a high-salt diet, further elucidating the pathogenesis of salt-sensitive hypertension.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Correction
Physiology
J. M. Moreno, A. Tapia, C. M. Martinez, V Reverte, L. Oltra, M. T. Llinas, F. J. Salazar
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2020)