Article
Biochemistry & Molecular Biology
Andrew Kataba, Tarryn L. Botha, Shouta M. M. Nakayama, Yared B. Yohannes, Yoshinori Ikenaka, Victor Wepener, Mayumi Ishizuka
Summary: The study found that environmentally relevant levels of lead can have negative impacts on the development and survival of zebrafish embryos, affecting embryo activity, cardiovascular effects, neuromuscular effects, and antioxidant system dysregulation.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rafael Xavier Martins, Leonardo Vieira, Juliana Alves Costa Ribeiro Souza, Marilia Guia Flor Silva, Marta Silva Muniz, Terezinha Souza, Fernando Ramos Queiroga, Monica Rodrigues Ferreira Machado, Patricia Mirella da Silva, Davi Farias
Summary: The herbicide 2,4-D was found to be hepatotoxic to zebrafish larvae, reducing their survival rate and causing severe changes in liver tissue structure, such as nuclear eccentricity and cytoplasmic vacuolization. Indications of liver damage were also observed through altered enzyme activity.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Ruirui Dong, Ningzhen Ye, Jing Wang, Shaojie Zhao, Tiejun Wang, Gaoying Wang, Xinrui Shi, Jing Cheng, Yan Zhang, Tingting Yao, Minjian Chen, Ting Zhang, Liang Luo
Summary: This study identified three serum exosome miRNAs with significantly lower expression levels in ICP patients, which could serve as potential biomarkers for the diagnosis of ICP. Multiple logistic regression analysis showed that a combination of hsa-miR-4271 and hsa-miR-1275 can improve the diagnostic accuracy of ICP. Furthermore, these three miRNAs are associated with lipid metabolism, apoptosis, oxidative stress, and the MAPK signaling pathway.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Katharina John, Martin Franck, Sherin Al Aoua, Monika Rau, Yvonne Huber, Joern M. Schattenberg, Andreas Geier, Matthias J. Bahr, Heiner Wedemeyer, Klaus Schulze-Osthoff, Heike Bantel
Summary: The combination of FIB-4 and M30 allows for a more reliable identification of patients at risk for progressed NAFLD and has the potential to improve patient stratification.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Yajun Li, Yang Xiang, Zhongxia Yang, Xiongzhe Han, Jiewen Lin, Zhengfang Hu
Summary: A novel laser irradiation method was proposed for controlling Pieris rapae larvae as an alternative to chemical pesticides, with optimal parameter combinations identified through experimentation. The validation experiment showed high antifeedant and mortality rates in treated larvae, indicating the effectiveness of the laser-based approach.
APPLIED SCIENCES-BASEL
(2021)
Article
Environmental Sciences
Yanhua Wang, Lu Lv, Chao Xu, Dou Wang, Guiling Yang, Xinquan Wang, Hongbiao Weng, Qiang Wang
Summary: The study found that the mixture of thiophanate-methyl and fenvalerate showed higher toxicity to zebrafish embryos compared to individual chemicals, and had a greater impact on the expression of related genes in zebrafish. Therefore, future environmental risk assessments need to consider the effects of pesticide mixtures on aquatic ecosystems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Maria Belen Rabaglino, Dessie Salilew-Wondim, Adriana Zolini, Dawit Tesfaye, Michael Hoelker, Pat Lonergan, Peter J. J. Hansen
Summary: This study developed a gene signature model to predict embryonic competence for survival by integrating transcriptomic data from blastocysts and elongating conceptuses. The potential biomarkers were validated with independent embryonic data sets using machine-learning algorithms. The results showed that the predictions of embryonic development fate based on these biomarkers were highly accurate.
Article
Environmental Sciences
Kayla Cayemitte, Nadege Aoki, Sophie R. Ferguson, T. Aran Mooney, Amy Apprill
Summary: The settlement of coral larvae is crucial for the success and longevity of coral reefs. However, the proliferation of Ramicrusta sp., a red-brown encrusting alga, poses a serious threat to coral recruitment by overgrowing corals and causing high mortality rates in larvae compared to crustose coralline algae (CCA) and control groups.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Ecology
Andrew P. Hopkins, Jason T. Hoverman
Summary: In this study, the acute toxicity of two widely used fungicides, chlorothalonil and pyraclostrobin, on six North American larval amphibian species was examined. The results showed that pyraclostrobin was approximately 3.5x more toxic than chlorothalonil, with estimated LC50 values ranging from 5-18 μg/L for pyraclostrobin and 15-50 μg/L for chlorothalonil. Salamanders were found to be 3x more sensitive to pyraclostrobin than anuran species and equally as sensitive to chlorothalonil. The estimated LC50 values fell within the expected environmental concentration, indicating potential direct mortality in these species. Additional research is needed to assess the overall risk of these fungicides to amphibians and their aquatic habitats.
Article
Environmental Sciences
Keyuan Zhong, Yunlong Meng, Juan Wu, You Wei, Yong Huang, Jinze Ma, Huiqiang Lu
Summary: The study revealed that flupyradifurone has toxic effects on zebrafish embryos, leading to decreased survival rate, heart rate, and body length, as well as abnormal heart development and increased oxidative stress levels. Moreover, flupyradifurone also affects the expression of genes related to apoptosis and heart development. The findings provide new evidence on the toxic effects of flupyradifurone and the potential risks associated with its residues in agricultural products and the environment.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Qibao He, Shiyu Zhang, Fang Yin, Qiongqiong Liu, Quan Gao, Jinjing Xiao, Yong Huang, Linsheng Yu, Haiqun Cao
Summary: This study investigated the residue of pyrethroid insecticides in bee bread and honey from multiple provinces in China and found that over half of the samples contained at least one type of insecticide. The acute toxicity of these insecticides on larvae was assessed based on the detection results, and the hazard quotient was calculated. These findings provide valuable guidance for the beekeeping industry and pesticide regulation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Zhaojun Geng, Yongxun Jin, Fushi Quan, Siyi Huang, Shuming Shi, Bing Hu, Zhichao Chi, Ilkeun Kong, Mingjun Zhang, Xianfeng Yu
Summary: This study found that MXC has significant effects on the development of early porcine embryos, leading to decreased cleavage rate, blastocyst rate, hatching rate, and total cell count. Moreover, MXC increases the production of reactive oxygen species, decreases mitochondrial membrane potential, and reduces mitochondrial copy number during early embryo development. Furthermore, MXC treatment leads to increased blastocyst apoptosis and DNA damage, decreased cell proliferation, and altered expression of pluripotency-related and apoptosis-related genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Bailey R. Tasker, Karli N. Honebein, Allie M. Erickson, Julia E. Misslin, Paul Hurst, Sarah Cooney, Skylar Riley, Scott A. Griffith, Betsy A. Bancroft
Summary: Climate change and invasive species have significant negative effects on Pacific chorus frogs, with the presence of invasive bullfrogs having a larger impact than climate conditions. Future climate conditions may lead to faster development and increased weight in Pacific chorus frogs, but in the presence of invasive bullfrogs, tadpoles may exhibit slower growth. The ability of Pacific chorus frogs to compensate for the negative effects of bullfrogs through increased allocation of energy towards mass suggests strong plasticity in response to changing environments.
Article
Marine & Freshwater Biology
Yiming Xiong, Xuanyue Chen, Feng Li, Zhaojing Chen, Zhanfen Qin
Summary: Aquatic toxicity is an important factor in chemical risk assessment. Researchers have developed a convenient and efficient zebrafish larvae acute toxicity (FLT) test, which involves exposing zebrafish larvae for 48 hours. The FLT test showed high correlation with the existing acute toxicity data.
AQUATIC TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anna Cecchele, Greta Chiara Cermisoni, Elisa Giacomini, Monica Pinna, Paola Vigano
Summary: This article provides a review on the cellular and molecular heterogeneity of embryo fragmentation, describing different embryo fragment-like cellular structures and their possible functions and origins. The occurrence of embryo fragmentation is associated with various mechanisms that may have different effects on embryo competence. Therefore, the practice of removing fragments from the embryo before transfer to improve implantation potential should be reconsidered based on the current observations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)