Article
Obstetrics & Gynecology
A. Volodarsky-Perel, T. N. Ton Nu, R. Orvieto, R. Mashiach, A. Machado-Gedeon, Y. Cui, J. Shaul, M. H. Dahan
Summary: The study suggests that embryo vitrification significantly affects placental histopathology pattern and may lead to a higher prevalence of dysfunctional labor in singleton live births.
HUMAN REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Lijuan Fan, Na Li, Xin Mu, Pengfei Qu, Juanzi Shi
Summary: This study aims to examine the effect of pre-gravid BMI on gestational hypertension (GH) in singleton pregnancy following frozen-thawed embryo transfer (FET). The retrospective cohort study included 7,502 women who achieved singleton pregnancy after FET in a tertiary hospital. The results showed that pre-gravid overweight and obesity are associated with a higher risk of GH.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Ambrogio P. Londero, Claudia Massarotti, Anjeza Xholli, Arrigo Fruscalzo, Angelo Cagnacci
Summary: This study reevaluated the association between assisted reproduction technologies (ART) and breech presentation, and found that both ART and other subfertility treatments (OST) were independent risk factors for breech at delivery. The prevalence of breech remained stable during the study period for both ART and OST.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Obstetrics & Gynecology
Caitlin R. Sacha, Daksha Gopal, Chia-Ling Liu, Howard R. Cabral, Judy E. Stern, Daniela A. Carusi, Catherine Racowsky, Charles L. Bormann
Summary: This study compares the obstetric and perinatal outcomes of single-step and sequential culture media systems for embryo conception. The results indicate that single-step culture is associated with increased odds of LGA, while there were no significant differences in other outcomes.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Zhe-xin Ni, Kun-ming Wan, Zhi-hao Zhou, Yan-ping Kuang, Chao-qin Yu
Summary: In frozen embryo transfer (FET) cycles, there were no significant differences observed in neonatal outcomes such as preterm birth, low birthweight, and small for gestational age between different maternal age groups.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jiarong Li, Jingyu Li, Yiyuan Zhang, Kuona Hu, Na Chen, Jie Gao, Jingmei Hu, Linlin Cui, Zi-Jiang Chen
Summary: The vanishing twin has an impact on the perinatal outcomes of the surviving singleton, with a greater impact when the twin vanishes later in gestation. Close monitoring during the perinatal period is recommended for these neonates, and elective single embryo transfer should be considered.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Mengmeng Li, Jonathan Kort, Valerie L. Baker
Summary: The study compared perinatal outcomes in singleton pregnancies conceived following frozen embryo transfer with or without preimplantation genetic testing. The findings suggested a slightly increased risk of preterm birth with preimplantation genetic testing, while other outcomes such as birthweight showed no significant differences. Further investigation is warranted to fully understand the implications.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Hanxiang Sun, Xiujuan Su, Yang Liu, Guohua Li, Xiaosong Liu, Qiaoling Du
Summary: This study aimed to explore the association between abortion history and the outcomes of singleton pregnancies after assisted reproductive technology (ART). The research found that pregnant women with a history of abortion were more likely to have gestational diabetes mellitus (GDM), thyroid-related diseases, and placenta-related diseases. Women who had only a history of induced abortion had a higher risk of placenta-related diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Cristina Bianchi, Alex Brocchi, Walter Baronti, Francesca Nicoli, Fabrizia Citro, Michele Aragona, Vito Cela, Stefano Del Prato, Alessandra Bertolotto
Summary: This study aimed to evaluate the impact of assisted reproductive technology (ART) on the risk of gestational diabetes mellitus (GDM) in single pregnancies. The study found that ART women had a significantly higher prevalence of GDM compared to women with spontaneous conception, and ART women above the age of 40 were more likely to develop GDM. Additionally, ART treatment appeared to be associated with an increased rate of preterm delivery, lower neonatal birth weight, and Apgar score, especially in women with GDM.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Obstetrics & Gynecology
Lihua Zhu, Jie Wang, Linjun Chen, Weihua Jiang, Junshun Fang, Shanshan Wang, Fei Lin, Ningyuan Zhang
Summary: The development rate of blastocysts can influence neonatal outcomes after blastocyst transfer cycles when the morphological score of the transferred blastocysts is similar. Day-6 single blastocyst transfer is associated with a higher risk of preterm birth compared to day-5 single blastocyst transfer in good and average morphological scoring blastocysts.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Kayhan Yakin, Bulent Urman, Basak Balaban
Summary: This study analyzed data on patient demographics and treatment practices in assisted reproductive technology (ART) in Turkey over a 25-year period. The results showed significant changes in patient characteristics, treatment indications, and clinical and laboratory practices. The use of single embryo transfer increased, and improvements in cryopreservation techniques contributed to higher clinical pregnancy rates while reducing multiple births.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Louise Laub Asserhoj, Anne Laerke Spangmose, Anna-Karina Aaris Henningsen, Tine Dalsgaard Clausen, Soren Ziebe, Rikke Beck Jensen, Anja Pinborg
Summary: The study suggests that programmed frozen embryo transfer cycles may lead to adverse obstetric and perinatal outcomes, and recommends considering natural cycle FET protocol when possible. Larger properly sized randomized controlled trials are needed in the future to further investigate the outcomes of FET in programmed versus natural cycles.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Guy Morris, Dimitrios Mavrelos, Rabi Odia, Xavier Vinals Gonzalez, Suzanne Cawood, Ephia Yasmin, Wael Saab, Paul Serhal, Srividya Seshadri
Summary: Studies have shown that paternal age has an impact on the outcomes of IVF/ICSI cycles, with older paternal age being associated with increased miscarriage rate and decreased live birth rate. However, paternal age over 50 is not independently associated with miscarriage risk following ART. It is important to communicate a public health message encouraging men not to delay fatherhood.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Zexin Yang, Xuelian Bai, Ying Han, Zhangxiang Zou, Yazhen Fan, Xinyan Wang, Haining Luo, Yunshan Zhang
Summary: This study investigates the influence of different endometrial preparation protocols on obstetric and perinatal outcomes and the role of BMI in it. The results suggest that programmed frozen embryo transfer cycles have an increasing risk of pregnancy-induced hypertension compared to true natural cycle frozen embryo transfer cycles, and this risk increases as BMI increases.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Medicine, General & Internal
Annacandida Villani, Andrea Fontana, Stefano Barone, Silvia de Stefani, Mariangela Primiterra, Massimiliano Copetti, Concetta Panebianco, Cristiana Parri, Natale Scianname, Pasqua Anna Quitadamo, Alessandra Tiezzi, Liliana Santana, Annamaria Maglione, Federica D'Amato, Francesco Perri, Simone Palini, Valerio Pazienza
Summary: This study aimed to analyze the microbiota of human cervical swab and its correlation with Assisted Reproductive Technologies (ART) outcomes. The results showed that different microorganisms were predictive of women's pregnancy outcomes, with significant differences found at the species level, including Lactobacillus salivarius and Lactobacillus rhamnosus. The abundance of Lactobacillus crispatus increased and Lactobacillus iners decreased in the favorable group compared to the unfavorable group, indicating their association with positive ART outcomes. Furthermore, the presence of Bifidobacterium, along with other lactobacilli, was more abundant in the favorable group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Sara J. Bergenheim, Marte Saupstad, Nina Pistoljevic, Anders Nyboe Andersen, Julie Lyng Forman, Kristine Lossl, Anja Pinborg
Summary: The number of frozen embryo transfer cycles in Europe has been steadily increasing, with immediate FET potentially leading to higher live birth and pregnancy rates compared to postponed FET. However, more high-quality evidence from randomized controlled trials is needed to confirm these findings and determine the best clinical practice.
HUMAN REPRODUCTION UPDATE
(2021)
Article
Obstetrics & Gynecology
Rebecka Hansen, Anne Laerke Spangmose, Veronika Markova Sommer, Charlotte Holm, Finn Stener Jorgensen, Lone Krebs, Anja Pinborg
Summary: This study aimed to assess the associations between first trimester iron deficiency and obstetric and perinatal outcomes in singleton pregnant women, as well as overall first trimester iron status and post-treatment iron status after intensified iron supplementation. The results showed that iron-deficiency anemia was associated with an increased risk of gestational diabetes, while non-anemic iron deficiency was associated with an increased risk of stillbirth. However, the risk estimates were imprecise due to the small number of events. Additionally, iron deficiency was present in the first trimester in a considerable number of women and often persisted despite 4 weeks of intensified iron supplementation.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Manuel Fernandez Sanchez, Hana Visnova, Per Larsson, Claus Yding Andersen, Marco Filicori, Christophe Blockeel, Anja Pinborg, Yacoub Khalaf, Bernadette Mannaerts
Summary: This study aimed to investigate whether the addition of CG beta to the long GnRH agonist protocol for ovarian stimulation increased the number of good-quality blastocysts. The results showed that the addition of CG beta reduced the number of intermediate follicles and related downstream parameters, including the number of oocytes and blastocysts.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
T. Kopp, A. Pinborg, C. H. Glazer, M. Magyari
Summary: The study found no direct association between female infertility and developing MS, but the prevalence of MS was slightly higher among women undergoing MAR treatment. Infertile women may undergo MAR treatment more often due to increased awareness about the possibility of treatment, sexual dysfunction related to MS, and the need to avoid long periods without disease modifying therapy.
HUMAN REPRODUCTION
(2022)
Article
Medicine, General & Internal
Anne Laerke Spangmose, Niels Skipper, Sine Knorr, Tina Wullum Gundersen, Rikke Beck Jensen, Peter Damm, Erik Lykke Mortensen, Anja Pinborg, Jannet Svensson, Tine Clausen
Summary: This study aimed to investigate the association between maternal type 1 diabetes during pregnancy and offspring cognition. The researchers used Danish registers to obtain test scores in math and reading from Danish children attending public schools. The study found that offspring of mothers with type 1 diabetes achieved lower test scores compared to the background population but similar test scores compared to offspring of fathers with type 1 diabetes.
Article
Obstetrics & Gynecology
R. Klemetti, B. Perry, A. K. Aaris Henningsen, A. Laerke Spangmose, A. Pinborg, S. Opdahl, L. Bente Romundstad, C. Bergh, U. B. Wennerholm, A. Tiitinen, M. Gissler
Summary: The study found that children conceived through ART are at a higher risk of puberty disorders, with girls more likely to experience early puberty and boys more likely to experience late puberty.
HUMAN REPRODUCTION
(2022)
Article
Medicine, General & Internal
Nona Sargisian, Birgitta Lannering, Max Petzold, Signe Opdahl, Mika Gissler, Anja Pinborg, Anna-Karina Aaris Henningsen, Aila Tiitinen, Liv Bente Romundstad, Anne Laerke Spangmose, Christina Bergh, Ulla-Britt Wennerholm
Summary: This study investigated the risk of childhood cancer in children born after assisted reproductive technology (ART), particularly after frozen-thawed embryo transfer (FET), compared to children born after fresh embryo transfer and spontaneous conception. The findings showed that children born after FET had a higher risk of childhood cancer. However, the results should be interpreted cautiously due to the small number of children with cancer in the study.
Article
Obstetrics & Gynecology
Allan A. Pacey, Guido Pennings, Edgar Mocanu, Janne Rothmar, Anja Pinborg, Stine Willum Adrian, Corey Burke, Anne-Bine Skytte
Summary: More applicants are accepted as donors in Denmark than in the USA, and those who choose ID release are more frequently accepted than those who do not.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
N. Friis Wang, J. W. Bogstad, S. E. Pors, M. R. Petersen, A. Pinborg, C. Yding Andersen, K. Lossl
Summary: Continuous low-dose hCG administration for 8 weeks does not increase the proportion of antral follicles reaching the preovulatory state in women with low ovarian reserve.
HUMAN REPRODUCTION
(2023)
Article
Public, Environmental & Occupational Health
Kjersti Westvik-Johari, Siri E. Haberg, Deborah A. Lawlor, Liv Bente Romundstad, Christina Bergh, Ulla-Britt Wennerholm, Mika Gissler, Anna-Karina A. Henningsen, Aila Tiitinen, Anja Pinborg, Signe Opdahl
Summary: Studies have shown that children conceived through assisted reproductive technology (ART) have lower perinatal mortality compared to those conceived naturally. However, this finding may be biased due to selective fertility and carryover effects.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Obstetrics & Gynecology
N. Friis Wang, J. W. Bogstad, M. R. Petersen, A. Pinborg, C. Yding Andersen, K. Lossl
Summary: Does 8 weeks of daily low-dose hCG administration affect androgen or inhibin B levels in serum and/or follicular fluid (FF) during the subsequent IVF/ICSI cycle in women with low ovarian reserve? Androgen levels in serum and FF, and inhibin B levels in serum, decreased following 8 weeks of hCG administration.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Louise Laub Asserhoj, Ikram Mizrak, Gerda Ferja Heldarskard, Tine Dalsgaard Clausen, Eva R. Hoffmann, Gorm Greisen, Katharina M. Main, Per Lav Madsen, Rikke Beck Jensen, Anja Pinborg
Summary: The study found that BMI in childhood does not differ between children conceived after frozen embryo transfer (FET), fresh embryo transfer (fresh-ET), or natural conception (NC). Previous studies have shown that high childhood BMI is strongly associated with obesity, cardiometabolic disease, and mortality in adulthood. Children conceived after FET have a higher risk of being born large for gestational age (LGA), which is associated with an increased risk of childhood obesity. The study suggests that ART-induced epigenetic variations may influence fetal size at birth as well as BMI and health later in life.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Nienke E. van Hoogenhuijze, Gemma Lahoz Casarramona, Sarah Lensen, Cindy Farquhar, Mohan S. Kamath, Aleyamma T. Kunjummen, Nick Raine-Fenning, Sine Berntsen, Anja Pinborg, Shari Mackens, Zeynep Ozturk Inal, Ernest H. Y. Ng, Jennifer S. M. Mak, Sachin A. Narvekar, Wellington P. Martins, Mia Steengaard Olesen, Helen L. Torrance, Ben W. Mol, Marinus J. C. Eijkemans, Rui Wang, Frank J. M. Broekmans
Summary: This meta-analysis based on individual participant data suggests that endometrial scratching may improve live birth rates in women undergoing IVF/ICSI. However, the effectiveness of scratching may vary in different subgroups, and the timing of the procedure may also play a role. Therefore, the use of endometrial scratching in clinical practice should be done cautiously and patients should be informed about the level of evidence and uncertainties.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Obstetrics & Gynecology
Nathalie Soderhamn Bulow, Agnieszka Katarzyna Warzecha, Mette Villads Nielsen, Claus Yding Andersen, Marianne Dreyer Holt, Morten Ronn Petersen, Negjyp Sopa, Anne Zedeler, Anne Lis Englund, Anja Pinborg, Marie Louise Grondahl, Sven Olaf Skouby, Nicholas Stephen Macklon
Summary: LZ co-treatment during ovarian stimulation with gonadotropins for in IVF does not impact follicle recruitment, oocyte number and quality, embryo quality, or live birth rate (LBR).
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Pietro Santulli, Christophe Blockeel, Mathilde Bourdon, Giovanni Coticchio, Alison Campbell, Michel De Vos, Kirsten Tryde Macklon, Anja Pinborg, Juan A. Garcia-Velasco
Summary: While there is extensive research on fertility preservation in women with malignant diseases, there is limited research on the role of fertility preservation in non-malignant conditions. This includes various benign gynaecological conditions that may affect reproductive potential. Currently, there is insufficient data to develop guidelines for clinical practice in fertility preservation for women with benign gynaecological conditions.
HUMAN REPRODUCTION OPEN
(2023)